Search Results - "Sekaly, Rafick P."

Normalizing the environment recapitulates adult human immune traits in laboratory mice by Beura, Lalit K., Hamilton, Sara E., Bi, Kevin, Schenkel, Jason M., Odumade, Oludare A., Casey, Kerry A., Thompson, Emily A., Fraser, Kathryn A., Rosato, Pamela C., Filali-Mouhim, Ali, Sekaly, Rafick P., Jenkins, Marc K., Vezys, Vaiva, Haining, W. Nicholas, Jameson, Stephen C., Masopust, David

“…The immune system of laboratory mice raised in an ultra-hygienic environment resembles that ofnewborn humans, but can be induced to resemble the immune system…”
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Barriers to a cure for HIV: new ways to target and eradicate HIV-1 reservoirs by Katlama, Christine, Prof, Deeks, Steven G, MD, Autran, Brigitte, Prof, Martinez-Picado, Javier, Prof, van Lunzen, Jan, Prof, Rouzioux, Christine, Prof, Miller, Michael, PhD, Vella, Stefano, MD, Schmitz, Joern E, Prof, Ahlers, Jeffrey, PhD, Richman, Douglas D, MD, Sekaly, Rafick P, Dr

“…Summary Antiretroviral therapy for HIV infection needs lifelong access and strict adherence to regimens that are both expensive and associated with toxic…”
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Increased homeostatic cytokines and stability of HIV-infected memory CD4 T-cells identify individuals with suboptimal CD4 T-cell recovery on-ART by Pino, Maria, Pereira Ribeiro, Susan, Pagliuzza, Amélie, Ghneim, Khader, Khan, Anum, Ryan, Emily, Harper, Justin L, King, Colin T, Welbourn, Sarah, Micci, Luca, Aldrete, Sol, Delman, Keith A, Stuart, Theron, Lowe, Michael, Brenchley, Jason M, Derdeyn, Cynthia A, Easley, Kirk, Sekaly, Rafick P, Chomont, Nicolas, Paiardini, Mirko, Marconi, Vincent C

“…Clinical outcomes are inferior for individuals with HIV having suboptimal CD4 T-cell recovery during antiretroviral therapy (ART). We investigated if the…”
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Myeloid Cells Enriched for a Dendritic Cell Population From People Living With HIV Have Altered Gene Expression Not Restored by Antiretroviral Therapy by Murray, Shannon M, Zhang, Yuwei, Douek, Daniel C, Sekaly, Rafick P

“…Antiretroviral therapy (ART) for human immunodeficiency virus (HIV) infections has been designed to optimize CD4 T-cell survival and limit HIV replication…”
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Anisocytosis is Associated With Short-Term Mortality in COVID-19 and May Reflect Proinflammatory Signature in Uninfected Ambulatory Adults by Hornick, Andrew, Tashtish, Nour, Osnard, Michael, Shah, Binita, Bradigan, Allison, Albar, Zainab, Tomalka, Jeffrey, Dalton, Jarrod, Sharma, Ashish, Sekaly, Rafick P., Hejal, Rana, Simon, Daniel I., Zidar, David A., Al-Kindi, Sadeer G.

“…BackgroundRed cell distribution width (RDW), a measure of anisocytosis, is observed in chronic inflammation and is a prognostic marker in critically ill…”
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Influence of HLA-B57 on clinical presentation and viral control during acute HIV-1 infection by ALTFELD, Marcus, ADDO, Marylyn M, ALLEN, Todd M, FEENEY, Margaret E, KAHN, James O, SEKALY, Rafick P, LEVY, Jay A, ROCKSTROH, Jürgen K, GOULDER, Philip J. R, WALKER, Bruce D, ROSENBERG, Eric S, HECHT, Frederick M, LEE, Paul K, VOGEL, Martin, YU, Xu G, DRAENERT, Rika, JOHNSTON, Mary N, STRICK, Daryld

“…HLA-B57, as well as cytotoxic T-lymphocyte (CTL) responses restricted by this allele, have been strongly associated with long-term non-progressive chronic…”
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Standardization of cytokine flow cytometry assays by Maecker, Holden T, Rinfret, Aline, D'Souza, Patricia, Darden, Janice, Roig, Eva, Landry, Claire, Hayes, Peter, Birungi, Josephine, Anzala, Omu, Garcia, Miguel, Harari, Alexandre, Frank, Ian, Baydo, Ruth, Baker, Megan, Holbrook, Jennifer, Ottinger, Janet, Lamoreaux, Laurie, Epling, C Lorrie, Sinclair, Elizabeth, Suni, Maria A, Punt, Kara, Calarota, Sandra, El-Bahi, Sophia, Alter, Gailet, Maila, Hazel, Kuta, Ellen, Cox, Josephine, Gray, Clive, Altfeld, Marcus, Nougarede, Nolwenn, Boyer, Jean, Tussey, Lynda, Tobery, Timothy, Bredt, Barry, Roederer, Mario, Koup, Richard, Maino, Vernon C, Weinhold, Kent, Pantaleo, Giuseppe, Gilmour, Jill, Horton, Helen, Sekaly, Rafick P

“…Cytokine flow cytometry (CFC) or intracellular cytokine staining (ICS) can quantitate antigen-specific T cell responses in settings such as experimental…”
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Innate antiviral immunity: how prior exposures can guide future responses by Tomalka, Jeffrey A., Suthar, Mehul S., Diamond, Michael S., Sekaly, Rafick P.

“…Innate immunity is an intrinsic baseline defense in cells, with its earliest origins in bacteria, and with key roles in defense against pathogens and in the…”
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A Cure for HIV Infection: "Not in My Lifetime" or "Just Around the Corner"? by Lederman, Michael M, Cannon, Paula M, Currier, Judith S, June, Carl H, Kiem, Hans Peter, Kuritzkes, Daniel R, Lewin, Sharon R, Margolis, David M, McCune, Joseph M, Mellors, John W, Schacker, Timothy W, Sekaly, Rafick P, Tebas, Pablo, Walker, Bruce D, Douek, Daniel C

“…With the advent and stunning success of combination antiretroviral therapy (ART) to prolong and improve quality of life for persons with HIV infection, HIV…”
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Residual immune dysregulation syndrome in treated HIV infection by Lederman, Michael M, Funderburg, Nicholas T, Sekaly, Rafick P, Klatt, Nichole R, Hunt, Peter W

“…Antiretroviral therapy has revolutionized the course of HIV infection, improving immune function and decreasing dramatically the mortality and morbidity due to…”
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Synthetic double-stranded RNA induces innate immune responses similar to a live viral vaccine in humans by Caskey, Marina, Lefebvre, François, Filali-Mouhim, Abdelali, Cameron, Mark J, Goulet, Jean-Philippe, Haddad, Elias K, Breton, Gaëlle, Trumpfheller, Christine, Pollak, Sarah, Shimeliovich, Irina, Duque-Alarcon, Angela, Pan, Li, Nelkenbaum, Annette, Salazar, Andres M, Schlesinger, Sarah J, Steinman, Ralph M, Sékaly, Rafick P

“…Adjuvants are critical for the success of vaccines. Agonists of microbial pattern recognition receptors (PRRs) are promising new adjuvant candidates. A…”
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A Common CD4 Gene Variant Is Associated with an Increased Risk of HIV-1 Infection in Kenyan Female Commercial Sex Workers by Oyugi, Julius O., Vouriot, Françoise C. M., Alimonti, Judie, Wayne, Stephen, Luo, Ma, Land, Allison M., AO, Zhujun, Yao, Xiaojian, Sekaly, Rafick P., Elliott, Lawrence J., Simonsen, J. Neil, Ball, T. Blake, Jaoko, Walter, Kimani, Joshua, Plummer, Francis A., Fowke, Keith R.

“…BackgroundIt has been predicted that CD4 C868T, a novel CD4 single-nucleotide polymorphism (SNP) that has been found to be highly prevalent among Africans,…”
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Combination Immune Checkpoint Blockade to Reverse HIV Latency by Van der Sluis, Renée M, Kumar, Nitasha A, Pascoe, Rachel D, Zerbato, Jennifer M, Evans, Vanessa A, Dantanarayana, Ashanti I, Anderson, Jenny L, Sékaly, Rafick P, Fromentin, Rémi, Chomont, Nicolas, Cameron, Paul U, Lewin, Sharon R

“…In people living with HIV on antiretroviral therapy, HIV latency is the major barrier to a cure. HIV persists preferentially in CD4 T cells expressing multiple…”
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CD4 Down-regulation by HIV-1 and Simian Immunodeficiency Virus (SIV) Nef Proteins Involves Both Internalization and Intracellular Retention Mechanisms by Rose, Jeremy J, Janvier, Katy, Chandrasekhar, Soundararajulu, Sekaly, Rafick P, Bonifacino, Juan S, Venkatesan, Sundararajan

“…Among the pleiotropic effects of Nef proteins of HIV and simian immunodeficiency virus (SIV), down-modulation of cell surface expression of CD4 is a prominent…”
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Translocated microbiome composition determines immunological outcome in treated HIV infection by Nganou-Makamdop, Krystelle, Talla, Aarthi, Sharma, Ashish Arunkumar, Darko, Sam, Ransier, Amy, Laboune, Farida, Chipman, Jeffrey G., Beilman, Gregory J., Hoskuldsson, Torfi, Fourati, Slim, Schmidt, Thomas E., Arumugam, Sahaana, Lima, Noemia S., Moon, Damee, Callisto, Samuel, Schoephoerster, Jordan, Tomalka, Jeffery, Mugyenyi, Peter, Ssali, Francis, Muloma, Proscovia, Ssengendo, Patrick, Leda, Ana R., Cheu, Ryan K., Flynn, Jacob K., Morou, Antigoni, Brunet-Ratnasingham, Elsa, Rodriguez, Benigno, Lederman, Michael M., Kaufmann, Daniel E., Klatt, Nichole R., Kityo, Cissy, Brenchley, Jason M., Schacker, Timothy W., Sekaly, Rafick P., Douek, Daniel C.

“…The impact of the microbiome on HIV disease is widely acknowledged although the mechanisms downstream of fluctuations in microbial composition remain…”
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Fc-mediated effector function contributes to the in vivo antiviral effect of an HIV neutralizing antibody by Asokan, Mangaiarkarasi, Dias, Joana, Liu, Cuiping, Maximova, Anna, Ernste, Keenan, Pegu, Amarendra, McKee, Krisha, Shi, Wei, Chen, Xuejun, Almasri, Cassandra, Promsote, Wanwisa, Ambrozak, David R., Gama, Lucio, Hu, Jianfei, Douek, Daniel C., Todd, John-Paul, Lifson, Jeffrey D., Fourati, Slim, Sekaly, Rafick P., Crowley, Andrew R., Ackerman, Margaret E., Ko, Sung Hee, Kilam, Divya, Boritz, Eli A., Liao, Laura E., Best, Katharine, Perelson, Alan S., Mascola, John R., Koup, Richard A.

“…Treatment of HIV infection with either antiretroviral (ARV) therapy or neutralizing monoclonal antibodies (NAbs) leads to a reduction in HIV plasma virus. Both…”
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Early Interferon Therapy for Hepatitis C Virus Infection Rescues Polyfunctional, Long-Lived CD8+ Memory T Cells by BADR, Gamal, BEDARD, Nathalie, ABDEL-HAKEEM, Mohamed S, TRAUTMANN, Lydie, WILLEMS, Bernard, VILLENEUVE, Jean-Pierre, HADDAD, Elias K, SEKALY, Rafick P, BRUNEAU, Julie, SHOUKRY, Naglaa H

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Translating known drivers of COVID-19 disease severity to design better SARS-CoV-2 vaccines by Pelletier, Adam N, Sekaly, Rafick P, Tomalka, Jeffrey A

“…•COVID-19 vaccine strategies need to improve to combat variants and continued spread.•Finding what drives effective/ineffective immunity to infection can…”
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Human immune organoids to decode B cell response in healthy donors and patients with lymphoma by Zhong, Zhe, Quiñones-Pérez, Manuel, Dai, Zhonghao, Juarez, Valeria M., Bhatia, Eshant, Carlson, Christopher R., Shah, Shivem B., Patel, Anjali, Fang, Zhou, Hu, Thomas, Allam, Mayar, Hicks, Sakeenah L., Gupta, Mansi, Gupta, Sneh Lata, Weeks, Ethan, Vagelos, Stephanie D., Molina, Alejandro, Mulero-Russe, Adriana, Mora-Boza, Ana, Joshi, Devyani J., Sekaly, Rafick P., Sulchek, Todd, Goudy, Steven L., Wrammert, Jens, Roy, Krishnendu, Boss, Jeremy M., Coskun, Ahmet F., Scharer, Christopher D., García, Andrés J., Koff, Jean L., Singh, Ankur

“…Antibodies are produced when naive B cells differentiate into plasma cells within germinal centres (GCs) of lymphoid tissues. Patients with B cell lymphoma on…”
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Dual blockade of IL-10 and PD-1 leads to control of SIV viral rebound following analytical treatment interruption by Pereira Ribeiro, Susan, Strongin, Zachary, Soudeyns, Hugo, ten-Caten, Felipe, Ghneim, Khader, Pacheco Sanchez, Gabriela, Xavier de Medeiros, Giuliana, Del Rio Estrada, Perla Mariana, Pelletier, Adam-Nicolas, Hoang, Timothy, Nguyen, Kevin, Harper, Justin, Jean, Sherrie, Wallace, Chelsea, Balderas, Robert, Lifson, Jeffrey D., Raghunathan, Gopalan, Rimmer, Eric, Pastuskova, Cinthia, Wu, Guoxin, Micci, Luca, Ribeiro, Ruy M., Chan, Chi Ngai, Estes, Jacob D., Silvestri, Guido, Gorman, Daniel M., Howell, Bonnie J., Hazuda, Daria J., Paiardini, Mirko, Sekaly, Rafick P.

“…Human immunodeficiency virus (HIV) persistence during antiretroviral therapy (ART) is associated with heightened plasma interleukin-10 (IL-10) levels and PD-1…”
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