Search Results - "Sekaly, RP"

Activation of HIV transcription with short-course vorinostat in HIV-infected patients on suppressive antiretroviral therapy by Elliott, Julian H, Wightman, Fiona, Solomon, Ajantha, Ghneim, Khader, Ahlers, Jeffrey, Cameron, Mark J, Smith, Miranda Z, Spelman, Tim, McMahon, James, Velayudham, Pushparaj, Brown, Gregor, Roney, Janine, Watson, Jo, Prince, Miles H, Hoy, Jennifer F, Chomont, Nicolas, Fromentin, Rémi, Procopio, Francesco A, Zeidan, Joumana, Palmer, Sarah, Odevall, Lina, Johnstone, Ricky W, Martin, Ben P, Sinclair, Elizabeth, Deeks, Steven G, Hazuda, Daria J, Cameron, Paul U, Sékaly, Rafick-Pierre, Lewin, Sharon R

“…Human immunodeficiency virus (HIV) persistence in latently infected resting memory CD4+ T-cells is the major barrier to HIV cure. Cellular histone deacetylases…”
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Quantification of T cell receptor rearrangement excision circles to estimate thymic function: an important new tool for endocrine-immune physiology by Geenen, V, Poulin, JF, Dion, ML, Martens, H, Castermans, E, I, Hansenne, Moutschen, M, Sekaly, RP, Cheynier, R

“…Although the thymus constitutes a target organ for most protein and steroid hormones, it has been quite difficult to determine the precise control exerted in…”
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HIV-1 viremia prevents the establishment of interleukin 2-producing HIV-specific memory CD4+ T cells endowed with proliferative capacity by Younes, Souheil-Antoine, Yassine-Diab, Bader, Dumont, Alain R, Boulassel, Mohamed-Rachid, Grossman, Zvi, Routy, Jean-Pierre, Sekaly, Rafick-Pierre

“…CD4+ T cell responses are associated with disease control in chronic viral infections. We analyzed human immunodeficiency virus (HIV)-specific responses in ten…”
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Adjuvant-dependent innate and adaptive immune signatures of risk of SIVmac251 acquisition by Vaccari, Monica, Gordon, Shari N, Fourati, Slim, Schifanella, Luca, Liyanage, Namal P M, Cameron, Mark, Keele, Brandon F, Shen, Xiaoying, Tomaras, Georgia D, Billings, Erik, Rao, Mangala, Chung, Amy W, Dowell, Karen G, Bailey-Kellogg, Chris, Brown, Eric P, Ackerman, Margaret E, Vargas-Inchaustegui, Diego A, Whitney, Stephen, Doster, Melvin N, Binello, Nicolo, Pegu, Poonam, Montefiori, David C, Foulds, Kathryn, Quinn, David S, Donaldson, Mitzi, Liang, Frank, Loré, Karin, Roederer, Mario, Koup, Richard A, McDermott, Adrian, Ma, Zhong-Min, Miller, Christopher J, Phan, Tran B, Forthal, Donald N, Blackburn, Matthew, Caccuri, Francesca, Bissa, Massimiliano, Ferrari, Guido, Kalyanaraman, Vaniambadi, Ferrari, Maria G, Thompson, DeVon, Robert-Guroff, Marjorie, Ratto-Kim, Silvia, Kim, Jerome H, Michael, Nelson L, Phogat, Sanjay, Barnett, Susan W, Tartaglia, Jim, Venzon, David, Stablein, Donald M, Alter, Galit, Sekaly, Rafick-Pierre, Franchini, Genoveffa

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Skewed maturation of memory HIV-specific CD8 T lymphocytes by Rowland-Jones, Sarah, Nobile, Massimo, Appay, Victor, Knabenhans, Christian, Rizzardi, G. Paolo, Ellefsen, Kim, Pantaleo, Giuseppe, Sékaly, Rafick-P, King, Abigail S, McMichael, Andrew J, Champagne, Patrick, Ogg, Graham S, Fleury, Sylvain, Lipp, Martin, Förster, Reinhold

“…Understanding the lineage differentiation of memory T cells is a central question in immunology. We investigated this issue by analysing the expression of the…”
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Early activation of caspases during T lymphocyte stimulation results in selective substrate cleavage in nonapoptotic cells by Alam, A, Cohen, L Y, Aouad, S, Sékaly, R P

“…Apoptosis induced by T cell receptor (TCR) triggering in T lymphocytes involves activation of cysteine proteases of the caspase family through their…”
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HIV Infection Rapidly Induces and Maintains a Substantial Suppression of Thymocyte Proliferation by Dion, Marie-Lise, Poulin, Jean-François, Bordi, Rebeka, Sylvestre, Myriam, Corsini, Rachel, Kettaf, Nadia, Dalloul, Ali, Boulassel, Mohamed-Rachid, Debré, Patrice, Routy, Jean-Pierre, Grossman, Zvi, Sékaly, Rafick-Pierre, Cheynier, Rémi

“…The supply of naive T cells by the thymus normally requires precursor T cell proliferation within the thymus and would be particularly important in the setting…”
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Influence of HLA-B57 on clinical presentation and viral control during acute HIV-1 infection by ALTFELD, Marcus, ADDO, Marylyn M, ALLEN, Todd M, FEENEY, Margaret E, KAHN, James O, SEKALY, Rafick P, LEVY, Jay A, ROCKSTROH, Jürgen K, GOULDER, Philip J. R, WALKER, Bruce D, ROSENBERG, Eric S, HECHT, Frederick M, LEE, Paul K, VOGEL, Martin, YU, Xu G, DRAENERT, Rika, JOHNSTON, Mary N, STRICK, Daryld

“…HLA-B57, as well as cytotoxic T-lymphocyte (CTL) responses restricted by this allele, have been strongly associated with long-term non-progressive chronic…”
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Type I IFN induced by adenovirus serotypes 28 and 35 has multiple effects on T cell immunogenicity by Johnson, Matthew J, Petrovas, Constantinos, Yamamoto, Takuya, Lindsay, Ross W B, Loré, Karin, Gall, Jason G D, Gostick, Emma, Lefebvre, François, Cameron, Mark J, Price, David A, Haddad, Elias, Sekaly, Rafick-Pierre, Seder, Robert A, Koup, Richard A

“…Recombinant adenovirus (rAd) vectors are being investigated as vaccine delivery vehicles in preclinical and clinical studies. rAds constructed from different…”
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Persistence and Fitness of Multidrug-Resistant Human Immunodeficiency Virus Type 1 Acquired in Primary Infection by Brenner, Bluma G, Routy, Jean-Pierre, Petrella, Marco, Moisi, Daniela, Oliveira, Maureen, Detorio, Mervi, Spira, Bonnie, Essabag, Vidal, Conway, Brian, Lalonde, Richard, Sekaly, Rafick-Pierre, Wainberg, Mark A

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Diminished Proliferation of Human Immunodeficiency Virus-Specific CD4+ T Cells Is Associated with Diminished Interleukin-2 (IL-2) Production and Is Recovered by Exogenous IL-2 by Iyasere, Christiana, Tilton, John C, Johnson, Alison J, Younes, Souheil, Yassine-Diab, Bader, Sekaly, Rafick-Pierre, Kwok, William W, Migueles, Stephen A, Laborico, Alisha C, Shupert, W Lesley, Hallahan, Claire W, Davey, Jr, Richard T, Dybul, Mark, Vogel, Susan, Metcalf, Julia, Connors, Mark

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Substantial differences in specificity of HIV-specific cytotoxic T cells in acute and chronic HIV infection by Goulder, P J, Altfeld, M A, Rosenberg, E S, Nguyen, T, Tang, Y, Eldridge, R L, Addo, M M, He, S, Mukherjee, J S, Phillips, M N, Bunce, M, Kalams, S A, Sekaly, R P, Walker, B D, Brander, C

“…Cytotoxic T lymphocytes (CTLs) play a vital part in controlling viral replication during human viral infections. Most studies in human infections have focused…”
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Evaluation of OX40 Ligand as a Costimulator of Human Antiviral Memory CD8 T Cell Responses: Comparison with B7.1 and 4-1BBL by Serghides, Lena, Bukczynski, Jacob, Wen, Tao, Wang, Chao, Routy, Jean-Pierre, Boulassel, Mohamed-Rachid, Sekaly, Rafick-Pierre, Ostrowski, Mario, Bernard, Nicole F, Watts, Tania H

“…CTL are important effectors of antiviral immunity. Designing adjuvants that can induce strong cytotoxic T cell responses in humans would greatly improve the…”
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Standardization of cytokine flow cytometry assays by Maecker, Holden T, Rinfret, Aline, D'Souza, Patricia, Darden, Janice, Roig, Eva, Landry, Claire, Hayes, Peter, Birungi, Josephine, Anzala, Omu, Garcia, Miguel, Harari, Alexandre, Frank, Ian, Baydo, Ruth, Baker, Megan, Holbrook, Jennifer, Ottinger, Janet, Lamoreaux, Laurie, Epling, C Lorrie, Sinclair, Elizabeth, Suni, Maria A, Punt, Kara, Calarota, Sandra, El-Bahi, Sophia, Alter, Gailet, Maila, Hazel, Kuta, Ellen, Cox, Josephine, Gray, Clive, Altfeld, Marcus, Nougarede, Nolwenn, Boyer, Jean, Tussey, Lynda, Tobery, Timothy, Bredt, Barry, Roederer, Mario, Koup, Richard, Maino, Vernon C, Weinhold, Kent, Pantaleo, Giuseppe, Gilmour, Jill, Horton, Helen, Sekaly, Rafick P

“…Cytokine flow cytometry (CFC) or intracellular cytokine staining (ICS) can quantitate antigen-specific T cell responses in settings such as experimental…”
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OA04-05. Safety and viral load changes in HIV-1 infected subjects treated with autologous dendritic immune therapy following ART discontinuation (CTN#239) by Routy, J, Boulassel, M, Mona, L, Sylvie, V, Cécile, T, Jonathan, A, John, G, Jean-Guy, B, Fiona, S, Renu, J, Don, H, Irina, T, Charles, N, Sékaly, RP

“…Meeting abstracts - A single PDF containing all abstracts in this Supplement is available at…”
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Direct evidence for thymic function in adult humans by Poulin, J F, Viswanathan, M N, Harris, J M, Komanduri, K V, Wieder, E, Ringuette, N, Jenkins, M, McCune, J M, Sékaly, R P

“…The understanding of human thymic function and evaluation of its contribution to T cell homeostasis are matters of great importance. Here we report the…”
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HIV-1 protease processes procaspase 8 to cause mitochondrial release of cytochrome c, caspase cleavage and nuclear fragmentation by Nie, Z, Phenix, B N, Lum, J J, Alam, A, Lynch, D H, Beckett, B, Krammer, P H, Sekaly, R P, Badley, A D

“…Infection of T cells with HIV-1 induces apoptosis and modulates apoptosis regulatory molecules. Similar effects occur following treatment of cells with…”
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Prevalence of HIV-1 resistant to antiretroviral drugs in 81 individuals newly infected by sexual contact or injecting drug use by SALOMON, H, WAINBERG, M. A, SEKALY, R.-P, CONWAY, B, MAYERS, D, ROUTY, J.-P, BRENNER, B, YUDONG QUAN, ROULEAU, D, COTE, P, LEBLANC, R, LEFEBVRE, E, SPIRA, B, TSOUKAS, C

“…Objective: Prolonged treatment with antiretroviral drugs results in the selection of HIV-1 variants with mutations conferring resistance to nucleoside and…”
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Distribution and functional analysis of memory antiviral CD8 T cell responses in HIV‐1 and cytomegalovirus infections by Ellefsen, Kim, Harari, Alexandre, Champagne, Patrick, Bart, Pierre‐Alexandre, Sékaly, Rafick‐Pierre, Pantaleo, Giuseppe

“…In the present study, we have investigated the anatomic distribution and the function of different populations of HIV‐1‐ and cytomegalovirus (CMV)‐specific…”
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Direct cleavage of the human DNA fragmentation factor-45 by granzyme B induces caspase-activated DNase release and DNA fragmentation by Sharif-Askari, Ehsan, Alam, Antoine, Rhéaume, Eric, Beresford, Paul J., Scotto, Christian, Sharma, Kamal, Lee, Dennis, DeWolf, Walter E., Nuttall, Mark E., Lieberman, Judy, Sékaly, Rafick-Pierre

“…The protease granzyme B (GrB) plays a key role in the cytocidal activity during cytotoxic T lymphocyte (CTL)‐mediated programmed cell death. Multiple caspases…”
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