Search Results - "Sejersted, Ole Mathias"
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Mapping the in vitro interactome of cardiac sodium (Na+)‐calcium (Ca2+) exchanger 1 (NCX1)
Published in Proteomics (Weinheim) (01-09-2017)“…The sodium (Na+)‐calcium (Ca2+) exchanger 1 (NCX1) is an antiporter membrane protein encoded by the SLC8A1 gene. In the heart, it maintains cytosolic Ca2+…”
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Development of a high-affinity peptide that prevents phospholemman (PLM) inhibition of the sodium/calcium exchanger 1 (NCX1)
Published in Biochemical journal (01-08-2016)“…NCX1 (Na(+)/Ca(2+) exchanger 1) is an important regulator of intracellular Ca(2+) and a potential therapeutic target for brain ischaemia and for diastolic…”
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Molecular Basis of Calpain Cleavage and Inactivation of the Sodium-Calcium Exchanger 1 in Heart Failure
Published in The Journal of biological chemistry (05-12-2014)“…Cardiac sodium (Na+)-calcium (Ca2+) exchanger 1 (NCX1) is central to the maintenance of normal Ca2+ homeostasis and contraction. Studies indicate that the…”
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Exercise Training Stabilizes RyR2-Dependent Ca2+ Release in Post-infarction Heart Failure
Published in Frontiers in cardiovascular medicine (25-01-2021)“…Aim: Dysfunction of the cardiac ryanodine receptor (RyR2) is an almost ubiquitous finding in animal models of heart failure (HF) and results in abnormal Ca 2+…”
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Coupling of the Na+/K+-ATPase to Ankyrin B controls Na+/Ca2+ exchanger activity in cardiomyocytes
Published in Cardiovascular research (01-01-2020)“…Abstract Aims Ankyrin B (AnkB) is an adaptor protein that assembles Na+/K+-ATPase (NKA) and Na+/Ca2+ exchanger (NCX) in the AnkB macromolecular complex…”
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Stretch Harmonizes Sarcomere Strain Across the Cardiomyocyte
Published in Circulation research (21-07-2023)“…Increasing cardiomyocyte contraction during myocardial stretch serves as the basis for the Frank-Starling mechanism in the heart. However, it remains unclear…”
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Protein Phosphatase 1c Associated with the Cardiac Sodium Calcium Exchanger 1 Regulates Its Activity by Dephosphorylating Serine 68-phosphorylated Phospholemman
Published in The Journal of biological chemistry (26-02-2016)“…The sodium (Na+)-calcium (Ca2+) exchanger 1 (NCX1) is an important regulator of intracellular Ca2+ homeostasis. Serine 68-phosphorylated phospholemman…”
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Liberation of Pser68-Plm Inhibition of NCX1 by an Optimized Anchoring Disruptor Peptide
Published in Biophysical journal (27-01-2015)Get full text
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Exercise Training Stabilizes RyR2-Dependent Ca 2+ Release in Post-infarction Heart Failure
Published in Frontiers in cardiovascular medicine (2020)“…Dysfunction of the cardiac ryanodine receptor (RyR2) is an almost ubiquitous finding in animal models of heart failure (HF) and results in abnormal Ca release…”
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Journal Article