Search Results - "Seizinger, B. R."

Induction of the growth inhibitor IGF-binding protein 3 by p53 by Buckbinder, Leonard, Talbott, Randy, Velasco-Miguel, Susana, Takenaka, Ivone, Faha, Barbara, Seizinger, Bernd R, Kley, Nikolai

“…Transcriptional activation of target genes represents an important component of the tumour-suppressor function of p53 and provides a functional link between…”
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Mutations in transcript isoforms of the neurofibromatosis 2 gene in multiple human tumour types by Gusella, James F, Ramesh, Vijaya, Menon, Anil G, Morin, Francine, Hara, Tetsuo, Bianchi, Albert B, Klein-Szanto, Andrés J. P, Gao, Jizong, Trofatter, James A, Kley, Nikolai, Seizinger, Bernd R

“…The neurofibromatosis 2 gene (NF2) has recently been isolated and predicted to encode a novel protein related to the moesin-ezrin-radixin family of…”
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A (CA)n dinucleotide repeat assay for evaluating loss of allelic heterozygosity in small and archival human brain tumor specimens by Louis, DN, von Deimling, A, Seizinger, BR

“…Southern blotting is a widely used method of determining loss of chromosomal alleles in tumors, but cannot be used to analyze small biopsies and most fixed,…”
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Molecular Genetic Approach to Human Meningioma: Loss of Genes on Chromosome 22 by Seizinger, Bernd R., De La Monte, Suzanne, Atkins, Leonard, Gusella, James F., Martuza, Robert L.

“…A molecular genetic approach employing polymorphic DNA markers has been used to investigate the role of chromosomal aberrations in meningioma, one of the most…”
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p53 mutations are associated with 17p allelic loss in grade II and grade III astrocytoma by VON DEIMLING, A, EIBL, R. H, OHGAKI, H, LOUIS, D. N, VON AMMON, K, PETERSEB, I, KLEIHUES, P, CHUNG, R. Y, WIESTLER, O. D, SEIZINGER, B. R

“…Loss of genetic material on the short arm of chromosome 17 is observed in approximately 40% of human astrocytomas (WHO grades II and III) and in approximately…”
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P-glycoprotein, HER-2/neu, and mutant p53 expression in human gynecologic tumors by Schneider, J, Rubio, M P, Barbazán, M J, Rodriguez-Escudero, F J, Seizinger, B R, Castresana, J S

“…Overexpression of P-glycoprotein has been associated with a worse prognosis for some groups of patients not receiving chemotherapy. Recently, it has been…”
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Evidence for a tumor suppressor gene on chromosome 19q associated with human astrocytomas, oligodendrogliomas, and mixed gliomas by VON DEIMLING, A, LOUIS, D. N, VON AMMON, K, PETERSEN, I, WIESTLER, O. D, SEIZINGER, B. R

“…Previous studies have shown frequent allelic losses of chromosomes 9p, 10, 17p, and 22q in glial tumors. Other researchers have briefly reported that glial…”
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Farnesyltransferase inhibitors block the neurofibromatosis type I (NF1) malignant phenotype by NING YAN, RICCA, C, GLOVER, T, SEIZINGER, B. R, MANNE, V, FLETCHER, J

“…Neurofibromatosis type I (NF1) is a hereditary tumor and developmental disorder whose defective gene was cloned previously. The protein product of the NF1…”
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Von Hippel-Lindau disease maps to the region of chromosome 3 associated with renal cell carcinoma by Seizinger, B. R, Rouleau, G. A, Ozelius, L. J, Lane, A. H, Farmer, G. E, Lamiell, J. M, Haines, J, Yuen, J. W. M, Collins, D, Majoor-Krakauer, D, Bonner, T, Mathew, C, Rubenstein, A, Halperin, J, McConkie-Rosell, A, Green, J. S, Trofatter, J. A, Ponder, B. A, Eierman, L, Bowmer, M. I, Schimke, R, Oostra, B, Aronin, N, Smith, D. I, Drabkin, H, Waziri, M. H, Hobbs, W. J, Martuza, R. L, Conneally, P. M, Hsia, Y. E, Gusella, J. F

“…Von Hippel-Lindau disease (VHL) is an autosomal dominant disorder with inherited susceptibility to various forms of cancer, including hemangioblastomas of the…”
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Comparative study of p53 gene and protein alterations in human astrocytic tumors by Louis, D N, von Deimling, A, Chung, R Y, Rubio, M P, Whaley, J M, Eibl, R H, Ohgaki, H, Wiestler, O D, Thor, A D, Seizinger, B R

“…The p53 gene is a tumor suppressor gene involved in many common malignancies, including astrocytomas. Genetic analysis of the p53 gene and immunohistochemistry…”
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Association of epidermal growth factor receptor gene amplification with loss of chromosome 10 in human glioblastoma multiforme by VON DEIMLING, A, LOUIS, D. N, SEIZINGER, B. R, VON AMMON, K, PETERSEN, I, HOELL, T, CHUNG, R. Y, MARTUZA, R. L, SCHOENFELD, D. A, YASARGIL, G, WIESTLER, O. D

“…Although the loss of tumor suppressor genes and the activation of oncogenes have been established as two of the fundamental mechanisms of tumorigenesis in…”
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Genetic Flanking Markers Refine Diagnostic Criteria and Provide Insights Into the Genetics of Von Hippel Lindau Disease by Seizinger, B. R., Smith, D. I., Filling-Katz, M. R., Neumann, H., Green, J. S., Choyke, P. L., Anderson, K. M., Freiman, R. N., Klauck, S. M., Whaley, J., H.-J. H. Decker, Hsia, Y. E., Collins, D., Halperin, J., Lamiell, J. M., Oostra, B., Waziri, M. H., Gorin, M. B., Scherer, G., Drabkin, H. A., Aronin, N., Schinzel, A., Martuza, R. L., Gusella, J. F., Haines, J. L.

“…Von Hippel Lindau disease (VHL) is a hereditary syndrome, associated with tumors and cysts in multiple organ systems, whose expression and age of onset are…”
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Frequent NF2 gene transcript mutations in sporadic meningiomas and vestibular schwannomas by DEPREZ, R. H. L, BIANCHI, A. B, ZWARTHOFF, E. C, GROEN, N. A, SEIZINGER, B. R, HAGEMEIJER, A, VAN DRUNEN, E, BOOTSMA, D, KOPER, J. W, AVEZAAT, C. J. J, KLEY, N

“…The gene for the hereditary disorder neurofibromatosis type 2 (NF2), which predisposes for benign CNS tumors such as vestibular schwannomas and meningiomas,…”
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Gene Regulation by Temperature-Sensitive p53 Mutants: Identification of p53 Response Genes by Buckbinder, Leonard, Talbott, Randy, Seizinger, Bernd R., Kley, Nikolai

“…The ability of the p53 protein to act as a sequence-specific transcriptional activator suggests that genes induced by p53 may encode critical mediators of p53…”
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Loss of genes on chromosome 22 in tumorigenesis of human acoustic neuroma by Seizinger, Bernd R, Martuza, Robert L, Gusella, James F

“…The application of recombinant DNA techniques has identified two fundamental mechanisms of tumorigenesis in man. The first involves a qualitative or…”
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Loss of Distinct Regions on the Short Arm of Chromosome 17 Associated with Tumorigenesis of Human Astrocytomas by El-Azouzi, M., Chung, R. Y., Farmer, G. E., Martuza, R. L., Black, P. M., Rouleau, G. A., Hettlich, C., Hedley-Whyte, E. T., Zervas, N. T., Panagopoulos, K., Nakamura, Y., Gusella, J. F., Seizinger, B. R.

“…Astrocytomas, including glioblastoma multiforme, represent the most frequent and deadly primary neoplasms of the human nervous system. Despite a number of…”
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Common Pathogenetic Mechanism for Three Tumor Types in Bilateral Acoustic Neurofibromatosis by Seizinger, Bernd R., Rouleau, Guy, Ozelius, Laurie J., Lane, Andrew H., St George-Hyslop, Peter, Huson, Susan, Gusella, James F., Martuza, Robert L.

“…Bilateral acoustic neurofibromatosis (BANF) is a genetic defect associated with multiple tumors of neural crest origin. Specific loss of alleles from…”
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Genetic linkage of von Recklinghausen neurofibromatosis to the nerve growth factor receptor gene by Seizinger, B R, Rouleau, G A, Ozelius, L J, Lane, A H, Faryniarz, A G, Chao, M V, Huson, S, Korf, B R, Parry, D M, Pericak-Vance, M A

“…von Recklinghausen neurofibromatosis (VRNF) is one of the most common inherited disorders affecting the human nervous system. VRNF is transmitted as an…”
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Development of Highly Potent Inhibitors of Ras Farnesyltransferase Possessing Cellular and in Vivo Activity by Leftheris, Katerina, Kline, Toni, Vite, Gregory D, Cho, Young H, Bhide, Rajeev S, Patel, Dinesh V, Patel, Manorama M, Schmidt, Robert J, Weller, Harold N, Andahazy, Mary L, Carboni, Joan M, Gullo-Brown, Johnni L, Lee, Francis Y. F, Ricca, Carol, Rose, William C, Yan, Ning, Barbacid, Mariano, Hunt, John T, Meyers, Chester A, Seizinger, Bernd R, Zahler, Robert, Manne, Veeraswamy

“…Analogs of CVFM (a known nonsubstrate farnesyltransferase (FT) inhibitor derived from a CA1A2X sequence where C is cysteine, A is an aliphatic residue, and X…”
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Lack of allelic deletion and point mutation as mechanisms of p53 activation in human malignant melanoma by Castresana, J S, Rubio, M P, Vázquez, J J, Idoate, M, Sober, A J, Seizinger, B R, Barnhill, R L

“…To investigate the role of the p53 tumor-suppressor gene in the development of human melanoma, loss of heterozygosity (LOH) of p53 was studied in 46 cases of…”
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