Search Results - "Seitz, Joshua D."

Design, Synthesis, and Biological Evaluations of Tumor-Targeting Dual-Warhead Conjugates for a Taxoid–Camptothecin Combination Chemotherapy by Vineberg, Jacob G, Zuniga, Edison S, Kamath, Anushree, Chen, Ying-Jen, Seitz, Joshua D, Ojima, Iwao

“…Novel tumor-targeting dual-warhead conjugates, 2 (DW-1) and 3 (DW-2), which consist of a next-generation taxoid, 1 (SB-T-1214), and camptothecin as two…”
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Design, synthesis and biological evaluation of a highly-potent and cancer cell selective folate–taxoid conjugate by Seitz, Joshua D., Vineberg, Jacob G., Herlihy, Evan, Park, Bora, Melief, Eduard, Ojima, Iwao

“…[Display omitted] The folate receptor (FR) has been widely recognized as an excellent target for the tumor-selective delivery of cytotoxic agents, and four…”
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Synthesis of a Next-Generation Taxoid by Rapid Methylation Amenable for 11 C-Labeling by Seitz, Joshua D, Wang, Tao, Vineberg, Jacob G, Honda, Tadashi, Ojima, Iwao

“…Next-generation taxoids, such as SB-T-1214, are highly potent cytotoxic agents that exhibit remarkable efficacy against drug-resistant tumors in vivo,…”
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Tumor-targeting drug delivery of new-generation taxoids by Ojima, Iwao, Zuniga, Edison S, Berger, William T, Seitz, Joshua D

“…A long-standing problem of conventional cancer chemotherapy is the lack of tumor specificity. Tumor-targeting drug-delivery systems have been explored to…”
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Design, synthesis and application of fluorine-labeled taxoids as 19F NMR probes for the metabolic stability assessment of tumor-targeted drug delivery systems by Seitz, Joshua D., Vineberg, Jacob G., Wei, Longfei, Khan, Jonathan F., Lichtenthal, Brendan, Lin, Chi-Feng, Ojima, Iwao

“…Novel biotin-linker-taxoid conjugates, BLT-F2 and BLT-S-F6, were synthesized with strategically incorporated fluorine substituents to observe disulfide linker…”
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Synthesis of a Next-Generation Taxoid by Rapid Methylation Amenable for 11C‑Labeling by Seitz, Joshua D, Wang, Tao, Vineberg, Jacob G, Honda, Tadashi, Ojima, Iwao

“…Next-generation taxoids, such as SB-T-1214, are highly potent cytotoxic agents that exhibit remarkable efficacy against drug-resistant tumors in vivo,…”
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Displacement reactions of 2-chloro- and 2,9-dichloro-1,10-phenanthroline: synthesis of a sulfur-bridged bis-1,10-phenanthroline macrocycle and a 2,2′-amino-substituted-bis-1,10-phenanthroline by Krapcho, A. Paul, Sparapani, Silvia, Leenstra, Amber, Seitz, Joshua D.

“…The synthesis and structural assignments of 9-chloro-1,1-phenanthroline-2(1 H)-thione and 1,10-dihydro-1,10-phenanthroline-2,9-dithione have been accomplished…”
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Design, Synthesis and Application of Fluorine-Labeled Taxoids as 19 F NMR Probes for the Metabolic Stability Assessment of Tumor-Targeted Drug Delivery Systems by Seitz, Joshua D, Vineberg, Jacob G, Wei, Longfei, Khan, Jonathan F, Lichtenthal, Brendan, Lin, Chi-Feng, Ojima, Iwao

“…Novel tumor-targeting drug conjugates, BLT-F ( ) and BLT-S-F ( ), bearing a fluorotaxoid as the warhead, a mechanism-based self-immolative disulfide linker,…”
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