Search Results - "Seita, Jun"

Hoxb5 marks long-term haematopoietic stem cells and reveals a homogenous perivascular niche by Chen, James Y., Miyanishi, Masanori, Wang, Sean K., Yamazaki, Satoshi, Sinha, Rahul, Kao, Kevin S., Seita, Jun, Sahoo, Debashis, Nakauchi, Hiromitsu, Weissman, Irving L.

“…Until recently, complex multi-parameters were required for the isolation and identification of haematopoietic stem cells, complicating study of their biology…”
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Hematopoietic stem cell: self-renewal versus differentiation by Seita, Jun, Weissman, Irving L.

“…The mammalian blood system, containing more than 10 distinct mature cell types, stands on one specific cell type, hematopoietic stem cell (HSC). Within the…”
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A molecular cell atlas of the human lung from single-cell RNA sequencing by Travaglini, Kyle J., Nabhan, Ahmad N., Penland, Lolita, Sinha, Rahul, Gillich, Astrid, Sit, Rene V., Chang, Stephen, Conley, Stephanie D., Mori, Yasuo, Seita, Jun, Berry, Gerald J., Shrager, Joseph B., Metzger, Ross J., Kuo, Christin S., Neff, Norma, Weissman, Irving L., Quake, Stephen R., Krasnow, Mark A.

“…Although single-cell RNA sequencing studies have begun to provide compendia of cell expression profiles 1 – 9 , it has been difficult to systematically…”
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Clonal-level lineage commitment pathways of hematopoietic stem cells in vivo by Lu, Rong, Czechowicz, Agnieszka, Seita, Jun, Jiang, Du, Weissman, Irving L.

“…While the aggregate differentiation of the hematopoietic stem cell (HSC) population has been extensively studied, little is known about the lineage commitment…”
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Anti-CD47 antibody–mediated phagocytosis of cancer by macrophages primes an effective antitumor T-cell response by Tseng, Diane, Volkmer, Jens-Peter, Willingham, Stephen B., Contreras-Trujillo, Humberto, Fathman, John W., Fernhoff, Nathaniel B., Seita, Jun, Inlay, Matthew A., Weiskopf, Kipp, Miyanishi, Masanori, Weissman, Irving L.

“…Mobilization of the T-cell response against cancer has the potential to achieve long-lasting cures. However, it is not known how to harness antigen-presenting…”
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Identification of the earliest natural killer cell–committed progenitor in murine bone marrow by Fathman, John W., Bhattacharya, Deepta, Inlay, Matthew A., Seita, Jun, Karsunky, Holger, Weissman, Irving L.

“…Natural killer (NK) cells develop in the bone marrow and are known to gradually acquire the ability to eliminate infected and malignant cells, yet the cellular…”
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Prospective isolation of human erythroid lineage-committed progenitors by Mori, Yasuo, Chen, James Y., Pluvinage, John V., Seita, Jun, Weissman, Irving L.

“…Determining the developmental pathway leading to erythrocytes and being able to isolate their progenitors are crucial to understanding and treating disorders…”
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CD153/CD30 signaling promotes age-dependent tertiary lymphoid tissue expansion and kidney injury by Sato, Yuki, Oguchi, Akiko, Fukushima, Yuji, Masuda, Kyoko, Toriu, Naoya, Taniguchi, Keisuke, Yoshikawa, Takahisa, Cui, Xiaotong, Kondo, Makiko, Hosoi, Takeshi, Komidori, Shota, Shimizu, Yoko, Fujita, Harumi, Jiang, Li, Kong, Yingyi, Yamanashi, Takashi, Seita, Jun, Yamamoto, Takuya, Toyokuni, Shinya, Hamazaki, Yoko, Hattori, Masakazu, Yoshikai, Yasunobu, Boor, Peter, Floege, Jürgen, Kawamoto, Hiroshi, Murakawa, Yasuhiro, Minato, Nagahiro, Yanagita, Motoko

“…Tertiary lymphoid tissues (TLTs) facilitate local T and B cell interactions in chronically inflamed organs. However, the cells and molecular pathways that…”
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Gene Expression Commons: an open platform for absolute gene expression profiling by Seita, Jun, Sahoo, Debashis, Rossi, Derrick J, Bhattacharya, Deepta, Serwold, Thomas, Inlay, Matthew A, Ehrlich, Lauren I R, Fathman, John W, Dill, David L, Weissman, Irving L

“…Gene expression profiling using microarrays has been limited to comparisons of gene expression between small numbers of samples within individual experiments…”
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The GABA receptor GABRR1 is expressed on and functional in hematopoietic stem cells and megakaryocyte progenitors by Zhu, Fangfang, Feng, Mingye, Sinha, Rahul, Murphy, Matthew Philip, Luo, Fujun, Kao, Kevin S., Szade, Krzysztof, Seita, Jun, Weissman, Irving L.

“…GABRR1 is a rho subunit receptor of GABA, the major inhibitory neurotransmitter in the mammalian brain. While most investigations of its function focused on…”
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Complex mammalian-like haematopoietic system found in a colonial chordate by Rosental, Benyamin, Kowarsky, Mark, Seita, Jun, Corey, Daniel M., Ishizuka, Katherine J., Palmeri, Karla J., Chen, Shih-Yu, Sinha, Rahul, Okamoto, Jennifer, Mantalas, Gary, Manni, Lucia, Raveh, Tal, Clarke, D. Nathaniel, Tsai, Jonathan M., Newman, Aaron M., Neff, Norma F., Nolan, Garry P., Quake, Stephen R., Weissman, Irving L., Voskoboynik, Ayelet

“…Haematopoiesis is an essential process that evolved in multicellular animals. At the heart of this process are haematopoietic stem cells (HSCs), which are…”
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Best practices for multimodal clinical data management and integration: An atopic dermatitis research case by Ohta, Tazro, Hananoe, Ayaka, Fukushima-Nomura, Ayano, Ashizaki, Koichi, Sekita, Aiko, Seita, Jun, Kawakami, Eiryo, Sakurada, Kazuhiro, Amagai, Masayuki, Koseki, Haruhiko, Kawasaki, Hiroshi

“…In clinical research on multifactorial diseases such as atopic dermatitis, data-driven medical research has become more widely used as means to clarify diverse…”
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HSC-independent definitive hematopoiesis persists into adult life by Kobayashi, Michihiro, Wei, Haichao, Yamanashi, Takashi, Azevedo Portilho, Nathalia, Cornelius, Samuel, Valiente, Noemi, Nishida, Chika, Cheng, Haizi, Latorre, Augusto, Zheng, W. Jim, Kang, Joonsoo, Seita, Jun, Shih, David J., Wu, Jia Qian, Yoshimoto, Momoko

“…It is widely believed that hematopoiesis after birth is established by hematopoietic stem cells (HSCs) in the bone marrow and that HSC-independent…”
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Multifaceted analysis of cross-tissue transcriptomes reveals phenotype–endotype associations in atopic dermatitis by Sekita, Aiko, Kawasaki, Hiroshi, Fukushima-Nomura, Ayano, Yashiro, Kiyoshi, Tanese, Keiji, Toshima, Susumu, Ashizaki, Koichi, Miyai, Tomohiro, Yazaki, Junshi, Kobayashi, Atsuo, Namba, Shinichi, Naito, Tatsuhiko, Wang, Qingbo S., Kawakami, Eiryo, Seita, Jun, Ohara, Osamu, Sakurada, Kazuhiro, Okada, Yukinori, Amagai, Masayuki, Koseki, Haruhiko

“…Atopic dermatitis (AD) is a skin disease that is heterogeneous both in terms of clinical manifestations and molecular profiles. It is increasingly recognized…”
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Sexually dimorphic estrogen sensing in skeletal stem cells controls skeletal regeneration by Andrew, Tom W., Koepke, Lauren S., Wang, Yuting, Lopez, Michael, Steininger, Holly, Struck, Danielle, Boyko, Tatiana, Ambrosi, Thomas H., Tong, Xinming, Sun, Yuxi, Gulati, Gunsagar S., Murphy, Matthew P., Marecic, Owen, Tevlin, Ruth, Schallmoser, Katharina, Strunk, Dirk, Seita, Jun, Goodman, Stuart B., Yang, Fan, Longaker, Michael T., Yang, George P., Chan, Charles K. F.

“…Sexually dimorphic tissues are formed by cells that are regulated by sex hormones. While a number of systemic hormones and transcription factors are known to…”
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Transcriptional activation of hypoxia-inducible factor-1 (HIF-1) in myeloid cells promotes angiogenesis through VEGF and S100A8 by Ahn, G-One, Seita, Jun, Hong, Beom-Ju, Kim, Young-Eun, Bok, Seoyeon, Lee, Chan-Ju, Kim, Kwang Soon, Lee, Jerry C., Leeper, Nicholas J., Cooke, John P., Kim, Hak Jae, Kim, Il Han, Weissman, Irving L., Brownb, J. Martin

“…Emerging evidence indicates that myeloid cells are essential for promoting new blood vessel formation by secreting various angiogenic factors. Given that…”
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Author Correction: Sexually dimorphic estrogen sensing in skeletal stem cells controls skeletal regeneration by Andrew, Tom W., Koepke, Lauren S., Wang, Yuting, Lopez, Michael, Steininger, Holly, Struck, Danielle, Boyko, Tatiana, Ambrosi, Thomas H., Tong, Xinming, Sun, Yuxi, Gulati, Gunsagar S., Murphy, Matthew P., Marecic, Owen, Tevlin, Ruth, Schallmoser, Katharina, Strunk, Dirk, Seita, Jun, Goodman, Stuart B., Yang, Fan, Longaker, Michael T., Yang, George P., Chan, Charles K. F.

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Global transcriptional profiling reveals distinct functions of thymic stromal subsets and age-related changes during thymic involution by Ki, Sanghee, Park, Daechan, Selden, Hilary J, Seita, Jun, Chung, Haewon, Kim, Jonghwan, Iyer, Vishwanath R, Ehrlich, Lauren I R

“…Age-associated thymic involution results in diminished T cell output and function in aged individuals. However, molecular mediators contributing to the decline…”
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Reliable and easy-to-use calculating tool for the Nail Psoriasis Severity Index using deep learning by Horikawa, Hiroto, Tanese, Keiji, Nonaka, Naoki, Seita, Jun, Amagai, Masayuki, Saito, Masataka

“…Since nail psoriasis restricts the patient’s daily activities, therapeutic intervention based on reliable and reproducible evaluation is critical. The Nail…”
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Aged skeletal stem cells generate an inflammatory degenerative niche by Ambrosi, Thomas H., Marecic, Owen, McArdle, Adrian, Sinha, Rahul, Gulati, Gunsagar S., Tong, Xinming, Wang, Yuting, Steininger, Holly M., Hoover, Malachia Y., Koepke, Lauren S., Murphy, Matthew P., Sokol, Jan, Seo, Eun Young, Tevlin, Ruth, Lopez, Michael, Brewer, Rachel E., Mascharak, Shamik, Lu, Laura, Ajanaku, Oyinkansola, Conley, Stephanie D., Seita, Jun, Morri, Maurizio, Neff, Norma F., Sahoo, Debashis, Yang, Fan, Weissman, Irving L., Longaker, Michael T., Chan, Charles K. F.

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