Search Results - "Seiler, Sarah"

Muscle-Specific Deletion of Carnitine Acetyltransferase Compromises Glucose Tolerance and Metabolic Flexibility by Muoio, Deborah M., Noland, Robert C., Kovalik, Jean-Paul, Seiler, Sarah E., Davies, Michael N., DeBalsi, Karen L., Ilkayeva, Olga R., Stevens, Robert D., Kheterpal, Indu, Zhang, Jingying, Covington, Jeffrey D., Bajpeyi, Sudip, Ravussin, Eric, Kraus, William, Koves, Timothy R., Mynatt, Randall L.

“…The concept of “metabolic inflexibility” was first introduced to describe the failure of insulin-resistant human subjects to appropriately adjust mitochondrial…”
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Carnitine Acetyltransferase Mitigates Metabolic Inertia and Muscle Fatigue during Exercise by Seiler, Sarah E., Koves, Timothy R., Gooding, Jessica R., Wong, Kari E., Stevens, Robert D., Ilkayeva, Olga R., Wittmann, April H., DeBalsi, Karen L., Davies, Michael N., Lindeboom, Lucas, Schrauwen, Patrick, Schrauwen-Hinderling, Vera B., Muoio, Deborah M.

“…Acylcarnitine metabolites have gained attention as biomarkers of nutrient stress, but their physiological relevance and metabolic purpose remain…”
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Carnitine Insufficiency Caused by Aging and Overnutrition Compromises Mitochondrial Performance and Metabolic Control by Noland, Robert C., Koves, Timothy R., Seiler, Sarah E., Lum, Helen, Lust, Robert M., Ilkayeva, Olga, Stevens, Robert D., Hegardt, Fausto G., Muoio, Deborah M.

“…In addition to its essential role in permitting mitochondrial import and oxidation of long chain fatty acids, carnitine also functions as an acyl group…”
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CD14++CD16+ Monocytes Independently Predict Cardiovascular Events by Rogacev, Kyrill S., MD, Cremers, Bodo, MD, Zawada, Adam M., MSc, Seiler, Sarah, MD, Binder, Nadine, MSc, Ege, Philipp, Große-Dunker, Gunnar, Heisel, Isabel, MD, Hornof, Florian, MD, Jeken, Jana, MD, Rebling, Niko M., MD, Ulrich, Christof, PhD, Scheller, Bruno, MD, Böhm, Michael, MD, Fliser, Danilo, MD, Heine, Gunnar H., MD

“…Objectives The aim of this study was to analyze the yet ill-defined relationship of distinct human monocyte subsets with cardiovascular outcomes in a broad…”
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Clinical relevance of FGF-23 in chronic kidney disease by Seiler, Sarah, Heine, Gunnar H., Fliser, Danilo

“…Fibroblast growth factor (FGF)-23 is a recently discovered regulator of calcium–phosphate metabolism. Whereas other known FGFs mainly act in a paracrine…”
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Muscle-Specific Overexpression of PGC-1α Does Not Augment Metabolic Improvements in Response to Exercise and Caloric Restriction by Wong, Kari E, Mikus, Catherine R, Slentz, Dorothy H, Seiler, Sarah E, DeBalsi, Karen L, Ilkayeva, Olga R, Crain, Karen I, Kinter, Michael T, Kien, C Lawrence, Stevens, Robert D, Muoio, Deborah M

“…This study used mice with muscle-specific overexpression of PGC-1α, a transcriptional coactivator that promotes mitochondrial biogenesis, to determine whether…”
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PCSK9 Plasma Concentrations Are Independent of GFR and Do Not Predict Cardiovascular Events in Patients with Decreased GFR by Rogacev, Kyrill S, Heine, Gunnar H, Silbernagel, Günther, Kleber, Marcus E, Seiler, Sarah, Emrich, Insa, Lennartz, Simone, Werner, Christian, Zawada, Adam M, Fliser, Danilo, Böhm, Michael, März, Winfried, Scharnagl, Hubert, Laufs, Ulrich

“…Impaired renal function causes dyslipidemia that contributes to elevated cardiovascular risk in patients with chronic kidney disease (CKD). The proprotein…”
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Targeted Metabolomics Connects Thioredoxin-interacting Protein (TXNIP) to Mitochondrial Fuel Selection and Regulation of Specific Oxidoreductase Enzymes in Skeletal Muscle by DeBalsi, Karen L., Wong, Kari E., Koves, Timothy R., Slentz, Dorothy H., Seiler, Sarah E., Wittmann, April H., Ilkayeva, Olga R., Stevens, Robert D., Perry, Christopher G.R., Lark, Daniel S., Hui, Simon T., Szweda, Luke, Neufer, P. Darrell, Muoio, Deborah M.

“…Thioredoxin-interacting protein (TXNIP) is an α-arrestin family member involved in redox sensing and metabolic control. Growing evidence links TXNIP to…”
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Fibroblast growth factor 23 in acute myocardial infarction complicated by cardiogenic shock: a biomarker substudy of the Intraaortic Balloon Pump in Cardiogenic Shock II (IABP-SHOCK II) trial by Fuernau, Georg, Pöss, Janine, Denks, Daniel, Desch, Steffen, Heine, Gunnar H, Eitel, Ingo, Seiler, Sarah, de Waha, Suzanne, Ewen, Sebastian, Link, Andreas, Schuler, Gerhard, Adams, Volker, Böhm, Michael, Thiele, Holger

“…Cardiogenic shock (CS) is the leading cause of death in patients hospitalized with acute myocardial infarction (AMI). Biomarkers might help in risk…”
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Response of fibroblast growth factor 23 to volume interventions in arterial hypertension and diabetic nephropathy by Humalda, Jelmer K., Seiler-Muler, Sarah, Kwakernaak, Arjan J., Vervloet, Marc G., Navis, Gerjan, Fliser, Danilo, Heine, Gunnar H., de Borst, Martin H.

“…Fibroblast growth factor 23 (FGF-23) rises progressively in chronic kidney disease and is associated with adverse cardiovascular outcomes. FGF-23 putatively…”
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Distinct immunologic effects of different intravenous iron preparations on monocytes by Fell, Lisa H, Zawada, Adam M, Rogacev, Kyrill S, Seiler, Sarah, Fliser, Danilo, Heine, Gunnar H

“…Iron deficiency contributes to anaemia in patients with chronic kidney disease. I.v. iron is therefore widely used for anaemia treatment, although it may…”
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Full-scale regional exercises: closing the gaps in disaster preparedness by Klima, David A, Seiler, Sarah H, Peterson, Jeff B, Christmas, A Britton, Green, John M, Fleming, Greg, Thomason, Michael H, Sing, Ronald F

“…Man-made (9/11) and natural (Hurricane Katrina) disasters have enlightened the medical community regarding the importance of disaster preparedness. In response…”
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Obesity and lipid stress inhibit carnitine acetyltransferase activity[S] by Seiler, Sarah E., Martin, Ola J., Noland, Robert C., Slentz, Dorothy H., DeBalsi, Karen L., Ilkayeva, Olga R., An, Jie, Newgard, Christopher B., Koves, Timothy R., Muoio, Deborah M.

“…Carnitine acetyltransferase (CrAT) is a mitochondrial matrix enzyme that catalyzes the interconversion of acetyl-CoA and acetylcarnitine. Emerging evidence…”
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Single FGF-23 Measurement and Time-Averaged Plasma Phosphate Levels in Hemodialysis Patients by Seiler, Sarah, Lucisano, Gaetano, Ege, Philipp, Fell, Lisa H, Rogacev, Kyrill S, Lerner-Gräber, Anne, Klingele, Matthias, Ziegler, Matthias, Fliser, Danilo, Heine, Gunnar H

“…Plasma phosphate levels display considerable intraindividual variability. The phosphatonin fibroblast growth factor 23 is a central regulator of plasma…”
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Characterization of a primary brown adipocyte culture system derived from human fetal interscapular fat by Seiler, Sarah E, Xu, Dan, Ho, Jia-Pei, Lo, Kinyui Alice, Buehrer, Benjamin M, Ludlow, Y John W, Kovalik, Jean-Paul, Sun, Lei

“…Brown fat has gained widespread attention as a potential therapeutic target to treat obesity and associated metabolic disorders. Indeed, the anti-obesity…”
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Validation of echocardiographic criteria for the clinical diagnosis of heart failure in chronic kidney disease by Untersteller, Kathrin, Seiler-Mußler, Sarah, Mallamaci, Francesca, Fliser, Danilo, London, Gérard M, Zoccali, Carmine, Heine, Gunnar H

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Efficacy of a remote web-based lung ultrasound training for nephrologists and cardiologists: a LUST trial sub-project by Gargani, Luna, Sicari, Rosa, Raciti, Mauro, Serasini, Luca, Passera, Mirko, Torino, Claudia, Letachowicz, Krzysztof, Ekart, Robert, Fliser, Danilo, Covic, Adrian, Balafa, Olga, Stavroulopoulos, Aristeidis, Massy, Ziad A, Fiaccadori, Enrico, Caiazza, Alberto, Bachelet, Thomas, Slotki, Itzchak, Shavit, Linda, Martinez-Castelao, Alberto, Coudert-Krier, Marie-Jeanne, Rossignol, Patrick, Kraemer, Thomas Daniel, Hannedouche, Thierry, Panichi, Vincenzo, Wiecek, Andrzej, Pontoriero, Giuseppe, Sarafidis, Pantelis, Klinger, Marian, Hojs, Radovan, Seiler-Mußler, Sarah, Lizzi, Fabio, Onofriescu, Mihai, Zarzoulas, Fotis, Tripepi, Rocco, Mallamaci, Francesca, Tripepi, Giovanni, Picano, Eugenio, London, Gérard Michel, Zoccali, Carmine

“…Within the framework of the LUST trial (LUng water by Ultra-Sound guided Treatment to prevent death and cardiovascular events in high-risk end-stage renal…”
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The long-term effect of a lung-ultrasound intervention on the risk for death, heart failure and myocardial infarction in dialysis patients by Torino, Claudia, Mallamaci, Francesca, Sarafidis, Pantelis, Papagianni, Aikaterini, Ekart, Robert, Hojs, Radovan, Klinger, Marian, Letachowicz, Krzysztof, Fliser, Danilo, Seiler-Mußler, Sarah, Lizzi, Fabio, Siamopoulos, Kostas, Balafa, Olga, Ntounousi, Evangelia, Slotki, Itzchak, Shavit, Linda, Stavroulopoulos, Aristeidis, Massy, Ziad A, Seidowsky, Alexandre, Battaglia, Yuri, Martinez-Castelao, Alberto, Villalobos, Gustavo, Fiaccadori, Enrico, Regolisti, Giuseppe, Hannedouche, Thierry, Bachelet, Thomas, Jager, Kitty J, Dekker, Friedo W, Tripepi, Rocco, Tripepi, Giovanni, Gargani, Luna, Sicari, Rosa, Picano, Eugenio, London, Gérard Michel, Zoccali, Carmine

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Plasma levels of the oxyphytosterol 7α-hydroxycampesterol are associated with cardiovascular events by Fuhrmann, Arne, Weingärtner, Oliver, Meyer, Sven, Cremers, Bodo, Seiler-Mußler, Sarah, Schött, Hans-F., Kerksiek, Anja, Friedrichs, Silvia, Ulbricht, Ursula, Zawada, Adam M., Laufs, Ulrich, Scheller, Bruno, Fliser, Danilo, Schulze, Paul Christian, Böhm, Michael, Heine, Gunnar H., Lütjohann, Dieter

“…There are safety issues regarding plant sterol ester-enriched functional food. Oxidized plant sterols, also called oxyphytosterols, are supposed to contribute…”
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FGFR4 and Klotho Polymorphisms Are Not Associated with Cardiovascular Outcomes in Chronic Kidney Disease by Sellier, Alexander B, Seiler-Mußler, Sarah, Emrich, Insa E, Böhm, Michael, Fliser, Danilo, Zawada, Adam M, Heine, Gunnar H

“…High plasma fibroblast growth factor 23 (FGF-23) predicts cardiovascular events in chronic kidney disease (CKD) patients. Experimental evidence suggests FGF…”
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