Search Results - "Seiler, Kristina"

Rational discovery of molecular glue degraders via scalable chemical profiling by Mayor-Ruiz, Cristina, Bauer, Sophie, Brand, Matthias, Kozicka, Zuzanna, Siklos, Marton, Imrichova, Hana, Kaltheuner, Ines H., Hahn, Elisa, Seiler, Kristina, Koren, Anna, Petzold, Georg, Fellner, Michaela, Bock, Christoph, Müller, André C., Zuber, Johannes, Geyer, Matthias, Thomä, Nicolas H., Kubicek, Stefan, Winter, Georg E.

“…Targeted protein degradation is a new therapeutic modality based on drugs that destabilize proteins by inducing their proximity to E3 ubiquitin ligases. Of…”
Get full text

Autophagy and coronavirus infection - a Trojan horse or Achilles heel? by Seiler, Kristina, Tschan, Mario P P

Get full text

Isoform-specific, Semi-quantitative Determination of Highly Homologous Protein Levels via CRISPR-Cas9-mediated HiBiT Tagging by Seiler, Kristina, Rafiq, Sreoshee, Tschan, Mario P

“…Many protein families consist of multiple highly homologous proteins, whether they are encoded by different genes or originating from the same genomic…”
Get full text

Hexokinase 3 enhances myeloid cell survival via non-glycolytic functions by Seiler, Kristina, Humbert, Magali, Minder, Petra, Mashimo, Iris, Schläfli, Anna M., Krauer, Deborah, Federzoni, Elena A., Vu, Bich, Moresco, James J., Yates, John R., Sadowski, Martin C., Radpour, Ramin, Kaufmann, Thomas, Sarry, Jean-Emmanuel, Dengjel, Joern, Tschan, Mario P., Torbett, Bruce E.

“…The family of hexokinases (HKs) catalyzes the first step of glycolysis, the ATP-dependent phosphorylation of glucose to glucose-6-phosphate. While HK1 and HK2…”
Get full text

Phosphate starvation signaling increases mitochondrial membrane potential through respiration-independent mechanisms by Ouyang, Yeyun, Jeong, Mi-Young, Cunningham, Corey N, Berg, Jordan A, Toshniwal, Ashish G, Hughes, Casey E, Seiler, Kristina, Van Vranken, Jonathan G, Cluntun, Ahmad A, Lam, Geanette, Winter, Jacob M, Akdogan, Emel, Dove, Katja K, Nowinski, Sara M, West, Matthew, Odorizzi, Greg, Gygi, Steven P, Dunn, Cory D, Winge, Dennis R, Rutter, Jared

“…Mitochondrial membrane potential directly powers many critical functions of mitochondria, including ATP production, mitochondrial protein import, and…”
Get full text

A Structural Analysis of Spiropyran and Spirooxazine Compounds and Their Polymorphs by Seiler, Vanessa, Tumanov, Nikolay, Robeyns, Koen, Wouters, Johan, Champagne, Benoit, Leyssens, Tom

“…In this work, crystal structures of commercially available photochromic compounds, i.e., spiropyrans and spirooxazines, were investigated by single-crystal…”
Get full text

Non-Glycolytic Role of the Myeloid Hexokinase 3 (HK3) in Therapy Responses of Myeloid Malignancies by Seiler, Kristina, Tschan, Mario P., Kalbermatter, Carmen, Muralt, Tanja, Rao, Tata Nageswara, Torbett, Bruce E.

Get full text

Reducing FASN expression sensitizes acute myeloid leukemia cells to differentiation therapy by Humbert, Magali, Seiler, Kristina, Mosimann, Severin, Rentsch, Vreni, Sharma, Katyayani, Pandey, Amit V., McKenna, Sharon L., Tschan, Mario P.

“…Fatty acid synthase (FASN) is the only human lipogenic enzyme available for de novo fatty acid synthesis and is often highly expressed in cancer cells. We…”
Get full text

Role of Hexokinase 2 and 3 in Energy Metabolism, Myeloid Differentiation and Cancer Development by Seiler, Kristina, Minder, Petra, Mashimo, Iris, Humbert, Magali, Federzoni, Elena, Moresco, James, Yates, John, Tschan, Mario, Torbett, Bruce

“…Abstract only Introduction Tight control of metabolic processes is crucial for normal hematopoietic cell development, proliferation and cancer cell expansion…”
Get full text

Hexokinase Proteins Impart Distinct Functions in Myeloid Development and Cell Death by Seiler, Kristina, Minder, Petra, Mashimo, Iris, Humbert, Magali, Simpson, Elizabeth, Tschan, Mario P., Torbett, Bruce E.

“…Many key oncogenic pathways converge to adapt tumor cell metabolism to requirements of cancer cells. Aberrant proliferation that is frequently associated with…”
Get full text

Publisher Correction: Rational discovery of molecular glue degraders via scalable chemical profiling by Mayor-Ruiz, Cristina, Bauer, Sophie, Brand, Matthias, Kozicka, Zuzanna, Siklos, Marton, Imrichova, Hana, Kaltheuner, Ines H., Hahn, Elisa, Seiler, Kristina, Koren, Anna, Petzold, Georg, Fellner, Michaela, Bock, Christoph, Müller, André C., Zuber, Johannes, Geyer, Matthias, Thomä, Nicolas H., Kubicek, Stefan, Winter, Georg E.

“…An amendment to this paper has been published and can be accessed via a link at the top of the paper…”
Get full text

Acidochromic spiropyran–merocyanine stabilisation in the solid state by Seiler, Vanessa Kristina, Callebaut, Kevin, Robeyns, Koen, Tumanov, Nikolay, Wouters, Johan, Champagne, Benoît, Leyssens, Tom

“…Abstract only…”
Get full text

Eight new crystal structures of 5-(hydroxymethyl)uracil, 5-carboxyuracil and 5-carboxy-2-thiouracil: insights into the hydrogen-bonded networks and the predominant conformations of the C5-bound residues by Seiler, Vanessa Kristina, Hützler, Wilhelm Maximilian, Bolte, Michael

“…In order to examine the preferred hydrogen‐bonding pattern of various uracil derivatives, namely 5‐(hydroxymethyl)uracil, 5‐carboxyuracil and…”
Get full text