Search Results - "Seifert, Hilary A"

The splenic response to stroke: from rodents to stroke subjects by Seifert, Hilary A, Offner, Halina

“…Stroke is the fifth leading cause of death and the leading cause of long-term disability in the USA, costing $40.2 billion in direct and indirect costs…”
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Estrogen-induced compensatory mechanisms protect IL-10-deficient mice from developing EAE by Seifert, Hilary A, Gerstner, Grant, Kent, Gail, Vandenbark, Arthur A, Offner, Halina

“…IL-10 knockout (KO) mice are protected from experimental autoimmune encephalomyelitis (EAE) with low-dose estrogen (E2) treatment similar to wild-type (WT)…”
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Antibiotics protect against EAE by increasing regulatory and anti-inflammatory cells by Seifert, Hilary A., Benedek, Gil, Nguyen, Ha, Gerstner, Grant, Zhang, Ying, Kent, Gail, Vandenbark, Arthur A., Bernhagen, Jürgen, Offner, Halina

“…A seven day pretreatment course of an oral antibiotic cocktail (Ampicillin, Metronidazole, Neomycin Sulfate, and Vancomycin) was shown to induce changes in…”
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Leukemia Inhibitory Factor Protects Neurons from Ischemic Damage via Upregulation of Superoxide Dismutase 3 by Davis, Stephanie M., Collier, Lisa A., Leonardo, Christopher C., Seifert, Hilary A., Ajmo, Craig T., Pennypacker, Keith R.

“…Leukemia inhibitory factor (LIF) has been shown to protect oligodendrocytes from ischemia by upregulating endogenous antioxidants. The goal of this study was…”
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Estrogen protects both sexes against EAE by promoting common regulatory cell subtypes independent of endogenous estrogen by Seifert, Hilary A., Benedek, Gil, Nguyen, Ha, Kent, Gail, Vandenbark, Arthur A., Offner, Halina

“…Autoimmune diseases including multiple sclerosis predominantly affect females. Although high levels of sex hormones, particularly estrogen (E2), can reduce…”
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The spleen contributes to stroke induced neurodegeneration through interferon gamma signaling by Seifert, Hilary A., Leonardo, Christopher C., Hall, Aaron A., Rowe, Derrick D., Collier, Lisa A., Benkovic, Stanley A., Willing, Alison E., Pennypacker, Keith R.

“…Delayed neuronal death associated with stroke has been increasingly linked to the immune response to the injury. Splenectomy prior to middle cerebral artery…”
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Regulatory B cells in experimental stroke by Seifert, Hilary A., Vandenbark, Arthur A., Offner, Halina

“…Summary Current treatment options for human stroke are limited mainly to the modestly effective infusion of tissue plasminogen activator (tPA), with additional…”
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Molecular and Cellular Immune Responses to Ischemic Brain Injury by Seifert, Hilary A., Pennypacker, Keith R.

“…Despite extensive research into stroke pathology, there have not been any major recent advancements in stroke therapeutics. Animal models of cerebral ischemia…”
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Estrogen protection against EAE modulates the microbiota and mucosal-associated regulatory cells by Benedek, Gil, Zhang, Jun, Nguyen, Ha, Kent, Gail, Seifert, Hilary, Davin, Sean, Stauffer, Patrick, Vandenbark, Arthur A, Karstens, Lisa, Asquith, Mark, Offner, Halina

“…Abstract Sex hormones promote immunoregulatory effects on multiple sclerosis. In the current study we evaluated the composition of the gut microbiota and the…”
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Sex differences in regulatory cells in experimental stroke by Seifert, Hilary A., Benedek, Gil, Liang, Jian, Nguyen, Ha, Kent, Gail, Vandenbark, Arthur A., Saugstad, Julie A., Offner, Halina

“…•Female mice with MCAO had smaller infarcts than males.•In brain, MCAO females had more Bregs and anti-inflammatory macrophages than males.•In spleen, females…”
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A Transient Decrease in Spleen Size Following Stroke Corresponds to Splenocyte Release into Systemic Circulation by Seifert, Hilary A., Hall, Aaron A., Chapman, Cortney B., Collier, Lisa A., Willing, Alison E., Pennypacker, Keith R.

“…The splenic response to stroke is a proinflammatory reaction to ischemic injury resulting in expanded neurodegeneration. Splenectomy reduces neural injury in…”
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Pro-Inflammatory Interferon Gamma Signaling is Directly Associated with Stroke Induced Neurodegeneration by Seifert, Hilary A., Collier, Lisa A., Chapman, Cortney B., Benkovic, Stanley A., Willing, Alison E., Pennypacker, Keith R.

“…The delayed immune response to stroke is responsible for the increased neural injury that continues to occur after the initial ischemic event. This delayed…”
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Sex differences in the therapeutic effects of anti-PDL2 neutralizing antibody on stroke by Seifert, Hilary A., Zhu, Wenbin, Vandenbark, Arthur A., Alkayed, Nabil J., Offner, Halina

“…Inflammation involving migration of immune cells across the damaged blood–brain barrier (BBB), activation of resident innate microglia and production of…”
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Leukemia inhibitor factor promotes functional recovery and oligodendrocyte survival in rat models of focal ischemia by Rowe, Derrick D., Collier, Lisa A., Seifert, Hilary A., Chapman, Cortney B., Leonardo, Christopher C., Willing, Alison E., Pennypacker, Keith R.

“…Human umbilical cord blood (HUCB) cells have shown efficacy in rodent models of focal ischemia and in vitro systems that recapitulate stroke conditions. One…”
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Molecular and Cellular Immune Responses to Ischemic Brain Injury by Seifert, Hilary A., Pennypacker, Keith R.

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Translational Evaluation of Acid/Base and Electrolyte Alterations in Rodent Model of Focal Ischemia by Martha, Sarah R., Collier, Lisa A., Davis, Stephanie M., Seifert, Hilary A., Leonardo, Christopher C., Ajmo, Craig T., Foran, Elspeth A., Fraser, Justin F., Pennypacker, Keith R.

“…Acid/base and electrolytes could provide clinically valuable information about cerebral infarct core and penumbra. We evaluated associations between acid/base…”
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Abstract T P248: Leukemia Inhibitory Factor Induced-Akt Activation Protects Neurons from Ischemic Damage by Increasing Superoxide Dismutase Activity and Expression by Davis, Stephanie M, Collier, Lisa A, Leonardo, Christopher C, Seifert, Hilary A, Ajmo, Craig T, Pennypacker, Keith R

“…Abstract only Objective: To determine the molecular mechanisms by which leukemia inhibitory factor (LIF) protects neurons during permanent middle cerebral…”
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Abstract WP265: Interferon-inducible Protein 10 Increases following Stroke by Seifert, Hilary A, Collier, Lisa A, Benkovic, Stanley A, Willing, Alison E, Pennypacker, Keith R

“…Abstract only Objective: The splenic response to injury furthers cellular degeneration as its removal is protective in ischemic injuries to several organ…”
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The Inflammatory Response Initiated by the Spleen to Ischemic Stroke by Seifert, Hilary A

“…The peripheral immune system plays a role in delayed neural injury after stroke. This response originates from the spleen as splenectomy prior to middle…”
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The Inflammatory Response Initiated by the Spleen to Ischemic Stroke by Seifert, Hilary A

“…The peripheral immune system plays a role in delayed neural injury after stroke. This response originates from the spleen as splenectomy prior to middle…”
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