Search Results - "Seifart, H I"

Pharmacokinetics of Isoniazid, Rifampin, and Pyrazinamide in Children Younger than Two Years of Age with Tuberculosis: Evidence for Implementation of Revised World Health Organization Recommendations by THEE, S, SEDDON, J. A, DONALD, P. R, SEIFART, H. I, WERELY, C. J, HESSELING, A. C, ROSENKRANZ, B, ROLL, S, MAGDORF, K, SCHAAF, H. S

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Pharmacokinetics of Isoniazid in Low-Birth-Weight and Premature Infants by BEKKER, A, SCHAAF, H. S, SEIFART, H. I, DRAPER, H. R, WERELY, C. J, COTTON, M. F, HESSELING, A. C

“…Isoniazid (INH) is recommended for use as posttuberculosis exposure preventive therapy in children. However, no pharmacokinetic data are available for INH…”
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Pharmacokinetics of Ethionamide in Children by THEE, S, SEIFART, H. I, ROSENKRANZ, B, HESSELING, A. C, MAGDORF, K, DONALD, P. R, SCHAAF, H. S

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The influence of dose and N-acetyltransferase-2 (NAT2) genotype and phenotype on the pharmacokinetics and pharmacodynamics of isoniazid by DONALD, P. R, PARKIN, D. P, SEIFART, H. I, SCHAAF, H. S, VAN HELDEN, P. D, WERELY, C. J, SIRGEL, F. A, VENTER, A, MARITZ, J. S

“…This study evaluated the pharmacokinetics of isoniazid (INH) associated with optimal early bactericidal activity (EBA), defined as 90% of the maximum EBA…”
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The Influence of Human N-Acetyltransferase Genotype on the Early Bactericidal Activity of Isoniazid by Donald, P.R, Sirgel, F.A., Venter, A., Parkin, D.P., Seifart, H.I., van de Wal, B.W., Werely, C., van Helden, P.D., Maritz, J.S.

“…The elimination of isoniazid is subject to the influence of the N-acetyltransferase 2 (NAT2) genotype, and individuals may be homozygotic slow, heterozygotic…”
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Para-Aminosalicylic Acid Plasma Concentrations in Children in Comparison with Adults after Receiving a Granular Slow-Release Preparation by LIWA, A. C, SCHAAF, H. S, ROSENKRANZ, B, SEIFART, H. I, DIACON, A. H, DONALD, P. R

“…There are no paediatric data regarding slow-release para-aminosalicylic acid (PAS). We studied PAS plasma concentrations in 10 children receiving a single 150…”
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Isoniazid pharmacokinetics in children treated for respiratory tuberculosis by Schaaf, H S, Parkin, D P, Seifart, H I, Werely, C J, Hesseling, P B, van Helden, P D, Maritz, J S, Donald, P R

“…Aims: To define the pharmacokinetics of isoniazid (INH) in children with tuberculosis in relation to the N-acetyltransferase 2 (NAT2) genotype. Methods: The…”
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Early bactericidal activity of antituberculosis agents by Donald, P R, Sirgel, F A, Venter, A, Parkin, D P, Seifart, H I, van de Wal, B W, Maritz, J S, Fourie, P B

“…The early bactericidal activity (EBA) of an antituberculosis agent is arbitrarily defined as the fall in log(10) colony forming units (cfu) of Mycobacterium…”
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Trimodality of isoniazid elimination: phenotype and genotype in patients with tuberculosis by Parkin, D P, Vandenplas, S, Botha, F J, Vandenplas, M L, Seifart, H I, van Helden, P D, van der Walt, B J, Donald, P R, van Jaarsveld, P P

“…The study was undertaken to show that polymorphic isoniazid elimination in humans is trimodal; that the acetylator genotype and eliminator phenotype of the…”
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The early bactericidal activity of isoniazid related to its dose size in pulmonary tuberculosis by DONALD, P. R, SIRGEL, F. A, BOTHA, F. J, SEIFART, H. I, PARKIN, D. P, VANDENPLAS, M. L, VAN DE WAL, B. W, MARITZ, J. S, MITCHISON, D. A

“…Collections of sputum from 105 patients with newly diagnosed pulmonary tuberculosis were made before and at 1 and 2 d after the start of chemotherapy with…”
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Early Bactericidal Activity of Paromomycin (Aminosidine) in Patients with Smear-Positive Pulmonary Tuberculosis by DONALD, P. R, SIRGEL, F. A, MITCHISON, D. A, KANYOK, T. P, DANZIGER, L. H, VENTER, A, BOTHA, F. J, PARKIN, D. P, SEIFART, H. I, VAN DE WAL, B. W, MARITZ, J. S

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The pharmacokinetics of enteral antituberculosis drugs in patients requiring intensive care by Koegelenberg, C F N, Nortje, A, Lalla, U, Enslin, A, Irusen, E M, Rosenkranz, B, Seifart, H I, Bolliger, C T

“…There is a paucity of data on the pharmacokinetics of fixed-dose combination enteral antituberculosis treatment in critically ill patients. To establish the…”
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Fluctuation of the volume of distribution of amikacin and its effect on once-daily dosage and clearance in a seriously ill patient by BOTHA, F. J. H, VAN DER BIJL, P, SEIFART, H. I, PARKIN, D. P

“…The main aim of the trial was to determine the extent to which the volume of distribution of amikacin fluctuates in a seriously ill patient receiving copious…”
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Second Episode of Tuberculosis in an HIV-infected Child: Relapse or Reinfection? by Schaff, H.S., Gie, R.P., van Rie, A., Seifart, H.I., van Helden, P.D., Cotton, M.F.

“…We report a case of an HIV-infected child with a second episode of tuberculosis 22 months after completing antituberculosis treatment. DNA fingerprinting of…”
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Massive posterior fossa tuberculous abscess developing in a young child treated for miliary tuberculosis. Possible role of very rapid acetylation of isoniazid by Schoeman, J F, Morkel, A, Seifart, H I, Parkin, D P, Van Helden, P D, Hewlett, R H, Donald, P R

“…A 21-month-old infant presented with acute obstructive hydrocephalus due to a large tuberculous abscess in the posterior fossa 3 months after starting…”
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Effect of Ultrasound on Transdermal Permeation of Diclofenac by Van Der Bijl, P., Basson, E., Van Eyk, A.D., Seifart, H.I.

“…During the last two decades the effects of ultrasound on the transdermal permeability to a wide variety of drugs have been extensively investigated. There is…”
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Practical management of therapeutic diphenylhydantoin concentrations in children by SMIT, A, SCHOEMAN, J. F, SEIFART, H. I, PARKIN, D. P

“…Development of easy, practical methods for the management and optimisation of therapeutic diphenylhydantoin (DPH) concentrations in children. Investigation of…”
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Cerebrospinal fluid concentrations of ethionamide in children with tuberculous meningitis by Donald, P R, Seifart, H I

“…Cerebrospinal fluid ethionamide concentrations were determined in 18 children (median age 26.5 months) with tuberculous meningitis complicated by raised…”
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Factors in hydrazine formation from isoniazid by paediatric and adult tuberculosis patients by GENT, W. L, SEIFART, H. I, PARKIN, D. P, DONALD, P. R, LAMPRECHT, J. H

“…An HPLC method is described for measurement of plasma hydrazine (Hz) concentrations (CHz) at the same time as isoniazid (INH) levels (CINH). Study has been…”
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Cerebrospinal fluid isoniazid concentrations in children with tuberculous meningitis: the influence of dosage and acetylation status by Donald, P R, Gent, W L, Seifart, H I, Lamprecht, J H, Parkin, D P

“…Cerebrospinal fluid (CSF) and plasma isoniazid (INH) concentrations were determined on 96 occasions in 38 children (median age 1.5 years) with tuberculous…”
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