Search Results - "Seifan, Sara"

Loss of tuberous sclerosis complex 2 sensitizes tumors to nelfinavir,eAEbortezomib therapy to intensify endoplasmic reticulum stress-induced cell death by Johnson, Charlotte E, Dunlop, Elaine A, Seifan, Sara, McCann, Henry D, Hay, Trevor, Parfitt, Geraint J, Jones, Ashley T

“…Cancer cells lose homeostatic flexibility because of mutations and dysregulated signaling pathways involved in maintaining homeostasis. Tuberous Sclerosis…”
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Disparities in the association of the ryanodine receptor and the FK506-binding proteins in mammalian heart by Zissimopoulos, Spyros, Seifan, Sara, Maxwell, Chloe, Williams, Alan J, Lai, F Anthony

“…The FK506-binding proteins (FKBP12 and FKBP12.6; also known as FKBP1A and FKBP1B, respectively) are accessory subunits of the ryanodine receptor (RyR) Ca(2+)…”
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FLCN, a novel autophagy component, interacts with GABARAP and is regulated by ULK1 phosphorylation by Dunlop, Elaine A, Seifan, Sara, Claessens, Tijs, Behrends, Christian, Kamps, Miriam AF, Rozycka, Ewelina, Kemp, Alain J, Nookala, Ravi K, Blenis, John, Coull, Barry J, Murray, James T, van Steensel, Maurice AM, Wilkinson, Simon, Tee, Andrew R

“…Birt-Hogg-Dubé (BHD) syndrome is a rare autosomal dominant condition caused by mutations in the FLCN gene and characterized by benign hair follicle tumors,…”
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Loss of tuberous sclerosis complex 2 sensitizes tumors to nelfinavir−bortezomib therapy to intensify endoplasmic reticulum stress-induced cell death by Johnson, Charlotte E., Dunlop, Elaine A., Seifan, Sara, McCann, Henry D., Hay, Trevor, Parfitt, Geraint J., Jones, Ashley T., Giles, Peter J., Shen, Ming H., Sampson, Julian R., Errington, Rachel J., Davies, D. Mark, Tee, Andrew R.

“…Cancer cells lose homeostatic flexibility because of mutations and dysregulated signaling pathways involved in maintaining homeostasis. Tuberous Sclerosis…”
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Drug Inhibition of Redox Factor-1 Restores Hypoxia-Driven Changes in Tuberous Sclerosis Complex 2 Deficient Cells by Champion, Jesse D, Dodd, Kayleigh M, Lam, Hilaire C, Alzahrani, Mohammad A M, Seifan, Sara, Rad, Ellie, Scourfield, David Oliver, Fishel, Melissa L, Calver, Brian L, Ager, Ann, Henske, Elizabeth P, Davies, David Mark, Kelley, Mark R, Tee, Andrew R

“…Therapies with the mechanistic target of rapamycin complex 1 (mTORC1) inhibitors are not fully curative for tuberous sclerosis complex (TSC) patients. Here, we…”
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Correction: Loss of tuberous sclerosis complex 2 sensitizes tumors to nelfinavir–bortezomib therapy to intensify endoplasmic reticulum stress-induced cell death by Johnson, Charlotte E., Dunlop, Elaine A., Seifan, Sara, McCann, Henry D., Hay, Trevor, Parfitt, Geraint J., Jones, Ashley T., Giles, Peter J., Shen, Ming H., Sampson, Julian R., Errington, Rachel J., Davies, D. Mark, Tee, Andrew R.

“…This article was originally published under standard licence, but has now been made available under a CC BY 4.0 license. The PDF and HTML versions of the paper…”
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Defining the role of folliculin and its interacting partners by Seifan, Sara

“…Birt-Hogg-Dubé (BHD) syndrome is a rare autosomal dominant condition caused by mutations in the FLCN gene and characterised by benign hair follicle tumours,…”
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Disparate Ryanodine Receptor Association with the FK506-binding Proteins in Mammalian Heart by Zissimopoulos, Spyros, Seifan, Sara, Maxwell, Chloe, Williams, Alan J., Lai, F. Anthony

“…The FK506-binding proteins (FKBP12 and FKBP12.6) are accessory subunits of the ryanodine receptor-calcium release channel (RyR). Aberrant RyR2-FKBP12.6…”
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