Search Results - "Seidman, Jason S."

Sympathetic neuron–associated macrophages contribute to obesity by importing and metabolizing norepinephrine by Pirzgalska, Roksana M, Seixas, Elsa, Seidman, Jason S, Link, Verena M, Sánchez, Noelia Martínez, Mahú, Inês, Mendes, Raquel, Gres, Vitka, Kubasova, Nadiya, Morris, Imogen, Arús, Bernardo A, Larabee, Chelsea M, Vasques, Miguel, Tortosa, Francisco, Sousa, Ana L, Anandan, Sathyavathy, Tranfield, Erin, Hahn, Maureen K, Iannacone, Matteo, Spann, Nathanael J, Glass, Christopher K, Domingos, Ana I

“…Sympathetic neuron–associated macrophages act as a local sink for norepinephrine, leading to reduced thermogenesis and increased obesity. The cellular…”
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Niche-Specific Reprogramming of Epigenetic Landscapes Drives Myeloid Cell Diversity in Nonalcoholic Steatohepatitis by Seidman, Jason S., Troutman, Ty D., Sakai, Mashito, Gola, Anita, Spann, Nathanael J., Bennett, Hunter, Bruni, Cassi M., Ouyang, Zhengyu, Li, Rick Z., Sun, Xiaoli, Vu, BaoChau T., Pasillas, Martina P., Ego, Kaori M., Gosselin, David, Link, Verena M., Chong, Ling-Wa, Evans, Ronald M., Thompson, Bonne M., McDonald, Jeffrey G., Hosseini, Mojgan, Witztum, Joseph L., Germain, Ronald N., Glass, Christopher K.

“…Tissue-resident and recruited macrophages contribute to both host defense and pathology. Multiple macrophage phenotypes are represented in diseased tissues,…”
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Neutralization of Oxidized Phospholipids Ameliorates Non-alcoholic Steatohepatitis by Sun, Xiaoli, Seidman, Jason S., Zhao, Peng, Troutman, Ty D., Spann, Nathanael J., Que, Xuchu, Zhou, Fangli, Liao, Zhongji, Pasillas, Martina, Yang, Xiaohong, Magida, Jason A., Kisseleva, Tatiana, Brenner, David A., Downes, Michael, Evans, Ronald M., Saltiel, Alan R., Tsimikas, Sotirios, Glass, Christopher K., Witztum, Joseph L.

“…Oxidized phospholipids (OxPLs), which arise due to oxidative stress, are proinflammatory and proatherogenic, but their roles in non-alcoholic steatohepatitis…”
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Cell-specific discrimination of desmosterol and desmosterol mimetics confers selective regulation of LXR and SREBP in macrophages by Muse, Evan D., Yu, Shan, Edillor, Chantle R., Tao, Jenhan, Spann, Nathanael J., Troutman, Ty D., Seidman, Jason S., Henke, Adam, Roland, Jason T., Ozeki, Katherine A., Thompson, Bonne M., McDonald, Jeffrey G., Bahadorani, John, Tsimikas, Sotirios, Grossman, Tamar R., Tremblay, Matthew S., Glass, Christopher K.

“…Activation of liver X receptors (LXRs) with synthetic agonists promotes reverse cholesterol transport and protects against atherosclerosis in mouse models…”
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Setd5 haploinsufficiency alters neuronal network connectivity and leads to autistic-like behaviors in mice by Moore, Spencer M., Seidman, Jason S., Ellegood, Jacob, Gao, Richard, Savchenko, Alex, Troutman, Ty D., Abe, Yohei, Stender, Josh, Lee, Daehoon, Wang, Sicong, Voytek, Bradley, Lerch, Jason P., Suh, Hoonkyo, Glass, Christopher K, Muotri, Alysson R.

“…SETD5 , a gene linked to intellectual disability (ID) and autism spectrum disorder (ASD), is a member of the SET-domain family and encodes a putative histone…”
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Purification of mouse hepatic non-parenchymal cells or nuclei for use in ChIP-seq and other next-generation sequencing approaches by Troutman, Ty D., Bennett, Hunter, Sakai, Mashito, Seidman, Jason S., Heinz, Sven, Glass, Christopher K.

“…Significant advancements in understanding disease mechanisms can occur through combined analysis of next-generation sequencing datasets generated using…”
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An optimized protocol for rapid, sensitive and robust on-bead ChIP-seq from primary cells by Texari, Lorane, Spann, Nathanael J., Troutman, Ty D., Sakai, Mashito, Seidman, Jason S., Heinz, Sven

“…Integrative analysis of next-generation sequencing data can help understand disease mechanisms. Specifically, ChIP-seq can illuminate where transcription…”
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Expansion of Islet-Resident Macrophages Leads to Inflammation Affecting β Cell Proliferation and Function in Obesity by Ying, Wei, Lee, Yun Sok, Dong, Yi, Seidman, Jason S., Yang, Meixiang, Isaac, Roi, Seo, Jong Bae, Yang, Bi-Huei, Wollam, Joshua, Riopel, Matthew, McNelis, Joanne, Glass, Christopher K., Olefsky, Jerrold M., Fu, Wenxian

“…The nature of obesity-associated islet inflammation and its impact on β cell abnormalities remains poorly defined. Here, we explore immune cell components of…”
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Liver-Derived Signals Sequentially Reprogram Myeloid Enhancers to Initiate and Maintain Kupffer Cell Identity by Sakai, Mashito, Troutman, Ty D., Seidman, Jason S., Ouyang, Zhengyu, Spann, Nathanael J., Abe, Yohei, Ego, Kaori M., Bruni, Cassi M., Deng, Zihou, Schlachetzki, Johannes C.M., Nott, Alexi, Bennett, Hunter, Chang, Jonathan, Vu, BaoChau T., Pasillas, Martina P., Link, Verena M., Texari, Lorane, Heinz, Sven, Thompson, Bonne M., McDonald, Jeffrey G., Geissmann, Frederic, Glass, Christopher K.

“…Tissue environment plays a powerful role in establishing and maintaining the distinct phenotypes of resident macrophages, but the underlying molecular…”
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Antimicrobial production by perifollicular dermal preadipocytes is essential to the pathophysiology of acne by O'Neill, Alan M, Liggins, Marc C, Seidman, Jason S, Do, Tran H, Li, Fengwu, Cavagnero, Kellen J, Dokoshi, Tatsuya, Cheng, Joyce Y, Shafiq, Faiza, Hata, Tissa R, Gudjonsson, Johann E, Modlin, Robert L, Gallo, Richard L

“…Innate immune defense against deep tissue infection by is orchestrated by fibroblasts that become antimicrobial when triggered to differentiate into…”
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Dupilumab for bullous pemphigoid with intractable pruritus by Seidman, Jason S, Eichenfield, Dawn Z, Orme, Charisse M

“…Bullous pemphigoid (BP) is an autoimmune blistering disorder that predominantly affects the elderly. Treatment regimens typically include topical and systemic…”
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Discrimination of cell-intrinsic and environment-dependent effects of natural genetic variation on Kupffer cell epigenomes and transcriptomes by Bennett, Hunter, Troutman, Ty D., Zhou, Enchen, Spann, Nathanael J., Link, Verena M., Seidman, Jason S., Nickl, Christian K., Abe, Yohei, Sakai, Mashito, Pasillas, Martina P., Marlman, Justin M., Guzman, Carlos, Hosseini, Mojgan, Schnabl, Bernd, Glass, Christopher K.

“…Noncoding genetic variation drives phenotypic diversity, but underlying mechanisms and affected cell types are incompletely understood. Here, investigation of…”
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Skin inflammation activates intestinal stromal fibroblasts and promotes colitis by Dokoshi, Tatsuya, Seidman, Jason S, Cavagnero, Kellen J, Li, Fengwu, Liggins, Marc C, Taylor, Bryn C, Olvera, Jocelyn, Knight, Rob, Chang, John T, Salzman, Nita H, Gallo, Richard L

“…Inflammatory disorders of the skin are frequently associated with inflammatory bowel diseases (IBDs). To explore mechanisms by which these organs communicate,…”
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Genetic and Functional Analyses of Cutibacterium Acnes Isolates Reveal the Association of a Linear Plasmid with Skin Inflammation by O'Neill, Alan M, Cavagnero, Kellen J, Seidman, Jason S, Zaramela, Livia, Chen, Yang, Li, Fengwu, Nakatsuji, Teruaki, Cheng, Joyce Y, Tong, Yun L, Do, Tran H, Brinton, Samantha L, Hata, Tissa R, Modlin, Robert L, Gallo, Richard L

“…Cutibacterium acnes is a commensal bacterium on the skin that is generally well-tolerated, but different strain types have been hypothesized to contribute to…”
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A TLR4/TRAF6-dependent signaling pathway mediates NCoR coactivator complex formation for inflammatory gene activation by Abe, Yohei, Kofman, Eric R, Ouyang, Zhengyu, Cruz-Becerra, Grisel, Spann, Nathanael J, Seidman, Jason S, Troutman, Ty D, Stender, Joshua D, Taylor, Havilah, Fan, Weiwei, Link, Verena M, Shen, Zeyang, Sakai, Juro, Downes, Michael, Evans, Ronald M, Kadonaga, James T, Rosenfeld, Michael G, Glass, Christopher K

“…The nuclear receptor corepressor (NCoR) forms a complex with histone deacetylase 3 (HDAC3) that mediates repressive functions of unliganded nuclear receptors…”
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RANK ligand converts the NCoR/HDAC3 co-repressor to a PGC1β- and RNA-dependent co-activator of osteoclast gene expression by Abe, Yohei, Kofman, Eric R., Almeida, Maria, Ouyang, Zhengyu, Ponte, Filipa, Mueller, Jasmine R., Cruz-Becerra, Grisel, Sakai, Mashito, Prohaska, Thomas A., Spann, Nathanael J., Resende-Coelho, Ana, Seidman, Jason S., Stender, Joshua D., Taylor, Havilah, Fan, Weiwei, Link, Verena M., Cobo, Isidoro, Schlachetzki, Johannes C.M., Hamakubo, Takao, Jepsen, Kristen, Sakai, Juro, Downes, Michael, Evans, Ronald M., Yeo, Gene W., Kadonaga, James T., Manolagas, Stavros C., Rosenfeld, Michael G., Glass, Christopher K.

“…The nuclear receptor co-repressor (NCoR) complex mediates transcriptional repression dependent on histone deacetylation by histone deacetylase 3 (HDAC3) as a…”
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Nevoid melanoma and eruptive nevi from erlotinib by Seidman, Jason S, Eichenfield, Dawn Z, Orme, Charisse M

“…Cutaneous side effects such as acneiform eruption, xerosis, and paronychia are frequently observed in patients undergoing treatment with epidermal growth…”
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Alternative Fates of Paused Ribosomes during Translation Termination by Seidman, Jason S., Janssen, Brian D., Hayes, Christopher S.

“…The bacterial tmRNA·SmpB system facilitates recycling of stalled translational complexes in a process termed “ribosome rescue.” During ribosome rescue, the…”
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Genome-Wide Approaches to Defining Macrophage Identity and Function by Fonseca, Gregory J, Seidman, Jason S, Glass, Christopher K

“…Macrophages play essential roles in the response to injury and infection and contribute to the development and/or homeostasis of the various tissues they…”
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Hepatic Myeloid Cell Diversity During Fibrosis and Nonalcoholic Steatohepatitis by Troutman, Ty Dale, Seidman, Jason S., Link, Verena M., Hosseini, Mojgan, Sakai, Mashito, Bruni, Cassi, Ouyang, Zhengyu, Pasillas, Martina, Glass, Christopher K.

“…Abstract Fatty liver diseases account for rapidly growing morbidity in the United States where it is estimated that 80 to 100 million individuals have…”
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