Search Results - "Seidlitz, Annekatrin"

“Radiobiology of Proton Therapy”: Results of an international expert workshop by Lühr, Armin, von Neubeck, Cläre, Pawelke, Jörg, Seidlitz, Annekatrin, Peitzsch, Claudia, Bentzen, Søren M., Bortfeld, Thomas, Debus, Jürgen, Deutsch, Eric, Langendijk, Johannes A., Loeffler, Jay S., Mohan, Radhe, Scholz, Michael, Sørensen, Brita S., Weber, Damien C., Baumann, Michael, Krause, Mechthild

“…The physical properties of proton beams offer the potential to reduce toxicity in tumor-adjacent normal tissues. Toward this end, the number of proton…”
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Radiomics for residual tumour detection and prognosis in newly diagnosed glioblastoma based on postoperative [11C] methionine PET and T1c-w MRI by Shahzadi, Iram, Seidlitz, Annekatrin, Beuthien-Baumann, Bettina, Zwanenburg, Alex, Platzek, Ivan, Kotzerke, Jörg, Baumann, Michael, Krause, Mechthild, Troost, Esther G. C., Löck, Steffen

“…Personalized treatment strategies based on non-invasive biomarkers have potential to improve patient management in patients with newly diagnosed glioblastoma…”
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Photon vs. proton radiochemotherapy: Effects on brain tissue volume and perfusion by Petr, Jan, Platzek, Ivan, Hofheinz, Frank, Mutsaerts, Henri J.M.M., Asllani, Iris, van Osch, Matthias J.P., Seidlitz, Annekatrin, Krukowski, Pawel, Gommlich, Andreas, Beuthien-Baumann, Bettina, Jentsch, Christina, Maus, Jens, Troost, Esther G.C., Baumann, Michael, Krause, Mechthild, van den Hoff, Jörg

“…To compare the structural and hemodynamic changes of healthy brain tissue in the cerebral hemisphere contralateral to the tumor following photon and proton…”
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Re‐irradiation of recurrent gliomas: pooled analysis and validation of an established prognostic score—report of the Radiation Oncology Group (ROG) of the German Cancer Consortium (DKTK) by Combs, Stephanie E., Niyazi, Maximilian, Adeberg, Sebastian, Bougatf, Nina, Kaul, David, Fleischmann, Daniel F., Gruen, Arne, Fokas, Emmanouil, Rödel, Claus M., Eckert, Franziska, Paulsen, Frank, Oehlke, Oliver, Grosu, Anca‐Ligia, Seidlitz, Annekatrin, Lattermann, Annika, Krause, Mechthild, Baumann, Michael, Guberina, Maja, Stuschke, Martin, Budach, Volker, Belka, Claus, Debus, Jürgen, Kessel, Kerstin A.

“…The heterogeneity of high‐grade glioma recurrences remains an ongoing challenge for the interdisciplinary neurooncology team. Response to re‐irradiation…”
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Individual patient data meta-analysis of FMISO and FAZA hypoxia PET scans from head and neck cancer patients undergoing definitive radio-chemotherapy by Zschaeck, Sebastian, Löck, Steffen, Hofheinz, Frank, Zips, Daniel, Saksø Mortensen, Lise, Zöphel, Klaus, Troost, Esther G.C., Boeke, Simon, Saksø, Mette, Mönnich, David, Seidlitz, Annekatrin, Johansen, Jørgen, Skripcak, Tomas, Gregoire, Vincent, Overgaard, Jens, Baumann, Michael, Krause, Mechthild

“…•The two most commonly used hypoxia PET tracers FMISO and FAZA can be analyzed jointly.•Hypoxia PET derived parameters delivered strong and independent…”
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Variable-RBE-induced NTCP predictions for various side-effects following proton therapy for brain tumors – Identification of high-risk patients and risk mitigation by Palkowitsch, Martina, Kaufmann, Lisa-Marie, Hennings, Fabian, Menkel, Stefan, Hahn, Christian, Bensberg, Jona, Lühr, Armin, Seidlitz, Annekatrin, Troost, Esther G.C., Krause, Mechthild, Löck, Steffen

“…Disregarding the increase of relative biological effectiveness (RBE) may raise the risk of acute and late adverse events after proton beam therapy (PBT). This…”
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Residual tumour hypoxia in head-and-neck cancer patients undergoing primary radiochemotherapy, final results of a prospective trial on repeat FMISO-PET imaging by Löck, Steffen, Perrin, Rosalind, Seidlitz, Annekatrin, Bandurska-Luque, Anna, Zschaeck, Sebastian, Zöphel, Klaus, Krause, Mechthild, Steinbach, Jörg, Kotzerke, Jörg, Zips, Daniel, Troost, Esther G.C., Baumann, Michael

“…Hypoxia is a well recognised parameter of tumour resistance to radiotherapy, a number of anticancer drugs and potentially immunotherapy. In a previously…”
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1579: NTCP reduction due to novel optimization strategies accounting for RBE variability in proton therapy by Palkowitsch, Martina, Kaufmann, Lisa-Marie, Hennings, Fabian, Menkel, Stefan, Hahn, Christian, Bensberg, Jona, Lühr, Armin, Seidlitz, Annekatrin, Troost, Esther G.C., Krause, Mechthild, Löck, Steffen

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Increased relative biological effectiveness and periventricular radiosensitivity in proton therapy of glioma patients by Eulitz, Jan, G. C. Troost, Esther, Klünder, Lauritz, Raschke, Felix, Hahn, Christian, Schulz, Erik, Seidlitz, Annekatrin, Thiem, Justus, Karpowitz, Caroline, Hahlbohm, Patricia, Grey, Arne, Engellandt, Kay, Löck, Steffen, Krause, Mechthild, Lühr, Armin

“…•Regional intra-cerebral variation in tissue response after proton therapy.•Increased relative biological effectiveness of proton therapy.•Spatial accumulation…”
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Subjective memory impairment in glioma patients with curative radiotherapy by Donix, Markus, Seidlitz, Annekatrin, Buthut, Maria, Löck, Steffen, Meissner, Gisa, Matthes, Claudia, Troost, Esther G.C., Baumann, Michael, Raschke, Felix, Linn, Jennifer, Krause, Mechthild

“…•Radiotherapy of brain tumors may cause dose-dependent side-effects.•HipPro Pilot study using structural MRI and comprehensive neurocognitive…”
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Final Results of the Prospective Biomarker Trial PETra: [ 11 C]-MET-Accumulation in Postoperative PET/MRI Predicts Outcome after Radiochemotherapy in Glioblastoma by Seidlitz, Annekatrin, Beuthien-Baumann, Bettina, Löck, Steffen, Jentsch, Christina, Platzek, Ivan, Zöphel, Klaus, Linge, Annett, Kotzerke, Jörg, Petr, Jan, van den Hoff, Jörg, Steinbach, Jörg, Krex, Dietmar, Schmitz-Schackert, Gabriele, Falk, Monique, Baumann, Michael, Krause, Mechthild

“…This prospective trial investigates the association of time to recurrence (TTR) in glioblastoma with [ C]methionine (MET) tracer uptake before postoperative…”
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Generation of biological hypotheses by functional imaging links tumor hypoxia to radiation induced tissue inflammation/glucose uptake in head and neck cancer by Zschaeck, Sebastian, Zöphel, Klaus, Seidlitz, Annekatrin, Zips, Daniel, Kotzerke, Jörg, Baumann, Michael, Troost, Esther G.C., Löck, Steffen, Krause, Mechthild

“…•PET measured tumor hypoxia is inversely correlated with PET measured glucose uptake of tumor surroundings especially during radiotherapy.•Both parameters bear…”
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Repeat FMISO-PET imaging weakly correlates with hypoxia-associated gene expressions for locally advanced HNSCC treated by primary radiochemotherapy by Löck, Steffen, Linge, Annett, Seidlitz, Annekatrin, Bandurska-Luque, Anna, Nowak, Alexander, Gudziol, Volker, Buchholz, Frank, Aust, Daniela E., Baretton, Gustavo B., Zöphel, Klaus, Steinbach, Jörg, Kotzerke, Jörg, Overgaard, Jens, Zips, Daniel, Krause, Mechthild, Baumann, Michael, Troost, Esther G.C.

“…•Weak correlation of repeat FMISO-PET with hypoxia-associated gene expressions.•Higher correlation at later imaging time points.•Moderate correlation of…”
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Impact of waiting time after surgery and overall time of postoperative radiochemotherapy on treatment outcome in glioblastoma multiforme by Seidlitz, Annekatrin, Siepmann, Timo, Löck, Steffen, Juratli, Tareq, Baumann, Michael, Krause, Mechthild

“…A time factor of radiooncological treatment has been demonstrated for several tumours, most prominently for head and neck squamous cell carcinoma and lung…”
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Independent validation of a new reirradiation risk score (RRRS) for glioma patients predicting post-recurrence survival: A multicenter DKTK/ROG analysis by Niyazi, Maximilian, Adeberg, Sebastian, Kaul, David, Boulesteix, Anne-Laure, Bougatf, Nina, Fleischmann, Daniel F., Grün, Arne, Krämer, Anna, Rödel, Claus, Eckert, Franziska, Paulsen, Frank, Kessel, Kerstin A., Combs, Stephanie E., Oehlke, Oliver, Grosu, Anca-Ligia, Seidlitz, Annekatrin, Lattermann, Annika, Krause, Mechthild, Baumann, Michael, Guberina, Maja, Stuschke, Martin, Budach, Volker, Belka, Claus, Debus, Jürgen

“…Reirradiation (reRT) is a valid option with considerable efficacy in patients with recurrent high-grade glioma, but it is still not known which patients might…”
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Glioneuronal tumor with ATRX alteration, kinase fusion and anaplastic features (GTAKA): a molecularly distinct brain tumor type with recurrent NTRK gene fusions by Bogumil, Henri, Sill, Martin, Schrimpf, Daniel, Ismer, Britta, Blume, Christina, Rahmanzade, Ramin, Hinz, Felix, Cherkezov, Asan, Banan, Rouzbeh, Friedel, Dennis, Reuss, David E., Selt, Florian, Ecker, Jonas, Milde, Till, Pajtler, Kristian W., Schittenhelm, Jens, Hench, Jürgen, Frank, Stephan, Boldt, Henning B., Kristensen, Bjarne Winther, Scheie, David, Melchior, Linea C., Olesen, Viola, Sehested, Astrid, Boué, Daniel R., Abdullaev, Zied, Satgunaseelan, Laveniya, Kurth, Ina, Seidlitz, Annekatrin, White, Christine L., Ng, Ho-Keung, Shi, Zhi-Feng, Haberler, Christine, Deckert, Martina, Timmer, Marco, Goldbrunner, Roland, Tauziède-Espariat, Arnault, Varlet, Pascale, Brandner, Sebastian, Alexandrescu, Sanda, Snuderl, Matija, Aldape, Kenneth, Korshunov, Andrey, Witt, Olaf, Herold-Mende, Christel, Unterberg, Andreas, Wick, Wolfgang, Pfister, Stefan M., von Deimling, Andreas, Jones, David T. W., Sahm, Felix, Sievers, Philipp

“…Glioneuronal tumors are a heterogenous group of CNS neoplasms that can be challenging to accurately diagnose. Molecular methods are highly useful in…”
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Dose dependent cerebellar atrophy in glioma patients after radio(chemo)therapy by Raschke, Felix, Seidlitz, Annekatrin, Wesemann, Tim, Löck, Steffen, Jentsch, Christina, Platzek, Ivan, Petr, Jan, van den Hoff, Jörg, Kotzerke, Jörg, Beuthien-Baumann, Bettina, Baumann, Michael, Linn, Jennifer, Krause, Mechthild, Troost, Esther G.C.

“…•Radiotherapy causes cerebellar atrophy in adult glioma patients.•Cerebellar atrophy is dose dependent and progressive over time.•Cerebellar dose is lower in…”
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Early and late effects of radiochemotherapy on cerebral blood flow in glioblastoma patients measured with non-invasive perfusion MRI by Petr, Jan, Platzek, Ivan, Seidlitz, Annekatrin, Mutsaerts, Henri J.M.M, Hofheinz, Frank, Schramm, Georg, Maus, Jens, Beuthien-Baumann, Bettina, Krause, Mechthild, van den Hoff, Jörg

“…Abstract Background and purpose To provide a systematic measure of changes of brain perfusion in healthy tissue following a fractionated radiotherapy of brain…”
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FMISO-PET-based lymph node hypoxia adds to the prognostic value of tumor only hypoxia in HNSCC patients by Bandurska-Luque, Anna, Löck, Steffen, Haase, Robert, Richter, Christian, Zöphel, Klaus, Abolmaali, Nasreddin, Seidlitz, Annekatrin, Appold, Steffen, Krause, Mechthild, Steinbach, Jörg, Kotzerke, Jörg, Zips, Daniel, Baumann, Michael, Troost, Esther G.C.

“…•Secondary analysis of largest FMISO-PET/CT study focusing on lymph node hypoxia.•Synchronous tumor and lymph node hypoxia correlates with loco-regional…”
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Subcortical volume changes in glioma patients after radiotherapy by Raschke, Felix, Seidlitz, Annekatrin, Wesemann, Tim, Jentsch, Christina, Platzek, Ivan, Kotzerke, Jorg, van den Hoff, Jorg, Beuthien-Baumann, Bettina, Baumann, Michael, Linn, Jennifer, Krause, Mechthild, Troost, Esther

“…Background: Radiotherapy of brain tumor patients causes brain atrophy [1] and neurocognitive dysfunction [2]. The hippocampus is a suspected focal point of…”
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