Search Results - "Seidler, F.J"

Sex-selective interaction of prenatal nicotine with neonatal chlorpyrifos on novel object recognition in rats by Cauley, M, Burke, D, Hall, B.J, Seidler, F.J, Slotkin, T.A, Levin, E.D

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Cellular Mechanisms for Developmental Toxicity of Chlorpyrifos: Targeting the Adenylyl Cyclase Signaling Cascade by Song, X., Seidler, F.J., Saleh, J.L., Zhang, J., Padilla, S., Slotkin, T.A.

“…Developmental neurotoxicity caused by chlorpyrifos exposure is generally thought to target cholinesterase but chlorpyrifos may also act on cellular…”
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Persistent cholinergic presynaptic deficits after neonatal chlorpyrifos exposure by Slotkin, T.A., Cousins, M.M., Tate, C.A., Seidler, F.J.

“…The commonly-used organophosphate insecticide, chlorpyrifos (CPF), impairs brain cell development, axonogenesis and synaptogenesis. In the current study, we…”
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Adolescent nicotine administration alters serotonin receptors and cell signaling mediated through adenylyl cyclase by Xu, Z, Seidler, F.J, Cousins, M.M, Slikker, W, Slotkin, T.A

“…Nicotine is a neuroteratogen that targets synaptic function during critical developmental stages and recent studies indicate that CNS vulnerability extends…”
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Developmental Neurotoxicity of Chlorpyrifos: Cellular Mechanisms by Whitney, K.D., Seidler, F.J., Slotkin, T.A.

“…Chlorpyrifos, one of the most widely used pesticides, exhibits greater toxicity during development than in adulthood. We administered chlorpyrifos to neonatal…”
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Early Biochemical Detection of Delayed Neurotoxicity Resulting from Developmental Exposure to Chlorpyrifos by Johnson, D.E, Seidler, F.J, Slotkin, T.A

“…Developing animals are more sensitive than adults to the delayed neurotoxicity caused by chlorpyrifos exposure. In developing rat brain, chlorpyrifos doses…”
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Deficits in development of central cholinergic pathways caused by fetal nicotine exposure: differential effects on choline acetyltransferase activity and [3H]hemicholinium-3 binding by Zahalka, E A, Seidler, F J, Lappi, S E, McCook, E C, Yanai, J, Slotkin, T A

“…Nicotine has been hypothesized to induce neurobehavioral teratology by mimicking prematurely the natural developmental signals ordinarily communicated by the…”
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Programming of brainstem serotonin transporter development by prenatal glucocorticoids by Slotkin, T.A., Barnes, G.A., McCook, E.C., Seidler, F.J.

“…Prenatal stress or exposure to excess glucocorticoids are known to alter central nervous system function and to result in lasting changes in reactions to…”
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Fetal and adolescent nicotine administration: effects on CNS serotonergic systems by Xu, Z, Seidler, F.J, Ali, S.F, Slikker, W, Slotkin, T.A

“…Nicotine is a neuroteratogen that targets synaptic function during critical developmental stages and recent studies indicate that CNS vulnerability extends…”
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Inhibition of DNA synthesis in neonatal rat brain regions caused by acute nicotine administration by McFarland, B J, Seidler, F J, Slotkin, T A

“…Perinatal exposure to nicotine has been shown to cause morphological and neurobehavioral abnormalities in developing brain. In the current study, neonatal rats…”
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Fetal nicotine exposure ablates the ability of postnatal nicotine challenge to release norepinephrine from rat brain regions by Seidler, F J, Levin, E D, Lappi, S E, Slotkin, T A

“…Exposure of the fetus to nicotine is known to affect the function of noradrenergic pathways in the central nervous system. In the current study, synaptic…”
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Adolescent nicotine exposure causes persistent upregulation of nicotinic cholinergic receptors in rat brain regions by Trauth, J.A, Seidler, F.J, McCook, E.C, Slotkin, T.A

“…Whereas numerous studies have explored the consequences of fetal or adult nicotine exposure, little or no basic research has been conducted for nicotine…”
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Developmental neurotoxicity of chlorpyrifos in vivo and in vitro: effects on nuclear transcription factors involved in cell replication and differentiation by Crumpton, T.L, Seidler, F.J, Slotkin, T.A

“…Chlorpyrifos is a widely used organophosphate insecticide that is a suspected developmental neurotoxin. Although chlorpyrifos exerts some effects through…”
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Does the developmental neurotoxicity of chlorpyrifos involve glial targets? Macromolecule synthesis, adenylyl cyclase signaling, nuclear transcription factors, and formation of reactive oxygen in C6 glioma cells by Garcia, S.J., Seidler, F.J., Crumpton, T.L., Slotkin, T.A.

“…The widespread use of chlorpyrifos (CPF) has raised major concerns about its potential to cause fetal or neonatal neurobehavioral damage, even at doses that do…”
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Prenatal terbutaline exposure in the rat: selective effects on development of noradrenergic projections to cerebellum by Slotkin, T A, Baker, F E, Dobbins, S S, Eylers, J P, Lappi, S E, Seidler, F J

“…Terbutaline, used in the treatment of premature labor and asthma, crosses the placenta and can stimulate beta 2-adrenergic receptors in the fetus. This study…”
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Persistent and delayed behavioral changes after nicotine treatment in adolescent rats by Trauth, J.A., Seidler, F.J., Slotkin, T.A.

“…Despite the increasing use of tobacco by adolescents, few animal studies have addressed the neurobehavioral consequences of nicotine exposure during this…”
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Modelling the developmental neurotoxicity of chlorpyrifos in vitro: macromolecule synthesis in PC12 cells by Song, X. (Duke University, Durham, NC.), Violin, J.D, Seidler, F.J, Slotkin, T.A

“…Exposure to apparently subtoxic doses of chlorpyrifos during late stages of brain development affects cell acquisition through a mixture of cholinergic and…”
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Chlorpyrifos exposure during a critical neonatal period elicits gender-selective deficits in the development of coordination skills and locomotor activity by Dam, K., Seidler, F.J., Slotkin, T.A.

“…The widespread use of chlorpyrifos has raised concern about the potential consequences of fetal and childhood exposure. Previous studies have shown that…”
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Chlorpyrifos interferes with cell development in rat brain regions by CAMPBELL, C. G, SEIDLER, F. J, SLOTKIN, T. A

“…Chlorpyrifos, one of the most widely used pesticides, exhibits greater toxicity during development than in adulthood. We administered chlorpyrifos to neonatal…”
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Functional alterations in CNS catecholamine systems in adolescence and adulthood after neonatal chlorpyrifos exposure by Slotkin, T.A, Tate, C.A, Cousins, M.M, Seidler, F.J

“…Chlorpyrifos (CPF), one of the most widely used pesticides, is a neurobehavioral teratogen in animals. We administered CPF to neonatal rats on postnatal days…”
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