Search Results - "Seidl, K J"

Late embryonic lethality and impaired V ( D ) J recombination in mice lacking DNA ligase IV by Alt, Frederick W, Frank, Karen M, Sekiguchi, JoAnn M, Seidl, Katherine J, Swat, Wojciech, Rathbun, Gary A, Cheng, Hwei-Ling, Davidson, Laurie, Kangaloo, Landy

“…The DNA-end-joining reactions used for repair of double-strand breaks in DNA and for V (D)J recombination, the process by which immunoglobulin and T-cell…”
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A Critical Role for DNA End-Joining Proteins in Both Lymphogenesis and Neurogenesis by Gao, Yijie, Sun, Yi, Frank, Karen M., Dikkes, Pieter, Fujiwara, Yuko, Seidl, Katherine J., Sekiguchi, JoAnn M., Rathbun, Gary A., Swat, Wojciech, Wang, Jiyang, Bronson, Roderick T., Malynn, Barbara A., Bryans, Margaret, Zhu, Chengming, Chaudhuri, Jayanta, Davidson, Laurie, Ferrini, Roger, Stamato, Thomas, Orkin, Stuart H., Greenberg, Michael E., Alt, Frederick W.

“…XRCC4 was identified via a complementation cloning method that employed an ionizing radiation (IR)-sensitive hamster cell line. By gene-targeted mutation, we…”
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Growth Retardation and Leaky SCID Phenotype of Ku70-Deficient Mice by Gu, Yansong, Seidl, Katherine J, Rathbun, Gary A, Zhu, Chengming, Manis, John P, van der Stoep, Nienke, Davidson, Laurie, Cheng, Hwei-Ling, Sekiguchi, JoAnn M, Frank, Karen, Stanhope-Baker, Patricia, Schlissel, Mark S, Roth, David B, Alt, Frederick W

“…Ku70, Ku80, and DNA-PKcs are subunits of the DNA-dependent protein kinase (DNA-PK), an enzyme implicated in DNA double-stranded break repair and V(D)J…”
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RAG2:GFP Knockin Mice Reveal Novel Aspects of RAG2 Expression in Primary and Peripheral Lymphoid Tissues by Monroe, Robert J, Seidl, Katherine J, Gaertner, Frank, Han, Shuhua, Chen, Feng, Sekiguchi, JoAnn, Wang, Jiyang, Ferrini, Roger, Davidson, Laurie, Kelsoe, Garnett, Alt, Frederick W

“…We generated mice in which a functional RAG2:GFP fusion gene is knocked in to the endogenous RAG2 locus. In bone marrow and thymus, RAG2:GFP expression occurs…”
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Crystal Structures of the FXIa Catalytic Domain in Complex with Ecotin Mutants Reveal Substrate-like Interactions by Jin, Lei, Pandey, Pramod, Babine, Robert E., Gorga, Joan C., Seidl, Katherine J., Gelfand, Ellen, Weaver, David T., Abdel-Meguid, Sherin S., Strickler, James E.

“…Thrombosis can lead to life-threatening conditions such as acute myocardial infarction, pulmonary embolism, and stroke. Although commonly used anti-coagulant…”
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Antigen-independent appearance of recombination activating gene (RAG)-positive bone marrow B cells in the spleens of immunized mice by Gärtner, F, Alt, F W, Monroe, R J, Seidl, K J

“…Splenic B lineage cells expressing recombination activation genes (RAG(+)) in mice immunized with 4-hydroxy-3-nitrophenyl-acetyl coupled to chicken…”
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Frequent occurrence of identical heavy and light chain Ig rearrangements by Seidl, K J, MacKenzie, J D, Wang, D, Kantor, A B, Kabat, E A, Herzenberg, L A

“…Single-cell PCR analyses of expressed Ig H and L chain sequences presented here show that certain rearrangements occur repeatedly and account for a major…”
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Recurrent Identical Rearrangement and Repeated Expression of Identical Heavy and Light Chains in Single Anti-phosphatidylcholine B Cells by SEIDL, KATHERINE J., MacKENZIE, JOHN D., WANG, DENONG, KANTOR, AARON B., KABAT, ELVIN A., HERZENBERG, LEONARD A., HERZENBERG, LEONORE A.

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Predominant VH genes expressed in innate antibodies are associated with distinctive antigen-binding sites by Seidl, K J, Wilshire, J A, MacKenzie, J D, Kantor, A B, Herzenberg, L A

“…Antibodies to phosphatidylcholine (PtC), a common constituent of mammalian and bacterial cell membranes, represent a large proportion of the natural antibody…”
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The three-dimensional structure of the ZAP-70 kinase domain in complex with staurosporine: implications for the design of selective inhibitors by Jin, Lei, Pluskey, Scott, Petrella, Eugene C, Cantin, Susan M, Gorga, Joan C, Rynkiewicz, Michael J, Pandey, Pramod, Strickler, James E, Babine, Robert E, Weaver, David T, Seidl, Katherine J

“…The ZAP-70 tyrosine kinase plays a critical role in T cell activation and the immune response and therefore is a logical target for immunomodulatory therapies…”
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Position-dependent inhibition of class-switch recombination by PGK-neo super(r) cassettes inserted into the immunoglobulin heavy chain constant region locus by Seidl, K J, Manis, J P, Bottaro, A, Zhang, J, Davidson, L, Kisselgof, A, Oettgen, H, Alt, F W

“…The Ig heavy chain (IgH) constant region (C sub(H)) genes are organized from 5' to 3' in the order C mu , C delta , C gamma 3, C gamma 1, C gamma 2b C gamma…”
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Predominant V sub(H) genes expressed in innate antibodies are associated with distinctive antigen-binding sites by Seidl, K J, Wilshire, JA, MacKenzie, J D, Kantor, AB, Herzenberg, LA

“…Antibodies to phosphatidylcholine (PtC), a common constituent of mammalian and bacterial cell membranes, represent a large proportion of the natural antibody…”
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An expressed neo super(r) cassette provides required functions of the I gamma 2b exon for class switching by Seidl, K J, Bottaro, A, Vo, A, Zhang, Jue, Davidson, L, Alt, F W

“…Germline C sub(H) transcripts initiate from a promoter upstream of a non-coding I exon, proceed through the switch (S) region and terminate downstream of the…”
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An expressed neo(r) cassette provides required functions of the 1gamma2b exon for class switching by Seidl, K J, Bottaro, A, Vo, A, Zhang, J, Davidson, L, Alt, F W

“…Germline CH transcripts initiate from a promoter upstream of a non-coding I exon, proceed through the switch (S) region and terminate downstream of the…”
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Position-dependent inhibition of class-switch recombination by PGK-neor cassettes inserted into the immunoglobulin heavy chain constant region locus by Seidl, K J, Manis, J P, Bottaro, A, Zhang, J, Davidson, L, Kisselgof, A, Oettgen, H, Alt, F W

“…The Ig heavy chain (IgH) constant region (C H ) genes are organized from 5′ to 3′ in the order Cμ, Cδ, Cγ3, Cγ1, Cγ2b, Cγ2a, Cɛ, and Cα. Expression of C H…”
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Predominant V H genes expressed in innate antibodies are associated with distinctive antigen-binding sites by Seidl, Katherine J., Wilshire, Jennifer A., MacKenzie, John D., Kantor, Aaron B., Herzenberg, Leonard A., Herzenberg, Leonore A.

“…Antibodies to phosphatidylcholine (PtC), a common constituent of mammalian and bacterial cell membranes, represent a large proportion of the natural antibody…”
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