Search Results - "Seidel, Shawn"

Use and validation of HT/HC assays to support 21st century toxicity evaluations by Patlewicz, Grace, Simon, Ted, Goyak, Katy, Phillips, Richard D., Rowlands, J. Craig, Seidel, Shawn D., Becker, Richard A.

“…► 21cTox assays have a great potential for streamlining and improving risk assessment. ► The challenge is validation. ► Scientific consensus is needed to…”
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Activation of the Ah Receptor by Tryptophan and Tryptophan Metabolites by Heath-Pagliuso, Sharon, Rogers, William J, Tullis, Kathryn, Seidel, Shawn D, Cenijn, Peter H, Brouwer, Abraham, Denison, Michael S

“…The aryl hydrocarbon receptor (AhR) is a ligand-dependent transcription factor that mediates many of the biological and toxicological actions of a variety of…”
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Background Gene Expression in Rat Kidney: Influence of Strain, Gender, and Diet by Seidel, Shawn D., Hung, Shao-Ching, Lynn Kan, H, Bhaskar Gollapudi, B

“…In order to gain better insight into factors (strain, gender, and diet) influencing background variability in kidney gene expression, we examined the…”
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Propylene oxide derived glycol ethers: A review of the alkyl glycol ethers potential to cause endocrine disruption by Kelsey, Jeffrey R., Seidel, Shawn

“…The ‘propylene glycol ethers’ (PGEs) are a group of chemical solvents and functional fluids produced through the reaction of propylene oxide (PO) and a…”
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Gene Expression Dose-Response of Liver with a Genotoxic and Nongenotoxic Carcinogen by Seidel, Shawn D., Stott, William T., Kan, H. Lynn, Sparrow, Barney R., Gollapudi, B. Bhaskar

“…Tumorigenic mechanisms due to chemical exposure are broadly classified as either genotoxic or nongenotoxic. Genotoxic mechanisms are generally well defined;…”
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Identification of transcriptome profiles for the DNA-damaging agents bleomycin and hydrogen peroxide in L5178Y mouse lymphoma cells by Seidel, Shawn D., Kan, H. Lynn, Stott, William T., Schisler, Melissa R., Gollapudi, B. Bhaskar

“…It is believed that some aspects of genotoxicity are associated with changes in the transcription levels of certain genes, especially those involved in DNA…”
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Activation of the Ah Receptor Signaling Pathway by Prostaglandins by Seidel, Shawn D., Winters, Greg M., Rogers, William J., Ziccardi, Michael H., Li, Violet, Keser, Bart, Denison, Michael S.

“…The aryl hydrocarbon receptor (AhR) is a ligand‐dependent transcription factor that mediates many of the biological and toxicological actions of a diverse…”
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Assessment of the skin sensitisation hazard of functional polysiloxanes and silanes in the SENS-IS assay by Petry, Thomas, Bosch, Axel, Koraïchi-Emeriau, Farah, Eigler, Dorothea, Germain, Pierre, Seidel, Shawn

“…In the context of a larger testing programme that aimed at assessing the skin sensitisation potential of functional polysiloxanes and silanes, this…”
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Corrigendum to “Assessment of the skin sensitisation hazard of functional polysiloxanes and silanes in the SENS-IS assay” [Regul. Toxicol. Pharmacol. 98 (2018) 209–214] by Petry, Thomas, Bosch, Axel, Koraïchi-Emeriau, Farah, Eigler, Dorothea, Germain, Pierre, Seidel, Shawn

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Profiles of gene expression changes in L5178Y mouse lymphoma cells treated with methyl methanesulfonate and sodium chloride by Seidel, Shawn D., Sparrow, Barney R., Kan, H.Lynn, Stott, William T., Schisler, Melissa R., Linscombe, V.Ann, Gollapudi, B.Bhaskar

“…Treatment of cells with genotoxic chemicals is expected to set into motion a series of events including gene expression changes to cope with the damage. We…”
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Repression of Hepatocyte Nuclear Factor 4α by Tumor Suppressor p53: Involvement of the Ligand-Binding Domain and Histone Deacetylase Activity by Maeda, Yutaka, Seidel, Shawn D, Wei, Gang, Liu, Xuan, Sladek, Frances M

“…Tumor suppressor p53 is known to inhibit transactivation by certain nuclear receptors, and overexpressed p53 is known to correlate with poor differentiation in…”
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Evaluation of in vitro assays for the assessment of the skin sensitization hazard of functional polysiloxanes and silanes by Petry, Thomas, Bosch, Axel, Coste, Xavier, Eigler, Dorothea, Germain, Pierre, Seidel, Shawn, Jean, Paul A.

“…The skin sensitization potential of chemicals has traditionally been evaluated in vivo according to OECD testing guidelines in guinea pigs or the mouse local…”
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Ah Receptor-Based Chemical Screening Bioassays: Application and Limitations for the Detection of Ah Receptor Agonists by Seidel, Shawn D., Li, Violet, Winter, Greg M., Rogers, William J., Martinez, Eugenio I., Denison, Michael S.

“…The aromatic hydrocarbon receptor (AhR) is a ligand-activated transcription factor that mediates many of the biologic and toxicologic effects of…”
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Repression of hepatocyte nuclear factor 4alpha tumor suppressor p53: involvement of the ligand-binding domain and histone deacetylase activity by Maeda, Yutaka, Seidel, Shawn D, Wei, Gang, Liu, Xuan, Sladek, Frances M

“…Tumor suppressor p53 is known to inhibit transactivation by certain nuclear receptors, and overexpressed p53 is known to correlate with poor differentiation in…”
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Differential gene expression in wild-type and Arnt-defective mouse hepatoma (Hepa1 c1 c7) cells by SEIDEL, S. D, DENISON, M. S

“…The aryl hydrocarbon nuclear translocator (Arnt) is a basic helix-loop-helix (per/Arnt/Ahr/sim) PAS-containing protein that can heterodimerize with the aryl…”
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Studies into the aryl hydrocarbon receptor signaling pathway by Seidel, Shawn David

“…The aromatic hydrocarbon receptor (AhR) is a ligand-activated transcription factor that mediates most, if not all, of the biological and toxicological effects…”
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