Search Results - "Seidel, H"

Targeting the NLRP3 inflammasome in inflammatory diseases by Mangan, Matthew S. J., Olhava, Edward J., Roush, William R., Seidel, H. Martin, Glick, Gary D., Latz, Eicke

“…The inflammasome is a key integration point for innate immunity. As such, targeting this signalling hub has the potential to be useful in numerous autoimmune…”
Get full text

Deep Shading: Convolutional Neural Networks for Screen Space Shading by Nalbach, O., Arabadzhiyska, E., Mehta, D., Seidel, H.‐P., Ritschel, T.

“…In computer vision, convolutional neural networks (CNNs) achieve unprecedented performance for inverse problems where RGB pixel appearance is mapped to…”
Get full text

A Statistical Model of Human Pose and Body Shape by Hasler, N., Stoll, C., Sunkel, M., Rosenhahn, B., Seidel, H.-P.

“…Generation and animation of realistic humans is an essential part of many projects in today's media industry. Especially, the games and special effects…”
Get full text

Discovery of Tropifexor (LJN452), a Highly Potent Non-bile Acid FXR Agonist for the Treatment of Cholestatic Liver Diseases and Nonalcoholic Steatohepatitis (NASH) by Tully, David C, Rucker, Paul V, Chianelli, Donatella, Williams, Jennifer, Vidal, Agnès, Alper, Phil B, Mutnick, Daniel, Bursulaya, Badry, Schmeits, James, Wu, Xiangdong, Bao, Dingjiu, Zoll, Jocelyn, Kim, Young, Groessl, Todd, McNamara, Peter, Seidel, H. Martin, Molteni, Valentina, Liu, Bo, Phimister, Andrew, Joseph, Sean B, Laffitte, Bryan

“…The farnesoid X receptor (FXR) is a nuclear receptor that acts as a master regulator of bile acid metabolism and signaling. Activation of FXR inhibits bile…”
Get full text

Intrinsic Shape Matching by Planned Landmark Sampling by Tevs, A., Berner, A., Wand, M., Ihrke, I., Seidel, H.-P.

“…Recently, the problem of intrinsic shape matching has received a lot of attention. A number of algorithms have been proposed, among which random‐sampling‐based…”
Get full text

Efficient Multi-image Correspondences for On-line Light Field Video Processing by Dąbała, Ł., Ziegler, M., Didyk, P., Zilly, F., Keinert, J., Myszkowski, K., Seidel, H.-P., Rokita, P., Ritschel, T.

“…Light field videos express the entire visual information of an animated scene, but their shear size typically makes capture, processing and display an off‐line…”
Get full text

Inhibition of DYRK1A and GSK3B induces human β-cell proliferation by Shen, Weijun, Taylor, Brandon, Jin, Qihui, Nguyen-Tran, Van, Meeusen, Shelly, Zhang, You-Qing, Kamireddy, Anwesh, Swafford, Austin, Powers, Andrew F., Walker, John, Lamb, John, Bursalaya, Badry, DiDonato, Michael, Harb, George, Qiu, Minhua, Filippi, Christophe M., Deaton, Lisa, Turk, Carolina N., Suarez-Pinzon, Wilma L., Liu, Yahu, Hao, Xueshi, Mo, Tingting, Yan, Shanshan, Li, Jing, Herman, Ann E., Hering, Bernhard J., Wu, Tom, Martin Seidel, H., McNamara, Peter, Glynne, Richard, Laffitte, Bryan

“…Insufficient pancreatic β-cell mass or function results in diabetes mellitus. While significant progress has been made in regulating insulin secretion from…”
Get full text

Targeting Wnt-driven cancer through the inhibition of Porcupine by LGK974 by Liu, Jun, Pan, Shifeng, Hsieh, Mindy H., Ng, Nicholas, Sun, Fangxian, Wang, Tao, Kasibhatla, Shailaja, Schuller, Alwin G., Li, Allen G., Cheng, Dai, Li, Jie, Tompkins, Celin, Pferdekamper, AnneMarie, Steffy, Auzon, Cheng, Jane, Kowal, Colleen, Van Phung, Guo, Guirong, Wang, Yan, Graham, Martin P., Flynn, Shannon, Brenner, J. Chad, Li, Chun, Villarroel, M. Cristina, Schultz, Peter G., Xu Wu, McNamara, Peter, Sellers, William R., Petruzzelli, Lilli, Boral, Anthony L., Seidel, H. Martin, McLaughlin, Margaret E., Che, Jianwei, Carey, Thomas E., Vanasse, Gary, Harris, Jennifer L.

“…Wnt signaling is one of the key oncogenic pathways in multiple cancers, and targeting this pathway is an attractive therapeutic approach. However, therapeutic…”
Get full text

Enhancing image quality prediction with self‐supervised visual masking by Çoğalan, U., Bemana, M., Seidel, HP, Myszkowski, K.

“…Full‐reference image quality metrics (FR‐IQMs) aim to measure the visual differences between a pair of reference and distorted images, with the goal of…”
Get full text

Thermal resonance model for micro-oscillators in the vicinity of a geometric boundary by Zengerle, T., Ababneh, A., Seidel, H.

“…This study explores the damping behavior of micro-oscillators within the transitional flow regime between molecular flow and viscous flow, including the…”
Get full text

Symmetry Detection Using Feature Lines by Bokeloh, M., Berner, A., Wand, M., Seidel, H.-P., Schilling, A.

“…In this paper, we describe a new algorithm for detecting structural redundancy in geometric data sets. Our algorithm computes rigid symmetries, i.e., subsets…”
Get full text

Video frame interpolation for high dynamic range sequences captured with dual‐exposure sensors by Çoğalan, U., Bemana, M., Seidel, HP, Myszkowski, K.

“…Video frame interpolation (VFI) enables many important applications such as slow motion playback and frame rate conversion. However, one major challenge in…”
Get full text

Practical Capture and Reproduction of Phosphorescent Appearance by Nalbach, O., Seidel, H.‐P., Ritschel, T.

“…This paper proposes a pipeline to accurately acquire, efficiently reproduce and intuitively manipulate phosphorescent appearance. In contrast to common…”
Get full text

Learning a self‐supervised tone mapping operator via feature contrast masking loss by Wang, C., Chen, B., Seidel, HP, Myszkowski, K., Serrano, A.

“…High Dynamic Range (HDR) content is becoming ubiquitous due to the rapid development of capture technologies. Nevertheless, the dynamic range of common display…”
Get full text

Computer Assisted Relief Generation-A Survey by Kerber, J., Wang, M., Chang, J., Zhang, J. J., Belyaev, A., Seidel, H.-P.

“…In this paper, we present an overview of the achievements accomplished to date in the field of computer‐aided relief generation. We delineate the problem,…”
Get full text

Synthesis, Structure–Activity Relationships, and in Vivo Efficacy of the Novel Potent and Selective Anaplastic Lymphoma Kinase (ALK) Inhibitor 5‑Chloro‑N2‑(2-isopropoxy-5-methyl-4-(piperidin-4-yl)phenyl)‑N4‑(2-(isopropylsulfonyl)phenyl)pyrimidine-2,4-diamine (LDK378) Currently in Phase 1 and Phase 2 Clinical Trials by Marsilje, Thomas H, Pei, Wei, Chen, Bei, Lu, Wenshuo, Uno, Tetsuo, Jin, Yunho, Jiang, Tao, Kim, Sungjoon, Li, Nanxin, Warmuth, Markus, Sarkisova, Yelena, Sun, Frank, Steffy, Auzon, Pferdekamper, AnneMarie C, Li, Allen G, Joseph, Sean B, Kim, Young, Liu, Bo, Tuntland, Tove, Cui, Xiaoming, Gray, Nathanael S, Steensma, Ruo, Wan, Yongqin, Jiang, Jiqing, Chopiuk, Greg, Li, Jie, Gordon, W. Perry, Richmond, Wendy, Johnson, Kevin, Chang, Jonathan, Groessl, Todd, He, You-Qun, Phimister, Andrew, Aycinena, Alex, Lee, Christian C, Bursulaya, Badry, Karanewsky, Donald S, Seidel, H. Martin, Harris, Jennifer L, Michellys, Pierre-Yves

“…The synthesis, preclinical profile, and in vivo efficacy in rat xenograft models of the novel and selective anaplastic lymphoma kinase inhibitor 15b (LDK378)…”
Get full text

Stream Line–Based Pattern Search in Flows by Wang, Z., Esturo, J. Martinez, Seidel, H.‐P., Weinkauf, T.

“…We propose a method that allows users to define flow features in form of patterns represented as sparse sets of stream line segments. Our approach finds…”
Get full text

SnakeBinning: Efficient Temporally Coherent Triangle Packing for Shading Streaming by Hladky, J., Seidel, H.P., Steinberger, M.

“…Streaming rendering, e.g., rendering in the cloud and streaming via a mobile connection, suffers from increased latency and unreliable connections. High…”
Get full text

Subdivision‐Specialized Linear Algebra Kernels for Static and Dynamic Mesh Connectivity on the GPU by Mlakar, D., Winter, M., Stadlbauer, P., Seidel, H.‐P., Steinberger, M., Zayer, R.

“…Subdivision surfaces have become an invaluable asset in production environments. While progress over the last years has allowed the use of graphics hardware to…”
Get full text

Interactive Modeling of Cellular Structures on Surfaces with Application to Additive Manufacturing by Stadlbauer, P., Mlakar, D., Seidel, H.‐P., Steinberger, M., Zayer, R.

“…The rich and evocative patterns of natural tessellations endow them with an unmistakable artistic appeal and structural properties which are echoed across…”
Get full text