Search Results - "Seid, Christopher A"
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Trichuris muris whey acidic protein induces type 2 protective immunity against whipworm
Published in PLoS pathogens (01-08-2018)“…Human whipworm (Trichuris trichiura) infects approximately 1 in 15 people worldwide, representing the leading infectious cause of colitis and subsequent,…”
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Cysteine mutagenesis improves the production without abrogating antigenicity of a recombinant protein vaccine candidate for human chagas disease
Published in Human vaccines & immunotherapeutics (04-03-2017)“…A therapeutic vaccine for human Chagas disease is under development by the Sabin Vaccine Institute Product Development Partnership. The aim of the vaccine is…”
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Structure of SALO, a leishmaniasis vaccine candidate from the sand fly Lutzomyia longipalpis
Published in PLoS neglected tropical diseases (09-03-2017)“…Immunity to the sand fly salivary protein SALO (Salivary Anticomplement of Lutzomyia longipalpis) protected hamsters against Leishmania infantum and L…”
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Optimization of the Production Process and Characterization of the Yeast-Expressed SARS-CoV Recombinant Receptor-Binding Domain (RBD219-N1), a SARS Vaccine Candidate
Published in Journal of pharmaceutical sciences (01-08-2017)“…From 2002 to 2003, a global pandemic of severe acute respiratory syndrome (SARS) spread to 5 continents and caused 8000 respiratory infections and 800 deaths…”
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Engineering a stable CHO cell line for the expression of a MERS-coronavirus vaccine antigen
Published in Vaccine (27-03-2018)“…Middle East respiratory syndrome coronavirus (MERS-CoV) has infected at least 2040 patients and caused 712 deaths since its first appearance in 2012, yet…”
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Expression, purification, immunogenicity, and protective efficacy of a recombinant Tc24 antigen as a vaccine against Trypanosoma cruzi infection in mice
Published in Vaccine (26-08-2015)“…Highlights • The Tc24 antigen from Trypanosoma cruzi is under evaluation as a vaccine candidate against Chagas disease. • We developed a suitable platform for…”
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Yeast-expressed recombinant protein of the receptor-binding domain in SARS-CoV spike protein with deglycosylated forms as a SARS vaccine candidate
Published in Human vaccines & immunotherapeutics (01-03-2014)“…Development of vaccines for preventing a future pandemic of severe acute respiratory syndrome (SARS) caused by SARS coronavirus (SARS-CoV) and for biodefense…”
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3M-052 as an adjuvant for a PLGA microparticle-based Leishmania donovani recombinant protein vaccine
Published in Journal of biomedical materials research. Part B, Applied biomaterials (01-05-2018)“…It is believed that an effective vaccine against leishmaniasis will require a T helper type 1 (T 1) immune response. In this study, we investigated the…”
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Expression, purification, immunogenicity and protective efficacy of a recombinant nucleoside hydrolase from Leishmania donovani, a vaccine candidate for preventing cutaneous leishmaniasis
Published in Protein expression and purification (01-02-2017)“…The nucleoside hydrolase gene from Leishmania donovani was cloned and expressed in Escherichia coli as a full length 36-kDa protein (LdNH36). Following lysis…”
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Mutations to Cysteine Residues in the Trypanosoma cruzi B-Cell Superantigen Tc24 Diminish Susceptibility to IgM-Mediated Hydrolysis
Published in The Journal of parasitology (01-10-2017)“…B-cell superantigens (BC-SAgs) are immunoevasins that have evolved in response to innate catalytic IgM antibodies; germ-line encoded immunoglobulins present in…”
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Expression, purification, and characterization of the Necator americanus aspartic protease-1 (Na-APR-1 (M74)) antigen, a component of the bivalent human hookworm vaccine
Published in Human vaccines & immunotherapeutics (03-06-2015)“…Over 400 million people living in the world's poorest developing nations are infected with hookworms, mostly of the genus Necator americanus. A bivalent human…”
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Expression, purification, crystallization and crystallographic study of Lutzomyia longipalpis LJL143
Published in Acta crystallographica. Section F, Structural biology communications (01-07-2015)“…Leishmaniasis is a neglected vector‐borne disease with a global prevalence of over 12 million cases and 59 000 annual deaths. Transmission of the parasite…”
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Optimization and revision of the production process of the Necator americanus glutathione S-transferase 1 (Na-GST-1), the lead hookworm vaccine recombinant protein candidate
Published in Human vaccines & immunotherapeutics (01-07-2014)“…Infection by the human hookworm Necator americanus is a leading cause of anemia and disability in the developing countries of Africa, Asia, and the Americas…”
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Expression and purification of an engineered, yeast-expressed Leishmania donovani nucleoside hydrolase with immunogenic properties
Published in Human vaccines & immunotherapeutics (02-07-2016)“…Leishmania donovani is the major cause of visceral leishmaniasis (kala-azar), now recognized as the parasitic disease with the highest level of mortality…”
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Optimization and revision of the production process of the Necator americanus glutathione S-transferase 1 (Na-GST-1), the lead hookworm vaccine recombinant protein candidate
Published in Human vaccines & immunotherapeutics (30-04-2014)“…Infection by the human hookworm Necator americanus is a leading cause of anemia and disability in the developing countries of Africa, Asia, and the Americas…”
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Expression and Purification of Recombinant Human Zona Pellucida Proteins
Published in Protein expression and purification (01-07-1999)“…Recombinant human zona pellucida (rhZP) proteins (minus the N-terminal leader and the C-terminal transmembrane-like domain) were expressed in four different…”
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Role for platelet‐derived growth factor‐like and epidermal growth factor‐like signaling pathways in gastrulation and spiculogenesis in the Lytechinus sea urchin embryo
Published in Developmental dynamics (01-09-1995)“…The mechanisms underlying sea urchin gastrulation and spiculogenesis have been sought for decades. We have identified two growth factor signaling pathways that…”
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An extracellular matrix response element in the promoter of the LpS1 genes of the sea urchin Lytechinus pictus
Published in Nucleic acids research (01-08-1997)“…The extracellular matrix (ECM) has been shown to play an important role in development and tissue-specific gene expression, yet the mechanism by which genes…”
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