Search Results - "Seibold, M A"

Overview of systematic reviews in allergy epidemiology by Genuneit, J., Seibold, A. M., Apfelbacher, C. J., Konstantinou, G. N., Koplin, J. J., La Grutta, S., Logan, K., Perkin, M. R., Flohr, C.

“…Background There is a substantial body of evidence on the epidemiology of allergic conditions, which has advanced the understanding of these conditions. We…”
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The role of LTA4H and ALOX5AP genes in the risk for asthma in Latinos by Via, M., De Giacomo, A., Corvol, H., Eng, C., Seibold, M. A., Gillett, C., Galanter, J., Sen, S., Tcheurekdjian, H., Chapela, R., Rodríguez-Santana, J. R., Rodríguez-Cintrón, W., Thyne, S., Avila, P. C., Choudhry, S., González Burchard, E.

“…Summary Background Leukotrienes play an important role in allergic and inflammatory diseases, but reports on the involvement of arachidonate…”
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Maternal age and asthma in Latino populations by Abid, Z., Oh, S. S., Hu, D., Sen, S., Huntsman, S., Eng, C., Farber, H. J., Rodriguez-Cintron, W., Rodriguez-Santana, J. R., Serebrisky, D., Avila, P. C., Thyne, S. M., Kim, K.-Y. A., Borrell, L. N., Williams, L. K., Seibold, M. A., Burchard, E. G., Kumar, R.

“…Summary Background Younger maternal age at birth is associated with increased risk of asthma in offspring in European descent populations, but has not been…”
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CRISPR–Cas9-mediated gene knockout in primary human airway epithelial cells reveals a proinflammatory role for MUC18 by Chu, H W, Rios, C, Huang, C, Wesolowska-Andersen, A, Burchard, E G, O’Connor, B P, Fingerlin, T E, Nichols, D, Reynolds, S D, Seibold, M A

“…Targeted knockout of genes in primary human cells using CRISPR–Cas9-mediated genome-editing represents a powerful approach to study gene function and to…”
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Genetic association between human chitinases and lung function in COPD by Aminuddin, F., Akhabir, L., Stefanowicz, D., Paré, P. D., Connett, J. E., Anthonisen, N. R., Fahy, J. V., Seibold, M. A., Burchard, E. G., Eng, C., Gulsvik, A., Bakke, P., Cho, M. H., Litonjua, A., Lomas, D. A., Anderson, W. H., Beaty, T. H., Crapo, J. D., Silverman, E. K., Sandford, A. J.

“…Two primary chitinases have been identified in humans—acid mammalian chitinase (AMCase) and chitotriosidase (CHIT1). Mammalian chitinases have been observed to…”
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Gene-based association identifies SPATA13-AS1 as a pharmacogenomic predictor of inhaled short-acting beta-agonist response in multiple population groups by Padhukasahasram, B, Yang, J J, Levin, A M, Yang, M, Burchard, E G, Kumar, R, Kwok, P-Y, Seibold, M A, Lanfear, D E, Williams, L K

“…Inhaled short-acting beta-agonist (SABA) medication is commonly used in asthma patients to rapidly reverse airway obstruction and improve acute symptoms. We…”
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PAI‐1 gain‐of‐function genotype, factors increasing PAI‐1 levels, and airway obstruction: The GALA II Cohort by Sherenian, M. G., Cho, S. H., Levin, A., Min, J‐Y., Oh, S. S., Hu, D., Galanter, J., Sen, S., Huntsman, S., Eng, C., Rodriguez‐Santana, J. R., Serebrisky, D., Avila, P. C., Kalhan, R., Smith, L. J., Borrell, L. N., Seibold, M. A., Keoki Williams, L., Burchard, E. G., Kumar, R.

“…Summary Background PAI‐1 gain‐of‐function variants promote airway fibrosis and are associated with asthma and with worse lung function in subjects with asthma…”
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para-Aminobenzoate Synthesis from Chorismate Occurs in Two Steps by Nichols, B P, Seibold, A M, Doktor, S Z

“…Escherichia coli p-aminobenzoate synthase is composed of two nonidentical subunits encoded by pabA and pabB and has been assumed to be the sole enzyme…”
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SARS-CoV-2 entry factors are highly expressed in nasal epithelial cells together with innate immune genes by Sungnak, Waradon, Huang, Ni, Bécavin, Christophe, Berg, Marijn, Queen, Rachel, Litvinukova, Monika, Talavera-López, Carlos, Maatz, Henrike, Reichart, Daniel, Sampaziotis, Fotios, Worlock, Kaylee B., Yoshida, Masahiro, Barnes, Josephine L.

“…We investigated SARS-CoV-2 potential tropism by surveying expression of viral entry-associated genes in single-cell RNA-sequencing data from multiple tissues…”
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A36 HOST DEFENSE AGAINST VIRAL INFECTION: Muc18 Inhibits Lung Eosinophilic Inflammation During Rhinovirus Infection In Mice by Berman, R, Jiang, D, Sajuthi, S, Schaefer, N, Wu, Q, Seibold, M A, Chu, H

“…Methods: MUC18 wildtype (WT) and knockout (KO) mice were intranasally infected with rhinovirus 1B (RV1B) or PBS (control) and sacrificed at day 1,3, and 7 post…”
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C13 TRANSLATIONAL RESEARCH IN ASTHMA: Using Paired eQTL Fine Mapping And Crispr-Cas9 Gene Editing To Determine The Causal Variants At The Il1rl1 Asthma Gwas Locus by Gordon, E D, Wesolowska-Andersen, A, Sharp, L Z, Seibold, M A, Ringel, L

“…Rationale: The IL1RL1 gene is among the most replicated asthma associated genes identified in large scale genome-wide association studies. Results: Our fine…”
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Nucleotide sequence of the Acinetobacter calcoaceticus trpGDC gene cluster by Kaplan, J B, Goncharoff, P, Seibold, A M, Nichols, B P

“…A plasmid library of Acinetobacter calcoaceticus HindIII fragments was constructed, and clones that complemented an Escherichia coli pabA mutant were selected…”
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B21 TRANSLATIONAL ASTHMA RESEARCH: Characterization Of Epithelial Cytokines Il33, Tlsp, Il25 In Human Asthma by Gordon, E D, Urbanek, C, Woodruff, P G, Seibold, M A, Fahy, J V

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An Afghan airlift by Seibold, M A

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C57 TOGETHER FOREVER: AIRWAY EPITHELIAL AND SMOOTH MUSCLE CELLS: The Asthma Biomarker Dipeptidyl Peptidase 4 (dpp4) Is Il-13 Inducible In Airway Epithelial Cells And Inhibits Rhinovirus Infection by Zhang, Y, Urbanek, C, Burchard, E G, Chu, H, Seibold, M A

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C31 BASIC AND TRANSLATIONAL STUDIES ON THE ROLE OF THE EPITHELIUM: Il-13 Induces A Unique Protein Secretome From Human Airway Epithelial Cells That Modulates Mucus-Related Proteins And Ciliary Motion by Everman, J L, Ringel, L, Chioccioli, M, Powell, R, Cruickshank-Quinn, C, Herrin, R, Rios, C, Feriani, L, Armstrong, M, Zhang, X, Chu, H, Cicuta, P, Reisdorph, N, Seibold, M A

“…Corresponding author's email: evermanj@njhealth.org RATIONALE Gene expression analyses of bronchial airway brushings have found ~50% of asthmatics exhibit…”
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D44 FIRST LINE OF DEFENSE: AIRWAY RESPONSE TO INFECTIONS AND IRRITANTS: Elucidation Of Nasal Airway Epithelial Transcriptome Responses To Low Dose Tobacco Smoke Exposure With An In Vitro Model by Wesolowska-Andersen, A, Oh, S S, Hu, D, Rios, C, Eng, C, Rodriguez-Santana, J, Chu, H W, Burchard, E G, Seibold, M A

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A96 BEST OF PEDIATRICS: Genetic Ancestry Modifies Risk Of Asthma Following Early-Life Chest Illness by Oh, S S, Seibold, M A, Rodriguez-Santana, J R, Thakur, N, Eng, C, Sen, S, Kumar, R, Avila, P C, Borrell, L N, Farber, H J, Davis, A, Serebrisky, D, Brigino-Buenaventura, E, Lurmann, F, d, J G, Meade, K, LeNoir, M A, Rodriguez-Cintron, W, Thyne, S, Burchard, E G

“…Methods: We used logistic regression to examine the association between reported chest illness in the first two years of life and physician-diagnosed asthma…”
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C21 OMICS IN LUNG DISEASE: Whole Genome Sequencing Study On Bronchodilator Drug Response In Ethnically Diverse Children With Asthma by Mak, A, White, M J, Szpiech, Z A, Eckalbar, W, Pino-Yanes, M, Oh, S, Hu, D, Huntsman, S, Eng, C, Davis, A, Serebrisky, D, Brigino-Buenaventura, E, Lurmann, F, Farber, H J, Rodriguez-Santana, J R, Meade, K, Borrell, L N, LeNoir, M A, Avila, P C, Kumar, R, Sen, S, Thyne, S, Rodriguez-Cintron, W, Kwok, P-Y, Torgerson, D G, Galanter, J, Ahituv, N, Ziv, E, Seibold, M A, Zaitlen, N, Hernandez, R D, Burchard, E G

“…Despite significant racial/ethnic variation in bronchodilator drug response (BDR), albuterol is often the only medication prescribed for asthma, regardless of…”
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A13 THE GENOME AND ASTHMA IN 2014: The Rs1420101 Asthma Gwas Variant Functions As An Expression Quantitative Loci For Airway Soluble St2 Gene Expression In Asthmatics by Gordon, E D, Lachowicz-Scroggins, M E, Urbanek, C, MacLeod, H J, Woodruff, P G, Fahy, J V, Seibold, M A

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