Search Results - "Seibert, Isabell"

The influence of OATP2B1 and atorvastatin on coproporphyrin isomers in rats by Kinzi, Jonny, Grube, Markus, Hussner, Janine, Seibert, Isabell, Hamburger, Matthias, Meyer zu Schwabedissen, Henriette E.

“…Coproporphyrin I (CPI) and III (CPIII) are discussed as biomarkers for organic anion transporting polypeptides (OATPs). We report on CPI and CPIII levels in…”
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Increased coproporphyrin serum levels in healthy volunteers treated with the cholesterol uptake inhibitor ezetimibe by Kinzi, Jonny, Grube, Markus, Seibert, Isabell, Siegmund, Werner, Meyer zu Schwabedissen, Henriette E.

“…Ezetimibe undergoes glucuronidation that results in the active metabolite ezetimibe phenoxy‐glucuronide (ezetimibe‐glucuronide). This phase‐II metabolite was…”
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Thyroid Hormones Are Transport Substrates and Transcriptional Regulators of Organic Anion Transporting Polypeptide 2B1 by Meyer Zu Schwabedissen, Henriette E, Ferreira, Celio, Schaefer, Anima M, Oufir, Mouhssin, Seibert, Isabell, Hamburger, Matthias, Tirona, Rommel G

“…Levothyroxine replacement therapy forms the cornerstone of hypothyroidism management. Variability in levothyroxine oral absorption may contribute to the…”
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Various effects of repeated rifampin dosing on coproporphyrin levels in humans by Kinzi, Jonny, Grube, Markus, Brecht, Karin, Seibert, Isabell, Siegmund, Werner, Meyer Zu Schwabedissen, Henriette E

“…In recent years, the identification of endogenous substrates as biomarkers became an uprising topic. Particularly coproporphyrins (CPs), byproducts of heme…”
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Differences in transport function of the human and rat orthologue of the Organic Anion Transporting Polypeptide 2B1 (OATP2B1) by Hussner, Janine, Foletti, Annalise, Seibert, Isabell, Fuchs, Anja, Schuler, Eveline, Malagnino, Vanessa, Grube, Markus, Meyer zu Schwabedissen, Henriette E.

“…The human drug transporter Organic Anion Transporting Polypeptide (hOATP)2B1 facilitates cellular uptake of its substrates. Various studies suggest that…”
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PDMS-PMOXA-Nanoparticles Featuring a Cathepsin B-Triggered Release Mechanism by Ehrsam, Daniel, Porta, Fabiola, Hussner, Janine, Seibert, Isabell, Meyer Zu Schwabedissen, Henriette E

“…It was our intention to develop cathepsin B-sensitive nanoparticles for tumor-site-directed release. These nanoparticles should be able to release their…”
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Genetic variants of SLCO1B7 are of relevance for the transport function of OATP1B3-1B7 by Meyer zu Schwabedissen, Henriette E., Seibert, Isabell, Grube, Markus, Alter, Claudio L., Siegmund, Werner, Hussner, Janine

“…[Display omitted] The family of Organic Anion Transporting Polypeptides are known to facilitate the transmembrane transport. OATP1B3-1B7 is a novel member of…”
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LST-3TM12 is a member of the OATP1B-family and a functional transporter influenced by genetic variants by Meyer zu Schwabedissen, Henriette, Malagnino, Vanessa, Hussner, Janine, Seibert, Isabell

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Pharmacogenetic Analysis of Voriconazole Treatment in Children by Tilen, Romy, Paioni, Paolo, Goetschi, Aljoscha N., Goers, Roland, Seibert, Isabell, Müller, Daniel, Bielicki, Julia A., Berger, Christoph, Krämer, Stefanie D., Meyer zu Schwabedissen, Henriette E.

“…Voriconazole is among the first-line antifungal drugs to treat invasive fungal infections in children and known for its pronounced inter- and intraindividual…”
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Ethnopharmacology in overdrive: The remarkable anti-HIV activity of Artemisia annua by Lubbe, Andrea, Seibert, Isabell, Klimkait, Thomas, van der Kooy, Frank

“…Artemisia annua contains the well-known antimalarial compound artemisinin, which forms the backbone of the global malaria treatment regime. In African…”
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Impact of OATP2B1 on pharmacokinetics of atorvastatin investigated in rSlco2b1 -knockout and SLCO2B1 -knockin rats by Kinzi, Jonny, Hussner, Janine, Seibert, Isabell, Vythilingam, Mirubagini, Vonwyl, Celina, Gherardi, Clarisse, Detampel, Pascal, Schwardt, Oliver, Ricklin, Daniel, Meyer Zu Schwabedissen, Henriette E

“…The organic anion transporting polypeptide (OATP) 2B1 is considered an emerging drug transporter that is found expressed in pharmacokinetically relevant organs…”
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Influence of Slco2b1‐knockout and SLCO2B1‐humanization on coproporphyrin I and III levels in rats by Kinzi, Jonny, Hussner, Janine, Schäfer, Anima M., Treyer, Andrea, Seibert, Isabell, Tillmann, Annika, Mueller, Vanessa, Gherardi, Clarisse, Vonwyl, Celina, Hamburger, Matthias, Meyer zu Schwabedissen, Henriette E.

“…Background and Purpose Coproporphyrin (CP) I and III are byproducts of haem synthesis currently investigated as biomarkers for drug–drug interactions involving…”
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Hyperforin-Induced Activation of the Pregnane X Receptor Is Influenced by the Organic Anion-Transporting Polypeptide 2B1 by Schäfer, Anima M, Potterat, Olivier, Seibert, Isabell, Fertig, Orlando, Meyer Zu Schwabedissen, Henriette E

“…The herbal remedy St. John's wort (SJW) is used in the treatment of mild depressive symptoms and is known for its drug-drug interaction potential when enhanced…”
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OATP1B3-1B7 (LST-3TM12) Is a Drug Transporter That Affects Endoplasmic Reticulum Access and the Metabolism of Ezetimibe by Malagnino, Vanessa, Duthaler, Urs, Seibert, Isabell, Krähenbühl, Stephan, Meyer Zu Schwabedissen, Henriette E

“…Drug transporters play a crucial role in pharmacokinetics. One subfamily of transporters with proven clinical relevance are the OATP1B transporters. Recently…”
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Simultaneous quantification of atorvastatin, erlotinib and OSI-420 in rat serum and liver microsomes using a novel liquid chromatography-mass spectrometry method by Rysz, Marta A., Kinzi, Jonny, Schäfer, Anima M., In-Albon, Katja, Zürcher, Simone, Schmidlin, Seraina, Seibert, Isabell, Schwardt, Oliver, Ricklin, Daniel, Meyer zu Schwabedissen, Henriette E.

“…Erlotinib is an epidermal growth factor receptor tyrosine kinase inhibitor used in the treatment of cancer. Atorvastatin is a statin commonly applied to treat…”
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Regulation of PDZ domain-containing 1 (PDZK1) expression by hepatocyte nuclear factor-1α (HNF1α) in human kidney by Prestin, Katharina, Hussner, Janine, Ferreira, Celio, Seibert, Isabell, Breitung, Vivien, Zimmermann, Uwe, Meyer Zu Schwabedissen, Henriette E

“…In the renal proximal tubule the secretion and reabsorption of glomerularly filtrated compounds is realized by a functional network of uptake and efflux…”
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LST-3TM12 is a member of the OATP1B family and a functional transporter by Malagnino, Vanessa, Hussner, Janine, Seibert, Isabell, Stolzenburg, Antje, Sager, Christoph P., Meyer zu Schwabedissen, Henriette E.

“…[Display omitted] Organic anion transporting polypeptides (OATPs) and particularly the two members of the OATP1B family are known for their role in…”
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Pimecrolimus increases the expression of interferon-inducible genes that modulate human coronary artery cells proliferation by Hussner, Janine, Sünwoldt, Juliane, Seibert, Isabell, Gliesche, Daniel G., zu Schwabedissen, Henriette E. Meyer

“…The pharmacodynamics of the loaded compounds defines clinical failure or success of a drug-eluting device. Various limus derivatives have entered clinics due…”
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Identification of anti-HIV active dicaffeoylquinic- and tricaffeoylquinic acids in Helichrysum populifolium by NMR-based metabolomic guided fractionation by Heyman, Heino Martin, Senejoux, François, Seibert, Isabell, Klimkait, Thomas, Maharaj, Vinesh Jaichand, Meyer, Jacobus Johannes Marion

“…South Africa being home to more than 35% of the world's Helichrysum species (c.a. 244) of which many are used in traditional medicine, is seen potentially as a…”
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