Search Results - "Sehrawat, Tejasav S"

Regulation and functional roles of chemokines in liver diseases by Cao, Sheng, Liu, Mengfei, Sehrawat, Tejasav S., Shah, Vijay H.

“…Inflammation is a major contributor to the pathogenesis of almost all liver diseases. Low-molecular-weight proteins called chemokines are the main drivers of…”
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The knowns and unknowns of treatment for alcoholic hepatitis by Sehrawat, Tejasav S, Liu, Mengfei, Shah, Vijay H

“…Alcoholic hepatitis is an acute, inflammatory liver disease associated with high morbidity and mortality both in the short term and long term. Alcoholic…”
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Super enhancer regulation of cytokine-induced chemokine production in alcoholic hepatitis by Liu, Mengfei, Cao, Sheng, He, Li, Gao, Jinhang, Arab, Juan P., Cui, Huarui, Xuan, Weixia, Gao, Yandong, Sehrawat, Tejasav S., Hamdan, Feda H., Ventura-Cots, Meritxell, Argemi, Josepmaria, Pomerantz, William C. K., Johnsen, Steven A., Lee, Jeong-Heon, Gao, Fei, Ordog, Tamas, Mathurin, Philippe, Revzin, Alexander, Bataller, Ramon, Yan, Huihuang, Shah, Vijay H.

“…Alcoholic hepatitis (AH) is associated with liver neutrophil infiltration through activated cytokine pathways leading to elevated chemokine expression…”
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Circulating Extracellular Vesicles Carrying Sphingolipid Cargo for the Diagnosis and Dynamic Risk Profiling of Alcoholic Hepatitis by Sehrawat, Tejasav S., Arab, Juan P., Liu, Mengfei, Amrollahi, Pouya, Wan, Meihua, Fan, Jia, Nakao, Yasuhiko, Pose, Elisa, Navarro‐Corcuera, Amaia, Dasgupta, Debanjali, Liao, Chieh‐Yu, He, Li, Mauer, Amy S., Avitabile, Emma, Ventura‐Cots, Meritxell, Bataller, Ramon A., Sanyal, Arun J., Chalasani, Naga P., Heimbach, Julie K., Watt, Kymberly D., Gores, Gregory J., Gines, Pere, Kamath, Patrick S., Simonetto, Douglas A., Hu, Tony Y., Shah, Vijay H., Malhi, Harmeet

“…Background and Aims Alcoholic hepatitis (AH) is diagnosed by clinical criteria, although several objective scores facilitate risk stratification. Extracellular…”
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Modulating sphingosine 1-phosphate receptor signaling skews intrahepatic leukocytes and attenuates murine nonalcoholic steatohepatitis by Liao, Chieh-Yu, Barrow, Fanta, Venkatesan, Nanditha, Nakao, Yasuhiko, Mauer, Amy S, Fredrickson, Gavin, Song, Myeong Jun, Sehrawat, Tejasav S, Dasgupta, Debanjali, Graham, Rondell P, Revelo, Xavier S, Malhi, Harmeet

“…Sphingosine 1-phosphate (S1P) is a bioactive sphingolipid associated with nonalcoholic steatohepatitis (NASH). Immune cell-driven inflammation is a key…”
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XIAP Knockdown in Alcohol-Associated Liver Disease Models Exhibits Divergent in vitro and in vivo Phenotypes Owing to a Potential Zonal Inhibitory Role of SMAC by He, Li, Sehrawat, Tejasav S, Verma, Vikas K, Navarro-Corcuera, Amaia, Sidhu, Guneet, Mauer, Amy, Luo, Xin, Katsumi, Tomohiro, Chen, Jingbiao, Shah, Soni, Arab, Juan Pablo, Cao, Sheng, Kashkar, Hamid, Gores, Gregory J, Malhi, Harmeet, Shah, Vijay H

“…Alcohol-associated liver disease (ALD) has been recognized as the most common cause of advanced liver disease worldwide, though mechanisms of pathogenesis…”
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GIPC-Regulated IGFBP-3 Promotes HSC Migration In Vitro and Portal Hypertension In Vivo Through a β1-Integrin Pathway by Yaqoob, Usman, Luo, Fanghong, Greuter, Thomas, Jalan Sakrikar, Nidhi, Sehrawat, Tejasav S., Lu, Jianwen, Hu, Xiao, Gao, Jinhang, Kostallari, Enis, Chen, Jingbiao, Arab, Juan Pablo, Martin-Mateos, Rosa, Cao, Sheng, Shah, Vijay H.

“…Transforming growth factor (TGF-β)–induced activation of quiescent hepatic stellate cells (HSCs) and their transformation to myofibroblasts is a key event in…”
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Post-acute COVID-19 syndrome by Nalbandian, Ani, Sehgal, Kartik, Gupta, Aakriti, Madhavan, Mahesh V., McGroder, Claire, Stevens, Jacob S., Cook, Joshua R., Nordvig, Anna S., Shalev, Daniel, Sehrawat, Tejasav S., Ahluwalia, Neha, Bikdeli, Behnood, Dietz, Donald, Der-Nigoghossian, Caroline, Liyanage-Don, Nadia, Rosner, Gregg F., Bernstein, Elana J., Mohan, Sumit, Beckley, Akinpelumi A., Seres, David S., Choueiri, Toni K., Uriel, Nir, Ausiello, John C., Accili, Domenico, Freedberg, Daniel E., Baldwin, Matthew, Schwartz, Allan, Brodie, Daniel, Garcia, Christine Kim, Elkind, Mitchell S. V., Connors, Jean M., Bilezikian, John P., Landry, Donald W., Wan, Elaine Y.

“…Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the pathogen responsible for the coronavirus disease 2019 (COVID-19) pandemic, which has…”
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Portal Fibrosis and the Ductular Reaction: Pathophysiological Role in the Progression of Liver Disease and Translational Opportunities by Gupta, Vikas, Sehrawat, Tejasav S., Pinzani, Massimo, Strazzabosco, Mario

“…A consistent feature of chronic liver diseases and the hallmark of pathologic repair is the so-called ductular reaction. This is a histological abnormality…”
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Extrapulmonary manifestations of COVID-19 by Gupta, Aakriti, Madhavan, Mahesh V., Sehgal, Kartik, Nair, Nandini, Mahajan, Shiwani, Sehrawat, Tejasav S., Bikdeli, Behnood, Ahluwalia, Neha, Ausiello, John C., Wan, Elaine Y., Freedberg, Daniel E., Kirtane, Ajay J., Parikh, Sahil A., Maurer, Mathew S., Nordvig, Anna S., Accili, Domenico, Bathon, Joan M., Mohan, Sumit, Bauer, Kenneth A., Leon, Martin B., Krumholz, Harlan M., Uriel, Nir, Mehra, Mandeep R., Elkind, Mitchell S. V., Stone, Gregg W., Schwartz, Allan, Ho, David D., Bilezikian, John P., Landry, Donald W.

“…Although COVID-19 is most well known for causing substantial respiratory pathology, it can also result in several extrapulmonary manifestations. These…”
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An Open‐Label, Dose‐Escalation Study to Assess the Safety and Efficacy of IL‐22 Agonist F‐652 in Patients With Alcohol‐associated Hepatitis by Arab, Juan P., Sehrawat, Tejasav S., Simonetto, Douglas A., Verma, Vikas K., Feng, Dechun, Tang, Tom, Dreyer, Kevin, Yan, Xiaoqiang, Daley, William L., Sanyal, Arun, Chalasani, Naga, Radaeva, Svetlana, Yang, Liu, Vargas, Hugo, Ibacache, Mauricio, Gao, Bin, Gores, Gregory J., Malhi, Harmeet, Kamath, Patrick S., Shah, Vijay H.

“…Background and Aims Interleukin‐22 has beneficial effects on inflammation and impaired hepatic regeneration that characterize alcohol‐associated hepatitis…”
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IRE1A Stimulates Hepatocyte-Derived Extracellular Vesicles That Promote Inflammation in Mice With Steatohepatitis by Dasgupta, Debanjali, Nakao, Yasuhiko, Mauer, Amy S., Thompson, Jill M., Sehrawat, Tejasav S., Liao, Chieh-Yu, Krishnan, Anuradha, Lucien, Fabrice, Guo, Qianqian, Liu, Mengfei, Xue, Fei, Fukushima, Masanori, Katsumi, Tomohiro, Bansal, Aditya, Pandey, Mukesh K., Maiers, Jessica L., DeGrado, Timothy, Ibrahim, Samar H., Revzin, Alexander, Pavelko, Kevin D., Barry, Michael A., Kaufman, Randal J., Malhi, Harmeet

“…Endoplasmic reticulum to nucleus signaling 1 (ERN1, also called IRE1A) is a sensor of the unfolded protein response that is activated in the livers of patients…”
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Endothelial p300 Promotes Portal Hypertension and Hepatic Fibrosis Through C‐C Motif Chemokine Ligand 2–Mediated Angiocrine Signaling by Gao, Jinhang, Wei, Bo, Liu, Mengfei, Hirsova, Petra, Sehrawat, Tejasav S., Cao, Sheng, Hu, Xiao, Xue, Fei, Yaqoob, Usman, Kang, Ningling, Cui, Huarui, Pomerantz, William C.K., Kostallari, Enis, Shah, Vijay H.

“…Background and Aims During liver fibrosis, liver sinusoidal endothelial cells (LSECs) release angiocrine signals to recruit inflammatory cells into the liver…”
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Mechanotransduction-induced glycolysis epigenetically regulates a CXCL1-dominant angiocrine signaling program in liver sinusoidal endothelial cells in vitro and in vivo by Greuter, Thomas, Yaqoob, Usman, Gan, Can, Jalan-Sakrikar, Nidhi, Kostallari, Enis, Lu, Jianwen, Gao, Jinhang, Sun, Liankang, Liu, Mengfei, Sehrawat, Tejasav S., Ibrahim, Samar H., Furuta, Kunimaro, Nozickova, Katerina, Huang, Bing Q., Gao, Bin, Simons, Michael, Cao, Sheng, Shah, Vijay H.

“…Liver sinusoidal endothelial cells (LSECs) are ideally situated to sense stiffness and generate angiocrine programs that potentially regulate liver fibrosis…”
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Hepatic stellate cell activation promotes alcohol-induced steatohepatitis through Igfbp3 and SerpinA12 by Arab, Juan P., Cabrera, Daniel, Sehrawat, Tejasav S., Jalan-Sakrikar, Nidhi, Verma, Vikas K., Simonetto, Douglas, Cao, Sheng, Yaqoob, Usman, Leon, Jonathan, Freire, Mariela, Vargas, Jose I., De Assuncao, Thiago M., Kwon, Jung H., Guo, Yi, Kostallari, Enis, Cai, Qing, Kisseleva, Tatiana, Oh, Youngman, Arrese, Marco, Huebert, Robert C., Shah, Vijay H.

“…Steatohepatitis drives fibrogenesis in alcohol-related liver disease. Recent studies have suggested that hepatic stellate cells (HSCs) may regulate the…”
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Long non-coding RNA ACTA2-AS1 promotes ductular reaction by interacting with the p300/ELK1 complex by Navarro-Corcuera, Amaia, Sehrawat, Tejasav S., Jalan-Sakrikar, Nidhi, Gibbons, Hunter R., Pirius, Nicholas E., Khanal, Shalil, Hamdan, Feda H., Aseem, Sayed Obaidullah, Cao, Sheng, Banales, Jesus M., Kang, Ningling, Faubion, William A., LaRusso, Nicholas F., Shah, Vijay H., Huebert, Robert C.

“…Biliary disease is associated with a proliferative/fibrogenic ductular reaction (DR). p300 is an epigenetic regulator that acetylates lysine 27 on histone 3…”
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Circulating extracellular vesicles are a biomarker for NAFLD resolution and response to weight loss surgery by Nakao, Yasuhiko, Amrollahi, Pouya, Parthasarathy, Gopanandan, Mauer, Amy S., Sehrawat, Tejasav S., Vanderboom, Patrick, Nair, K Sreekumaran, Nakao, Kazuhiko, Allen, Alina M., Hu, Tony Y., Malhi, Harmeet

“…There is increasing interest in the development of minimally invasive biomarkers for the diagnosis and prognosis of NAFLD via extracellular vesicles (EV)…”
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Epigenetics of alcohol-related liver diseases by Habash, Nawras W., Sehrawat, Tejasav S., Shah, Vijay H., Cao, Sheng

“…Alcohol-related liver disease (ARLD) is a primary cause of chronic liver disease in the United States. Despite advances in the diagnosis and management of…”
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Adding Inflammatory Markers and Refining National Institute on Alcohol Abuse and Alcoholism Criteria Improve Diagnostic Accuracy for Alcohol-associated Hepatitis by Avitabile, Emma, Díaz, Alba, Montironi, Carla, Pérez-Guasch, Martina, Gratacós-Ginès, Jordi, Hernández-Évole, Helena, Moreira, Roger K., Sehrawat, Tejasav S., Malhi, Harmeet, Olivas, Pol, Hernández-Gea, Virginia, Bataller, Ramón, Shah, Vijay H., Kamath, Patrick S., Ginès, Pere, Pose, Elisa

“…Although histology is considered the gold standard for diagnosis of alcohol-associated hepatitis (AH), it is not required for entry into therapeutic studies if…”
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Loss of CEACAM1 in endothelial cells causes hepatic fibrosis by Muturi, Harrison T., Ghadieh, Hilda E., Abdolahipour, Raziyeh, Stankus, Hannah L., Belew, Getachew Debas, Liu, James K., Jahromi, Marziyeh Salehi, Lee, Abraham D., Singer, Bernhard B., Angeli-Pahim, Isabella, Sehrawat, Tejasav S., Malhi, Harmeet, Verhulst, Stefaan, van Grunsven, Leo A., Zarrinpar, Ali, Duarte, Sergio, Najjar, Sonia M.

“…Hepatocytic CEACAM1 plays a critical role in NASH pathogenesis, as bolstered by the development of insulin resistance, visceral obesity, steatohepatitis and…”
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