Search Results - "Sehlin, D."

Amyloid-β deposits in human astrocytes contain truncated and highly resistant proteoforms by Beretta, C., Svensson, E., Dakhel, A., Zyśk, M., Hanrieder, J., Sehlin, D., Michno, W., Erlandsson, A.

“…Alzheimer's disease (AD) is a neurodegenerative disorder that develops over decades. Glial cells, including astrocytes are tightly connected to the AD…”
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Transferrin Receptor Binding BBB-Shuttle Facilitates Brain Delivery of Anti-Aβ-Affibodies by Faresjö, Rebecca, Lindberg, Hanna, Ståhl, Stefan, Löfblom, John, Syvänen, Stina, Sehlin, Dag

“…Affibodies targeting amyloid-beta (Aβ) could potentially be used as therapeutic and diagnostic agents in Alzheimer’s disease (AD). Affibodies display suitable…”
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The Uppsala APP deletion causes early onset autosomal dominant Alzheimer's disease by altering APP processing and increasing amyloid β fibril formation by Pagnon de la Vega, María, Giedraitis, Vilmantas, Michno, Wojciech, Kilander, Lena, Güner, Gökhan, Zielinski, Mara, Löwenmark, Malin, Brundin, RoseMarie, Danfors, Torsten, Söderberg, Linda, Alafuzoff, Irina, Nilsson, Lars N G, Erlandsson, Anna, Willbold, Dieter, Müller, Stephan A, Schröder, Gunnar F, Hanrieder, Jörg, Lichtenthaler, Stefan F, Lannfelt, Lars, Sehlin, Dag, Ingelsson, Martin

“…Point mutations in the amyloid precursor protein gene ( ) cause familial Alzheimer's disease (AD) by increasing generation or altering conformation of amyloid…”
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Enhanced neprilysin-mediated degradation of hippocampal Aβ42 with a somatostatin peptide that enters the brain by Rofo, Fadi, Ugur Yilmaz, Canan, Metzendorf, Nicole, Gustavsson, Tobias, Beretta, Chiara, Erlandsson, Anna, Sehlin, Dag, Syvänen, Stina, Nilsson, Per, Hultqvist, Greta

“…Aggregation of the amyloid-beta (Aβ) peptide is one of the main neuropathological events in Alzheimer's disease (AD). Neprilysin is the major enzyme degrading…”
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Delineating Amyloid Plaque Associated Neuronal Sphingolipids in Transgenic Alzheimer’s Disease Mice (tgArcSwe) Using MALDI Imaging Mass Spectrometry by Kaya, Ibrahim, Brinet, Dimitri, Michno, Wojciech, Syvänen, Stina, Sehlin, Dag, Zetterberg, Henrik, Blennow, Kaj, Hanrieder, Jörg

“…The major pathological hallmarks of Alzheimer’s disease (AD) are the progressive aggregation and accumulation of beta-amyloid (Aβ) and hyperphosphorylated tau…”
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Long-term effects of immunotherapy with a brain penetrating Aβ antibody in a mouse model of Alzheimer's disease by Gustavsson, Tobias, Metzendorf, Nicole G, Wik, Elin, Roshanbin, Sahar, Julku, Ulrika, Chourlia, Aikaterini, Nilsson, Per, Andersson, Ken G, Laudon, Hanna, Hultqvist, Greta, Syvänen, Stina, Sehlin, Dag

“…Brain-directed immunotherapy is a promising strategy to target amyloid-β (Aβ) deposits in Alzheimer's disease (AD). In the present study, we compared the…”
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Engineered antibodies: new possibilities for brain PET? by Sehlin, Dag, Syvänen, Stina

“…Almost 50 million people worldwide are affected by Alzheimer’s disease (AD), the most common neurodegenerative disorder. Development of disease-modifying…”
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S.23.01 Pathogenic mechanisms in Alzheimer's disease by Lannfelt, L., Sehlin, D., Englund, H., Lord, A., Johansson, A.S., Nilsson, L., Ekholm-Pettersson, F.

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