Search Results - "Sehgal, Kartik"

Post-acute COVID-19 syndrome by Nalbandian, Ani, Sehgal, Kartik, Gupta, Aakriti, Madhavan, Mahesh V., McGroder, Claire, Stevens, Jacob S., Cook, Joshua R., Nordvig, Anna S., Shalev, Daniel, Sehrawat, Tejasav S., Ahluwalia, Neha, Bikdeli, Behnood, Dietz, Donald, Der-Nigoghossian, Caroline, Liyanage-Don, Nadia, Rosner, Gregg F., Bernstein, Elana J., Mohan, Sumit, Beckley, Akinpelumi A., Seres, David S., Choueiri, Toni K., Uriel, Nir, Ausiello, John C., Accili, Domenico, Freedberg, Daniel E., Baldwin, Matthew, Schwartz, Allan, Brodie, Daniel, Garcia, Christine Kim, Elkind, Mitchell S. V., Connors, Jean M., Bilezikian, John P., Landry, Donald W., Wan, Elaine Y.

“…Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the pathogen responsible for the coronavirus disease 2019 (COVID-19) pandemic, which has…”
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Extrapulmonary manifestations of COVID-19 by Gupta, Aakriti, Madhavan, Mahesh V., Sehgal, Kartik, Nair, Nandini, Mahajan, Shiwani, Sehrawat, Tejasav S., Bikdeli, Behnood, Ahluwalia, Neha, Ausiello, John C., Wan, Elaine Y., Freedberg, Daniel E., Kirtane, Ajay J., Parikh, Sahil A., Maurer, Mathew S., Nordvig, Anna S., Accili, Domenico, Bathon, Joan M., Mohan, Sumit, Bauer, Kenneth A., Leon, Martin B., Krumholz, Harlan M., Uriel, Nir, Mehra, Mandeep R., Elkind, Mitchell S. V., Stone, Gregg W., Schwartz, Allan, Ho, David D., Bilezikian, John P., Landry, Donald W.

“…Although COVID-19 is most well known for causing substantial respiratory pathology, it can also result in several extrapulmonary manifestations. These…”
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Extended-Interval Dosing Strategy of Immune Checkpoint Inhibitors in Lung Cancer: Will it Outlast the COVID-19 Pandemic? by Sehgal, Kartik, Costa, Daniel B, Rangachari, Deepa

“…Patients with lung cancer are particularly vulnerable to complications from coronavirus disease-2019 (COVID-19). Recurrent hospital visits and hospital…”
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Clinical and pharmacodynamic analysis of pomalidomide dosing strategies in myeloma: impact of immune activation and cereblon targets by Sehgal, Kartik, Das, Rituparna, Zhang, Lin, Verma, Rakesh, Deng, Yanhong, Kocoglu, Mehmet, Vasquez, Juan, Koduru, Srinivas, Ren, Yan, Wang, Maria, Couto, Suzana, Breider, Mike, Hansel, Donna, Seropian, Stuart, Cooper, Dennis, Thakurta, Anjan, Yao, Xiaopan, Dhodapkar, Kavita M., Dhodapkar, Madhav V.

“…In preclinical studies, pomalidomide mediated both direct antitumor effects and immune activation by binding cereblon. However, the impact of drug-induced…”
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The ERK inhibitor GDC-0994 selectively inhibits growth of BRAF mutant cancer cells by Chen, Yulu, Sang, Ye, Li, Shiyong, Xue, Junyu, Chen, Mengke, Hong, Shubin, Lv, Weiming, Sehgal, Kartik, Xiao, Haipeng, Liu, Rengyun

“…•GDC-0994 inhibits the growth of BRAF mutant cancer cells in vitro and in vivo.•GDC-0994 induces cell cycle arrest in BRAF mutation positive cancer…”
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Small cell transformation of non-small cell lung cancer on immune checkpoint inhibitors: uncommon or under-recognized? by Sehgal, Kartik, Varkaris, Andreas, Viray, Hollis, VanderLaan, Paul A, Rangachari, Deepa, Costa, Daniel B

“…BackgroundHistological transformation of oncogene-driven lung adenocarcinoma to small cell lung cancer (SCLC) following treatment with tyrosine kinase…”
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Low PD-L1 expression, MAP2K2 alterations, and enriched HPV gene signatures characterize brain metastases in head and neck squamous cell carcinoma by Dennis, Michael J, Pavlick, Dean C, Kacew, Alec, Wotman, Michael, MacConaill, Laura E, Jones, Stephanie M, Pfaff, Kathleen L, Rodig, Scott J, Eacker, Stephen, Malig, Maika, Reister, Emily, Piccioni, David, Kesari, Santosh, Sehgal, Kartik, Haddad, Robert I, Cohen, Ezra, Posner, Marshall R, Deichaite, Ida, Hanna, Glenn J

“…Brain metastasis (BM) is a rare but severe complication of head and neck squamous cell carcinoma (HNSCC), with limited knowledge of molecular characteristics…”
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Size of atrial septal defect after balloon atrial septostomy does not correlate with immediate improvement in oxygenation by Sehgal, Kartik, Sehgal, Kunal, Varma, Suraj

“…ObjectiveTransposition of great arteries is a common cyanotic heart defect. Balloon atrial septostomy aims to improve circulatory mixing and oxygenation…”
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Activity of Brigatinib in the Setting of Alectinib Resistance Mediated by ALK I1171S in ALK-Rearranged Lung Cancer by Sehgal, Kartik, Peters, Mary Linton B, VanderLaan, Paul A, Rangachari, Deepa, Kobayashi, Susumu S, Costa, Daniel B

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Association Between Immune-Related Adverse Events and Clinical Outcomes to Programmed Cell Death Protein 1/Programmed Death-Ligand 1 Blockade in SCLC by Ricciuti, Biagio, Naqash, Abdul Rafeh, Naidoo, Jarushka, Sehgal, Kartik, Miller, Adam, Kehl, Kenneth, Venkatraman, Deepti, Sands, Jacob, Lamberti, Giuseppe, Recondo, Gonzalo, Zhang, Jiajia, Macherla, Shravanti, Baig, Sameer, Walker, Paul, Rangachari, Deepa, Gainor, Justin F., Costa, Daniel B., Rizvi, Naiyer, Sholl, Lynette M., Nishino, Mizuki, Henick, Brian, Farago, Anna F., Awad, Mark M.

“…The development of immune-related adverse events (irAEs) has been associated with improved efficacy of immune checkpoint inhibitors in patients with urothelial…”
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47 Baseline blood DNA methylation-based immune profiles and tumor mutational burden predict survival outcomes in anti-PD-1 treated head and neck cancer patient by Zhang, Ze, Sehgal, Kartik, Shirai, Keisuke, Butler, Rondi, Wiencke, John, Koestler, Devin, Ramush, Geat, Lee, Min Kyung, Molinaro, Annette, Stolrow, Hannah, Salas, Lucas A, Haddad, Robert, Kelsey, Karl, Christensen, Brock

“…BackgroundImmune checkpoint inhibitors (ICIs) are approved to treat patients with recurrent/metastatic head and neck squamous cell carcinoma (HNSCC). However,…”
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756 First-in-human, open-label, multicenter, phase 1 clinical study to evaluate safety, tolerability, pharmacokinetics and pharmacodynamics of anti Siglec-15 PYX-106 in subjects with advanced solid tumors by Spira, Alexander I, Gordon, Michael S, Henry, Jason, Patel, Sandip P, Sehgal, Kartik, Sen, Shiraj, Sweis, Randy, Crochiere, Marsha, He, Shui, Smyrnios, Sondra, Unadkat, Dipali, Zhang, Bin, Tolcher, Anthony W

“…BackgroundAnti-programmed cell death-1 (PD-1)/PD ligand 1 (PD-L1) checkpoint blockade has not been effective for all solid tumors and alternative therapies are…”
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Hyperprogression in Patients With Cancer Receiving Immune Checkpoint Inhibitors by Sehgal, Kartik

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Targeting the mutant p53 secretome by Sehgal, Kartik, Barbie, David A

“…While p53 is the most highly mutated and perhaps best studied tumor suppressor protein related to cancer, it remains refractory to targeted therapeutic…”
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Targeting the mutant p53 secretome by Sehgal, Kartik, Barbie, David A

“…While p53 is the most highly mutated and perhaps best studied tumor suppressor protein related to cancer, it remains refractory to targeted therapeutic…”
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Clonal Selection Drives NF-κB Activation in Recurrent Nasopharyngeal Carcinoma by Sehgal, Kartik, Barbie, David A

“…Cancer genomic profiling has improved our understanding of the key drivers of tumor development, clonal evolution, and recurrence, and aided precision medicine…”
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Targeting human dendritic cells in situ to improve vaccines by Sehgal, Kartik, Dhodapkar, Kavita M, Dhodapkar, Madhav V

“…Highlights • The specialized antigen-presentation capability of dendritic cells and the plasticity of different DC subsets make them valuable targets for…”
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Pharmacological Agents Targeting Thromboinflammation in COVID-19: Review and Implications for Future Research by Bikdeli, Behnood, Madhavan, Mahesh V, Gupta, Aakriti, Jimenez, David, Burton, John R, Der Nigoghossian, Caroline, Chuich, Taylor, Nouri, Shayan Nabavi, Dreyfus, Isaac, Driggin, Elissa, Sethi, Sanjum, Sehgal, Kartik, Chatterjee, Saurav, Ageno, Walter, Madjid, Mohammad, Guo, Yutao, Tang, Liang V, Hu, Yu, Bertoletti, Laurent, Giri, Jay, Cushman, Mary, Quéré, Isabelle, Dimakakos, Evangelos P, Gibson, C Michael, Lippi, Giuseppe, Favaloro, Emmanuel J, Fareed, Jawed, Tafur, Alfonso J, Francese, Dominic P, Batra, Jaya, Falanga, Anna, Clerkin, Kevin J, Uriel, Nir, Kirtane, Ajay, McLintock, Claire, Hunt, Beverley J, Spyropoulos, Alex C, Barnes, Geoffrey D, Eikelboom, John W, Weinberg, Ido, Schulman, Sam, Carrier, Marc, Piazza, Gregory, Beckman, Joshua A, Leon, Martin B, Stone, Gregg W, Rosenkranz, Stephan, Goldhaber, Samuel Z, Parikh, Sahil A, Monreal, Manuel, Krumholz, Harlan M, Konstantinides, Stavros V, Weitz, Jeffrey I, Lip, Gregory Y H

“…Coronavirus disease 2019 (COVID-19), currently a worldwide pandemic, is a viral illness caused by the severe acute respiratory syndrome coronavirus 2…”
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Phase II trial of regorafenib in metastatic medullary thyroid carcinoma (MTC) and radioactive iodine refractory differentiated thyroid carcinoma (RAIR DTC) by Sehgal, Kartik, Shi, Ruichao, Pappa, Theodora, Min, Judy K, Oakley, Liam B, ONeill, Anne, Dennis, Michael J., Deshpande, Hari Anant, Haddad, Robert I., Lorch, Jochen H.

“…6109 Background: Multi-kinase inhibitors show activity in both MTC & RAIR DTC. However, therapeutic options are limited after disease becomes refractory to one…”
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Diuretic use in infants with developing or established chronic lung disease: A practice looking for evidence by Tan, Catherine, Sehgal, Kartik, Sehgal, Kunal, Krishnappa, Srinath B, Sehgal, Arvind

“…Aim The objective was to assess respiratory efficacy of hydrochlorothiazide and spironolactone and ascertain any adverse effects. Methods Data from 2014 to…”
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