Search Results - "Seher, Axel"

Fibroblast Growth Factor Inducible (Fn14)-specific Antibodies Concomitantly Display Signaling Pathway-specific Agonistic and Antagonistic Activity by Salzmann, Steffen, Seher, Axel, Trebing, Johannes, Weisenberger, Daniela, Rosenthal, Alevtina, Siegmund, Daniela, Wajant, Harald

“…The Fn14-specific monoclonal antibodies PDL192 and P4A8, which are under consideration in clinical trials, showed no agonistic activity with respect to IL8…”
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Mass Spectrometric Metabolic Fingerprinting of 2-Deoxy-D-Glucose (2-DG)-Induced Inhibition of Glycolysis and Comparative Analysis of Methionine Restriction versus Glucose Restriction under Perfusion Culture in the Murine L929 Model System by Volland, Julian Manuel, Kaupp, Johannes, Schmitz, Werner, Wünsch, Anna Chiara, Balint, Julia, Möllmann, Marc, El-Mesery, Mohamed, Frackmann, Kyra, Peter, Leslie, Hartmann, Stefan, Kübler, Alexander Christian, Seher, Axel

“…All forms of restriction, from caloric to amino acid to glucose restriction, have been established in recent years as therapeutic options for various diseases,…”
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Receptor oligomerization and beyond: a case study in bone morphogenetic proteins by Heinecke, Kai, Seher, Axel, Schmitz, Werner, Mueller, Thomas D, Sebald, Walter, Nickel, Joachim

“…Transforming growth factor (TGF)beta superfamily members transduce signals by oligomerizing two classes of serine/threonine kinase receptors, termed type I and…”
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The Influence of Met Receptor Level on HGF-Induced Glycolytic Reprogramming in Head and Neck Squamous Cell Carcinoma by Boschert, Verena, Klenk, Nicola, Abt, Alexander, Janaki Raman, Sudha, Fischer, Markus, Brands, Roman C, Seher, Axel, Linz, Christian, Müller-Richter, Urs D A, Bischler, Thorsten, Hartmann, Stefan

“…Head and neck squamous cell carcinoma (HNSCC) is known to overexpress a variety of receptor tyrosine kinases, such as the HGF receptor Met. Like other…”
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HGF-Induced PD-L1 Expression in Head and Neck Cancer: Preclinical and Clinical Findings by Boschert, Verena, Teusch, Jonas, Aljasem, Anwar, Schmucker, Philipp, Klenk, Nicola, Straub, Anton, Bittrich, Max, Seher, Axel, Linz, Christian, Müller-Richter, Urs D A, Hartmann, Stefan

“…Head and neck squamous cell carcinoma (HNSCC) is a widespread disease with a low survival rate and a high risk of recurrence. Nowadays, immune checkpoint…”
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Cysteine Restriction in Murine L929 Fibroblasts as an Alternative Strategy to Methionine Restriction in Cancer Therapy by Schmitz, Werner, Ries, Elena, Koderer, Corinna, Völter, Maximilian Friedrich, Wünsch, Anna Chiara, El-Mesery, Mohamed, Frackmann, Kyra, Kübler, Alexander Christian, Linz, Christian, Seher, Axel

“…Methionine restriction (MetR) is an efficient method of amino acid restriction (AR) in cells and organisms that induces low energy metabolism (LEM) similar to…”
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Metabolic Silencing via Methionine-Based Amino Acid Restriction in Head and Neck Cancer by Wünsch, Anna Chiara, Ries, Elena, Heinzelmann, Sina, Frabschka, Andrea, Wagner, Peter Christoph, Rauch, Theresa, Koderer, Corinna, El-Mesery, Mohamed, Volland, Julian Manuel, Kübler, Alexander Christian, Hartmann, Stefan, Seher, Axel

“…In recent years, various forms of caloric restriction (CR) and amino acid or protein restriction (AAR or PR) have shown not only success in preventing…”
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The Selection of NFκB Inhibitors to Block Inflammation and Induce Sensitisation to FasL-Induced Apoptosis in HNSCC Cell Lines Is Critical for Their Use as a Prospective Cancer Therapy by Scheurer, Mario Joachim Johannes, Brands, Roman Camillus, El-Mesery, Mohamed, Hartmann, Stefan, Müller-Richter, Urs Dietmar Achim, Kübler, Alexander Christian, Seher, Axel

“…Inflammation is a central aspect of tumour biology and can contribute significantly to both the origination and progression of tumours. The NFκB pathway is one…”
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Metabolic Fingerprinting of Murine L929 Fibroblasts as a Cell-Based Tumour Suppressor Model System for Methionine Restriction by Schmitz, Werner, Koderer, Corinna, El-Mesery, Mohamed, Gubik, Sebastian, Sampers, Rene, Straub, Anton, Kübler, Alexander Christian, Seher, Axel

“…Since Otto Warburg reported in 1924 that cancer cells address their increased energy requirement through a massive intake of glucose, the cellular energy level…”
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Crystal structure analysis reveals a spring-loaded latch as molecular mechanism for GDF-5-type I receptor specificity by Kotzsch, Alexander, Nickel, Joachim, Seher, Axel, Sebald, Walter, Müller, Thomas D

“…Dysregulation of growth and differentiation factor 5 (GDF‐5) signalling, a member of the TGF‐β superfamily, is strongly linked to skeletal malformation…”
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The anti-myeloma activity of bone morphogenetic protein 2 predominantly relies on the induction of growth arrest and is apoptosis-independent by Lagler, Charlotte, El-Mesery, Mohamed, Kübler, Alexander Christian, Müller-Richter, Urs Dietmar Achim, Stühmer, Thorsten, Nickel, Joachim, Müller, Thomas Dieter, Wajant, Harald, Seher, Axel

“…Multiple myeloma (MM), a malignancy of the bone marrow, is characterized by a pathological increase in antibody-producing plasma cells and an increase in…”
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Utilizing BMP-2 muteins for treatment of multiple myeloma by Seher, Axel, Lagler, Charlotte, Stühmer, Thorsten, Müller-Richter, Urs Dietmar Achim, Kübler, Alexander Christian, Sebald, Walter, Müller, Thomas Dieter, Nickel, Joachim

“…Multiple myeloma (MM) represents a haematological cancer characterized by the pathological hyper proliferation of antibody-producing B-lymphocytes. Patients…”
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Type I receptor binding of bone morphogenetic protein 6 is dependent on N-glycosylation of the ligand by Saremba, Stefan, Nickel, Joachim, Seher, Axel, Kotzsch, Alexander, Sebald, Walter, Mueller, Thomas D

“…Bone morphogenetic proteins (BMPs), together with transforming growth factor (TGF)-β and activins/inhibins, constitute the TGF-β superfamily of ligands. This…”
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Low Energy Status under Methionine Restriction Is Essentially Independent of Proliferation or Cell Contact Inhibition by Koderer, Corinna, Schmitz, Werner, Wünsch, Anna Chiara, Balint, Julia, El-Mesery, Mohamed, Volland, Julian Manuel, Hartmann, Stefan, Linz, Christian, Kübler, Alexander Christian, Seher, Axel

“…Nonlimited proliferation is one of the most striking features of neoplastic cells. The basis of cell division is the sufficient presence of mass (amino acids)…”
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Structure Analysis of Bone Morphogenetic Protein-2 Type I Receptor Complexes Reveals a Mechanism of Receptor Inactivation in Juvenile Polyposis Syndrome by Kotzsch, Alexander, Nickel, Joachim, Seher, Axel, Heinecke, Kai, van Geersdaele, Laura, Herrmann, Thomas, Sebald, Walter, Mueller, Thomas D.

“…Bone morphogenetic proteins regulate many developmental processes during embryogenesis as well as tissue homeostasis in the adult. Signaling of bone…”
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Exogenous TNFR2 activation protects from acute GvHD via host T reg cell expansion by Chopra, Martin, Biehl, Marlene, Steinfatt, Tim, Brandl, Andreas, Kums, Juliane, Amich, Jorge, Vaeth, Martin, Kuen, Janina, Holtappels, Rafaela, Podlech, Jürgen, Mottok, Anja, Kraus, Sabrina, Jordán-Garrote, Ana-Laura, Bäuerlein, Carina A, Brede, Christian, Ribechini, Eliana, Fick, Andrea, Seher, Axel, Polz, Johannes, Ottmüller, Katja J, Baker, Jeanette, Nishikii, Hidekazu, Ritz, Miriam, Mattenheimer, Katharina, Schwinn, Stefanie, Winter, Thorsten, Schäfer, Viktoria, Krappmann, Sven, Einsele, Hermann, Müller, Thomas D, Reddehase, Matthias J, Lutz, Manfred B, Männel, Daniela N, Berberich-Siebelt, Friederike, Wajant, Harald, Beilhack, Andreas

“…Donor CD4(+)Foxp3(+) regulatory T cells (T reg cells) suppress graft-versus-host disease (GvHD) after allogeneic hematopoietic stem cell transplantation (HCT…”
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Studies of Binding of Tumor Necrosis Factor (TNF)-like Weak Inducer of Apoptosis (TWEAK) to Fibroblast Growth Factor Inducible 14 (Fn14) by Fick, Andrea, Lang, Isabell, Schäfer, Viktoria, Seher, Axel, Trebing, Johannes, Weisenberger, Daniela, Wajant, Harald

“…To perform highly sensitive cellular binding studies with TNF-like weak inducer of apoptosis (TWEAK), we developed a bioluminescent variant of soluble TWEAK…”
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MLN4924 sensitizes monocytes and maturing dendritic cells for TNF‐dependent and ‐independent necroptosis by El‐Mesery, Mohamed, Seher, Axel, Stühmer, Thorsten, Siegmund, Daniela, Wajant, Harald

“…Background and Purpose MLN4924 prevents the formation of active cullin‐RING ubiquitin ligase complexes and thus inhibits NF‐κB signalling. Here, we evaluated…”
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Repurposing of quinoline alkaloids identifies their ability to enhance doxorubicin‐induced sub‐G0/G1 phase cell cycle arrest and apoptosis in cervical and hepatocellular carcinoma cells by El‐Mesery, Mohamed, Seher, Axel, El‐Shafey, Mohamed, El‐Dosoky, Mohamed, Badria, Farid A

“…The ability of quinoline alkaloids (cinchonine, cinchonidine, quinine, and quinidine) to sensitize different human cancer cell lines to doxorubicin…”
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Soluble and transmembrane TNF-like weak inducer of apoptosis differentially activate the classical and noncanonical NF-kappa B pathway by Roos, Claudia, Wicovsky, Andreas, Müller, Nicole, Salzmann, Steffen, Rosenthal, Tina, Kalthoff, Holger, Trauzold, Anna, Seher, Axel, Henkler, Frank, Kneitz, Christian, Wajant, Harald

“…TNF-like weak inducer of apoptosis, TWEAK, is a typical member of the TNF ligand family. Thus, it is initially expressed as a type II transmembrane protein…”
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