Search Results - "Segura, Carlos Moran"

Challenges and Opportunities in the Statistical Analysis of Multiplex Immunofluorescence Data by Wilson, Christopher M, Ospina, Oscar E, Townsend, Mary K, Nguyen, Jonathan, Moran Segura, Carlos, Schildkraut, Joellen M, Tworoger, Shelley S, Peres, Lauren C, Fridley, Brooke L

“…Immune modulation is considered a hallmark of cancer initiation and progression. The recent development of immunotherapies has ushered in a new era of cancer…”
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Combined nivolumab and ipilimumab with or without stereotactic body radiation therapy for advanced Merkel cell carcinoma: a randomised, open label, phase 2 trial by Kim, Sungjune, Wuthrick, Evan, Blakaj, Dukagjin, Eroglu, Zeynep, Verschraegen, Claire, Thapa, Ram, Mills, Matthew, Dibs, Khaled, Liveringhouse, Casey, Russell, Jeffery, Caudell, Jimmy J, Tarhini, Ahmad, Markowitz, Joseph, Kendra, Kari, Wu, Richard, Chen, Dung-Tsa, Berglund, Anders, Michael, Lauren, Aoki, Mia, Wang, Min-Hsuan, Hamaidi, Imene, Cheng, Pingyan, de la Iglesia, Janis, Slebos, Robbert J, Chung, Christine H, Knepper, Todd C, Moran-Segura, Carlos M, Nguyen, Jonathan V, Perez, Bradford A, Rose, Trevor, Harrison, Louis, Messina, Jane L, Sondak, Vernon K, Tsai, Kenneth Y, Khushalani, Nikhil I, Brohl, Andrew S

“…Merkel cell carcinoma is among the most aggressive and lethal of primary skin cancers, with a high rate of distant metastasis. Anti-programmed death receptor 1…”
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Ablation of the endoplasmic reticulum stress kinase PERK induces paraptosis and type I interferon to promote anti-tumor T cell responses by Mandula, Jessica K., Chang, Shiun, Mohamed, Eslam, Jimenez, Rachel, Sierra-Mondragon, Rosa A., Chang, Darwin C., Obermayer, Alyssa N., Moran-Segura, Carlos M., Das, Satyajit, Vazquez-Martinez, Julio A., Prieto, Karol, Chen, Ann, Smalley, Keiran S.M., Czerniecki, Brian, Forsyth, Peter, Koya, Richard C., Ruffell, Brian, Cubillos-Ruiz, Juan R., Munn, David H., Shaw, Timothy I., Conejo-Garcia, Jose R., Rodriguez, Paulo C.

“…Activation of unfolded protein responses (UPRs) in cancer cells undergoing endoplasmic reticulum (ER) stress promotes survival. However, how UPR in tumor cells…”
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Rapid Autopsy to Define Dendritic Cell Spatial Distribution and T Cell Association in Lung Adenocarcinoma by Ozakinci, Hilal, Song, Xiaofei, Nazario, Gina S, Lila, Thomas, Chen, Benjamin, Simpson, Tyler, Nguyen, Jonathan V, Moran Segura, Carlos M, Thompson, Zachary J, Thapa, Ram, Rose, Trevor A, Haura, Eric B, Pellini, Bruna, Yu, Xiaoqing, Ruffell, Brian H, Chen, Dung-Tsa, Boyle, Theresa A, Beg, Amer A

“…Immunotherapy response is associated with the presence of conventional dendritic cells (cDCs). cDC type 1 (cDC1) is critically important for CD8+ T cell…”
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Case Report: Durable complete pathologic response and organ preservation following ipilimumab and nivolumab for locally advanced primary vaginal mucosal melanoma by Tarhini, Ahmad A, Hanayneh, Wissam B, Powers, John J, Segura, Carlos M Moran, Conejo-Garcia, Jose R, Lam, Cesar A, Hakam, Ardeshir, Hoffman, Mitchel S

“…Optimal management of locally advanced vaginal mucosal melanoma is poorly understood because of its rarity and unique biology. Patients have a poor prognosis…”
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Measurement of Ovarian Tumor Immune Profiles by Multiplex Immunohistochemistry: Implications for Epidemiologic Studies by Hathaway, Cassandra A, Conejo-Garcia, Jose R, Fridley, Brooke L, Rosner, Bernard, Saeed-Vafa, Daryoush, Moran Segura, Carlos, Nguyen, Jonathan V, Hecht, Jonathan L, Sasamoto, Naoko, Terry, Kathryn L, Tworoger, Shelley S, Townsend, Mary K

“…Despite the immunogenic nature of many ovarian tumors, treatment with immune checkpoint therapies has not led to substantial improvements in ovarian cancer…”
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Lifetime Exposure to Cigarette Smoke and Risk of Ovarian Cancer by T-cell Tumor Immune Infiltration by Hathaway, Cassandra A, Wang, Tianyi, Townsend, Mary K, Vinci, Christine, Jake-Schoffman, Danielle E, Saeed-Vafa, Daryoush, Moran Segura, Carlos, Nguyen, Jonathan V, Conejo-Garcia, Jose R, Fridley, Brooke L, Tworoger, Shelley S

“…Exposure to cigarette smoke, particularly in early life, is modestly associated with ovarian cancer risk and may impact systemic immunity and the tumor immune…”
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Tumor immune cell clustering and its association with survival in African American women with ovarian cancer by Wilson, Christopher, Soupir, Alex C, Thapa, Ram, Creed, Jordan, Nguyen, Jonathan, Segura, Carlos Moran, Gerke, Travis, Schildkraut, Joellen M, Peres, Lauren C, Fridley, Brooke L

“…New technologies, such as multiplex immunofluorescence microscopy (mIF), are being developed and used for the assessment and visualization of the tumor immune…”
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Jagged2 targeting in lung cancer activates anti-tumor immunity via Notch-induced functional reprogramming of tumor-associated macrophages by Mandula, Jay K, Sierra-Mondragon, Rosa A, Jimenez, Rachel V, Chang, Darwin, Mohamed, Eslam, Chang, Shiun, Vazquez-Martinez, Julio A, Cao, Yu, Anadon, Carmen M, Lee, Sae Bom, Das, Satyajit, Rocha-Munguba, Léo, Pham, Vincent M, Li, Roger, Tarhini, Ahmad A, Furqan, Muhammad, Dalton, William, Churchman, Michelle, Moran-Segura, Carlos M, Nguyen, Jonathan, Perez, Bradford, Kojetin, Douglas J, Obermayer, Alyssa, Yu, Xiaoqing, Chen, Ann, Shaw, Timothy I, Conejo-Garcia, Jose R, Rodriguez, Paulo C

“…Signaling through Notch receptors intrinsically regulates tumor cell development and growth. Here, we studied the role of the Notch ligand Jagged2 on immune…”
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The relationship of lifetime history of depression on the ovarian tumor immune microenvironment by Hathaway, Cassandra A., Townsend, Mary K., Conejo-Garcia, Jose R., Fridley, Brooke L., Moran Segura, Carlos, Nguyen, Jonathan V., Armaiz-Pena, Guillermo N., Sasamoto, Naoko, Saeed-Vafa, Daryoush, Terry, Kathryn L., Kubzansky, Laura D., Tworoger, Shelley S.

“…•Depression may alter the ovarian tumor immune microenvironment.•Depression was related to higher abundance of recently activated cytotoxic and exhausted T…”
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Oncolytic immunotherapy with nivolumab in muscle-invasive bladder cancer: a phase 1b trial by Li, Roger, Villa, Nancy Y., Yu, Xiaoqing, Johnson, Joseph O., Borjas, Gustavo, Dhillon, Jasreman, Moran-Segura, Carlos M., Kim, Youngchul, Francis, Natasha, Dorman, Denise, Powers, John J., Sexton, Wade J., Spiess, Philippe E., Poch, Michael A., Zemp, Logan, Gilbert, Scott M., Zhang, Jingsong, Pow-Sang, Julio M., Anderson, Alexander R. A., Li, Tingyi, Wang, Xuefeng, Grass, G. Daniel, Burke, James M., Dinney, Colin P. N., Rodriguez, Paulo C., Jain, Rohit K., Mulé, James J., Conejo-Garcia, Jose R.

“…There is a critical unmet need for safe and efficacious neoadjuvant treatment for cisplatin-ineligible patients with muscle-invasive bladder cancer. Here we…”
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Racial Differences in the Tumor Immune Landscape and Survival of Women with High-Grade Serous Ovarian Carcinoma by Peres, Lauren C, Colin-Leitzinger, Christelle, Sinha, Sweta, Marks, Jeffrey R, Conejo-Garcia, Jose R, Alberg, Anthony J, Bandera, Elisa V, Berchuck, Andrew, Bondy, Melissa L, Christensen, Brock C, Cote, Michele L, Doherty, Jennifer Anne, Moorman, Patricia G, Peters, Edward S, Moran Segura, Carlos, Nguyen, Jonathan V, Schwartz, Ann G, Terry, Paul D, Wilson, Christopher M, Fridley, Brooke L, Schildkraut, Joellen M

“…Tumor-infiltrating lymphocytes (TIL) confer a survival benefit among patients with ovarian cancer; however, little work has been conducted in racially diverse…”
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Spatial clustering of CD68+ tumor associated macrophages with tumor cells is associated with worse overall survival in metastatic clear cell renal cell carcinoma by Chakiryan, Nicholas H, Kimmel, Gregory J, Kim, Youngchul, Hajiran, Ali, Aydin, Ahmet M, Zemp, Logan, Katende, Esther, Nguyen, Jonathan, Lopez-Blanco, Neale, Chahoud, Jad, Spiess, Philippe E, Fournier, Michelle, Dhillon, Jasreman, Wang, Liang, Moran-Segura, Carlos, El-Kenawi, Asmaa, Mulé, James, Altrock, Philipp M, Manley, Brandon J

“…Immune infiltration is typically quantified using cellular density, not accounting for cellular clustering. Tumor-associated macrophages (TAM) activate…”
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Multiplex Immunofluorescence Captures Progressive Immune Exhaustion with Advancing Penile Squamous Cell Cancer Stage by Ionescu, Filip, Nguyen, Jonathan, Segura, Carlos Moran, Paravathaneni, Mahati, Grass, G Daniel, Johnstone, Peter, Zacharias, Niki M, Pettaway, Curtis A, Lu, Xin, Kim, Youngchul, Whiting, Junmin, Dhillon, Jasreman, Eschrich, Steven A, Chadha, Juskaran, Gullapalli, Keerthi, Roman Souza, Gabriel, Miyagi, Hiroko, Manley, Brandon J, Spiess, Philippe E, Chahoud, Jad

“…Penile squamous cell carcinoma (PSCC) is a rare and deadly malignancy. Therapeutic advances have been stifled by a poor understanding of disease biology…”
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Immune effector cell-associated enterocolitis following chimeric antigen receptor T-cell therapy in multiple myeloma by Fortuna, Gliceida Galarza, Banerjee, Rahul, Savid-Frontera, Constanza, Song, Jinming, Morán-Segura, Carlos M., Nguyen, Jonathan V., Lekakis, Lazaros, Fernandez-Pol, Sebastian, Samraj, Annie N., Naresh, Kikkeri N., Vazquez-Martinez, Mariola, Baz, Rachid C., Spiegel, Jay Y., Mikkilineni, Lekha, Gubatan, John M., Sidana, Surbhi, de Menezes Silva Corraes, Andre, Kalariya, Nilesh M., Patel, Krina K., Shim, Kevin G., Fonseca, Rafael, Ferreri, Christopher, Voorhees, Peter M., Richard, Shambavi, Valdes, Cesar Rodriguez, Sireesha Asoori, Wolf, Jeffrey L., Cowan, Andrew J., Sborov, Douglas W., Locke, Frederick L., Lin, Yi, Wang, Yinghong, Hansen, Doris K.

“…We report 14 cases of immune effector cell (IEC)-associated enterocolitis following chimeric antigen receptor T-cell (CAR-T) therapy in multiple myeloma, with…”
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Geospatial characterization of immune cell distributions and dynamics across the microenvironment in clear cell renal cell carcinoma by Chakiryan, Nicholas H, Kim, Youngchul, Berglund, Anders, Chang, Andrew, Kimmel, Gregory J, Hajiran, Ali, Nguyen, Jonathan, Moran-Segura, Carlos, Saeed-Vafa, Daryoush, Katende, Esther N, Lopez-Blanco, Neale, Chahoud, Jad, Rappold, Phillip, Spiess, Philippe E, Fournier, Michelle, Jeong, Daniel, Wang, Liang, Teer, Jamie K, Dhillon, Jasreman, Kuo, Fengshen, Hakimi, Abraham Ari, Altrock, Philipp M, Mulé, James J, Manley, Brandon J

“…IntroductionIn clear cell renal cell carcinoma (ccRCC), tumor-associated macrophage (TAM) induction of CD8+T cells into a terminally exhausted state has been…”
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CX3CR1 deficiency-induced TIL tumor restriction as a novel addition for CAR-T design in solid malignancies by Trinh, ThuLe, Adams, William A., Calescibetta, Alexandra, Tu, Nhan, Dalton, Robert, So, Tina, Wei, Max, Ward, Grace, Kostenko, Elena, Christiansen, Sean, Cen, Ling, McLemore, Amy, Reed, Kayla, Whitting, Junmin, Gilvary, Danielle, Blanco, Neale Lopez, Segura, Carlos Moran, Nguyen, Jonathan, Kandell, Wendy, Chen, Xianghong, Cheng, Pingyan, Wright, Gabriela M., Cress, W. Douglas, Liu, Jinghong, Wright, Kenneth L., Wei, Sheng, Eksioglu, Erika A.

“…Advances in the understanding of the tumor microenvironment have led to development of immunotherapeutic strategies, such as chimeric antigen receptor T cells…”
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Development of a MEK inhibitor, NFX-179, as a chemoprevention agent for squamous cell carcinoma by Sarin, Kavita Y, Kincaid, John, Sell, Brittney, Shahryari, Jahanbanoo, Duncton, Matthew A J, Morefield, Elaine, Sun, Wenchao, Prieto, Karol, Chavez-Chiang, Omar, de Moran Segura, Carlos, Nguyen, Jonathan, Bronson, Roderick T, Plotkin, Scott R, Kochendoerfer, Gerd G, Fenn, Peter, Wootton, Michael A, Powala, Christopher, de Souza, Mark P, Tsai, Kenneth Y

“…Cutaneous squamous cell carcinoma (cSCC) is the second most common skin cancer. Although cSCC contributes to substantial morbidity and mortality in high-risk…”
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PD16-01 SPATIAL ANALYSIS OF THE TUMOR IMMUNE MICROENVIRONMENT IN PAPILLARY RENAL CELL CARCINOMA by Hayes, Mitchell T., Laborde, Jose, Soupir, Alex, Sabitov, Kirill, Peak, Taylor, Nguyen, Jonathan, Moran-Segura, Carlos, Saeed-Vafa, Daryoush, Lopez-Blanco, Neale, Echevarria, Paola Ramos, Guske, Christopher, Balasi, Jodi, Dhillon, Jasremon, Kim, Youngchul, Mule, James, Fridley, Brooke L., Manley, Brandon J.

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Spatial analysis of the tumor immune microenvironment in papillary renal cell carcinoma by Hayes, Mitch, Sabitov, Kirill, Soupir, Alex C., Peak, Taylor, Nguyen, Jonathan, Moran-Segura, Carlos, Saeed-Vafa, Daryoush, Lopez-Blanco, Neale, Ramos Echevarria, Paola, Guske, Christopher, Balasi, Jodi, Dhillon, Jasreman, Kim, Youngchul, Mule, James J, Fridley, Brooke, Manley, Brandon J.

“…471 Background: Spatial analysis of the tumor immune microenvironment (TIME) has yet to be explored in papillary renal cell carcinoma (pRCC). We utilized…”
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