Search Results - "Segrest, J.P."

Osmotically Induced Membrane Tension Modulates Membrane Permeabilization by Class L Amphipathic Helical Peptides: Nucleation Model of Defect Formation by Polozov, I.V., Anantharamaiah, G.M., Segrest, J.P., Epand, R.M.

“…The mechanism of action of lytic peptides on membranes is widely studied and is important in view of potential medical applications. Previously (I. V. Polozov,…”
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Reciprocal effects of apolipoprotein and lytic peptide analogs on membranes. Cross-sectional molecular shapes of amphipathic alpha helixes control membrane stability by Tytler, E M, Segrest, J P, Epand, R M, Nie, S Q, Epand, R F, Mishra, V K, Venkatachalapathi, Y V, Anantharamaiah, G M

“…Apolipoprotein (class A) amphipathic helixes are postulated to act as detergents by virtue of their cross-section being wedge-shaped. Using computer analysis…”
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Membrane interactions of synthetic peptides corresponding to amphipathic helical segments of the human immunodeficiency virus type-1 envelope glycoprotein by Srinivas, S K, Srinivas, R V, Anantharamaiah, G M, Segrest, J P, Compans, R W

“…The human and simian immunodeficiency virus envelope glycoproteins, which mediate virus-induced cell fusion, contain two putative amphipathic helical segments…”
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The influence of apolipoprotein structure on the efflux of cellular free cholesterol to high density lipoprotein by Davidson, W S, Lund-Katz, S, Johnson, W J, Anantharamaiah, G M, Palgunachari, M N, Segrest, J P, Rothblat, G H, Phillips, M C

“…The influence of apolipoprotein conformation on the ability of high density lipoprotein (HDL) to remove cellular free cholesterol (FC) has not been studied in…”
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Binding of apolipoprotein A-I model peptides to lipid bilayers. Measurement of binding isotherms and peptide-lipid headgroup interactions by Spuhler, P, Anantharamaiah, G M, Segrest, J P, Seelig, J

“…Amphiphatic alpha-helices are the lipid-binding motif in many apolipoproteins. Two model peptides, namely…”
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Antiviral effects of apolipoprotein A-I and its synthetic amphipathic peptide analogs by Srinivas, R V, Birkedal, B, Owens, R J, Anantharamaiah, G M, Segrest, J P, Compans, R W

“…Apolipoprotein A-I (apo A-I), the major protein component of serum high density lipoproteins, was found to inhibit herpes simplex virus (HSV)-induced cell…”
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A Detailed Molecular Belt Model for Apolipoprotein A-I in Discoidal High Density Lipoprotein by Segrest, Jere P., Jones, Martin K., Klon, Anthony E., Sheldahl, Christopher J., Hellinger, Matthew, De Loof, Hans, Harvey, Stephen C.

“…Apolipoprotein A-I (apoA-I) is the principal protein of high density lipoprotein particles (HDL). ApoA-I contains a globular N-terminal domain (residues 1–43)…”
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Thyroid function and other clinical chemistry parameters in subjects eating iodine-enriched eggs by Garber, D W, Henkin, Y, Osterlund, L C, Woolley, T W, Segrest, J P

“…Iodine-enriched (IE) eggs are produced by chickens fed a diet containing kelp. These eggs, which contain an average of 711 micrograms iodine/egg, have been…”
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Apolipoprotein-mediated plasma membrane microsolubilization. Role of lipid affinity and membrane penetration in the efflux of cellular cholesterol and phospholipid by Gillotte, K.L. (University of California, San Diego, CA.), Zaiou, M, Lund-Katz, S, Anantharamaiah, G.M, Holvoet, P, Dhoest, A, Palgunachari, M.N, Segrest, J.P, Weisgraber, K.H, Rothblat, G.H

“…Lipid-free apolipoprotein (apo) A-I contributes to the reverse transport of cholesterol from the periphery to the liver by solubilizing plasma membrane…”
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Human erythrocyte membrane glycoprotein: a re-evaluation of the molecular weight as determined by SDS polyacrylamide gel electrophoresis by Segrest, J P, Jackson, R L, Andrews, E P, Marchesi, V T

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Studies of synthetic peptide analogs of the amphipathic helix. Effect of charged amino acid residue topography on lipid affinity by P Kanellis, A Y Romans, B J Johnson, H Kercret, R Chiovetti, Jr, T M Allen, J P Segrest

“…The amphipathic helix hypothesis for plasma lipoproteins was investigated using synthetic peptides. The lipid-associating properties of two potentially…”
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Efflux of cholesterol on human atherosclsrotic plaques does not occur as readily as that on normal cell membranes by Chung, Byung-Hong, Segrest, J.P., Hart, Karen

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Interactions of synthetic peptide analogs of the class A amphipathic helix with lipids. Evidence for the snorkel hypothesis by MISHRA, V. K, PALGUNACHARI, M. N, SEGREST, J. P, ANANTHARAMAIAH, G. M

“…Class A amphipathic helixes present in exchangeable plasma apolipoproteins are characterized by the location of positively charged amino acid residues at the…”
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Quantification of cholesterol in all lipoprotein classes by the VAP-II method by Kulkarni, K.R, Garber, D.W, Marcovina, S.M, Segrest, J.P

“…We have developed a high resolution microvolume Vertical Auto Profile (VAP) method for the simultaneous measurement of cholesterol in all lipoprotein classes,…”
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Identification and Characterization of a New Human Gene (APOC4) in the Apolipoprotein E, C-I, and C-II Gene Locus by Allan, Charles M., Walker, David, Segrest, Jere P., Taylor, John M.

“…We have identified and characterized a previously unreported human gene that is found within the apolipoprotein (apo) E/C-I/C-II gene locus. On the basis of…”
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Cytosolic domain of the human immunodeficiency virus envelope glycoproteins binds to calmodulin and inhibits calmodulin-regulated proteins by Srinivas, S.K., Srinivas, R.V., Anantharamaiah, G.M., Compans, R.W., Segrest, J.P.

“…Calmodulin (CaM), the major intracellular receptor for calcium, is involved in regulation of diverse cellular functions. Positively charged amphipathic helical…”
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Studies of kinetics and equilibrium membrane binding of class A and class L model amphipathic peptides by Polozov, I.V, Polozova, A.I, Mishra, V.K, Anantharamaiah, G.M, Segrest, J.P, Epand, R.M

“…We studied the kinetics and equilibrium membrane binding of two amphipathic α-helical peptides: the 18L peptide, which belongs to the class L (lytic peptides),…”
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Potencies of Lipoproteins in Fasting and Postprandial Plasma to Accept Additional Cholesterol Molecules Released From Cell Membranes by Chung, Byung Hong, Franklin, Frank, Cho, B.H. Simon, Segrest, J.P, Hart, Karen, Darnell, Betty E

“…To investigate the role of various lipoproteins in plasma to promote cholesterol efflux from cell membranes, potencies of lipoproteins in normolipidemic…”
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Identification and cholesterol quantification of low density lipoprotein subclasses in young adults by VAP-II methodology by Kulkarni, K.R. (University of Alabama at Birmingham, Birmingham, AL.), Garber, D.W, Jones, M.K, Segrest, J.P

“…Low density lipoprotein (LDL) particles are heterogeneous in size, density, and chemical composition; small, dense LDL may be more atherogenic than large,…”
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Studies of kinetics and equilibrium membrane binding of class A and class L model amphipathic peptides1This work was supported by the Medical Research Council of Canada, grant MT-7654 and in part by NIH 90734343.1 by Polozov, I.V, Polozova, A.I, Mishra, V.K, Anantharamaiah, G.M, Segrest, J.P, Epand, R.M

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