Search Results - "Segrelles, Carmen"

Inhibition of a G9a/DNMT network triggers immune-mediated bladder cancer regression by Segovia, Cristina, San José-Enériz, Edurne, Munera-Maravilla, Ester, Martínez-Fernández, Mónica, Garate, Leire, Miranda, Estíbaliz, Vilas-Zornoza, Amaia, Lodewijk, Iris, Rubio, Carolina, Segrelles, Carmen, Valcárcel, Luis Vitores, Rabal, Obdulia, Casares, Noelia, Bernardini, Alejandra, Suarez-Cabrera, Cristian, López-Calderón, Fernando F., Fortes, Puri, Casado, José A., Dueñas, Marta, Villacampa, Felipe, Lasarte, Juan José, Guerrero-Ramos, Félix, de Velasco, Guillermo, Oyarzabal, Julen, Castellano, Daniel, Agirre, Xabier, Prósper, Felipe, Paramio, Jesús M.

“…Bladder cancer is lethal in its advanced, muscle-invasive phase with very limited therapeutic advances 1 , 2 . Recent molecular characterization has defined…”
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The transcriptional co-activator YAP: A new player in head and neck cancer by Segrelles, Carmen, Paramio, Jesús M., Lorz, Corina

“…The activation of the Hippo pathway effector Yes-associated protein (YAP) is modulated by different upstream cues. Phosphorylated YAP accumulates in the…”
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CDK4/6 Inhibitor as a Novel Therapeutic Approach for Advanced Bladder Cancer Independently of RB1 Status by Rubio, Carolina, Martínez-Fernández, Mónica, Segovia, Cristina, Lodewijk, Iris, Suarez-Cabrera, Cristian, Segrelles, Carmen, López-Calderón, Fernando, Munera-Maravilla, Ester, Santos, Mirentxu, Bernardini, Alejandra, García-Escudero, Ramón, Lorz, Corina, Gómez-Rodriguez, Maria José, de Velasco, Guillermo, Otero, Irene, Villacampa, Felipe, Guerrero-Ramos, Felix, Ruiz, Sergio, de la Rosa, Federico, Domínguez-Rodríguez, Sara, Real, Francisco X, Malats, Núria, Castellano, Daniel, Dueñas, Marta, Paramio, Jesus M

“…Bladder cancer is a clinical and social problem due to its high incidence and recurrence rates. It frequently appears in elderly patients showing other medical…”
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VAV2 signaling promotes regenerative proliferation in both cutaneous and head and neck squamous cell carcinoma by Lorenzo-Martín, L. Francisco, Fernández-Parejo, Natalia, Menacho-Márquez, Mauricio, Rodríguez-Fdez, Sonia, Robles-Valero, Javier, Zumalave, Sonia, Fabbiano, Salvatore, Pascual, Gloria, García-Pedrero, Juana M., Abad, Antonio, García-Macías, María C., González, Nazareno, Lorenzano-Menna, Pablo, Pavón, Miguel A., González-Sarmiento, Rogelio, Segrelles, Carmen, Paramio, Jesús M., Tubío, José M. C., Rodrigo, Juan P., Benitah, Salvador A., Cuadrado, Myriam, Bustelo, Xosé R.

“…Regenerative proliferation capacity and poor differentiation are histological features usually linked to poor prognosis in head and neck squamous cell…”
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Anti-EGFR conjugated nanoparticles to deliver Alpelisib as targeted therapy for head and neck cancer by Juan, Alberto, Segrelles, Carmen, del Campo-Balguerías, Almudena, Bravo, Iván, Silva, Ignacio, Peral, Jorge, Ocaña, Alberto, Clemente-Casares, Pilar, Alonso-Moreno, Carlos, Lorz, Corina

“…Background Head and neck squamous cell carcinoma (SCC) is one of the most prevalent and deadly cancers worldwide. Even though surgical approaches, radiation…”
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Bosutinib Inhibits EGFR Activation in Head and Neck Cancer by Segrelles, Carmen, Contreras, David, Navarro, Elena M, Gutiérrez-Muñoz, Carmen, García-Escudero, Ramón, Paramio, Jesús M, Lorz, Corina

“…Head and neck squamous cell carcinoma (HNSCC) is the sixth most common cancer worldwide, and although new therapeutic approaches have been recently evaluated,…”
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IKKβ-Mediated Resistance to Skin Cancer Development Is Ink4a/Arf- Dependent by Page, Angustias, Bravo, Ana, Suarez-Cabrera, Cristian, Alameda, Josefa P, Casanova, M Llanos, Lorz, Corina, Segrelles, Carmen, Segovia, José C, Paramio, Jesús M, Navarro, Manuel, Ramirez, Angel

“…IKKβ (encoded by ) is a protein kinase that regulates the activity of numerous proteins important in several signaling pathways, such as the NF-κB pathway…”
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Unique and overlapping functions of pRb and p107 in the control of proliferation and differentiation in epidermis by Ruiz, Sergio, Santos, Mirentxu, Segrelles, Carmen, Leis, Hugo, Jorcano, José Luis, Berns, Anton, Paramio, Jesús M, Vooijs, Marc

“…The retinoblastoma gene product, pRb, plays a crucial role in cell cycle regulation, differentiation and inhibition of oncogenic transformation. pRb and its…”
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Deregulated Activity of Akt in Epithelial Basal Cells Induces Spontaneous Tumors and Heightened Sensitivity to Skin Carcinogenesis by SEGRELLES, Carmen, LU, Jerry, BELTRAN, Linda, MARTINEZ-CRUZ, Ana Belén, GARCIA-ESCUDERO, Ramon, LORZ, Corina, RUIZ, Sergio, BRAVO, Ana, PARAMIO, Jesus M, DIGIOVANNI, John, HAMMANN, Brian, SANTOS, Mirentxu, MORAL, Marta, CASCALLANA, José Luis, FERNANDA LARA, M, RHO, Okkyung, CARBAJAL, Steve, TRAAG, Jeanine

“…Aberrant activation of the phosphoinositide-3-kinase (PI3K)/PTEN/Akt pathway, leading to increased proliferation and decreased apoptosis, has been implicated…”
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The thyroid hormone receptors modulate the skin response to retinoids by García-Serrano, Laura, Gomez-Ferrería, María Ana, Contreras-Jurado, Constanza, Segrelles, Carmen, Paramio, Jesus M, Aranda, Ana

“…Retinoids play an important role in skin homeostasis and when administered topically cause skin hyperplasia, abnormal epidermal differentiation and…”
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Functional roles of Akt signaling in mouse skin tumorigenesis by SEGRELLES, Carmen, RUIZ, Sergio, JORCANO, Jose L, PARAMIO, Jesus M, PEREZ, Paloma, MURGA, Cristina, SANTOS, Mirentxu, BUDUNOVA, Irina V, MARTINEZ, Jesus, LARCHER, Fernando, SLAGA, Thomas J, GUTKIND, J. Silvio

“…The mouse skin carcinogenesis protocol is a unique model for understanding the molecular events leading to oncogenic transformation. Mutations in the Ha-ras…”
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Inhibition of Protein Kinase B (PKB) and PKCζ Mediates Keratin K10-Induced Cell Cycle Arrest by Paramio, Jesus M., Segrelles, Carmen, Ruiz, Sergio, Jorcano, José L.

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Modulation of Cell Proliferation by Cytokeratins K10 and K16 by Paramio, Jesús M., Casanova, M. Llanos, Segrelles, Carmen, Mittnacht, Sybille, Lane, E. Birgitte, Jorcano, José L.

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Gene expression profiling of mouse p53-deficient epidermal carcinoma defines molecular determinants of human cancer malignancy by García-Escudero, Ramón, Martínez-Cruz, Ana B, Santos, Mirentxu, Lorz, Corina, Segrelles, Carmen, Garaulet, Guillermo, Saiz-Ladera, Cristina, Costa, Clotilde, Buitrago-Pérez, Agueda, Dueñas, Marta, Paramio, Jesús M

“…The epidermal specific ablation of Trp53 gene leads to the spontaneous development of aggressive tumors in mice through a process that is accelerated by the…”
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PTEN tumour suppressor is linked to the cell cycle control through the retinoblastoma protein by PARAMIO, J. M, NAVARRO, M, SEGRELLES, C, GOMEZ-CASERO, E, JORCANO, J. L

“…The tumour suppressor PTEN, also named MMAC1 or TEP1, is associated with a number of malignancies in human populations. This protein has a dual protein…”
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Gene profiling approaches help to define the specific functions of retinoblastoma family in epidermis by Lara, M. Fernanda, García-Escudero, Ramón, Ruiz, Sergio, Santos, Mirentxu, Moral, Marta, Martínez-Cruz, Ana B., Segrelles, Carmen, Lorz, Corina, Paramio, Jesús M.

“…The epidermal‐specific ablation of Rb gene leads to increased proliferation, aberrant differentiation, and the disengagement of these processes in vivo and in…”
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Abnormal epidermal differentiation and impaired epithelial-mesenchymal tissue interactions in mice lacking the retinoblastoma relatives p107 and p130 by Ruiz, Sergio, Segrelles, Carmen, Bravo, Ana, Santos, Mirentxu, Perez, Paloma, Leis, Hugo, Jorcano, Jose L, Paramio, Jesús M

“…The functions of p107 and p130, members of the retinoblastoma family, include the control of cell cycle progression and differentiation in several tissues. Our…”
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Spontaneous Tumor Formation in Trp53-deficient Epidermis Mediated by Chromosomal Instability and Inflammation by MARTINEZ-CRUZ, Ana Belen, SANTOS, Mirentxu, GARCIA-ESCUDERO, Ramón, MORAL, Marta, SEGRELLES, Carmen, LORZ, Corina, SAIZ, Cristina, BUITRAGO-PEREZ, Agueda, COSTA, Clotilde, PARAMIO, Jesús M

“…Background: The specific ablation of Trp53 gene in mouse epidermis leads to the spontaneous development of aggressive squamous cell carcinoma, a process that…”
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Differential expression and functionally co-operative roles for the retinoblastoma family of proteins in epidermal differentiation by PARAMIO, J. M, LAIN, S, SEGRELLES, C, LANE, E. B, JORCANO, J. L

“…Terminal differentiation requires cell cycle withdrawal, suggesting the involvement of negative cell cycle controllers in the process. We have analysed the…”
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Opposite Functions for E2F1 and E2F4 in Human Epidermal Keratinocyte Differentiation by Paramio, Jesús M., Segrelles, Carmen, Casanova, M. Llanos, Jorcano, José L.

“…Proteins of the retinoblastoma family (pRb, p107, and p130) modulate cell proliferation, a function related to their capacity to control the activity of the…”
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