Search Results - "Segre, G V"

Hedgehog promotes primary osteoblast differentiation and increases PTHrP mRNA expression and iPTHrP secretion by Jemtland, R, Divieti, P, Lee, K, Segre, G.V

“…We used both clonal osteoblast-like cells and primary calvarial osteoblastic cells to examine the role of Hedgehog in osteoblast biology. Primary osteoblasts…”
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Regulation of Rate of Cartilage Differentiation by Indian Hedgehog and PTH-Related Protein by Vortkamp, Andrea, Lee, Kaechoong, Lanske, Beate, Segre, Gino V., Kronenberg, Henry M., Tabin, Clifford J.

“…Proper regulation of chondrocyte differentiation is necessary for the morphogenesis of skeletal elements, yet little is known about the molecular regulation of…”
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Localization of the extracellular Ca(2+)-sensing receptor and PTH/PTHrP receptor in rat kidney by Riccardi, D, Lee, W S, Lee, K, Segre, G V, Brown, E M, Hebert, S C

“…Using a strategy based on homology to the bovine parathyroid Ca(2+)-sensing receptor previously identified by us (5), we have recently isolated an…”
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PTH/PTHrP Receptor in Early Development and Indian Hedgehog-Regulated Bone Growth by Lanske, Beate, Karaplis, Andrew C., Lee, Kaechong, Luz, Arne, Vortkamp, Andrea, Pirro, Alison, Karperien, Marcel, Libert H. K. Defize, Ho, Chrystal, Mulligan, Richard C., Abou-Samra, Abdul-Badi, Jüppner, Harald, Segre, Gino V., Kronenberg, Henry M.

“…The PTH/PTHrP receptor binds to two ligands with distinct functions: the calcium-regulating hormone, parathyroid hormone (PTH), and the paracrine factor,…”
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Aplastic osteodystrophy without aluminum: The role of “suppressed” parathyroid function by Hercz, Gavril, Pei, Y., Greenwood, C., Manuel, A., Saiphoo, C., Goodman, W.G., Segre, G.V., Fenton, S., Sherrard, D.J.

“…Aplastic osteodystrophy without aluminum: The role of “suppressed” parathyroid function. We evaluated 259 dialysis patients using serum parathyroid hormone…”
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Intermittent calcitriol therapy in secondary hyperparathyroidism: A comparison between oral and intraperitoneal administration by Salusky, Isidro B., Kuizon, Beatriz D., Belin, Thomas R., Ramirez, Jorge A., Gales, Barbara, Segre, Gino V., Goodman, William G.

“…Intermittent calcitriol therapy in secondary hyperparathyroidism: A comparison between oral and intraperitoneal administration. Intermittent oral or…”
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The spectrum of bone disease in end-stage renal failure—An evolving disorder by Sherrard, Donald J., Hercz, Gavril, Pei, York, Maloney, Norma A., Greenwood, Celia, Manuel, Arif, Saiphoo, Carl, Fenton, Stanley S., Segre, Gino V.

“…The spectrum of bone disease in end-stage renal failure—An evolving disorder. We have assessed the bone histology in 259 chronic dialysis patients, all of whom…”
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Parathyroid hormone induces sequential c-fos expression in bone cells in vivo: in situ localization of its receptor and c-fos messenger ribonucleic acids by Lee, K, Deeds, J D, Chiba, S, Un-No, M, Bond, A T, Segre, G V

“…Localization of PTH/PTH-related peptide (PTH/PTHrP) receptor mRNA and PTH induction of c-fos expression were examined in bones of 4-week-old rats by in situ…”
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Cloned, stably expressed parathyroid hormone (PTH)/PTH-related peptide receptors activate multiple messenger signals and biological responses in LLC-PK1 kidney cells by Bringhurst, F R, Juppner, H, Guo, J, Urena, P, Potts, Jr, J T, Kronenberg, H M, Abou-Samra, A B, Segre, G V

“…PTH elicits multiple second messenger signals in target cells. This signaling diversity may reflect coupling of a single species of PTH receptors to multiple…”
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Localization of parathyroid hormone/parathyroid hormone-related peptide receptor mRNA in kidney by Lee, K, Brown, D, Ureña, P, Ardaillou, N, Ardaillou, R, Deeds, J, Segre, G V

“…In kidney, parathyroid hormone (PTH) exerts differential distal effects along the nephron. To define cells expressing receptors for PTH in kidney, we localized…”
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Relationship between intact 1-84 parathyroid hormone and bone histomorphometric parameters in dialysis patients without aluminum toxicity by Wang, M, Hercz, G, Sherrard, D J, Maloney, N A, Segre, G V, Pei, Y

“…With the markedly reduced usage of aluminum salts in renal failure, parathyroid hormone (PTH) has become the major determinant of currently seen bone disease…”
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The extracellular amino-terminal region of the parathyroid hormone (PTH)/PTH-related peptide receptor determines the binding affinity for carboxyl-terminal fragments of PTH-(1-34) by Jüppner, H, Schipani, E, Bringhurst, F R, McClure, I, Keutmann, H T, Potts, Jr, J T, Kronenberg, H M, Abou-Samra, A B, Segre, G V, Gardella, T J

“…The recombinant human PTH/PTH-related peptide (PTHrP) receptor, when transiently expressed in COS-7 cells, binds [Nle8,18,Tyr34] bovine PTH-(7-34)amide…”
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Parathyroid hormone-related protein and Indian hedgehog control the pace of cartilage differentiation by Kronenberg, H M, Lee, K, Lanske, B, Segre, G V

“…Introduction Parathyroid hormone (PTH) controls calcium homeostasis through its actions on kidney and bone to raise blood calcium. Calcium, in turn, suppresses…”
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Highly sensitive two-site immunoradiometric assay of parathyrin, and its clinical utility in evaluating patients with hypercalcemia by Nussbaum, S R, Zahradnik, R J, Lavigne, J R, Brennan, G L, Nozawa-Ung, K, Kim, L Y, Keutmann, H T, Wang, C A, Potts, Jr, J T, Segre, G V

“…We have developed a highly sensitive, two-site immunoradiometric assay (IRMA) for human parathyrin (PTH) that is specific for the intact, secreted,…”
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Biochemical markers of renal osteodystrophy in pediatric patients undergoing CAPD/CCPD by Salusky, Isidro B., Ramirez, Jorge A., Oppenheim, William, Gales, Barbara, Segre, Gino V., Goodman, William G.

“…Biochemical markers of renal osteodystrophy in pediatric patients undergoing CAPD/CCPD. Serum intact PTH [1–84] levels were evaluated as a potential…”
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PTH secretion in patients with chronic renal failure assessed by a modified CiCa clamp method: effects of 1-year calcitriol therapy by Schindler, S, Mannstadt, M, Urena, P, Segre, G V, Stein, G

“…Secondary hyperparathyroidism (secondary HPT) in patients with chronic renal failure (CRF) is characterized by parathyroid gland hyperplasia and an intrinsic…”
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A novel putative transporter maps to the osteosclerosis (oc) mutation and is not expressed in the oc mutant mouse by BRADY, K. P, DUSHKIN, H, FÖRNZLER, D, KOIKE, T, MAGNER, F, HER, H, GULLANS, S, SEGRE, G. V, GREEN, R. M, BEIER, D. R

“…The phenotype of mice homozygous for the osteosclerosis (oc) mutation includes osteopetrosis, and a variety of studies demonstrate that osteoclasts in these…”
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Identical complementary deoxyribonucleic acids encode a human renal and bone parathyroid hormone (PTH)/PTH-related peptide receptor by Schipani, E, Karga, H, Karaplis, A C, Potts, Jr, J T, Kronenberg, H M, Segre, G V, Abou-Samra, A B, Jüppner, H

“…Identical complementary DNAs (cDNAs) that encode a 593-amino acid human PTH (PTH)/PTH-related peptide (PTHrP) receptor were isolated by hybridization…”
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The parathyroid hormone-like peptide associated with humoral hypercalcemia of malignancy and parathyroid hormone bind to the same receptor on the plasma membrane of ROS 17/2.8 cells by Jüppner, H, Abou-Samra, A B, Uneno, S, Gu, W X, Potts, J T, Segre, G V

“…[Tyr36]human adenylate cyclase stimulating peptide (1-36)-NH2, an amino-terminal analog of a tumor peptide which is associated with hypercalcemia of…”
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Roles of Growth Hormone and Insulin-like Growth Factor 1 in Mouse Postnatal Growth by Lupu, Floria, Terwilliger, Joseph D., Lee, Kaechoong, Segre, Gino V., Efstratiadis, Argiris

“…To examine the relationship between growth hormone (GH) and insulin-like growth factor 1 (IGF1) in controlling postnatal growth, we performed a comparative…”
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