Search Results - "Segovia, J C"

In vivo CRISPR/Cas9 targeting of fusion oncogenes for selective elimination of cancer cells by Martinez-Lage, M., Torres-Ruiz, R., Puig-Serra, P., Moreno-Gaona, P., Martin, M. C., Moya, F. J., Quintana-Bustamante, O., Garcia-Silva, S., Carcaboso, A. M., Petazzi, P., Bueno, C., Mora, J., Peinado, H., Segovia, J. C., Menendez, P., Rodriguez-Perales, S.

“…Fusion oncogenes (FOs) are common in many cancer types and are powerful drivers of tumor development. Because their expression is exclusive to cancer cells and…”
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IGF-I mediates regeneration of endocrine pancreas by increasing beta cell replication through cell cycle protein modulation in mice by Agudo, J, Ayuso, E, Jimenez, V, Salavert, A, Casellas, A, Tafuro, S, Haurigot, V, Ruberte, J, Segovia, J. C, Bueren, J, Bosch, F

“…Aims/hypothesis Recovery from diabetes requires restoration of beta cell mass. Igf1 expression in beta cells of transgenic mice regenerates the endocrine…”
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P1431: MOLECULAR CHARACTERIZATION AND LENTIVIRAL CORRECTION OF IN VITRO ERYTHROPOIEIS IN PATIENTS WITH A NOVEL RECESSIVE CONGENITAL DYSERYTHROPOIETIC ANEMIA TYPE III (CDA TYPE IIIB) by Hernández, G., Romero‐Cortadellas, L., Ferrer‐Cortès, X., Venturi, V., Dessy‐Rodriguez, M., Olivella, M., Husami, A., Pérez de Soto, C., Morales‐Camacho, R. M., Villegas, A., González‐Fernández, F.‐A., Morado, M., Kalfa, T. A., Quintana‐Bustamante, O., Pérez‐Montero, S., Tornador, C., Segovia, J.‐C., Sánchez, M.

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Generation of iPSCs from Genetically Corrected Brca2 Hypomorphic Cells: Implications in Cell Reprogramming and Stem Cell Therapy by Navarro, S., Moleiro, V., Molina‐Estevez, F.J., Lozano, M.L., Chinchon, R., Almarza, E., Quintana‐Bustamante, O., Mostoslavsky, G., Maetzig, T., Galla, M., Heinz, N., Schiedlmeier, B., Torres, Y., Modlich, U., Samper, E., Río, P., Segovia, J.C., Raya, A., Güenechea, G., Izpisua‐Belmonte, J.C., Bueren, J.A.

“…Fanconi anemia (FA) is a complex genetic disease associated with a defective DNA repair pathway known as the FA pathway. In contrast to many other FA proteins,…”
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Peritoneal repairing cells: a type of bone marrow derived progenitor cells involved in mesothelial regeneration by Carmona, R., Cano, E., Grueso, E., Ruiz‐Villalba, A., Bera, T. K., Gaztambide, J., Segovia, J. C., Muñoz‐Chápuli, R.

“…The peritoneal mesothelium exhibits a high regenerative ability. Peritoneal regeneration is concomitant with the appearance, in the coelomic cavity, of a…”
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Immunoresponse against the transgene limits hematopoietic engraftment of mice transplanted in utero with virally transduced fetal liver by Alonso-Ferrero, M E, Valeri, A, Yañez, R, Navarro, S, Garin, M I, Ramirez, J C, Bueren, J A, Segovia, J C

“…In utero cell and gene therapies constitute alternative strategies to the postnatal treatment of inherited diseases. Fetal hematopoietic progenitors could be a…”
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Delayed Engraftment of Nonobese Diabetic/Severe Combined Immunodeficient Mice Transplanted With Ex Vivo–Expanded Human CD34+ Cord Blood Cells by Güenechea, G., Segovia, J.C., Albella, B., Lamana, M., Ramı́rez, M., Regidor, C., Fernández, M.N., Bueren, J.A.

“…The ex vivo expansion of hematopoietic progenitors is a promising approach for accelerating the engraftment of recipients, particularly when cord blood (CB) is…”
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A simplified approach to improve the efficiency and safety of ex vivo hematopoietic gene therapy in fanconi anemia patients by Jacome, A, Navarro, S, Casado, J A, Rio, P, Madero, L, Estella, J, Sevilla, J, Badell, I, Ortega, J J, Olivé, T, Hanenberg, H, Segovia, J C, Bueren, J A

“…Fanconi anemia (FA) is an inherited DNA repair disorder characterized by genetic instability of cells lacking a functional FA/BRCA pathway. Previous studies…”
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Reprogramming human B cells into induced pluripotent stem cells and its enhancement by C/EBPα by Bueno, C, Sardina, J L, Di Stefano, B, Romero-Moya, D, Muñoz-López, A, Ariza, L, Chillón, M C, Balanzategui, A, Castaño, J, Herreros, A, Fraga, M F, Fernández, A, Granada, I, Quintana-Bustamante, O, Segovia, J C, Nishimura, K, Ohtaka, M, Nakanishi, M, Graf, T, Menendez, P

“…B cells have been shown to be refractory to reprogramming and B-cell-derived induced pluripotent stem cells (iPSC) have only been generated from murine B cells…”
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Efficient engraftment of in utero transplanted mice with retrovirally transduced hematopoietic stem cells by RIO, P, MARTINEZ-PALACIO, J, RAMIREZ, A, BUEREN, J. A, SEGOVIA, J. C

“…Using an experimental mouse model, we have investigated the kinetics of hematopoietic reconstitution of recipients transplanted during fetal development with…”
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In vitro and in vivo expression of human erythrocyte pyruvate kinase in erythroid cells: a gene therapy approach by Meza, N W, Quintana-Bustamante, O, Puyet, A, Rio, P, Navarro, S, Diez, A, Bueren, J A, Bautista, J M, Segovia, J C

“…Human pyruvate kinase deficiency (PKD), an autosomal recessive disorder produced by mutations in the PKLR gene, is the most common cause of chronic…”
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Nonviral transfer of genes to pig primary keratinocytes. Induction of angiogenesis by composite grafts of modified keratinocytes overexpressing VEGF driven by a keratin promoter by DEL RIO, M, LARCHER, F, MEANA, A, SEGOVIA, J. C, ALVAREZ, A, JORCANO, J. L

“…Cultured epithelial grafts have proven to be life-saving in the treatment of large skin losses. It has become apparent that one of the main difficulties of…”
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Purging of leukemia-contaminated bone marrow grafts using suicide adenoviral vectors: an in vivo murine experimental model by GARCIA-CASTRO, J, RIO, P, LILLO, R, GARCIA-SANCHEZ, F, SEGOVIA, J. C, BUEREN, J. A

“…Autologous bone marrow transplantation is an alternative therapeutic option for acute myeloid leukemia patients lacking a compatible donor. However, bone…”
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The expression of Bcl-x is downregulated during differentiation of human hematopoietic progenitor cells along the granulocyte but not the monocyte/macrophage lineage by SANZ, C, BENITO, A, SILVA, M, ALBELLA, B, RICHARD, C, SEGOVIA, J. C, INSUNZA, A, BUEREN, J. A, FERNANDEZ-LUNA, J. L

“…Expression of the apoptosis inhibitory protein Bcl-x was studied in CD34+ hematopoietic precursor cells and in the promyelocytic leukemia cell line HL-60. The…”
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Resistance to chemotherapy via Stat3-dependent overexpression of Bcl-2 in metastatic breast cancer cells by REAL, Pedro J, SIERRA, Angels, DE JUAN, Ana, SEGOVIA, Jose C, LOPEZ-VEGA, Jose M, FERNANDEZ-LUNA, Jose L

“…Disruption of apoptosis may allow metastatic cell survival and confer resistance to chemotherapeutic drugs. We have analysed the molecular pathways that…”
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Preserved long-term repopulation and differentiation properties of hematopoietic grafts subjected to ex vivo expansion with stem cell factor and interleukin 11 by ALBELLA, B, SEGOVIA, J. C, GUENECHEA, G, PRAGNELL, I. B, BUEREN, J. A

“…The ex vivo expansion of hematopoietic grafts has been proposed as an efficient procedure for improving the hematological recovery of recipients. The fate of…”
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Transplantation of syngenic bone marrow contaminated with NGFr-marked WEHI-3B cells : an improved model of leukemia relapse in mice by GARCIA-CASTRO, J, SEGOVIA, J. C, BUEREN, J. A

“…With the aim of developing a model mimicking the relapse of patients transplanted with leukemia-contaminated grafts, myelomonocytic leukemia WEHI-3B D+ cells…”
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Myeloid depression follows infection of susceptible newborn mice with the parvovirus minute virus of mice (strain i) by Segovia, J C, Bueren, J A, Almendral, J M

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Does the granulocyte-macrophage colony-forming unit content in ex vivo-expanded grafts predict the recovery of the recipient leukocytes? by ALBELLA, B, SEGOVIA, J. C, BUEREN, J. A

“…We have investigated the leukocyte-repopulating-predictive value of granulocyte-macrophage colony-forming unit (CFU-GM) analyses in ex vivo-expanded versus…”
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Functional analysis of gammaretroviral vector transduction by quantitative PCR by Meza, N. W., Puyet, A., Pérez-Benavente, S., Quintana-Bustamante, O., Diez, A., Bueren, J. A., Segovia, J. C., Bautista, J. M.

“…Background In a clinical setting of gene therapy, quantitative methods are required to determine recombinant viral titres and transgene mRNA expression,…”
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