Search Results - "Segel, L"

G-CSF Control of Neutrophils Dynamics in the Blood by Shochat, E, Rom-Kedar, V, Segel, L. A

“…White blood cell neutrophil is a key component in the fast initial immune response against bacterial and fungal infections. Granulocyte colony stimulating…”
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Generation of Oscillations by the p53-Mdm2 Feedback Loop: A Theoretical and Experimental Study by Bar-Or, Ruth Lev, Maya, Ruth, Segel, Lee A., Alon, Uri, Levine, Arnold J., Oren, Moshe

“…The intracellular activity of the p53 tumor suppressor protein is regulated through a feedback loop involving its transcriptional target, mdm2. We present a…”
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How growth affects the fate of cellular metabolites by Kooijman, S.A.L.M., Segel, L.A.

“…Cellular metabolites frequently have more than a single function in the cell. For example they may be sources of energy as well as building blocks for several…”
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Computing an Organism by Segel, Lee A.

“…Segel describes a study by Maree and Hogeweg in which they provide a computer simulation of the frog-prince transformation of the slug into a fruiting body…”
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On the validity of the steady state assumption of enzyme kinetics by Segel, Lee A.

“…By estimating relevant time scales, a simple new condition can be found that ensures the validity of the steady state assumption for a standard…”
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Diffusion cannot govern the discharge of neurotransmitter in fast synapses by Khanin, R., Parnas, H., Segel, L.

“…In the present work we show that diffusion cannot provide the observed fast discharge of neurotransmitter from a synaptic vesicle during neurotransmitter…”
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Theory for the Feedback Inhibition of Fast Release of Neurotransmitter by Yusim, K., Parnas, H., Segel, L.A.

“…Autoinhibition of neurotransmitter release occurs via binding of transmitter to appropriate receptors. Experiments have provided evidence suggesting that the…”
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One-vesicle Hypothesis for Neurotransmitter Release: a Possible Molecular Mechanism by Yusim, K., Parnas, H., Segel, L.A.

“…Neurotransmitter-containing vesicles are clustered in release sites. Although a given site can contain tens of vesicles, there is evidence that under a wide…”
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On the Role of Feedback in Promoting Conflicting Goals of the Adaptive Immune System by Segel, Lee A, Bar-Or, Ruth Lev

“…We explored here the implications of two premises. 1) In their response over days or weeks to pathogen invasion, cells of the immune system combine several…”
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Pattern formation in one- and two-dimensional shape-space models of the immune system by De Boer, R J, Segel, L A, Perelson, A S

“…A large-scale model of the immune network is analyzed, using the shape-space formalism. In this formalism, it is assumed that the immunoglobulin receptors on B…”
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Cardiac function and glycogen content after twenty-four-hour preservation with various metabolic substrates by Segel, L D, Follette, D M

“…Previous work has suggested that recovery of cardiac function after long preservation periods is improved if a suitable exogenous substrate is provided…”
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On the validity of the steady state assumption of enzyme kinetics by SEGEL, L. A

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The Quasi-Steady-State Assumption: A Case Study in Perturbation by Segel, Lee A., Slemrod, Marshall

“…The quasi-steady-state assumption (QSSA) of biochemistry is studied as an approximation that is important in itself and also that exemplifies an approach to…”
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Theory of Fast Neurotransmitter Release Control Based on Voltage-dependent Interaction Between Autoreceptors and Proteins of the Exocytotic Machinery by Yusim, K., Parnas, H., Segel, L.

“…A molecular-level theory is constructed for the control of fast neurotransmitter release, based on recent experimental findings that depolarization shifts…”
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A basic biophysical model for bursting neurons by AV-RON, E, PARNAS, H, SEGEL, L. A

“…Presented here is a basic biophysical cell model for bursting, an extension of our previous model (Av-Ron et al. 1991) for excitability and oscillations. By…”
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Neurotransmitter discharge and postsynaptic rise times by Khanin, R., Segel, L., Parnas, H., Ratner, E.

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Th1 or Th2: How an Appropriate T Helper Response can be Made by Bergmann, Claudia, van Hemmen, J.Leo, Segel, Lee A.

“…Two types of T helper (Th) cells have been defined on the basis of their cytokine secretion patterns. The decision of a naive T cell to differentiate into Th1…”
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Steroid pretreatment improves graft recovery in a sheep orthotopic heart transplantation model by Segel, L D, Follette, D M, Castellanos, L M, Hayes, R, Baker, J M, Smolens, I V

“…Previous reports provide conflicting evidence concerning effects of steroids on recovery of cardiac function during procedures involving cardiopulmonary…”
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Recovery of sheep hearts after perfusion preservation or static storage with crystalloid media by Segel, L D, Follette, D M, Baker, J M, Rintoul, T C

“…These experiments were designed to evaluate the viability of large hearts after preservation by use of procedures that have shown good results with small…”
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Direct cardiac effects of vasopressin and their reversal by a vascular antagonist by Boyle, 3rd, W A, Segel, L D

“…We studied the direct cardiac effects of arginine vasopressin (AVP) by use of an isolated working rat heart model perfused with Krebs-Henseleit medium. At a…”
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