Search Results - "Segatto, Oreste"

Current and novel therapeutic opportunities for systemic therapy in biliary cancer by Marin, José J. G., Prete, Maria Giuseppina, Lamarca, Angela, Tavolari, Simona, Landa-Magdalena, Ana, Brandi, Giovanni, Segatto, Oreste, Vogel, Arndt, Macias, Rocío I. R., Rodrigues, Pedro M., Casta, Adelaida La, Mertens, Joachim, Rodrigues, Cecilia M. P., Fernandez-Barrena, Maite G., Da Silva Ruivo, Ana, Marzioni, Marco, Mentrasti, Giulia, Acedo, Pilar, Munoz-Garrido, Patricia, Cardinale, Vincenzo, Banales, Jesus M., Valle, Juan W., Bridgewater, John, Braconi, Chiara

“…Biliary tract cancers (BTCs) are a group of rare and aggressive malignancies that arise in the biliary tree within and outside the liver. Beyond surgical…”
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Combination therapies for targeting FGFR2 fusions in cholangiocarcinoma by Saborowski, Anna, Vogel, Arndt, Segatto, Oreste

“…Fibroblast growth factor receptor 2 (FGFR2) fusion proteins (FFs) are oncogenic drivers in 10-15% of intrahepatic cholangiocarcinoma (iCCA). FGFR-specific…”
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Regulation of the ErbB network by the MIG6 feedback loop in physiology, tumor suppression and responses to oncogene-targeted therapeutics by Anastasi, Sergio, Lamberti, Dante, Alemà, Stefano, Segatto, Oreste

“…•MIG6 plays a necessary role of in negative feedback regulation of ErbB receptors.•MIG6 suppresses EGFR signaling via kinase inhibition and…”
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two-tiered mechanism of EGFR inhibition by RALT/MIG6 via kinase suppression and receptor degradation by Frosi, Yuri, Anastasi, Sergio, Ballarò, Costanza, Varsano, Giulia, Castellani, Loriana, Maspero, Elena, Polo, Simona, Alemà, Stefano, Segatto, Oreste

“…Signaling by epidermal growth factor receptor (EGFR) must be controlled tightly because aberrant EGFR activity may cause cell transformation…”
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Epigenetic silencing of miR-145-5p contributes to brain metastasis by Donzelli, Sara, Mori, Federica, Bellissimo, Teresa, Sacconi, Andrea, Casini, Beatrice, Frixa, Tania, Roscilli, Giuseppe, Aurisicchio, Luigi, Facciolo, Francesco, Pompili, Alfredo, Carosi, Maria Antonia, Pescarmona, Edoardo, Segatto, Oreste, Pond, Greg, Muti, Paola, Telera, Stefano, Strano, Sabrina, Yarden, Yosef, Blandino, Giovanni

“…Brain metastasis is a major cause of morbidity and mortality of lung cancer patients. We assessed whether aberrant expression of specific microRNAs could…”
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miR‐205 mediates adaptive resistance to MET inhibition via ERRFI1 targeting and raised EGFR signaling by Migliore, Cristina, Morando, Elena, Ghiso, Elena, Anastasi, Sergio, Leoni, Vera P, Apicella, Maria, Cora', Davide, Sapino, Anna, Pietrantonio, Filippo, De Braud, Filippo, Columbano, Amedeo, Segatto, Oreste, Giordano, Silvia

“…The onset of secondary resistance represents a major limitation to long‐term efficacy of target therapies in cancer patients. Thus, the identification of…”
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Mig-6 controls EGFR trafficking and suppresses gliomagenesis by Ying, Haoqiang, Zheng, Hongwu, Scott, Kenneth, Wiedemeyer, Ruprecht, Yan, Haiyan, Lim, Carol, Huang, Joseph, Dhakal, Sabin, Ivanova, Elena, Xiao, Yonghong, Zhang, Hailei, Hu, Jian, Stommel, Jayne M, Lee, Michelle A, Chen, An-Jou, Paik, Ji-Hye, Segatto, Oreste, Brennan, Cameron, Elferink, Lisa A, Wang, Y. Alan, Chin, Lynda, DePinho, Ronald A

“…Glioblastoma multiforme (GBM) is the most common and lethal primary brain cancer that is driven by aberrant signaling of growth factor receptors, particularly…”
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Loss of RALT/MIG-6 expression in ERBB2-amplified breast carcinomas enhances ErbB-2 oncogenic potency and favors resistance to Herceptin by ANASTASI, Sergio, SALA, Gianluca, CHEN HUIPING, CAPRINI, Elisabetta, RUSSO, Giandomenico, IACOVELLI, Stefano, LUCINI, Fabiana, INGVARSSON, Sigurdur, SEGATTO, Oreste

“…An emerging paradigm holds that loss of negative signalling to receptor tyrosine kinases (RTKs) is permissive for their oncogenic activity. Herein, we have…”
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Mitogen-Inducible Gene-6 Mediates Feedback Inhibition from Mutated BRAF towards the Epidermal Growth Factor Receptor and Thereby Limits Malignant Transformation by Milewska, Malgorzata, Romano, David, Herrero, Ana, Guerriero, Maria Luisa, Birtwistle, Marc, Quehenberger, Franz, Hatzl, Stefan, Kholodenko, Boris N, Segatto, Oreste, Kolch, Walter, Zebisch, Armin

“…BRAF functions in the RAS-extracellular signal-regulated kinase (ERK) signaling cascade. Activation of this pathway is necessary to mediate the transforming…”
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Feedback inhibition by RALT controls signal output by the ErbB network by ANASTASI, Sergio, FIORENTINO, Loredana, FIORINI, Monia, FRAIOLI, Rocco, SALA, Gianluca, GASTELLANI, L, ALEMA, Stefano, ALIMANDI, Maurizio, SEGATTO, Oreste

“…The ErbB-2 interacting protein receptor-associated late transducer (RALT) was previously identified as a feedback inhibitor of ErbB-2 mitogenic signals. We now…”
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Expression of RALT, a feedback inhibitor of ErbB receptors, is subjected to an integrated transcriptional and post-translational control by FIORINI, Monia, BALLARO, Costanza, SALA, Gianluca, FALCONE, Germana, ALEMA, Stefano, SEGATTO, Oreste

“…Over-expression studies have demonstrated that RALT (receptor associated late transducer) is a feedback inhibitor of ErbB-2 mitogenic and transforming signals…”
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Inhibition of ErbB-2 Mitogenic and Transforming Activity by RALT, a Mitogen-Induced Signal Transducer Which Binds to the ErbB-2 Kinase Domain by Fiorentino, Loredana, Pertica, Chiara, Fiorini, Monia, Talora, Claudio, Crescenzi, Marco, Castellani, Loriana, Alemà, Stefano, Benedetti, Piero, Segatto, Oreste

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Charting co-mutation patterns associated with actionable drivers in intrahepatic cholangiocarcinoma by Kendre, Gajanan, Murugesan, Karthikeyan, Brummer, Tilman, Segatto, Oreste, Saborowski, Anna, Vogel, Arndt

“…In recent years, intrahepatic cholangiocarcinoma (iCCA) has evolved as a “role model” for precision oncology in gastrointestinal cancers. However, its rarity,…”
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FGFR2 Inhibition in Cholangiocarcinoma by Vogel, Arndt, Segatto, Oreste, Stenzinger, Albrecht, Saborowski, Anna

“…Biliary tract cancer (BTC) is the second most common primary liver cancer after hepatocellular carcinoma and accounts for 2% of cancer-related deaths. BTCs are…”
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Making sense of Cbp/p300 loss of function mutations in skin tumorigenesis by Anastasi, Sergio, Alemà, Stefano, Segatto, Oreste

“…CBP and p300 are highly homologous lysine acetyltransferases involved in cell cycle regulation, DNA synthesis and DNA repair. Loss of function mutations of CBP…”
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Regulation of epidermal growth factor receptor signalling by inducible feedback inhibitors by Segatto, Oreste, Anastasi, Sergio, Alemà, Stefano

“…Signalling by the epidermal growth factor receptor (EGFR) controls morphogenesis and/or homeostasis of several tissues from worms to mammals. The correct…”
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erbB-2 is a Potent Oncogene When Overexpressed in NIH/3T3 Cells by Di Fiore, Pier Paolo, Pierce, Jacalyn H., Kraus, Matthias H., Segatto, Oreste, King, C. Richter, Aaronson, Stuart A.

“…A wide variety of human tumors contain an amplified or overexpressed erbB-2 gene, which encodes a growth factor receptor-like protein. When erbB-2…”
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Therapeutic targeting of ERBB2 in breast cancer: understanding resistance in the laboratory and combating it in the clinic by Fabi, Alessandra, Mottolese, Marcella, Segatto, Oreste

“…ERBB2 gene amplification occurs in about one quarter of breast carcinomas (BCs) and identifies a distinct clinical subset of BC. The introduction in the clinic…”
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FGFR2 fusion proteins drive oncogenic transformation of mouse liver organoids towards cholangiocarcinoma by Cristinziano, Giulia, Porru, Manuela, Lamberti, Dante, Buglioni, Simonetta, Rollo, Francesca, Amoreo, Carla Azzurra, Manni, Isabella, Giannarelli, Diana, Cristofoletti, Cristina, Russo, Giandomenico, Borad, Mitesh J., Grazi, Gian Luca, Diodoro, Maria Grazia, Giordano, Silvia, Sacconi, Andrea, Forcato, Mattia, Anastasi, Sergio, Leonetti, Carlo, Segatto, Oreste

“…About 15% of intrahepatic cholangiocarcinomas (iCCAs) express fibroblast growth factor receptor 2 (FGFR2) fusion proteins (FFs), usually alongside mutational…”
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Signalling networks in cholangiocarcinoma: Molecular pathogenesis, targeted therapies and drug resistance by Fouassier, Laura, Marzioni, Marco, Afonso, Marta B., Dooley, Steven, Gaston, Kevin, Giannelli, Gianluigi, Rodrigues, Cecilia M. P., Lozano, Elisa, Mancarella, Serena, Segatto, Oreste, Vaquero, Javier, Marin, Jose J. G., Coulouarn, Cédric

“…Cholangiocarcinoma (CCA) is a deadly disease. While surgery may attain cure in a minor fraction of cases, therapeutic options in either the adjuvant or…”
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