Search Results - "Segal, Rosalind"

Hedgehog Signal Transduction: Key Players, Oncogenic Drivers, and Cancer Therapy by Pak, Ekaterina, Segal, Rosalind A.

“…The Hedgehog (Hh) signaling pathway governs complex developmental processes, including proliferation and patterning within diverse tissues. These activities…”
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A Mechanistic Understanding of Axon Degeneration in Chemotherapy-Induced Peripheral Neuropathy by Fukuda, Yusuke, Li, Yihang, Segal, Rosalind A

“…Chemotherapeutic agents cause many short and long term toxic side effects to peripheral nervous system (PNS) that drastically alter quality of life…”
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Pathogenesis of paclitaxel-induced peripheral neuropathy: A current review of in vitro and in vivo findings using rodent and human model systems by Staff, Nathan P., Fehrenbacher, Jill C., Caillaud, Martial, Damaj, M. Imad, Segal, Rosalind A., Rieger, Sandra

“…Paclitaxel (Brand name Taxol) is widely used in the treatment of common cancers like breast, ovarian and lung cancer. Although highly effective in blocking…”
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The RNA-binding protein SFPQ orchestrates an RNA regulon to promote axon viability by Cosker, Katharina E, Fenstermacher, Sara J, Pazyra-Murphy, Maria F, Elliott, Hunter L, Segal, Rosalind A

“…This study identifies SFPQ (splicing factor, poly-glutamine rich) as an RNA binding protein that binds and coassembles multiple mRNAs in axonal transport…”
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Roadmap for the Emerging Field of Cancer Neuroscience by Monje, Michelle, Borniger, Jeremy C., D’Silva, Nisha J., Deneen, Benjamin, Dirks, Peter B., Fattahi, Faranak, Frenette, Paul S., Garzia, Livia, Gutmann, David H., Hanahan, Douglas, Hervey-Jumper, Shawn L., Hondermarck, Hubert, Hurov, Jonathan B., Kepecs, Adam, Knox, Sarah M., Lloyd, Alison C., Magnon, Claire, Saloman, Jami L., Segal, Rosalind A., Sloan, Erica K., Sun, Xin, Taylor, Michael D., Tracey, Kevin J., Trotman, Lloyd C., Tuveson, David A., Wang, Timothy C., White, Ruth A., Winkler, Frank

“…Mounting evidence indicates that the nervous system plays a central role in cancer pathogenesis. In turn, cancers and cancer therapies can alter nervous system…”
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Neuronal signaling through endocytosis by Cosker, Katharina E, Segal, Rosalind A

“…The distinctive morphology of neurons, with complex dendritic arbors and extensive axons, presents spatial challenges for intracellular signal transduction…”
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Uncomfortably numb: how Nav1.7 mediates paclitaxel-induced peripheral neuropathy by Silagi, Elizabeth S, Segal, Rosalind A

“…This scientific commentary refers to ‘Paclitaxel increases axonal localization and vesicular trafficking of Nav1.7’ by Akin et al. (doi: 10.1093/brain/awab113)…”
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Selectivity in neurotrophin signaling: Theme and variations by SEGAL, Rosalind A

“…Neurotrophins are a family of growth factors critical for the development and functioning of the nervous system. Although originally identified as neuronal…”
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RAS/MAPK Activation Drives Resistance to Smo Inhibition, Metastasis, and Tumor Evolution in Shh Pathway-Dependent Tumors by Zhao, Xuesong, Ponomaryov, Tatyana, Ornell, Kimberly J, Zhou, Pengcheng, Dabral, Sukriti K, Pak, Ekaterina, Li, Wei, Atwood, Scott X, Whitson, Ramon J, Chang, Anne Lynn S, Li, Jiang, Oro, Anthony E, Chan, Jennifer A, Kelleher, Joseph F, Segal, Rosalind A

“…Aberrant Shh signaling promotes tumor growth in diverse cancers. The importance of Shh signaling is particularly evident in medulloblastoma and basal cell…”
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Lessons from a bridge generation by Segal, Rosalind A

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Paclitaxel Reduces Axonal Bclw to Initiate IP3R1-Dependent Axon Degeneration by Pease-Raissi, Sarah E., Pazyra-Murphy, Maria F., Li, Yihang, Wachter, Franziska, Fukuda, Yusuke, Fenstermacher, Sara J., Barclay, Lauren A., Bird, Gregory H., Walensky, Loren D., Segal, Rosalind A.

“…Chemotherapy-induced peripheral neuropathy (CIPN) is a debilitating side effect of many cancer treatments. The hallmark of CIPN is degeneration of long axons…”
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An Architect of the Hindbrain: DDX3X Regulates Normal and Malignant Development by Hwang, Grace H., Segal, Rosalind A.

“…Hallmark mutations in WNT and SHH medulloblastoma are usually distinct, but DDX3X is often mutated in both subgroups. In this issue of Developmental Cell,…”
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The National Cancer Institute Clinical Trials Planning Meeting for Prevention and Treatment of Chemotherapy-Induced Peripheral Neuropathy by Dorsey, Susan G, Kleckner, Ian R, Barton, Debra, Mustian, Karen, O’Mara, Ann, St. Germain, Diane, Cavaletti, Guido, Danhauer, Suzanne C, Hershman, Dawn L, Hohmann, Andrea G, Hoke, Ahmet, Hopkins, Judith O, Kelly, Katherine P, Loprinzi, Charles L, McLeod, Howard L, Mohile, Supriya, Paice, Judith, Rowland, Julia H, Salvemini, Daniela, Segal, Rosalind A, Smith, Ellen Lavoie, Stevens, Worta McCaskill, Janelsins, Michelle C

“…Abstract Although recent scientific advances have improved our understanding of basic biological mechanisms underlying chemotherapy-induced peripheral…”
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Sarm1 activation produces cADPR to increase intra-axonal Ca++ and promote axon degeneration in PIPN by Li, Yihang, Pazyra-Murphy, Maria F, Avizonis, Daina, de Sá Tavares Russo, Mariana, Tang, Sophia, Chen, Chiung-Ya, Hsueh, Yi-Ping, Bergholz, Johann S, Jiang, Tao, Zhao, Jean J, Zhu, Jian, Ko, Kwang Woo, Milbrandt, Jeffrey, DiAntonio, Aaron, Segal, Rosalind A

“…Cancer patients frequently develop chemotherapy-induced peripheral neuropathy (CIPN), a painful and long-lasting disorder with profound somatosensory deficits…”
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Sonic Hedgehog Signaling is Blue: Insights from the Patched Mutant Mice by Merk, Daniel J., Segal, Rosalind A.

“…The Hedgehog (Hh) pathway is a highly conserved signaling system regulating a range of developmental processes. A 1997 paper by Goodrich and colleagues…”
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Diversity of developing peripheral glia revealed by single-cell RNA sequencing by Tasdemir-Yilmaz, Ozge E., Druckenbrod, Noah R., Olukoya, Olubusola O., Dong, Weixiu, Yung, Andrea R., Bastille, Isle, Pazyra-Murphy, Maria F., Sitko, Austen A., Hale, Evan B., Vigneau, Sébastien, Gimelbrant, Alexander A., Kharchenko, Peter V., Goodrich, Lisa V., Segal, Rosalind A.

“…The peripheral nervous system responds to a wide variety of sensory stimuli, a process that requires great neuronal diversity. These diverse neurons are…”
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Mitogenic and progenitor gene programmes in single pilocytic astrocytoma cells by Reitman, Zachary J., Paolella, Brenton R., Bergthold, Guillaume, Pelton, Kristine, Becker, Sarah, Jones, Robert, Sinai, Claire E., Malkin, Hayley, Huang, Ying, Grimmet, Leslie, Herbert, Zachary T., Sun, Yu, Weatherbee, Jessica L., Alberta, John A., Daley, John F., Rozenblatt-Rosen, Orit, Condurat, Alexandra L., Qian, Kenin, Khadka, Prasidda, Segal, Rosalind A., Haas-Kogan, Daphne, Filbin, Mariella G., Suva, Mario L., Regev, Aviv, Stiles, Charles D., Kieran, Mark W., Goumnerova, Liliana, Ligon, Keith L., Shalek, Alex K., Bandopadhayay, Pratiti, Beroukhim, Rameen

“…Pilocytic astrocytoma (PA), the most common childhood brain tumor, is a low-grade glioma with a single driver BRAF rearrangement. Here, we perform scRNAseq in…”
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There and back again: coordinated transcription, translation and transport in axonal survival and regeneration by Tasdemir-Yilmaz, Ozge E, Segal, Rosalind A

“…Highlights • Cues in the axonal microenvironment induce local and global changes in neurons. • Bidirectional transport enables coordination of local and global…”
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Binding and transport of SFPQ-RNA granules by KIF5A/KLC1 motors promotes axon survival by Fukuda, Yusuke, Pazyra-Murphy, Maria F, Silagi, Elizabeth S, Tasdemir-Yilmaz, Ozge E, Li, Yihang, Rose, Lillian, Yeoh, Zoe C, Vangos, Nicholas E, Geffken, Ezekiel A, Seo, Hyuk-Soo, Adelmant, Guillaume, Bird, Gregory H, Walensky, Loren D, Marto, Jarrod A, Dhe-Paganon, Sirano, Segal, Rosalind A

“…Complex neural circuitry requires stable connections formed by lengthy axons. To maintain these functional circuits, fast transport delivers RNAs to distal…”
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Preserve and protect: maintaining axons within functional circuits by Pease, Sarah E, Segal, Rosalind A

“…Highlights • Pro-survival molecules protect axons from developmental pruning. • Apoptotic machinery mediates axonal pruning during development. • Lifelong axon…”
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