Search Results - "Segal, Joanna"

Glucocorticoids and the Brain after Critical Illness by Hill, Alice R, Spencer-Segal, Joanna L

“…Treatment for critical illness typically focuses on a patient’s short-term physical recovery; however, recent work has broadened our understanding of the…”
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Adapt and conquer: Metabolic flexibility in cancer growth, invasion and evasion by Kreuzaler, Peter, Panina, Yulia, Segal, Joanna, Yuneva, Mariia

“…It has been known for close to a century that, on average, tumors have a metabolism that is different from those found in healthy tissues. Typically, tumors…”
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Glucocorticoids and resilience by Spencer-Segal, Joanna L., Akil, Huda

“…All organisms endure frequent challenges to homeostasis, or stressors, that require adaptation. Depending on the individual, the context, and the magnitude of…”
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Future Directions for Corticosteroids in Treatment of Sepsis by Spencer-Segal, Joanna L

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Lysine harvesting is an antioxidant strategy and triggers underground polyamine metabolism by Olin-Sandoval, Viridiana, Yu, Jason Shu Lim, Miller-Fleming, Leonor, Alam, Mohammad Tauqeer, Kamrad, Stephan, Correia-Melo, Clara, Haas, Robert, Segal, Joanna, Peña Navarro, David Alejandro, Herrera-Dominguez, Lucia, Méndez-Lucio, Oscar, Vowinckel, Jakob, Mülleder, Michael, Ralser, Markus

“…Both single and multicellular organisms depend on anti-stress mechanisms that enable them to deal with sudden changes in the environment, including exposure to…”
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Estrogen Effects on the Brain: Actions Beyond the Hypothalamus Via Novel Mechanisms by McEwen, Bruce S, Akama, Keith T, Spencer-Segal, Joanna L, Milner, Teresa A, Waters, Elizabeth M

“…From its origins in how the brain controls the endocrine system via the hypothalamus and pituitary gland, neuroendocrinology has evolved into a science that…”
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Octreotide subcutaneous depot for acromegaly: A randomized, double-blind, placebo-controlled phase 3 trial, ACROINNOVA 1 by Ferone, Diego, Freda, Pamela, Katznelson, Laurence, Gatto, Federico, Kadioğlu, Pinar, Maffei, Pietro, Seufert, Jochen, Silverstein, Julie M, Spencer-Segal, Joanna L, Isaeva, Elena, Dreval, Alexander, Harrie, Maria, Svedberg, Agneta, Tiberg, Fredrik

“…Acromegaly, characterized by excessive growth hormone (GH) and insulin-like growth factor-1 (IGF-1), impacts quality of life (QoL) and mortality. Standard of…”
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Ventral subiculum control of avoidance behavior and hypothalamic-pituitary-adrenal axis reactivity via the bed nucleus of the stria terminalis in male and female mice – ISPNE 2024 Dirk Helhammer Award by Marsh, Jena S., Teixeira, Cara, Gavade, Swapnil, Johnston, Colin, Baranwal, Salisha, Snyder, Christen N., Chang, Chih-Lin, Yang, Shany, Spencer-Segal, Joanna L.

“…Avoidance or anxiety-like behavior is accompanied by corresponding changes in hypothalamic-pituitary-adrenal (HPA) axis activation. The underlying neural…”
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S100A8/A9 Drives Neuroinflammatory Priming and Protects against Anxiety-like Behavior after Sepsis by Denstaedt, Scott J, Spencer-Segal, Joanna L, Newstead, Michael W, Laborc, Klaudia, Zhao, Anne P, Hjelmaas, Alexander, Zeng, Xianying, Akil, Huda, Standiford, Theodore J, Singer, Benjamin H

“…Sepsis commonly results in acute and chronic brain dysfunction, which dramatically increases the morbidity associated with this common disease. Chronic brain…”
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Persistent Neuroinflammation and Brain-Specific Immune Priming in a Novel Survival Model of Murine Pneumosepsis by Denstaedt, Scott J., Spencer-Segal, Joanna L., Newstead, Michael, Laborc, Klaudia, Zeng, Xianying, Standiford, Theodore J., Singer, Benjamin H.

“…ABSTRACTPneumonia is the leading cause of sepsis and septic shock. Patients who survive pneumonia are vulnerable to long-term complications including increased…”
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Sepsis survivor mice exhibit a behavioral endocrine syndrome with ventral hippocampal dysfunction by Spencer-Segal, Joanna L., Singer, Benjamin H., Laborc, Klaudia, Somayaji, Khyati, Watson, Stanley J., Standiford, Theodore J., Akil, Huda

“…•Sepsis survivor mice show anxiety- and depressive-like behavior long after resolution of their acute illness.•Sepsis survivor mice show increased…”
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Sex- and stress-dependent effects of a single injection of ketamine on open field and forced swim behavior by Fitzgerald, Paul J, Kounelis-Wuillaume, Savannah K, Gheidi, Ali, Morrow, Jonathan D, Spencer-Segal, Joanna L, Watson, Brendon O

“…Ketamine has emerged as a novel treatment for common psychiatric conditions such as Major Depressive Disorder (MDD) and anxiety disorders, many of which can be…”
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Variant Brain-Derived Neurotrophic Factor (Valine66Methionine) Polymorphism Contributes to Developmental and Estrous Stage-Specific Expression of Anxiety-Like Behavior in Female Mice by Bath, Kevin G, Chuang, Jocelyn, Spencer-Segal, Joanna L, Amso, Dima, Altemus, Margaret, McEwen, Bruce S, Lee, Francis S

“…Background Most anxiety and depressive disorders are twice as common in women compared with men, and the sex difference in prevalence typically emerges during…”
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Psychiatric Symptoms in Survivors of Acute Respiratory Distress Syndrome. Effects of Age, Sex, and Immune Modulation by Spencer-Segal, Joanna L, Hyzy, Robert C, Iwashyna, Theodore J, Standiford, Theodore J

“…Psychiatric morbidity after acute respiratory distress syndrome (ARDS) is common, and our current ability to predict psychiatric symptoms based on patient- and…”
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Mental health outcomes after hospitalization with or without COVID-19 by Spencer-Segal, Joanna L., Smith, Christopher A., Slavin, Alana, Sampang, Leilani, DiGiovine, Domenic, Spencer, Andrea E., Zhang, Qisu, Horowitz, Jennifer, Vaughn, Valerie M.

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Single-Dose Study of a Corticotropin-Releasing Factor Receptor-1 Antagonist in Women With 21-Hydroxylase Deficiency by Turcu, Adina F, Spencer-Segal, Joanna L, Farber, Robert H, Luo, Rosa, Grigoriadis, Dimitri E, Ramm, Carole A, Madrigal, David, Muth, Tim, O'Brien, Christopher F, Auchus, Richard J

“…Context: Treatment of 21-hydroxylase deficiency (21OHD) is difficult to optimize. Normalization of excessive ACTH and adrenal steroid production commonly…”
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Reply: Comments on "Stressing the Brain…Acute Respiratory Distress Syndrome" by Spencer-Segal, Joanna L, Standiford, Theodore J

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Distribution of phosphorylated TrkB receptor in the mouse hippocampal formation depends on sex and estrous cycle stage by Spencer-Segal, Joanna L, Waters, Elizabeth M, Bath, Kevin G, Chao, Moses V, McEwen, Bruce S, Milner, Teresa A

“…Tropomyosin-related kinase B receptor (TrkB) is a neurotrophin receptor important for the synaptic plasticity underlying hippocampal-dependent learning and…”
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Rapid response of Nelson’s syndrome to pasireotide in radiotherapy-naive patient by He, Xin, Spencer-Segal, Joanna L

“…Background Nelson's syndrome is a well-described complication following bilateral adrenalectomy for management of Cushing's disease. There is no consensus on…”
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Corticosteroid Treatment During Sepsis Alters Hippocampal Function in Male and Female Survivors by Hill, Alice, Khalil, Huzefa, Laborc, Klaudia, Kounelis-Wuillaume, Savannah, Gavade, Swapnil, Johnston, Colin, Singer, Benjamin H., Spencer-Segal, Joanna L.

“…Millions of sepsis survivors annually face neuropsychiatric sequelae of their illness. Corticosteroids are frequently administered for sepsis, and their use…”
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