Search Results - "Segal, Gil"

Computational modeling and experimental validation of the Legionella and Coxiella virulence-related type-IVB secretion signal by Lifshitz, Ziv, Burstein, David, Peeri, Michael, Zusman, Tal, Schwartz, Kierstyn, Shuman, Howard A, Pupko, Tal, Segal, Gil

“…Legionella and Coxiella are intracellular pathogens that use the virulence-related Icm/Dot type-IVB secretion system to translocate effector proteins into host…”
Get full text

The Response Regulator CpxR Directly Regulates Expression of Several Legionella pneumophila icm/dot Components as Well as New Translocated Substrates by ALTMAN, Efrat, SEGAL, Gil

“…Article Usage Stats Services JB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
Get full text

Genome-scale identification of Legionella pneumophila effectors using a machine learning approach by Burstein, David, Zusman, Tal, Degtyar, Elena, Viner, Ram, Segal, Gil, Pupko, Tal

“…A large number of highly pathogenic bacteria utilize secretion systems to translocate effector proteins into host cells. Using these effectors, the bacteria…”
Get full text

Identification of two Legionella pneumophila effectors that manipulate host phospholipids biosynthesis by Viner, Ram, Chetrit, David, Ehrlich, Marcelo, Segal, Gil

“…The intracellular pathogen Legionella pneumophila translocates a large number of effector proteins into host cells via the Icm/Dot type-IVB secretion system…”
Get full text

Identification of Legionella pneumophila Effectors Regulated by the LetAS-RsmYZ-CsrA Regulatory Cascade, Many of Which Modulate Vesicular Trafficking by Nevo, Oded, Zusman, Tal, Rasis, Michal, Lifshitz, Ziv, Segal, Gil

“…Legionella pneumophila, the causative agent of Legionnaires' disease, is an intracellular human pathogen that utilizes the Icm/Dot type IVB secretion system to…”
Get full text

The single‐domain response regulator LerC functions as a connector protein in the Legionella pneumophila effectors regulatory network by Feldheim, Yaron S., Zusman, Tal, Kapach, Anya, Segal, Gil

“…Summary The intracellular pathogen Legionella pneumophila translocates more than 300 effector proteins into host cells during infection. The PmrAB…”
Get full text

response regulator PmrA is a major regulator of the icm/dot type IV secretion system in Legionella pneumophila and Coxiella burnetii by Zusman, Tal, Aloni, Gali, Halperin, Einat, Kotzer, Hani, Degtyar, Elena, Feldman, Michal, Segal, Gil

“…Legionella pneumophila and Coxiella burnetii have been shown to utilize the icm/dot type IV secretion system for pathogenesis and recently a large number of…”
Get full text

The emergency department length of stay: Is the time running out? by Becker, Alexander, Segal, Gil, Berlin, Yuri, Hershko, Dan

“…To examine the relationships between emergency department length of stay (EDLOS) with hospital length of stay (HLOS) and clinical outcome in hemodynamically…”
Get full text

The Legionella genus core effectors display functional conservation among orthologs by themselves or combined with an accessory protein by Wexler, Michael, Zusman, Tal, Linsky, Marika, Lifshitz, Ziv, Segal, Gil

“…•The Legionella genus contains nine core effectors.•Three Legionella pneumophila core effectors are required for intracellular growth.•The Legionella genus…”
Get full text

Genetic evidence for a regulated cysteine protease catalytic triad in LegA7, a Legionella pneumophila protein that impinges on a stress response pathway by Hershkovitz, Dar, Chen, Emy J, Ensminger, Alexander W, Dugan, Aisling S, Conway, Kaleigh T, Joyce, Alex C, Segal, Gil, Isberg, Ralph R

“…grows within membrane-bound vacuoles in phylogenetically diverse hosts. Intracellular growth requires the function of the Icm/Dot type-IVb secretion system,…”
Get full text

Identification of CpxR as a Positive Regulator of icm and dot Virulence Genes of Legionella pneumophila by Ohad Gal-Mor, Gil Segal

“…Article Usage Stats Services JB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
Get full text

Identification of a Hypervariable Region Containing New Legionella pneumophila Icm/Dot Translocated Substrates by Using the Conserved icmQ Regulatory Signature by Zusman, Tal, Degtyar, Elena, Segal, Gil

“…Legionella pneumophila is an intracellular pathogen that has been shown to utilize the Icm/Dot type IV secretion system for pathogenesis. This system was shown…”
Get full text

Functional Similarities between the icm/dot Pathogenesis Systems of Coxiella burnetii and Legionella pneumophila by ZUSMAN, Tal, YERUSHALMI, Gal, SEGAL, Gil

“…Classifications Services IAI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
Get full text

Host Cell Killing and Bacterial Conjugation Require Overlapping Sets of Genes within a 22-kb Region of the Legionella pneumophila Genome by Segal, Gil, Purcell, Mary, Shuman, Howard A.

“…A 22-kb DNA locus of Legionella pneumophila is described that contains 18 genes, 16 of which are required for macrophage killing (icm genes). In this paper two…”
Get full text

Legionella pneumophila Utilizes the Same Genes To Multiply within Acanthamoeba castellanii and Human Macrophages by SEGAL, G, SHUMAN, H. A

“…Classifications Services IAI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
Get full text

Icm/Dot‐dependent upregulation of phagocytosis by Legionella pneumophila by Hilbi, Hubert, Segal, Gil, Shuman, Howard A.

“…Legionella pneumophila is the causative agent of Legionnaires' disease, a severe pneumonia. Dependent on the icm/dot loci, L. pneumophila survives and…”
Get full text

A Pair of Highly Conserved Two-Component Systems Participates in the Regulation of the Hypervariable FIR Proteins in Different Legionella Species by FELDMAN, Michal, SEGAL, Gil

“…Article Usage Stats Services JB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
Get full text

Characterization of a Legionella pneumophila relA Insertion Mutant and Roles of RelA and RpoS in Virulence Gene Expression by Zusman, Tal, Gal-Mor, Ohad, Segal, Gil

“…Article Usage Stats Services JB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
Get full text

Coevolution between Nonhomologous but Functionally Similar Proteins and Their Conserved Partners in the Legionella Pathogenesis System by Feldman, Michal, Zusman, Tal, Hagag, Shelly, Segal, Gil

“…Legionella pneumophila, the causative agent of Legionnaires' disease, and other pathogenic Legionella species multiply inside protozoa and human macrophages by…”
Get full text

A horizontally acquired Legionella genomic island encoding a LuxR type regulator and effector proteins displays variation in gene content and regulation by Linsky, Marika, Segal, Gil

“…The intracellular pathogen Legionella pneumophila translocates >300 effector proteins into host cells, many of which are regulated at the transcriptional…”
Get full text