Search Results - "Segal, Andrei"

Bimodal Action of Menthol on the Transient Receptor Potential Channel TRPA1 by Karashima, Yuji, Damann, Nils, Prenen, Jean, Talavera, Karel, Segal, Andrei, Voets, Thomas, Nilius, Bernd

“…TRPA1 is a calcium-permeable nonselective cation transient receptor potential (TRP) channel that functions as an excitatory ionotropic receptor in nociceptive…”
Get full text

Steviol glycosides enhance pancreatic beta-cell function and taste sensation by potentiation of TRPM5 channel activity by Philippaert, Koenraad, Pironet, Andy, Mesuere, Margot, Sones, William, Vermeiren, Laura, Kerselaers, Sara, Pinto, Sílvia, Segal, Andrei, Antoine, Nancy, Gysemans, Conny, Laureys, Jos, Lemaire, Katleen, Gilon, Patrick, Cuypers, Eva, Tytgat, Jan, Mathieu, Chantal, Schuit, Frans, Rorsman, Patrik, Talavera, Karel, Voets, Thomas, Vennekens, Rudi

“…Steviol glycosides (SGs), such as stevioside and rebaudioside A, are natural, non-caloric sweet-tasting organic molecules, present in extracts of the scrub…”
Get full text

The Agonist Action of Alkylphenols on TRPA1 Relates to Their Effects on Membrane Lipid Order: Implications for TRPA1-Mediated Chemosensation by Startek, Justyna B, Milici, Alina, Naert, Robbe, Segal, Andrei, Alpizar, Yeranddy A, Voets, Thomas, Talavera, Karel

“…The Transient Receptor Potential Ankyrin 1 cation channel (TRPA1) is a broadly-tuned chemosensor expressed in nociceptive neurons. Multiple TRPA1 agonists are…”
Get full text

Deletion of the transient receptor potential cation channel TRPV4 impairs murine bladder voiding by Gevaert, Thomas, Vriens, Joris, Segal, Andrei, Everaerts, Wouter, Roskams, Tania, Talavera, Karel, Owsianik, Grzegorz, Liedtke, Wolfgang, Daelemans, Dirk, Dewachter, Ilse, Van Leuven, Fred, Voets, Thomas, De Ridder, Dirk, Nilius, Bernd

“…Here we provide evidence for a critical role of the transient receptor potential cation channel, subfamily V, member 4 (TRPV4) in normal bladder function…”
Get full text

Mechanisms of transient receptor potential vanilloid 1 activation and sensitization by allyl isothiocyanate by Gees, Maarten, Alpizar, Yeranddy A, Boonen, Brett, Sanchez, Alicia, Everaerts, Wouter, Segal, Andrei, Xue, Fenqin, Janssens, Annelies, Owsianik, Grzegorz, Nilius, Bernd, Voets, Thomas, Talavera, Karel

“…Allyl isothiocyanate (AITC; aka, mustard oil) is a powerful irritant produced by Brassica plants as a defensive trait against herbivores and confers pungency…”
Get more information

Loss of high-frequency glucose-induced Ca²⁺ oscillations in pancreatic islets correlates with impaired glucose tolerance in Trpm5⁻/⁻ mice by Colsoul, Barbara, Schraenen, Anica, Lemaire, Katleen, Quintens, Roel, Van Lommel, Leentje, Segal, Andrei, Owsianik, Grzegorz, Talavera, Karel, Voets, Thomas, Margolskee, Robert F, Kokrashvili, Zaza, Gilon, Patrick, Nilius, Bernd, Schuit, Frans C, Vennekens, Rudi

“…Glucose homeostasis is critically dependent on insulin release from pancreatic β-cells, which is strictly regulated by glucose-induced oscillations in membrane…”
Get full text

VAMP7 regulates constitutive membrane incorporation of the cold-activated channel TRPM8 by Ghosh, Debapriya, Pinto, Silvia, Danglot, Lydia, Vandewauw, Ine, Segal, Andrei, Van Ranst, Nele, Benoit, Melissa, Janssens, Annelies, Vennekens, Rudi, Vanden Berghe, Pieter, Galli, Thierry, Vriens, Joris, Voets, Thomas

“…The cation channel TRPM8 plays a central role in the somatosensory system, as a key sensor of innocuously cold temperatures and cooling agents. Although…”
Get full text

Distinct modes of perimembrane TRP channel turnover revealed by TIR-FRAP by Ghosh, Debapriya, Segal, Andrei, Voets, Thomas

“…Transient Receptor Potential (TRP) channels form a broadly expressed and functionally diverse family of cation channels involved in various…”
Get full text

Insulin downregulates the expression of the Ca2+-activated nonselective cation channel TRPM5 in pancreatic islets from leptin-deficient mouse models by Colsoul, Barbara, Jacobs, Griet, Philippaert, Koenraad, Owsianik, Grzegorz, Segal, Andrei, Nilius, Bernd, Voets, Thomas, Schuit, Frans, Vennekens, Rudi

“…We recently proposed that the transient receptor potential melastatin 5 (TRPM5) cation channel contributes to glucose-induced electrical activity of the β cell…”
Get full text

A TRP channel trio mediates acute noxious heat sensing by Vandewauw, Ine, De Clercq, Katrien, Mulier, Marie, Held, Katharina, Pinto, Silvia, Van Ranst, Nele, Segal, Andrei, Voet, Thierry, Vennekens, Rudi, Zimmermann, Katharina, Vriens, Joris, Voets, Thomas

“…Three transient receptor potential channels (TRPA1, TRPV1 and TRPM3) mediate sensitivity to acute noxious heat in mice in a redundant system; mice lacking all…”
Get full text

Hypotonic treatment evokes biphasic ATP release across the basolateral membrane of cultured renal epithelia (A6) by Jans, Danny, Srinivas, S. P., Waelkens, Etienne, Segal, Andrei, Larivière, Els, Simaels, Jeannine, Driessche, Willy

“…In renal A6 epithelia, an acute hypotonic shock evokes a transient increase in the intracellular Ca 2+ concentration ([Ca 2+ ] i ) through a mechanism that is…”
Get full text

Transient receptor potential channels in sensory mechanisms of the lower urinary tract by Vanneste, Matthias, Segal, Andrei, Voets, Thomas, Everaerts, Wouter

“…Disruptions to sensory pathways in the lower urinary tract commonly occur and can give rise to lower urinary tract symptoms (LUTS). The unmet clinical need for…”
Get full text

Rat ENaC expressed in Xenopus laevis oocytes is activated by cAMP and blocked by Ni2 by Segal, Andrei, Cucu, Dana, Van Driessche, Willy, Weber, Wolf-Michael

“…We used oocytes of the South African clawed toad Xenopus laevis to express the three subunits of the epithelial Na+ channel from rat distal colon (rENaC). We…”
Get full text

Zinc is a voltage-dependent blocker of native and heterologously expressed epithelial Na+ channels by Amuzescu, Bogdan, Segal, Andrei, Flonta, Maria-Luiza, Simaels, Jeannine, Van Driessche, Willy

“…Zn(2+) (1-1,000 microM) applied to the apical side of polarized A6 epithelia inhibits Na(+) transport, as reflected in short-circuit current and conductance…”
Get full text

Pharmacological properties of TRPM3 isoforms are determined by the length of the pore loop by Held, Katharina, Aloi, Vincenzo Davide, Freitas, Ana Cristina Nogueira, Janssens, Annelies, Segal, Andrei, Przibilla, Julia, Philipp, Stephan Ernst, Wang, Yu Tian, Voets, Thomas, Vriens, Joris

“…Background and Purpose Transient receptor potential melastatin 3 (TRPM3) is a non‐selective cation channel that plays a pivotal role in the peripheral nervous…”
Get full text

Modulation by Phenolic Compounds Provides Novel Insight into the Mechanisms of TRPA1 Activation by Startek, Justyna B., Segal, Andrei, Voets, Thomas, Talavera, Karel

Get full text

TRPM4 inhibition by meclofenamate suppresses Ca2+-dependent triggered arrhythmias by Vandewiele, Frone, Pironet, Andy, Jacobs, Griet, Kecskés, Miklos, Wegener, Jörg, Kerselaers, Sara, Hendrikx, Lio, Verelst, Joren, Philippaert, Koenraad, Oosterlinck, Wouter, Segal, Andrei, Van Den Broeck, Evy, Pinto, Silvia, Priori, Silvia G, Lehnart, Stephan E, Nilius, Bernd, Voets, Thomas, Vennekens, Rudi

“…Abstract Aims Cardiac arrhythmias are a major factor in the occurrence of morbidity and sudden death in patients with cardiovascular disease. Disturbances of…”
Get full text

TRPM4-dependent post-synaptic depolarization is essential for the induction of NMDA receptor-dependent LTP in CA1 hippocampal neurons by Menigoz, Aurélie, Ahmed, Tariq, Sabanov, Victor, Philippaert, Koenraad, Pinto, Silvia, Kerselaers, Sara, Segal, Andrei, Freichel, Marc, Voets, Thomas, Nilius, Bernd, Vennekens, Rudi, Balschun, Detlef

“…TRPM4 is a calcium-activated but calcium-impermeable non-selective cation (CAN) channel. Previous studies have shown that TRPM4 is an important regulator of Ca…”
Get full text

Functional Analysis of the Thermosensor TRPM3 in Intact Sensory Fibers Using the Skin-Nerve Assay by Vandewauw, Ine, Vriens, Joris, Segal, Andrei, Zimmermann, Katharina, Voets, Thomas

Get full text

Publisher Correction: A TRP channel trio mediates acute noxious heat sensing by Vandewauw, Ine, De Clercq, Katrien, Mulier, Marie, Held, Katharina, Pinto, Silvia, Van Ranst, Nele, Segal, Andrei, Voet, Thierry, Vennekens, Rudi, Zimmermann, Katharina, Vriens, Joris, Voets, Thomas

“…In this Letter, the trace is missing in Fig. 1e. This error has been corrected online…”
Get full text