Search Results - "Segal, A."

Hedgehog Signal Transduction: Key Players, Oncogenic Drivers, and Cancer Therapy by Pak, Ekaterina, Segal, Rosalind A.

“…The Hedgehog (Hh) signaling pathway governs complex developmental processes, including proliferation and patterning within diverse tissues. These activities…”
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Studies on patients establish Crohn's disease as a manifestation of impaired innate immunity by Segal, A. W.

“…The fruitless search for the cause of Crohn's disease has been conducted for more than a century. Various theories, including autoimmunity, mycobacterial…”
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A Mechanistic Understanding of Axon Degeneration in Chemotherapy-Induced Peripheral Neuropathy by Fukuda, Yusuke, Li, Yihang, Segal, Rosalind A

“…Chemotherapeutic agents cause many short and long term toxic side effects to peripheral nervous system (PNS) that drastically alter quality of life…”
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The Role of Empathy in Burnout, Compassion Satisfaction, and Secondary Traumatic Stress among Social Workers by Wagaman, M. Alex, Geiger, Jennifer M., Shockley, Clara, Segal, Elizabeth A.

“…Social workers are at risk for experiencing burnout and secondary traumatic stress (STS) as a result of the nature of their work and the contexts within which…”
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Acceleration of thaw slump activity in glaciated landscapes of the Western Canadian Arctic by Segal, Rebecca A, Lantz, Trevor C, Kokelj, Steven V

“…Climate change is increasing the frequency and intensity of thermokarst, but the influences of regional climate and physiography remain poorly understood…”
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Neuronal signaling through endocytosis by Cosker, Katharina E, Segal, Rosalind A

“…The distinctive morphology of neurons, with complex dendritic arbors and extensive axons, presents spatial challenges for intracellular signal transduction…”
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The RNA-binding protein SFPQ orchestrates an RNA regulon to promote axon viability by Cosker, Katharina E, Fenstermacher, Sara J, Pazyra-Murphy, Maria F, Elliott, Hunter L, Segal, Rosalind A

“…This study identifies SFPQ (splicing factor, poly-glutamine rich) as an RNA binding protein that binds and coassembles multiple mRNAs in axonal transport…”
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Selectivity in neurotrophin signaling: Theme and variations by SEGAL, Rosalind A

“…Neurotrophins are a family of growth factors critical for the development and functioning of the nervous system. Although originally identified as neuronal…”
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Study TPX-100-5: intra-articular TPX-100 significantly delays pathological bone shape change and stabilizes cartilage in moderate to severe bilateral knee OA by McGuire, Dawn, Bowes, Michael, Brett, Alan, Segal, Neil A, Miller, Meghan, Rosen, David, Kumagai, Yoshinari

“…Abstract Background TPX-100, a promotor of osteoblast and chondroblast differentiation, is a potential osteoarthritis (OA) therapy. This retrospective study…”
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RAS/MAPK Activation Drives Resistance to Smo Inhibition, Metastasis, and Tumor Evolution in Shh Pathway-Dependent Tumors by Zhao, Xuesong, Ponomaryov, Tatyana, Ornell, Kimberly J, Zhou, Pengcheng, Dabral, Sukriti K, Pak, Ekaterina, Li, Wei, Atwood, Scott X, Whitson, Ramon J, Chang, Anne Lynn S, Li, Jiang, Oro, Anthony E, Chan, Jennifer A, Kelleher, Joseph F, Segal, Rosalind A

“…Aberrant Shh signaling promotes tumor growth in diverse cancers. The importance of Shh signaling is particularly evident in medulloblastoma and basal cell…”
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Globalization, migration, and ethnicity by Segal, U.A.

“…This article presents an overview of global migration and the unique issues facing immigrants, host countries, and practitioners, identifying considerations…”
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Meta-analysis of open and endovascular repair of popliteal artery aneurysms by Leake, Andrew E., MD, Segal, Michael A., BS, Chaer, Rabih A., MD, Eslami, Mohammad H., MD, Al-Khoury, Georges, MD, Makaroun, Michel S., MD, Avgerinos, Efthymios D., MD

“…Abstract Objective Endovascular popliteal artery aneurysm repair (EPAR) is increasingly used over open surgical repair (OPAR). The purpose of this study was to…”
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Characterizing winter landfast sea-ice surface roughness in the Canadian Arctic Archipelago using Sentinel-1 synthetic aperture radar and the Multi-angle Imaging SpectroRadiometer by Segal, Rebecca A., Scharien, Randall K., Cafarella, Silvie, Tedstone, Andrew

“…Two satellite datasets are used to characterize winter landfast first-year sea-ice (FYI), deformed FYI (DFYI) and multiyear sea-ice (MYI) roughness in the…”
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Cost-effectiveness and clinical utility of universal pre-admission MRSA screening in total joint arthroplasty patients by Suratwala, S., Kommareddy, D., Duvvuri, P., Woltmann, J., Segal, A., Krauss, E.

“…For patients undergoing total joint arthroplasty (TJA), pre-admission meticillin-resistant Staphylococcus aureus (MRSA) nasal screening has been widely adopted…”
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Stroke in patients with cancer: Incidence and etiology by CESTARI, D. M, WEINE, D. M, PANAGEAS, K. S, SEGAL, A. Z, DEANGELIS, L. M

“…To assess the incidence and type of strokes in patients with cancer at Memorial Sloan-Kettering Cancer Center. Retrospective review of all ischemic strokes…”
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Sex‐Specific Influence of Quadriceps Weakness on Worsening Patellofemoral and Tibiofemoral Cartilage Damage: A Prospective Cohort Study by Culvenor, Adam G., Segal, Neil A., Guermazi, Ali, Roemer, Frank, Felson, David T., Nevitt, Michael C., Lewis, Cora E., Stefanik, Joshua J.

“…Objective Reports on quadriceps weakness as a risk factor for incident and progressive knee osteoarthritis are conflicting, potentially due to differing…”
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Identifying important parameters in the inflammatory process with a mathematical model of immune cell influx and macrophage polarization by Torres, Marcella, Wang, Jing, Yannie, Paul J, Ghosh, Shobha, Segal, Rebecca A, Reynolds, Angela M

“…In an inflammatory setting, macrophages can be polarized to an inflammatory M1 phenotype or to an anti-inflammatory M2 phenotype, as well as existing on a…”
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Home Training, Local Corticosteroid Injection, or Radial Shock Wave Therapy for Greater Trochanter Pain Syndrome by Rompe, Jan D., Segal, Neil A., Cacchio, Angelo, Furia, John P., Morral, Antonio, Maffulli, Nicola

“…Background There are no controlled studies testing the efficacy of various nonoperative strategies for treatment of greater trochanter pain syndrome…”
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Greater Trochanteric Pain Syndrome: Epidemiology and Associated Factors by Segal, Neil A., MD, Felson, David T., MD, Torner, James C., PhD, Zhu, Yanyan, MSc, Curtis, Jeffrey R., MD, MPH, Niu, Jingbo, DSc, Nevitt, Michael C., PhD

“…Abstract Segal NA, Felson DT, Torner JC, Zhu Y, Curtis JR, Niu J, Nevitt MC, for the Multicenter Osteoarthritis (MOST) Study Group. Greater trochanteric pain…”
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Mitogenic and progenitor gene programmes in single pilocytic astrocytoma cells by Reitman, Zachary J., Paolella, Brenton R., Bergthold, Guillaume, Pelton, Kristine, Becker, Sarah, Jones, Robert, Sinai, Claire E., Malkin, Hayley, Huang, Ying, Grimmet, Leslie, Herbert, Zachary T., Sun, Yu, Weatherbee, Jessica L., Alberta, John A., Daley, John F., Rozenblatt-Rosen, Orit, Condurat, Alexandra L., Qian, Kenin, Khadka, Prasidda, Segal, Rosalind A., Haas-Kogan, Daphne, Filbin, Mariella G., Suva, Mario L., Regev, Aviv, Stiles, Charles D., Kieran, Mark W., Goumnerova, Liliana, Ligon, Keith L., Shalek, Alex K., Bandopadhayay, Pratiti, Beroukhim, Rameen

“…Pilocytic astrocytoma (PA), the most common childhood brain tumor, is a low-grade glioma with a single driver BRAF rearrangement. Here, we perform scRNAseq in…”
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