Search Results - "Sega, Emanuela I."

Tumor detection using folate receptor-targeted imaging agents by Sega, Emanuela I., Low, Philip S.

“…Folate receptors are up-regulated on a variety of human cancers, including cancers of the breast, ovaries, endometrium, lungs, kidneys, colon, brain, and…”
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Role of lymphocyte activation gene-3 (Lag-3) in conventional and regulatory T cell function in allogeneic transplantation by Sega, Emanuela I, Leveson-Gower, Dennis B, Florek, Mareike, Schneidawind, Dominik, Luong, Richard H, Negrin, Robert S

“…Lag-3 has emerged as an important molecule in T cell biology. We investigated the role of Lag-3 in conventional T cell (Tcon) and regulatory T cell (Treg)…”
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In vivo trafficking and survival of cytokine-induced killer cells resulting in minimal GVHD with retention of antitumor activity by Nishimura, Ryosei, Baker, Jeanette, Beilhack, Andreas, Zeiser, Robert, Olson, Janelle A., Sega, Emanuela I., Karimi, Mobin, Negrin, Robert S.

“…Cytokine-induced killer (CIK) cells are ex vivo–expanded T lymphocytes expressing both natural killer (NK)– and T-cell markers. CIK cells are cytotoxic against…”
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Rapamycin and IL-2 reduce lethal acute graft-versus-host disease associated with increased expansion of donor type CD4+CD25+Foxp3+ regulatory T cells by Shin, Ho-Jin, Baker, Jeanette, Leveson-Gower, Dennis B., Smith, Aaron T., Sega, Emanuela I., Negrin, Robert S.

“…Previous work has demonstrated that both rapamycin (RAPA) and IL-2 enhance CD4+CD25+Foxp3+ regulatory T-cell (Treg) proliferation and function in vitro. We…”
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Low doses of natural killer T cells provide protection from acute graft-versus-host disease via an IL-4–dependent mechanism by Leveson-Gower, Dennis B., Olson, Janelle A., Sega, Emanuela I., Luong, Richard H., Baker, Jeanette, Zeiser, Robert, Negrin, Robert S.

“…CD4+ natural killer T (NKT) cells, along with CD4+CD25+ regulatory T cells (Tregs), are capable of controlling aberrant immune reactions. We explored the…”
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Low-Dose Radiation Potentiates the Therapeutic Efficacy of Folate Receptor–Targeted Hapten Therapy by Sega, Emanuela I., Ph.D, Lu, Yingjuan, Ph.D, Ringor, Michael, Ph.D, Leamon, Christopher P., Ph.D, Low, Philip S., Ph.D

“…Purpose Human cancers frequently overexpress a high-affinity cell-surface receptor for the vitamin folic acid. Highly immunogenic haptens can be targeted to…”
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Mast cells suppress murine GVHD in a mechanism independent of CD4+CD25+ regulatory T cells by Leveson-Gower, Dennis B., Sega, Emanuela I., Kalesnikoff, Janet, Florek, Mareike, Pan, Yuqiong, Pierini, Antonio, Galli, Stephen J., Negrin, Robert S.

“…To investigate the role of mast cells in hematopoietic cell transplantation, we assessed graft-versus-host disease (GVHD) in C57BL/6-KitW-sh/W-sh recipients,…”
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Autologous apoptotic cells preceding transplantation enhance survival in lethal murine graft-versus-host models by Florek, Mareike, Sega, Emanuela I., Leveson-Gower, Dennis B., Baker, Jeanette, Müller, Antonia M.S., Schneidawind, Dominik, Meyer, Everett, Negrin, Robert S.

“…Acute graft-versus-host disease (GVHD) is induced by alloreactivity of donor T cells toward host antigens presented on antigen-presenting cells (APCs)…”
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Natural and Expanded CD4+ CD25+ Regulatory T Cells in Bone Marrow Transplantation by Colonna, Lucrezia, Sega, Emanuela I, Negrin, Robert S

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IL-17 Gene Ablation Does Not Impact Treg-Mediated Suppression of Graft-Versus-Host Disease after Bone Marrow Transplantation by Colonna, Lucrezia, Florek, Mareike, Leveson-Gower, Dennis B, Sega, Emanuela I, Baker, Jeanette, Smith, Aaron T, Negrin, Robert S

“…Abstract Regulatory T cell (Treg) immunotherapy is a promising strategy for the treatment of graft rejection responses and autoimmune disorders. Our and other…”
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Role of Lymphocyte Activation Gene-3 by Sega, Emanuela I, Leveson-Gower, Dennis B, Florek, Mareike, Schneidawind, Dominik, Luong, Richard H, Negrin, Robert S

“…Lag-3 has emerged as an important molecule in T cell biology. We investigated the role of Lag-3 in conventional T cell (Tcon) and regulatory T cell (Treg)…”
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The Inhibitory Receptor LAG-3 Is Not Essential for Regulatory T Cells Function but Influences Donor T Cell Potency in Acute Graft-Versus-Host-Disease by Sega, Emanuela I, Leveson-Gower, Dennis B, Florek, Mareike, Negrin, Robert S

“…Abstract 1900 GVHD is a major complication of bone marrow transplantation (BMT) and results from donor T cells becoming activated and reacting to host…”
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IL-17 Gene Ablation Does Not Impact Treg-Mediated Suppression of Graft-Versus-Host Disease Following Bone Marrow Transplantation by Colonna, Lucrezia, Florek, Mareike, Leveson-Gower, Dennis B, Sega, Emanuela I, Zeiser, Robert, Buess, Martin, Negrin, Robert S

“…Abstract 4037 Allogeneic hematopoietic cell transplantation (HCT) is an effective treatment for many hematologic malignancies such as leukemia, lymphoma and…”
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A Novel Model of Pre-Emptive ECP Treatment Shows Significant Reduction of Gvhd-Related Mortality In Mice by Florek, Mareike, Sega, Emanuela I, Mueller, Antonia MS, Leveson-Gower, Dennis B, Shizuru, Judith A, Negrin, Robert S

“…Abstract 4025 Graft versus host disease (Gvhd) remains the major cause of morbidity and mortality after bone marrow transplantation (BMT). To prevent Gvhd the…”
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Mast Cells Reduce Gvhd Severity In Allogeneic Transplantation by Reducing the Proliferation of Conventional T Cells by Leveson-Gower, Dennis B, Sega, Emanuela I, Kalesnikoff, Janet, Florek, Mareike, Galli, Stephen J, Negrin, Robert

“…Abstract 243 Mast cells are important effector cells in many innate and adaptive immune responses, and can influence the function of several immune cells…”
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Tumor detection using folate receptor-targeted imaging agents: Imaging of Molecular Pathways Associated with Cancer by SEGA, Emanuela I, LOW, Philip S

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Gvhd Severity Is Regulated by the Adoptive Transfer Low Numbers of NKT Cells by a Mechanism Distinct From CD4+CD25+ Regulatory T Cells by Leveson-Gower, Dennis, Olson, Janelle, Sega, Emanuela I, Baker, Jeanette, Zeiser, Robert, Negrin, Robert

“…Abstract 229 NKT cells, a subset of which are CD1d reactive, play an important immunoregulatory role in suppressing dysfunctional immune reactions, including…”
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Rapamycin and IL-2 Prevents Lethal Acute Graft-Versus Host Disease by Expansion of Donor Type CD4+CD25+Foxp3+ Regulatory T Cells by Shin, Ho-Jin, Baker, Jeanette, Leveson-Gower, Dennis, Sega, Emanuela I, Negrin, Robert

“…Abstract 1334 Poster Board I-356 Previous work has demonstrated that both rapamycin (RAPA) and IL-2 enhance CD4+CD25+Foxp3+ regulatory T cells (Treg)…”
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Functional Comparison of Freshly Isolated and Ex-Vivo Expanded CD4+CD25+Foxp3+ Regulatory T Cells in Suppressing Murine Acute GvHD by Sega, Emanuela I, Leveson-Gower, Dennis, Nguyen, Vu H., Negrin, Robert

“…Graft versus host disease (GVHD) is a major complication of hematopoietic stem cell transplantation resulting from donor T cell reactivity against host tissue…”
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Biology Contribution: Low-Dose Radiation Potentiates the Therapeutic Efficacy of Folate Receptor-Targeted Hapten Therapy by Sega, Emanuela I, Lu, Yingjuan, Ringor, Michael, Leamon, Christopher P, Low, Philip S

“…Purpose: Human cancers frequently overexpress a high-affinity cell-surface receptor for the vitamin folic acid. Highly immunogenic haptens can be targeted to…”
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