Search Results - "Seflova, Jaroslava"

Newly Discovered Micropeptide Regulators of SERCA Form Oligomers but Bind to the Pump as Monomers by Singh, Deo R., Dalton, Michael P., Cho, Ellen E., Pribadi, Marsha P., Zak, Taylor J., Šeflová, Jaroslava, Makarewich, Catherine A., Olson, Eric N., Robia, Seth L.

“…The recently-discovered single-span transmembrane proteins endoregulin (ELN), dwarf open reading frame (DWORF), myoregulin (MLN), and another-regulin (ALN) are…”
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RyR2 Binding of an Antiarrhythmic Cyclic Depsipeptide Mapped Using Confocal Fluorescence Lifetime Detection of FRET by Šeflová, Jaroslava, Schwarz, Jacob A., Smith, Abigail N., Svensson, Bengt, Blackwell, Daniel J., Phillips, Taylor A., Nikolaienko, Roman, Bovo, Elisa, Rebbeck, Robyn T., Zima, Aleksey V., Thomas, David D., Van Petegem, Filip, Knollmann, Björn C., Johnston, Jeffrey N., Robia, Seth L., Cornea, Răzvan L.

“…Hyperactivity of cardiac sarcoplasmic reticulum (SR) ryanodine receptor (RyR2) Ca2+-release channels contributes to heart failure and arrhythmias. Reducing the…”
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Inhibition of Na+/K+-ATPase by 5,6,7,8-tetrafluoro-3-hydroxy-2-phenylquinolin-4(1H)-one by Šeflová, Jaroslava, Čechová, Petra, Biler, Michal, Hradil, Pavel, Kubala, Martin

“…Na+/K+-ATPase (NKA) is an enzyme of crucial importance for all animal cells. We examined the inhibitory effects of halogenated phenylquinolinones on NKA. The…”
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Identification of cisplatin-binding sites on the large cytoplasmic loop of the Na+/K+-ATPase by Šeflová, Jaroslava, Čechová, Petra, Štenclová, Tereza, Šebela, Marek, Kubala, Martin

“…Cisplatin is the most widely used chemotherapeutic drug for the treatment of various types of cancer; however, its administration brings also numerous side…”
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Dimerization of SERCA2a Enhances Transport Rate and Improves Energetic Efficiency in Living Cells by Bovo, Elisa, Nikolaienko, Roman, Cleary, Sean R., Seflova, Jaroslava, Kahn, Daniel, Robia, Seth L., Zima, Aleksey V.

“…The type 2a sarco/endoplasmic reticulum (ER) Ca2+-ATPase (SERCA2a) plays a key role in intracellular Ca2+ regulation in the heart. We have previously shown…”
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Mechanisms for cardiac calcium pump activation by its substrate and a synthetic allosteric modulator using fluorescence lifetime imaging by Šeflová, Jaroslava, Cruz-Cortés, Carlos, Guerrero-Serna, Guadalupe, Robia, Seth L, Espinoza-Fonseca, L Michel

“…The discovery of allosteric modulators is an emerging paradigm in drug discovery, and signal transduction is a subtle and dynamic process that is challenging…”
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The Ile191Val is a partial loss-of-function variant of the TAS1R2 sweet-taste receptor and is associated with reduced glucose excursions in humans by Serrano, Joan, Seflova, Jaroslava, Park, Jihye, Pribadi, Marsha, Sanematsu, Keisuke, Shigemura, Noriatsu, Serna, Vanida, Yi, Fanchao, Mari, Andrea, Procko, Erik, Pratley, Richard E., Robia, Seth L., Kyriazis, George A.

“…Sweet taste receptors (STR) are expressed in the gut and other extra-oral tissues, suggesting that STR-mediated nutrient sensing may contribute to human…”
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Protein carbonylation causes sarcoplasmic reticulum Ca2+ overload by increasing intracellular Na+ level in ventricular myocytes by Bovo, Elisa, Seflova, Jaroslava, Robia, Seth L., Zima, Aleksey V.

“…Diabetes is commonly associated with an elevated level of reactive carbonyl species due to alteration of glucose and fatty acid metabolism. These metabolic…”
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Abstract Mo042: Poison Peptides May Contribute to Dysregulation of SERCA in Heart Failure by Phillips, Taylor, Cunningham, Jacob, Seflova, Jaroslava, Cho, Ellen, Edassery, Seby, Bovo, Elisa, Zima, Aleksey, Kirk, Jonathan, Robia, Seth

“…Abstract only Proteolysis increases in heart disease, resulting in an accumulation of degraded membrane protein fragments in heart cells. Previous studies have…”
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FXYD6 dimerization in heart failure by Yap, John Q., Seflova, Jaroslava, Miller, Carson S., Robia, Seth L.

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Inhibition of Na+-K+ ATPase by carbonylation causes SR Ca2+ overload and spontaneous SR Ca2+ release in ventricular myocytes by Bovo, Elisa, Seflova, Jaroslava, Kuo, Ivana Y., Robia, Seth L., Zima, Aleksey V.

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FXYD proteins and sodium pump regulatory mechanisms by Yap, John Q, Seflova, Jaroslava, Sweazey, Ryan, Artigas, Pablo, Robia, Seth L

“…The sodium/potassium-ATPase (NKA) is the enzyme that establishes gradients of sodium and potassium across the plasma membrane. NKA activity is tightly…”
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A switch in FXYD proteins dysregulates NKA in dilated cardiomyopathy by Yap, John Q., Phillips, Taylor, Seflova, Jaroslava, Cunningham, Jacob, Robia, Seth L.

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Protein carbonylation causes sarcoplasmic reticulum Ca 2+ overload by increasing intracellular Na + level in ventricular myocytes by Bovo, Elisa, Seflova, Jaroslava, Robia, Seth L, Zima, Aleksey V

“…Diabetes is commonly associated with an elevated level of reactive carbonyl species due to alteration of glucose and fatty acid metabolism. These metabolic…”
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Poison peptides interactions with the sarcoplasmic reticulum Ca-ATPase (SERCA) by Cunningham, Jacob, Phillips, Taylor, Seflova, Jaroslava, Cho, Ellen E., Kirk, Jonothan A., Robia, Seth L.

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Phospholamban inhibits the cardiac calcium pump by reversing allosteric effects of ATP on calcium affinity by Cleary, Sean R., Seflova, Jaroslava, Cho, Ellen E., Espinoza-Fonseca, L. Michel, Robia, Seth L.

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Insight into Sodium Pump Regulation in the Failing Human Heart by Seflova, Jaroslava, Pribadi, Marsha, Kirk, Jonathan, Heroux, Alain, Zima, Aleksey V., Robia, Seth L.

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Phospholamban inhibits the cardiac calcium pump by interrupting an allosteric activation pathway by Cleary, Sean R., Seflova, Jaroslava, Cho, Ellen E., Bisht, Konark, Khandelia, Himanshu, Espinoza-Fonseca, L. Michel, Robia, Seth L.

“…Phospholamban (PLB) is a transmembrane micropeptide that regulates the sarcoplasmic reticulum Ca2+-ATPase (SERCA) in cardiac muscle, but the physical mechanism…”
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Insight into Sodium Pump Regulation by FXYD Proteins by Seflova, Jaroslava, Yap, John Q., Delligatti, Christine E., Pribadi, Marsha P., Artigas, Pablo, Bossuyt, Julie, Robia, Seth L.

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Stoichiometry of the sodium pump-phospholemman regulatory complex by Seflova, Jaroslava, Habibi, Nima R., Yap, John, Cleary, Sean R., Fang, Xuan, Kekenes-Huskey, Peter M., Espinoza-Fonseca, L. Michel, Bossuyt, Julie, Robia, Seth L.

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