Search Results - "Sefcik, Lauren S"

Optimizing the alignment of thermoresponsive poly(N-isopropyl acrylamide) electrospun nanofibers for tissue engineering applications: A factorial design of experiments approach by Young, Rachel E, Graf, Jodi, Miserocchi, Isabella, Van Horn, Ryan M, Gordon, Melissa B, Anderson, Christopher R, Sefcik, Lauren S

“…Thermoresponsive polymers, such as poly(N-isopropyl acrylamide) (PNIPAM), have been identified and used as cell culture substrates, taking advantage of the…”
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Sphingosine 1-phosphate receptor 3 regulates recruitment of anti-inflammatory monocytes to microvessels during implant arteriogenesis by Awojoodu, Anthony O., Ogle, Molly E., Sefcik, Lauren S., Bowers, Daniel T., Martin, Kyle, Brayman, Kenneth L., Lynch, Kevin R., Peirce-Cottler, Shayn M., Botchwey, Edward

“…Endothelial cells play significant roles in conditioning tissues after injury by the production and secretion of angiocrine factors. At least two distinct…”
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Tuning reversible cell adhesion to methacrylate‐based thermoresponsive polymers: Effects of composition on substrate hydrophobicity and cellular responses by Anderson, Christopher R., Gambinossi, Filippo, DiLillo, Katarina M., Laschewsky, André, Wischerhoff, Erik, Ferri, James K., Sefcik, Lauren S.

“…Thermoresponsive polymer (TRP) cell culture substrates are widely utilized for nonenzymatic, temperature‐triggered release of adherent cells. Increasingly,…”
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The enhancement of bone allograft incorporation by the local delivery of the sphingosine 1-phosphate receptor targeted drug FTY720 by Petrie Aronin, Caren E, Shin, Soo J, Naden, Kimberly B, Rios, Peter D, Sefcik, Lauren S, Zawodny, Sarah R, Bagayoko, Namory D, Cui, Quanjun, Khan, Yusuf, Botchwey, Edward A

“…Abstract Poor vascularization coupled with mechanical instability is the leading cause of post-operative complications and poor functional prognosis of massive…”
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Sustained release of sphingosine 1-phosphate for therapeutic arteriogenesis and bone tissue engineering by Sefcik, Lauren S, Petrie Aronin, Caren E, Wieghaus, Kristen A, Botchwey, Edward A

“…Abstract Sphingosine 1-phosphate (S1P) is a bioactive phospholipid that impacts migration, proliferation, and survival in diverse cell types, including…”
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Effects of PEG-Based Thermoresponsive Polymer Brushes on Fibroblast Spreading and Gene Expression by Sefcik, Lauren S., Kaminski, Ashley, Ling, Kevin, Laschewsky, André, Lutz, Jean-François, Wischerhoff, Erik

“…The use of thermoresponsive polymer (TRP) substrates, such as PNIPAM, has become a valuable tool for the gentle detachment of cells from their culture surface…”
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Collagen nanofibres are a biomimetic substrate for the serum-free osteogenic differentiation of human adipose stem cells by Sefcik, Lauren S., Neal, Rebekah A., Kaszuba, Stephanie N., Parker, Anna M., Katz, Adam J., Ogle, Roy C., Botchwey, Edward A.

“…Electrospinning has recently gained widespread attention as a process capable of producing nanoscale fibres that mimic native extracellular matrix. In this…”
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Engineering vascularized tissues using natural and synthetic small molecules by Sefcik, Lauren S., Petrie Aronin, Caren E., Botchwey, Edward A.

“…Vascular growth and remodeling are complex processes that depend on the proper spatial and temporal regulation of many different signaling molecules to form…”
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Engineering Adhesion to Thermoresponsive Substrates: Effect of Polymer Composition on Liquid–Liquid–Solid Wetting by Gambinossi, Filippo, Sefcik, Lauren S, Wischerhoff, Erik, Laschewsky, Andre, Ferri, James K

“…Adhesion control in liquid–liquid–solid systems represents a challenge for applications ranging from self-cleaning to biocompatibility of engineered materials…”
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Laminin nanofiber meshes that mimic morphological properties and bioactivity of basement membranes by Neal, Rebekah A, McClugage, Samuel G, Link, Mia C, Sefcik, Lauren S, Ogle, Roy C, Botchwey, Edward A

“…The basement membrane protein, laminin I, has been used broadly as a planar two-dimensional film or in a three-dimensional form as a reconstituted basement…”
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Selective activation of sphingosine 1-phosphate receptors 1 and 3 promotes local microvascular network growth by Sefcik, Lauren S, Aronin, Caren E Petrie, Awojoodu, Anthony O, Shin, Soo J, Mac Gabhann, Feilim, MacDonald, Timothy L, Wamhoff, Brian R, Lynch, Kevin R, Peirce, Shayn M, Botchwey, Edward A

“…Proper spatial and temporal regulation of microvascular remodeling is critical to the formation of functional vascular networks, spanning the various arterial,…”
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FTY720 promotes local microvascular network formation and regeneration of cranial bone defects by Petrie Aronin, Caren E, Sefcik, Lauren S, Tholpady, Sunil S, Tholpady, Ashok, Sadik, Karim W, Macdonald, Timothy L, Peirce, Shayn M, Wamhoff, Brian R, Lynch, Kevin R, Ogle, Roy C, Botchwey, Edward A

“…The calvarial bone microenvironment contains a unique progenitor niche that should be considered for therapeutic manipulation when designing regeneration…”
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Engineering in vivo gradients of sphingosine-1-phosphate receptor ligands for localized microvascular remodeling and inflammatory cell positioning by Ogle, Molly E., Sefcik, Lauren S., Awojoodu, Anthony O., Chiappa, Nathan F., Lynch, Kevin, Peirce-Cottler, Shayn, Botchwey, Edward A.

“…Localized drug gradient depends on tissue metabolic network activity. [Display omitted] Biomaterial-mediated controlled release of soluble signaling molecules…”
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Harnessing systems biology approaches to engineer functional microvascular networks by Sefcik, Lauren S, Wilson, Jennifer L, Papin, Jason A, Botchwey, Edward A

“…Microvascular remodeling is a complex process that includes many cell types and molecular signals. Despite a continued growth in the understanding of signaling…”
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Expansion of microvascular networks in vivo by phthalimide neovascular factor 1 (PNF1) by Wieghaus, Kristen A, Nickerson, Meghan M, Petrie Aronin, Caren E, Sefcik, Lauren S, Price, Richard J, Paige, Mikell A, Brown, Milton L, Botchwey, Edward A

“…Abstract Phthalimide neovascular factor (PNF1, formerly SC-3-149) is a potent stimulator of proangiogenic signaling pathways in endothelial cells. In this…”
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Optimizing the alignment of thermoresponsive poly by Young, Rachel E, Graf, Jodi, Miserocchi, Isabella, Van Horn, Ryan M, Gordon, Melissa B, Anderson, Christopher R, Sefcik, Lauren S

“…Thermoresponsive polymers, such as poly(N-isopropyl acrylamide) (PNIPAM), have been identified and used as cell culture substrates, taking advantage of the…”
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Regulation of sphingosine 1 -phosphate (S1P) signaling for therapeutic arteriogenesis and tissue engineering by Sefcik, Lauren S

“…The development of effective strategies to stimulate neovascularization and to develop sustainable microvascular networks is a critically important clinical…”
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Regulation of sphingosine 1-phosphate (S1P) signaling for therapeutic arteriogenesis and tissue engineering by Sefcik, Lauren S

“…The development of effective strategies to stimulate neovascularization and to develop sustainable microvascular networks is a critically important clinical…”
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