Search Results - "Seest, E P"

Tipranavir (PNU-140690):  A Potent, Orally Bioavailable Nonpeptidic HIV Protease Inhibitor of the 5,6-Dihydro-4-hydroxy-2-pyrone Sulfonamide Class by Turner, Steve R, Strohbach, Joseph W, Tommasi, Ruben A, Aristoff, Paul A, Johnson, Paul D, Skulnick, Harvey I, Dolak, Lester A, Seest, Eric P, Tomich, Paul K, Bohanon, Michael J, Horng, Miao-Miao, Lynn, Janet C, Chong, Kong-Teck, Hinshaw, Roger R, Watenpaugh, Keith D, Janakiraman, Musiri N, Thaisrivongs, Suvit

“…A broad screening program previously identified phenprocoumon (1) as a small molecule template for inhibition of HIV protease. Subsequent modification of this…”
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(-)-6-chloro-2-[(1-furo[2,3-c]pyridin-5-yl-ethyl)thio]-4-pyrimidinamine, PNU-142721, a new broad spectrum HIV-1 non-nucleoside reverse transcriptase inhibitor by WISHKA, D. G, GRABER, D. R, KEISER, B. J, YAGI, Y, JEGANATHAN, A, SCHLACHTER, S. T, MURPHY, M. J, CLEEK, G. J, NUGENT, R. A, POPPE, S. M, SWANEY, S. M, HAN, F, KOPTA, L. A, WATT, W, WHITE, W. L, POEL, T.-J, THOMAS, R. C, VOORMAN, R. L, STEFANSKI, K. J, STEHLE, R. G, TARPLEY, W. G, MORRIS, J, OLMSTED, R. A, FRIIS, J. M, HOSLEY, J. D, ADAMS, W. J, SEEST, E. P, CASTLE, T. M, DOLAK, L. A

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Identification of Phenylisoxazolines as Novel and Viable Antibacterial Agents Active against Gram-Positive Pathogens by Barbachyn, Michael R, Cleek, Gary J, Dolak, Lester A, Garmon, Stuart A, Morris, Joel, Seest, Eric P, Thomas, Richard C, Toops, Dana S, Watt, William, Wishka, Donn G, Ford, Charles W, Zurenko, Gary E, Hamel, Judith C, Schaadt, Ronda D, Stapert, Douglas, Yagi, Betty H, Adams, Wade J, Friis, Janice M, Slatter, J. Gregory, Sams, James P, Oien, Nancee L, Zaya, Matthew J, Wienkers, Larry C, Wynalda, Michael A

“…A new and promising group of antibacterial agents, collectively known as the oxazolidinones and exemplified by linezolid (PNU-100766, marketed as Zyvox), have…”
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Structure-Based Design of Nonpeptidic HIV Protease Inhibitors:  The Sulfonamide-Substituted Cyclooctylpyranones by Skulnick, Harvey I, Johnson, Paul D, Aristoff, Paul A, Morris, Jeanette K, Lovasz, Kristine D, Howe, W. Jeffrey, Watenpaugh, Keith D, Janakiraman, Musiri N, Anderson, David J, Reischer, Robert J, Schwartz, Theresa M, Banitt, Lee S, Tomich, Paul K, Lynn, Janet C, Horng, Miao-Miao, Chong, Kong-Teck, Hinshaw, Roger R, Dolak, Lester A, Seest, Eric P, Schwende, Francis J, Rush, Bob D, Howard, Gina M, Toth, Lisa N, Wilkinson, Karen R, Kakuk, Thomas J, Johnson, Carol W, Cole, Serena L, Zaya, Renee M, Zipp, Gail L, Possert, Peggy L, Dalga, Robert J, Zhong, Wei-Zhu, Williams, Marta G, Romines, Karen R

“…Recently, cyclooctylpyranone derivatives with m-carboxamide substituents (e.g. 2c) were identified as potent, nonpeptidic HIV protease inhibitors, but these…”
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Carbon–carbon-linked (pyrazolylphenyl)oxazolidinones with antibacterial activity against multiple drug resistant gram-positive and fastidious gram-negative bacteria by Lee, Chi Sing, Allwine, Debra A, Barbachyn, Michael R, Grega, Kevin C, Dolak, Lester A, Ford, Charles W, Jensen, Randy M, Seest, Eric P, Hamel, Judith C, Schaadt, Ronda D, Stapert, Douglas, Yagi, Betty H, Zurenko, Gary E, Genin, Michael J

“…In an effort to expand the spectrum of activity of the oxazolidinone class of antibacterial agents to include Gram-negative bacteria, a series of new…”
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Identification of novel potent hydroxamic acid inhibitors of peptidyl deformylase and the importance of the hydroxamic acid functionality on inhibition by Thorarensen, Atli, Douglas, Jr, Martin R., Rohrer, Douglas C., Vosters, Anne F., Yem, Anthony W., Marshall, Vincent D., Lynn, Janet C., Bohanon, Michael J., Tomich, Paul K., Zurenko, Gary E., Sweeney, Michael T., Jensen, Randy M., Nielsen, James W., Seest, Eric P., Dolak, Lester A.

“…Peptidyl deformylase (PDF) is a metallo protease that catalyzes the removal of a formyl group from the N-termini of prokaryotic prepared polypeptides, an…”
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The Effect on Naturally Occurring Naphthoquinones on Velvetleaf (Abutilon theophrasti) Germination by Spencer, Gayland F, Tjarks, Larry W, England, Roger E, Seest, Eric P

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Structure-Based Design of HIV Protease Inhibitors:  Sulfonamide-Containing 5,6-Dihydro-4-hydroxy-2-pyrones as Non-Peptidic Inhibitors by Thaisrivongs, Suvit, Skulnick, Harvey I, Turner, Steve R, Strohbach, Joseph W, Tommasi, Ruben A, Johnson, Paul D, Aristoff, Paul A, Judge, Thomas M, Gammill, Ronald B, Morris, Jeanette K, Romines, Karen R, Chrusciel, Robert A, Hinshaw, Roger R, Chong, Kong-Teck, Tarpley, W. Gary, Poppe, Susan M, Slade, David E, Lynn, Janet C, Horng, Miao-Miao, Tomich, Paul K, Seest, Eric P, Dolak, Lester A, Howe, W. Jeffrey, Howard, Gina M, Schwende, Francis J, Toth, Lisa N, Padbury, Guy E, Wilson, Grace J, Shiou, Lihua, Zipp, Gail L, Wilkinson, Karen F, Rush, Bob D, Ruwart, Mary J, Koeplinger, Kenneth A, Zhao, Zhiyang, Cole, Serena, Zaya, Renee M, Kakuk, Thomas J, Janakiraman, Musiri N, Watenpaugh, Keith D

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Stereoselective Synthesis of Furo[2,3-c]pyridine Pyrimidine Thioethers, A New Class of Potent HIV-1 Non-nucleoside Reverse Transcriptase Inhibitors by Wishka, Donn G, Graber, David R, Seest, Eric P, Dolak, Lester A, Han, Fusen, Watt, William, Morris, Joel

“…An efficient stereoselective total synthesis of the furo[2,3-c]pyridine thiopyrimidine HIV-1 reverse transcriptase inhibitors, PNU-142721 and PNU-109886, has…”
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The effect of remote chirality on the antibacterial activity of indolinyl, tetrahydroquinolyl and dihydrobenzoxazinyl oxazolidinones by Ciske, Fred L, Barbachyn, Michael R, Genin, Michael J, Grega, Kevin C, Lee, Chi Sing, Dolak, Lester A, Seest, Eric P, Watt, William, Adams, Wade J, Friis, Janice M, Ford, Charles W, Zurenko, Gary E

“…The oxazolidinones are promising agents for the treatment of infections caused by gram-positive bacteria, including multidrug-resistant strains. In ongoing…”
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(-)-6-Chloro-2-[(1-furo[2,3-c] pyridin-5-yl-ethyl)thio]-4-p yrimidinamine, PNU-142721, a New Broad Spectrum HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitor by Wishka, D G, Graber, DR, Kopta, LA, Olmsted, R A, Friis, J M, Hosley, J D, Adams, W J, Seest, E P, Castle, T M, Dolak, LA, Keiser, B J, Yagi, Yoshihiko, Jeganathan, A, Schlachter, ST

“…Considerable effort has been focused over the past decade on the development of the HIV-1 specific non-nucleoside reverse transcriptase inhibitors (NNRTIs),…”
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Structure-based design of nonpeptidic HIV protease inhibitors: the sulfonamide-substituted cyclooctylpyramones by Skulnick, H I, Johnson, P D, Aristoff, P A, Morris, J K, Lovasz, K D, Howe, W J, Watenpaugh, K D, Janakiraman, M N, Anderson, D J, Reischer, R J, Schwartz, T M, Banitt, L S, Tomich, P K, Lynn, J C, Horng, M M, Chong, K T, Hinshaw, R R, Dolak, L A, Seest, E P, Schwende, F J, Rush, B D, Howard, G M, Toth, L N, Wilkinson, K R, Romines, K R

“…Recently, cyclooctylpyranone derivatives with m-carboxamide substituents (e.g. 2c) were identified as potent, nonpeptidic HIV protease inhibitors, but these…”
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(−)-6-Chloro-2-[(1-furo[2,3-c]pyridin-5-ylethyl)thio]-4-pyrimidinamine, PNU-142721, a New Broad Spectrum HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitor by Wishka, Donn G, Graber, David R, Kopta, Laurice A, Olmsted, Robert A, Friis, Janice M, Hosley, John D, Adams, Wade J, Seest, Eric P, Castle, Thomas M, Dolak, Lester A, Keiser, Barbara J, Yagi, Yoshihiko, Jeganathan, Azhwarsamy, Schlachter, Stephen T, Murphy, Michael J, Cleek, Gary J, Nugent, Richard A, Poppe, Susan M, Swaney, Steven M, Han, Fusen, Watt, William, White, Wendy L, Poel, Toni-Jo, Thomas, Richard C, Voorman, Richard L, Stefanski, Kevin J, Stehle, Randall G, Tarpley, W. Gary, Morris, Joel

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A Facile Asymmetric Synthesis of 1,2,3-Substituted Indenes by Romines, Karen R, Lovasz, Kristine D, Mizsak, Stephen A, Morris, Jeanette K, Seest, Eric P, Han, Fusen, Tulinsky, John, Judge, Thomas M, Gammill, Ronald B

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Isolation and 1H and 13C NMR of Ammiol and Khellol Glucosides by Tjarks, Larry W, Spencer, Gayland F, Seest, Eric P

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Asymmetric Synthesis of an HIV Protease Inhibitor via a Novel .alpha.-Oxoketene/Ketene [4 + 2] Cycloaddition Reaction by Gammill, Ronald B, Judge, Thomas M, Phillips, Gillian, Zhang, Qingwei, Sowell, C. Gregory, Cheney, B. Vernon, Mizsak, Stephen A, Dolak, Lester A, Seest, Eric P

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