Predictors of the yield of mobilized peripheral blood CD34+ cells in HLA-matched sibling donor

Predictors of the yield of mobilized peripheral blood CD34+ cells in HLA-matched sibling donor

Abstract We examined the donor factors that may affect the yield of peripheral blood stem cell (PBSC) mobilized from healthy donors. Pre-apheresis PB-CD34+ cell count was the only factor that correlated with PBSC yield. Leukocyte count (LC) and monocyte count (MC) correlated with PB-CD34+ cell. Male...

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Bibliographic Details
Published in:Transfusion and apheresis science Vol. 49; no. 3; pp. 583 - 589
Main Authors: Fadilah, S.A.W, Mohd-Razif, M.I, Seery, Z.A.Z, Nor-Rafeah, T, Wan-Fariza, W.J, Habsah, A, Leong, C.F
Format: Journal Article
Language:English
Published: England Elsevier Ltd 01-12-2013
Subjects:
Adolescent
Adult
Antigens, CD34 - immunology
Blood Component Removal - methods
Child
Female
Health technology assessment
Healthy donors
Hematology, Oncology and Palliative Medicine
Hematopoietic Stem Cell Mobilization - methods
HLA Antigens - immunology
Humans
Male
Middle Aged
Peripheral blood CD34+ cell count
Peripheral blood stem cell (PBSC) mobilization
Peripheral Blood Stem Cell Transplantation - methods
Retrospective Studies
Siblings
Tissue Donors
Young Adult
Peripheral blood CD34 + cell count
Healthy donors
Peripheral blood stem cell (PBSC) mobilization
Peripheral blood CD34+ cell count
Peripheral blood CD34(+) cell count
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Summary:Abstract We examined the donor factors that may affect the yield of peripheral blood stem cell (PBSC) mobilized from healthy donors. Pre-apheresis PB-CD34+ cell count was the only factor that correlated with PBSC yield. Leukocyte count (LC) and monocyte count (MC) correlated with PB-CD34+ cell. Male gender and PB-CD34+ cell count of at least 87.1/μL and 69.8/μL on day-4 and -5 of G-CSF were associated with the ability to harvest at least 5 × 106 /kg CD34+ cells after one apheresis. We concluded that gender and PB-CD34+ cell count are important predictors of PBSC yield. LC and MC may serve as surrogate markers for estimating the PB-CD34+ cell count.
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ISSN:1473-0502
1878-1683
DOI:10.1016/j.transci.2013.07.032