Search Results - "Seergobin, Ken N"

Alprazolam Reduces Freezing of Gait (FOG) and Improves FOG-Related Gait Deficiencies by Al Jaja, Abdullah, Sue, Téa, Prenger, Margaret, Seergobin, Ken N., Grahn, Jessica A., MacDonald, Penny A.

“…Background. Freezing of gait (FOG) is an intractable motor symptom in Parkinson’s disease (PD) that increases fall risk and impairs the quality of life. FOG…”
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Biomarkers of Parkinson's disease: Striatal sub-regional structural morphometry and diffusion MRI by Khan, Ali R., Hiebert, Nole M., Vo, Andrew, Wang, Brian T., Owen, Adrian M., Seergobin, Ken N., MacDonald, Penny A.

“…Parkinson's disease (PD) is a progressive neurological disorder that has no reliable biomarkers. The aim of this study was to explore the potential of…”
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Pramipexole Impairs Stimulus-Response Learning in Healthy Young Adults by Gallant, Haley, Vo, Andrew, Seergobin, Ken N, MacDonald, Penny A

“…Dopaminergic therapy has paradoxical effects on cognition in Parkinson's disease (PD) patients, with some functions worsened and others improved. The dopamine…”
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Differential effects of Parkinson's disease and dopamine replacement on memory encoding and retrieval by MacDonald, Alex A, Seergobin, Ken N, Owen, Adrian M, Tamjeedi, Ruzbeh, Monchi, Oury, Ganjavi, Hooman, MacDonald, Penny A

“…Increasingly memory deficits are recognized in Parkinson's disease (PD). In PD, the dopamine-producing cells of the substantia nigra (SN) are significantly…”
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Dopaminergic Therapy Increases Go Timeouts in the Go/No-Go Task in Patients with Parkinson's Disease by Yang, Xue Q, Lauzon, Brian, Seergobin, Ken N, MacDonald, Penny A

“…Parkinson's disease (PD) is characterized by resting tremor, rigidity and bradykinesia. Dopaminergic medications such as L-dopa treat these motor symptoms, but…”
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Increased mean diffusivity of the caudal motor SNc identifies patients with REM sleep behaviour disorder and Parkinson’s disease by Alushaj, Erind, Hemachandra, Dimuthu, Ganjavi, Hooman, Seergobin, Ken N., Sharma, Manas, Kashgari, Alia, Barr, Jennifer, Reisman, William, Khan, Ali R., MacDonald, Penny A.

“…Idiopathic rapid eye movement sleep behaviour disorder (iRBD)—a Parkinson’s disease (PD) prodrome—might exhibit neural changes similar to those in PD…”
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Dopaminergic medication impairs feedback-based stimulus-response learning but not response selection in Parkinson's disease by Vo, Andrew, Hiebert, Nole M, Seergobin, Ken N, Solcz, Stephanie, Partridge, Allison, MacDonald, Penny A

“…Cognitive dysfunction is a feature of Parkinson's Disease (PD). Some cognitive functions are impaired by dopaminergic medications prescribed to address the…”
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Striatum-Mediated Deficits in Stimulus-Response Learning and Decision-Making in OCD by Hiebert, Nole M, Lawrence, Marc R, Ganjavi, Hooman, Watling, Mark, Owen, Adrian M, Seergobin, Ken N, MacDonald, Penny A

“…Obsessive compulsive disorder (OCD) is a prevalent psychiatric disorder characterized by obsessions and compulsions. Studies investigating symptomatology and…”
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SLC6A3 Polymorphism Predisposes to Dopamine Overdose in Parkinson's Disease by Robertson, Brian D, Al Jaja, Abdullah S, MacDonald, Alex A, Hiebert, Nole M, Tamjeedi, Ruzbeh, Seergobin, Ken N, Schwarz, Ute I, Kim, Richard B, MacDonald, Penny A

“…In Parkinson's disease (PD), cognitive functions mediated by brain regions innervated by ventral tegmental area (VTA) worsen with dopamine replacement therapy,…”
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Establishing the Roles of the Dorsal and Ventral Striatum in Humor Comprehension and Appreciation with fMRI by Prenger, Margaret, Gilchrist, Madeline, Van Hedger, Kathryne, Seergobin, Ken N, Owen, Adrian M, MacDonald, Penny A

“…Humor comprehension (i.e., getting a joke) and humor appreciation (i.e., enjoying a joke) are distinct, cognitively complex processes. Functional magnetic…”
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Independent effects of age and levodopa on reversal learning in healthy volunteers by Vo, Andrew, Seergobin, Ken N., MacDonald, Penny A.

“…The dopamine overdose hypothesis has provided an important theoretical framework for understanding cognition in Parkinson's disease. It posits that effects of…”
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Levodopa impairs probabilistic reversal learning in healthy young adults by Vo, Andrew, Seergobin, Ken N., Morrow, Sarah A., MacDonald, Penny A.

“…Rationale Dopaminergic therapy improves some cognitive functions and worsens others in patients with Parkinson’s disease (PD). These paradoxical effects are…”
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Effects of levodopa on stimulus-response learning versus response selection in healthy young adults by Vo, Andrew, Seergobin, Ken N., MacDonald, Penny A.

“…•A single first dose of levodopa impaired learning of stimulus-response associations.•Levodopa did not affect enactment of learned stimulus-specific…”
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The effect of dopamine therapy on ventral and dorsal striatum-mediated cognition in Parkinson's disease: support from functional MRI by MACDONALD, Penny A, MACDONALD, Alex A, SEERGOBIN, Ken N, TAMJEEDI, Ruzbeh, GANJAVI, Hooman, PROVOST, Jean-Sebastien, MONCHI, Oury

“…The central aim of our study was to elucidate functions mediated by the ventral and dorsal striatum, respectively, to better understand the cognitive effects…”
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Dorsal striatum mediates cognitive control, not cognitive effort per se, in decision-making: An event-related fMRI study by Robertson, Brian D., Hiebert, Nole M., Seergobin, Ken N., Owen, Adrian M., MacDonald, Penny A.

“…Whether the dorsal striatum (DS) mediates cognitive control or cognitive effort per se in decision-making is unclear given that these effects are highly…”
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Dorsal striatum does not mediate feedback-based, stimulus-response learning: An event-related fMRI study in patients with Parkinson's disease tested on and off dopaminergic therapy by Hiebert, Nole M., Owen, Adrian M., Ganjavi, Hooman, Mendonça, Daniel, Jenkins, Mary E., Seergobin, Ken N., MacDonald, Penny A.

“…Learning associations between stimuli and responses is essential to everyday life. Dorsal striatum (DS) has long been implicated in stimulus-response learning,…”
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Striatum in stimulus–response learning via feedback and in decision making by Hiebert, Nole M., Vo, Andrew, Hampshire, Adam, Owen, Adrian M., Seergobin, Ken N., MacDonald, Penny A.

“…Cognitive deficits are recognized in Parkinson's disease. Understanding cognitive functions mediated by the striatum can clarify some of these impairments and…”
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Parkinson's disease duration determines effect of dopaminergic therapy on ventral striatum function by MacDonald, Alex A., Monchi, Oury, Seergobin, Ken N., Ganjavi, Hooman, Tamjeedi, Ruzbeh, MacDonald, Penny A.

“…We investigated the hypothesis that variation in endogenous dopamine (DA) across brain regions explains dissimilar effects of dopaminergic therapy on aspects…”
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Dorsal striatum mediates deliberate decision making, not late‐stage, stimulus–response learning by Hiebert, Nole M., Owen, Adrian M., Seergobin, Ken N., MacDonald, Penny A.

“…We investigated a controversy regarding the role of the dorsal striatum (DS) in deliberate decision‐making versus late‐stage, stimulus–response learning to the…”
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Pramipexole Increases Go Timeouts but Not No-go Errors in Healthy Volunteers by Yang, Xue Qing, Glizer, Daniel, Vo, Andrew, Seergobin, Ken N, MacDonald, Penny A

“…Parkinson's disease (PD) is characterized by motor symptoms, such as resting tremor, bradykinesia and rigidity, but also features non-motor complications. PD…”
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