Search Results - "Seemayer, Christian"

Macroautophagy in Dendritic Cells Controls the Homeostasis and Stability of Regulatory T Cells by Niven, Jennifer, Madelon, Natacha, Page, Nicolas, Caruso, Assunta, Harlé, Guillaume, Lemeille, Sylvain, Seemayer, Christian A., Hugues, Stéphanie, Gannagé, Monique

“…Regulatory T cells (Tregs) play a crucial role in controlling autoimmune and inflammatory responses. Recent studies have demonstrated that dendritic cells…”
Get full text

The severity of experimental arthritis is independent of IL-36 receptor signaling by Lamacchia, Céline, Palmer, Gaby, Rodriguez, Emiliana, Martin, Praxedis, Vigne, Solenne, Seemayer, Christian A, Talabot-Ayer, Dominique, Towne, Jennifer E, Gabay, Cem

“…Interleukin (IL)-36 refers to three related IL-1 family cytokines, IL-36α, IL-36β, and IL-36γ, that bind to the IL-36 receptor (IL-36R). IL-36 exerts…”
Get full text

GLPG1205 for idiopathic pulmonary fibrosis: a phase 2 randomised placebo-controlled trial by Strambu, Irina R, Seemayer, Christian A, Fagard, Liesbeth M-C A, Ford, Paul A, Van der Aa, Tom A K, de Haas-Amatsaleh, Angela A, Modgill, Vikas, Santermans, Eva, Sondag, Eric N, Helmer, Eric G, Maher, Toby M, Costabel, Ulrich, Cottin, Vincent

“…GLPG1205 is a selective functional antagonist of G-protein-coupled receptor 84, which plays an important role in fibrotic processes. This study assessed the…”
Get full text

Deficiency in IL-1 Receptor Type 2 Aggravates K/BxN Serum Transfer-Induced Arthritis in Mice but Has No Impact on Systemic Inflammatory Responses by Martin, Praxedis, Palmer, Gaby, Rodriguez, Emiliana, Seemayer, Christian Alexander, Palomo, Jennifer, Talabot-Ayer, Dominique, Gabay, Cem

“…The biological activity of IL-1 is tightly regulated by the specific receptor antagonist (IL-1Ra) and the decoy receptor IL-1 receptor type 2 (IL-1R2). The…”
Get full text

Dexamethasone-containing PLGA superparamagnetic microparticles as carriers for the local treatment of arthritis by Butoescu, Nicoleta, Seemayer, Christian A, Foti, Michelangelo, Jordan, Olivier, Doelker, Eric

“…Abstract Superparamagnetic iron oxide nanoparticles (SPIONs) are attractive materials that have been widely used in medicine for diagnostic imaging and…”
Get full text

Modeling the Effect of the Selective S1P1 Receptor Modulator Ponesimod on Subsets of Blood Lymphocytes by Lott, Dominik, Krause, Andreas, Seemayer, Christian A., Strasser, Daniel S., Dingemanse, Jasper, Lehr, Thorsten

“…Purpose This analysis aimed at describing the effect of the selective sphingosine-1-phosphate receptor 1 modulator ponesimod on lymphocyte subsets in…”
Get full text

Effect of particle size on the biodistribution of nano- and microparticles following intra-articular injection in mice by Pradal, Julie, Maudens, Pierre, Gabay, Cem, Seemayer, Christian Alexander, Jordan, Olivier, Allémann, Eric

“…Intra-articular injection of drug delivery systems: retention in the joint cavity or elimination through blood and lymphatic pathways depending on the size of…”
Get full text

The Induction of Matrix Metalloproteinase and Cytokine Expression in Synovial Fibroblasts Stimulated with Immune Cell Microparticles by Jörg H. W. Distler, Jüngel, Astrid, Huber, Lars C., Seemayer, Christian A., Reich, Charles F., Gay, Renate E., Michel, Beat A., Fontana, Adriano, Gay, Steffen, Pisetsky, David S., Distler, Oliver, Dinarello, Charles A.

“…Rheumatoid arthritis is a chronic inflammatory disease characterized by destruction of cartilage and bone that is mediated by synovial fibroblasts. To…”
Get full text

Synovial tissues concentrate secreted APRIL by Gabay, Cem, Krenn, Veit, Bosshard, Carine, Seemayer, Christian Alexander, Chizzolini, Carlo, Huard, Bertrand

“…A proliferation-inducing ligand (APRIL) from the TNF family, owing to its role in the generation and survival of plasma cells (PCs), is currently targeted for…”
Get full text

C4d staining of renal allograft biopsies: a comparative analysis of different staining techniques by Seemayer, Christian A., Gaspert, Ariana, Nickeleit, Volker, Mihatsch, Michael J.

“…Background. Detection of C4d along peritubular capillaries (PTC) in renal allograft biopsies is an independent prognostic marker of poor long-term graft…”
Get full text

Disease severity in K/BxN serum transfer-induced arthritis is not affected by IL-33 deficiency by Martin, Praxedis, Talabot-Ayer, Dominique, Seemayer, Christian Alexander, Vigne, Solenne, Lamacchia, Céline, Rodriguez, Emiliana, Finckh, Axel, Smith, Dirk E, Gabay, Cem, Palmer, Gaby

“…Interleukin (IL)-33 is a cytokine of the IL-1 family, which signals through the ST2 receptor. Previous work suggested implication of the IL-33/ST2 axis in the…”
Get full text

Mice deficient in hepatocyte‐specific IL‐1Ra show delayed resolution of concanavalin A‐induced hepatitis by Lamacchia, Céline, Rodriguez, Emiliana, Palmer, Gaby, Vesin, Christian, Seemayer, Christian A., Rubbia‐Brandt, Laura, Gabay, Cem

“…Interleukin‐1 receptor antagonist (IL‐1Ra) is a specific IL‐1 inhibitor that possesses anti‐inflammatory activities. Several studies in human and mouse…”
Get full text

Magnetically retainable microparticles for drug delivery to the joint: efficacy studies in an antigen-induced arthritis model in mice by Butoescu, Nicoleta, Seemayer, Christian A, Palmer, Gaby, Guerne, Pierre-André, Gabay, Cem, Doelker, Eric, Jordan, Olivier

“…Conventional corticosteroid suspensions for the intra-articular treatment of arthritis suffer from limitations such as crystal formation or rapid clearance…”
Get full text

Articular inflammation is controlled by myeloid cell-derived interleukin 1 receptor antagonist during the acute phase of arthritis in mice by Lamacchia, Céline, Rodriguez, Emiliana, Palmer, Gaby, Vigne, Solenne, Martin, Praxedis, Talabot-Ayer, Dominique, Seemayer, Christian A, Gabay, Cem

“…To define the cell type (myeloid vs other cells) specific effect of interleukin 1 (IL-1) receptor antagonist (IL-1Ra) deficiency on the acute inflammatory…”
Get more information

[Lys40(Ahx-DTPA-111In)NH2]-Exendin-4 Is a Highly Efficient Radiotherapeutic for Glucagon-Like Peptide-1 Receptor–Targeted Therapy for Insulinoma by WICKI, Andreas, WILD, Damian, CHRISTOFORI, Gerhard, STORCH, Daniel, SEEMAYER, Christian, GOTTHARDT, Martin, BEHE, Martin, KNEIFEL, Stefan, MIHATSCH, Michael J, REUBI, Jean-Claude, MÄCKE, Helmut R

“…Purpose: Although metabolic changes make diagnosis of insulinoma relatively easy, surgical removal is hampered by difficulties in locating it, and there is no…”
Get full text

Close association between HER-2 amplification and overexpression in human tumors of non-breast origin by Tapia, Coya, Glatz, Katharina, Novotny, Hedvika, Lugli, Alessandro, Horcic, Milo, Seemayer, Christian A, Tornillo, Luigi, Terracciano, Luigi, Spichtin, Hanspeter, Mirlacher, Martina, Simon, Ronald, Sauter, Guido

“…The relationship between HER-2 overexpression and gene amplification is well evaluated in breast cancers but remains unclear or controversial in many other…”
Get full text

Autoimmunity and inflammation are independent of class II transactivator type PIV–dependent class II major histocompatibility complex expression in peripheral tissues during collagen‐induced arthritis by Waldburger, Jean‐Marc, Palmer, Gaby, Seemayer, Christian, Lamacchia, Celine, Finckh, Axel, Christofilopoulos, Panayiotis, Baeten, Dominique, Reith, Walter, Gabay, Cem

“…Objective To determine the regulation of class II major histocompatibility complex (MHC) expression in fibroblast‐like synoviocytes (FLS) in order to…”
Get full text

BK virus large T and VP-1 expression in infected human renal allografts by Seemayer, Christian A., Seemayer, Norbert H., Dürmüller, Ursula, Gudat, Fred, Schaub, Stefan, Hirsch, Hans H., Mihatsch, Michael J.

“…Objective. We investigated the expression of early and late phase BK virus (BKV) proteins and their interactions with host cell proteins in renal allografts,…”
Get full text

Detection of synovial macrophages in an experimental rabbit model of antigen-induced arthritis: ultrasmall superparamagnetic iron oxide-enhanced MR imaging by Lutz, Amelie M, Seemayer, Christian, Corot, Claire, Gay, Renate E, Goepfert, Kerstin, Michel, Beat A, Marincek, Borut, Gay, Steffen, Weishaupt, Dominik

“…To evaluate intravenously administered ultrasmall superparamagnetic iron oxide (USPIO) as a marker of macrophage activity in an experimental rabbit model of…”
Get more information

Cartilage Destruction Mediated by Synovial Fibroblasts Does Not Depend on Proliferation in Rheumatoid Arthritis by Seemayer, Christian A., Kuchen, Stefan, Kuenzler, Peter, Řihošková, Veronika, Rethage, Janine, Aicher, Wilhelm K., Michel, Beat A., Gay, Renate E., Kyburz, Diego, Neidhart, Michel, Gay, Steffen

“…The aim of the study was to investigate the relationship between invasion and proliferation in rheumatoid arthritis synovial fibroblasts (RASFs). In vitro ,…”
Get full text