Search Results - "Seemann, Gunnar"

Macrophages Facilitate Electrical Conduction in the Heart by Hulsmans, Maarten, Clauss, Sebastian, Xiao, Ling, Aguirre, Aaron D., King, Kevin R., Hanley, Alan, Hucker, William J., Wülfers, Eike M., Seemann, Gunnar, Courties, Gabriel, Iwamoto, Yoshiko, Sun, Yuan, Savol, Andrej J., Sager, Hendrik B., Lavine, Kory J., Fishbein, Gregory A., Capen, Diane E., Da Silva, Nicolas, Miquerol, Lucile, Wakimoto, Hiroko, Seidman, Christine E., Seidman, Jonathan G., Sadreyev, Ruslan I., Naxerova, Kamila, Mitchell, Richard N., Brown, Dennis, Libby, Peter, Weissleder, Ralph, Swirski, Filip K., Kohl, Peter, Vinegoni, Claudio, Milan, David J., Ellinor, Patrick T., Nahrendorf, Matthias

“…Organ-specific functions of tissue-resident macrophages in the steady-state heart are unknown. Here, we show that cardiac macrophages facilitate electrical…”
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The openCARP simulation environment for cardiac electrophysiology by Plank, Gernot, Loewe, Axel, Neic, Aurel, Augustin, Christoph, Huang, Yung-Lin, Gsell, Matthias A.F., Karabelas, Elias, Nothstein, Mark, Prassl, Anton J., Sánchez, Jorge, Seemann, Gunnar, Vigmond, Edward J.

“…•We present the openCARP simulation environment as a solution that could foster the needs of large parts of the computational cardiac electrophysiology…”
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Slow Conduction in the Border Zones of Patchy Fibrosis Stabilizes the Drivers for Atrial Fibrillation: Insights from Multi-Scale Human Atrial Modeling by Morgan, Ross, Colman, Michael A, Chubb, Henry, Seemann, Gunnar, Aslanidi, Oleg V

“…The genesis of atrial fibrillation (AF) and success of AF ablation therapy have been strongly linked with atrial fibrosis. Increasing evidence suggests that…”
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A Fully-Coupled Electro-Mechanical Whole-Heart Computational Model: Influence of Cardiac Contraction on the ECG by Moss, Robin, Wülfers, Eike Moritz, Schuler, Steffen, Loewe, Axel, Seemann, Gunnar

“…The ECG is one of the most commonly used non-invasive tools to gain insights into the electrical functioning of the heart. It has been crucial as a foundation…”
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Effects of early afterdepolarizations on excitation patterns in an accurate model of the human ventricles by Van Nieuwenhuyse, Enid, Seemann, Gunnar, Panfilov, Alexander V, Vandersickel, Nele

“…Early Afterdepolarizations, EADs, are defined as the reversal of the action potential before completion of the repolarization phase, which can result in…”
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A computational model of rabbit geometry and ECG: Optimizing ventricular activation sequence and APD distribution by Moss, Robin, Wülfers, Eike M, Lewetag, Raphaela, Hornyik, Tibor, Perez-Feliz, Stefanie, Strohbach, Tim, Menza, Marius, Krafft, Axel, Odening, Katja E, Seemann, Gunnar

“…Computational modeling of electrophysiological properties of the rabbit heart is a commonly used way to enhance and/or complement findings from classic lab…”
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Computational modeling of the human atrial anatomy and electrophysiology by Dössel, Olaf, Krueger, Martin W., Weber, Frank M., Wilhelms, Mathias, Seemann, Gunnar

“…This review article gives a comprehensive survey of the progress made in computational modeling of the human atria during the last 10 years. Modeling the…”
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Electro-Mechanical Whole-Heart Digital Twins: A Fully Coupled Multi-Physics Approach by Gerach, Tobias, Schuler, Steffen, Fröhlich, Jonathan, Lindner, Laura, Kovacheva, Ekaterina, Moss, Robin, Wülfers, Eike Moritz, Seemann, Gunnar, Wieners, Christian, Loewe, Axel

“…Mathematical models of the human heart are evolving to become a cornerstone of precision medicine and support clinical decision making by providing a powerful…”
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Patient-Specific Identification of Atrial Flutter Vulnerability-A Computational Approach to Reveal Latent Reentry Pathways by Loewe, Axel, Poremba, Emanuel, Oesterlein, Tobias, Luik, Armin, Schmitt, Claus, Seemann, Gunnar, Dössel, Olaf

“…Atypical atrial flutter (AFlut) is a reentrant arrhythmia which patients frequently develop after ablation for atrial fibrillation (AF). Indeed, substrate…”
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In silico screening of the key cellular remodeling targets in chronic atrial fibrillation by Koivumäki, Jussi T, Seemann, Gunnar, Maleckar, Mary M, Tavi, Pasi

“…Chronic atrial fibrillation (AF) is a complex disease with underlying changes in electrophysiology, calcium signaling and the structure of atrial myocytes. How…”
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Molecular Mechanism of Autosomal Recessive Long QT-Syndrome 1 without Deafness by Oertli, Annemarie, Rinné, Susanne, Moss, Robin, Kääb, Stefan, Seemann, Gunnar, Beckmann, Britt-Maria, Decher, Niels

“…encodes the voltage-gated potassium (Kv) channel KCNQ1, also known as KvLQT1 or Kv7.1. Together with its ß-subunit KCNE1, also denoted as minK, this channel…”
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Hyperinsulinemic Hypoglycemia Associated with a CaV1.2 Variant with Mixed Gain- and Loss-of-Function Effects by Kummer, Sebastian, Rinné, Susanne, Seemann, Gunnar, Bachmann, Nadine, Timothy, Katherine, Thornton, Paul S., Pillekamp, Frank, Mayatepek, Ertan, Bergmann, Carsten, Meissner, Thomas, Decher, Niels

“…The voltage-dependent L-type calcium channel isoform CaV1.2 is critically involved in many physiological processes, e.g., in cardiac action potential…”
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Modeling effects of voltage dependent properties of the cardiac muscarinic receptor on human sinus node function by Moss, Robin, Sachse, Frank B, Moreno-Galindo, Eloy G, Navarro-Polanco, Ricardo A, Tristani-Firouzi, Martin, Seemann, Gunnar

“…The cardiac muscarinic receptor (M2R) regulates heart rate, in part, by modulating the acetylcholine (ACh) activated K+ current IK,ACh through dissociation of…”
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Sodium permeable and “hypersensitive” TREK‐1 channels cause ventricular tachycardia by Decher, Niels, Ortiz‐Bonnin, Beatriz, Friedrich, Corinna, Schewe, Marcus, Kiper, Aytug K, Rinné, Susanne, Seemann, Gunnar, Peyronnet, Rémi, Zumhagen, Sven, Bustos, Daniel, Kockskämper, Jens, Kohl, Peter, Just, Steffen, González, Wendy, Baukrowitz, Thomas, Stallmeyer, Birgit, Schulze‐Bahr, Eric

“…In a patient with right ventricular outflow tract (RVOT) tachycardia, we identified a heterozygous point mutation in the selectivity filter of the…”
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Confocal Microscopy-Based Estimation of Parameters for Computational Modeling of Electrical Conduction in the Normal and Infarcted Heart by Greiner, Joachim, Sankarankutty, Aparna C, Seemann, Gunnar, Seidel, Thomas, Sachse, Frank B

“…Computational modeling is an important tool to advance our knowledge on cardiac diseases and their underlying mechanisms. Computational models of conduction in…”
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Heterogeneous three-dimensional anatomical and electrophysiological model of human atria by Seemann, Gunnar, Höper, Christine, Sachse, Frank B, Dössel, Olaf, Holden, Arun V, Zhang, Henggui

“… model of a human atrial cell. Maximum conductances of…”
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Pharmacologic TWIK-Related Acid-Sensitive K+ Channel (TASK-1) Potassium Channel Inhibitor A293 Facilitates Acute Cardioversion of Paroxysmal Atrial Fibrillation in a Porcine Large Animal Model by Wiedmann, Felix, Beyersdorf, Christoph, Zhou, Xiaobo, Büscher, Antonius, Kraft, Manuel, Nietfeld, Jendrik, Walz, Teo Puig, Unger, Laura A, Loewe, Axel, Schmack, Bastian, Ruhparwar, Arjang, Karck, Matthias, Thomas, Dierk, Borggrefe, Martin, Seemann, Gunnar, Katus, Hugo A, Schmidt, Constanze

“…Background The tandem of P domains in a weak inward rectifying K+ channel (TWIK)-related acid-sensitive K channel (TASK-1; hK 3.1) two-pore-domain potassium…”
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Spatial Patterns of Excitation at Tissue and Whole Organ Level Due to Early Afterdepolarizations by Vandersickel, Nele, Van Nieuwenhuyse, Enid, Seemann, Gunnar, Panfilov, Alexander V

“…Early after depolarizations (EAD) occur in many pathological conditions, such as congenital or acquired channelopathies, drug induced arrhythmias, and several…”
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CVAR-Seg: An Automated Signal Segmentation Pipeline for Conduction Velocity and Amplitude Restitution by Nothstein, Mark, Luik, Armin, Jadidi, Amir, Sánchez, Jorge, Unger, Laura A, Wülfers, Eike M, Dössel, Olaf, Seemann, Gunnar, Schmitt, Claus, Loewe, Axel

“…Rate-varying S1S2 stimulation protocols can be used for restitution studies to characterize atrial substrate, ionic remodeling, and atrial fibrillation risk…”
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Myocyte Remodeling Due to Fibro-Fatty Infiltrations Influences Arrhythmogenicity by De Coster, Tim, Claus, Piet, Seemann, Gunnar, Willems, Rik, Sipido, Karin R, Panfilov, Alexander V

“…The onset of cardiac arrhythmias depends on the electrophysiological and structural properties of cardiac tissue. Electrophysiological remodeling of myocytes…”
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