Search Results - "Seelige, Ruth"

Nrf2 Induces IL-17D to Mediate Tumor and Virus Surveillance by Saddawi-Konefka, Robert, Seelige, Ruth, Gross, Emilie T.E., Levy, Eric, Searles, Stephen C., Washington, Allen, Santosa, Endi K., Liu, Beichen, O’Sullivan, Timothy E., Harismendy, Olivier, Bui, Jack D.

“…Cells undergoing xenobiotic or oxidative stress activate the transcription factor nuclear factor erythroid-derived 2-like 2 (Nrf2), which initiates an…”
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Endothelial CD99 supports arrest of mouse neutrophils in venules and binds to neutrophil PILRs by Goswami, Debashree, März, Sigrid, Li, Yu-Tung, Artz, Annette, Schäfer, Kerstin, Seelige, Ruth, Pacheco-Blanco, Mariana, Jing, Ding, Bixel, Maria Gabriele, Araki, Masatake, Araki, Kimi, Yamamura, Ken-Ichi, Vestweber, Dietmar

“…CD99 is a crucial regulator of the transmigration (diapedesis) of leukocytes through the blood vessel wall. Here, we report that CD99 acts at 2 different steps…”
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Cutting edge: Endothelial-specific gene ablation of CD99L2 impairs leukocyte extravasation in vivo by Seelige, Ruth, Natsch, Christiane, März, Sigrid, Jing, Ding, Frye, Maike, Butz, Stefan, Vestweber, Dietmar

“…CD99-like 2 (CD99L2) is a membrane protein with moderate sequence homology to CD99, which initiates cell aggregation of transfected cells and that is strongly…”
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Heparan sulfate expression in the neural crest is essential for mouse cardiogenesis by Pan, Yi, Carbe, Christian, Kupich, Sabine, Pickhinke, Ute, Ohlig, Stefanie, Frye, Maike, Seelige, Ruth, Pallerla, Srinivas R., Moon, Anne M., Lawrence, Roger, Esko, Jeffrey D., Zhang, Xin, Grobe, Kay

“…Impaired heparan sulfate (HS) synthesis in vertebrate development causes complex malformations due to the functional disruption of multiple HS-binding growth…”
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Role of the Heparan Sulfate Proteoglycan Syndecan-1 (CD138) in Delayed-Type Hypersensitivity by Masouleh, Behzad Kharabi, Ten Dam, Gerdy B, Wild, Martin K, Seelige, Ruth, van der Vlag, Johan, Rops, Angelique L, Echtermeyer, Frank G, Vestweber, Dietmar, van Kuppevelt, Toin H, Kiesel, Ludwig, Gotte, Martin

“…The cell surface heparan sulfate proteoglycan syndecan-1 (CD138) modulates the activity of chemokines, cytokines, integrins, and other adhesion molecules which…”
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Cell death-inducing reagents activate cancer immune surveillance via inducing Interleukin-17D in macrophages by Seelige, Ruth, Bui, Jack D.

“…We have previously established a role for the cytokine IL-17D during cancer immune surveillance in that its cancer-intrinsic expression recruits NK cells into…”
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Mechanisms regulating immune surveillance of cellular stress in cancer by Seelige, Ruth, Searles, Stephen, Bui, Jack D.

“…The purpose of this review is to explore immune-mediated mechanisms of stress surveillance in cancer, with particular emphasis on the idea that all cancers…”
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Innate sensing of cancer's non-immunologic hallmarks by Seelige, Ruth, Searles, Stephen, Bui, Jack D

“…•The cancer cell as a sensing innate cell.•Cancer cells sense intrinsic and extrinsic non-immunologic hallmarks.•Cancer cells sense nucleic acids, proteotoxic…”
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Immuno-oncological Efficacy of RXDX-106, a Novel TAM (TYRO3, AXL, MER) Family Small-Molecule Kinase Inhibitor by Yokoyama, Yumi, Lew, Erin D, Seelige, Ruth, Tindall, Elizabeth A, Walsh, Colin, Fagan, Patrick C, Lee, Jack Y, Nevarez, Robin, Oh, Joanne, Tucker, Kathleen D, Chen, Marissa, Diliberto, Amy, Vaaler, Heather, Smith, Kristen M, Albert, Amanda, Li, Gary, Bui, Jack D

“…Expression of the TAM (TYRO3, AXL, MER) family of receptor tyrosine kinases (RTK) has been associated with cancer progression, metastasis, and drug resistance…”
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CD99L2 deficiency inhibits leukocyte entry into the central nervous system and ameliorates neuroinflammation by Samus, Maryna, Seelige, Ruth, Schäfer, Kerstin, Sorokin, Lydia, Vestweber, Dietmar

“…Leukocyte entry into the CNS is a crucial step in the development of multiple sclerosis and its animal model experimental autoimmune encephalomyelitis (EAE)…”
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The ancient cytokine IL-17D is regulated by Nrf2 and mediates tumor and virus surveillance by Seelige, Ruth, Washington, Allen, Bui, Jack D.

“…Early stage immune responses can dictate the severity and outcome of inflammatory processes such as tumor growth and viral infection. Cytokines such as the…”
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Interleukin-17D and Nrf2 mediate initial innate immune cell recruitment and restrict MCMV infection by Seelige, Ruth, Saddawi-Konefka, Robert, Adams, Nicholas M., Picarda, Gaëlle, Sun, Joseph C., Benedict, Chris A., Bui, Jack D.

“…Innate immune cells quickly infiltrate the site of pathogen entry and not only stave off infection but also initiate antigen presentation and promote adaptive…”
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Nrf2 induces IL-17D to mediate tumor and virus surveillance by Saddawi-Konefka, Robert, Seelige, Ruth, Gross, Emilie T.E., O’Sullivan, Timothy Edward, Harismendy, Olivier, Bui, Jack D

“…Cells undergoing xenobiotic or oxidative stress activate the transcription factor Nrf2, which initiates an intrinsic “stress surveillance” pathway involving…”
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Isoflurane Impacts Murine Melanoma Growth in a Sex-Specific, Immune-Dependent Manner: A Brief Report by Meier, Angela, Gross, Emilie T. E., Schilling, Jan M., Seelige, Ruth, Jung, Yujin, Santosa, Endi, Searles, Stephen, Lin, Tuo, Tu, Xin M., Patel, Hemal H., Bui, Jack D.

“…The impact of volatile anesthetics on cancer progression has been observed for decades, but sex differences have not been described. Male and female immune…”
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Abstract 4698: Immuno-oncological efficacy of RXDX-106, a novel, selective and potent small molecule TAM (TYRO3, AXL, MER) inhibitor by Yokoyama, Yumi, Lew, Erin D., Seelige, Ruth, Walsh, Colin, Barrera, Maria, Tindall, Elizabeth, Oh, Joanne, Ely, Heather, Diliberto, Amy, Albert, Amanda, Bui, Jack, Li, Gary

“…The TAM family of receptor tyrosine kinases (RTKs), TYRO3, AXL, and MER, has been implicated in the pathogenesis and progression of many cancer types. In…”
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The Nrf2/Interleukin-17D axis as a novel target for cancer immune therapy by Seelige, Ruth, Saddawi-Konefka, Robert, Gross, Emilie T.E., Levy, Eric, Searles, Stephen C., Washington, Allen, Santosa, Endi K., Liu, Beichen, O’Sullivan, Timothy E., Harismendy, Olivier, Bui, Jack D

“…The oxidative stress-sensing transcription factor Nrf2 has been studied by cancer researchers as a double-edged sword that can either promote or inhibit…”
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Dual CD47 and PD‐L1 blockade elicits anti‐tumor immunity by intratumoral CD8+ T cells by Christo, Susan N, McDonald, Keely M, Burn, Thomas N, Kurd, Nadia, Stanfield, Jessica, Kaneda, Megan M, Seelige, Ruth, Dillon, Christopher P, Fisher, Timothy S, Baaten, Bas, Mackay, Laura K

“…Objectives Bispecific antibodies targeting CD47 and PD‐L1 (CD47 × PD‐L1 BisAb) demonstrate efficacy against a range of solid cancers. While dual blockade…”
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