Search Results - "Seelen, Marc A."

Age and Sex-Associated Changes of Complement Activity and Complement Levels in a Healthy Caucasian Population by Gaya da Costa, Mariana, Poppelaars, Felix, van Kooten, Cees, Mollnes, Tom E, Tedesco, Francesco, Würzner, Reinhard, Trouw, Leendert A, Truedsson, Lennart, Daha, Mohamed R, Roos, Anja, Seelen, Marc A

“…The complement system is essential for an adequate immune response. Much attention has been given to the role of complement in disease. However, to better…”
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The Complement System in Dialysis: A Forgotten Story? by Poppelaars, Felix, Faria, Bernardo, Gaya da Costa, Mariana, Franssen, Casper F M, van Son, Willem J, Berger, Stefan P, Daha, Mohamed R, Seelen, Marc A

“…Significant advances have lead to a greater understanding of the role of the complement system within nephrology. The success of the first clinically approved…”
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Donor genetic variants in interleukin-6 and interleukin-6 receptor associate with biopsy-proven rejection following kidney transplantation by Poppelaars, Felix, Gaya da Costa, Mariana, Eskandari, Siawosh K., Damman, Jeffrey, Seelen, Marc A.

“…Rejection after kidney transplantation remains an important cause of allograft failure that markedly impacts morbidity. Cytokines are a major player in…”
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Dysregulation of Complement Activation and Placental Dysfunction: A Potential Target to Treat Preeclampsia? by Pierik, E, Prins, Jelmer R, van Goor, Harry, Dekker, Gustaaf A, Daha, Mohamed R, Seelen, Marc A J, Scherjon, Sicco A

“…Preeclampsia is one of the leading causes of maternal and neonatal mortality and morbidity worldwide, affecting 2-8% of all pregnancies. Studies suggest a link…”
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Complement Activation in Inflammatory Skin Diseases by Giang, Jenny, Seelen, Marc A J, van Doorn, Martijn B A, Rissmann, Robert, Prens, Errol P, Damman, Jeffrey

“…The complement system is a fundamental part of the innate immune system, playing a crucial role in host defense against various pathogens, such as bacteria,…”
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Non-invasive quantification of collagen turnover in renal transplant recipients by Stribos, Elisabeth G D, Nielsen, Signe Holm, Brix, Susanne, Karsdal, Morten Asser, Seelen, Marc A, van Goor, Harry, Bakker, Stephan J L, Olinga, Peter, Mutsaers, Henricus A M, Genovese, Federica

“…Kidney allograft failure due to chronic injury/rejection remains the main cause of graft loss in renal transplant recipients (RTR). Here, we investigated…”
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A non-muscle myosin heavy chain 9 genetic variant is associated with graft failure following kidney transplantation by Poppelaars, Felix, Eskandari, Siawosh K, Damman, Jeffrey, Seelen, Marc A, Faria, Bernardo, da Costa, Mariana Gaya

“…Despite current matching efforts to identify optimal donor-recipient pairs for kidney transplantation, alloimmunity remains a major source of late transplant…”
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Soluble CD59 in peritoneal dialysis: a potential biomarker for peritoneal membrane function by Faria, Bernardo, Gaya da Costa, Mariana, Lima, Carla, Willems, Loek, Brandwijk, Ricardo, Berger, Stefan P., Daha, Mohamed R., Pestana, Manuel, Seelen, Marc A., Poppelaars, Felix

“…Introduction Various studies have reported the importance of complement regulators in preventing mesothelial damage during peritoneal dialysis (PD). Its…”
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Functional Studies on Primary Tubular Epithelial Cells Indicate a Tumor Suppressor Role of SETD2 in Clear Cell Renal Cell Carcinoma by Li, Jun, Kluiver, Joost, Osinga, Jan, Westers, Helga, van Werkhoven, Maaike B, Seelen, Marc A, Sijmons, Rolf H, van den Berg, Anke, Kok, Klaas

“…Abstract SET domain-containing 2 ( SETD2 ) is responsible for the trimethylation of histone H3 lysine36 (H3K36me3) and is one of the genes most frequently…”
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Strong predictive value of mannose-binding lectin levels for cardiovascular risk of hemodialysis patients by Poppelaars, Felix, Gaya da Costa, Mariana, Berger, Stefan P, Assa, Solmaz, Meter-Arkema, Anita H, Daha, Mohamed R, van Son, Willem J, Franssen, Casper F M, Seelen, Marc A J

“…Hemodialysis patients have higher rates of cardiovascular morbidity and mortality compared to the general population. Mannose-binding lectin (MBL) plays an…”
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Murine Precision-Cut Kidney Slices as an ex vivo Model to Evaluate the Role of Transforming Growth Factor-β1 Signaling in the Onset of Renal Fibrosis by Stribos, Elisabeth G D, Seelen, Marc A, van Goor, Harry, Olinga, Peter, Mutsaers, Henricus A M

“…Renal fibrosis is characterized by progressive accumulation of extracellular matrix (ECM) proteins, resulting in loss of organ function and eventually…”
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Complement Therapeutics in the Multi-Organ Donor: Do or Don't? by van Zanden, Judith E, Jager, Neeltina M, Daha, Mohamed R, Erasmus, Michiel E, Leuvenink, Henri G D, Seelen, Marc A

“…Over the last decade, striking progress has been made in the field of organ transplantation, such as better surgical expertise and preservation techniques…”
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Intradialytic Complement Activation Precedes the Development of Cardiovascular Events in Hemodialysis Patients by Poppelaars, Felix, Gaya da Costa, Mariana, Faria, Bernardo, Berger, Stefan P, Assa, Solmaz, Daha, Mohamed R, Medina Pestana, José Osmar, van Son, Willem J, Franssen, Casper F M, Seelen, Marc A

“…Hemodialysis (HD) is a life-saving treatment for patients with end stage renal disease. However, HD patients have markedly increased rates of cardiovascular…”
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Complement Activation in Autoimmune Bullous Dermatoses: A Comprehensive Review by Edwards, Gareth, Diercks, Gilles F H, Seelen, Marc A J, Horvath, Barbara, van Doorn, Martijn B A, Damman, Jeffrey

“…Autoimmune bullous dermatoses (AIBD) are characterized by circulating autoantibodies that are either directed against epidermal antigens or deposited as immune…”
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Weak Expression of Terminal Complement in Active Antibody-Mediated Rejection of the Kidney by Tiller, Gesa, Lammerts, Rosa G M, Karijosemito, Jessy J, Alkaff, Firas F, Diepstra, Arjan, Pol, Robert A, Meter-Arkema, Anita H, Seelen, Marc A, van den Heuvel, Marius C, Hepkema, Bouke G, Daha, Mohamed R, van den Born, Jacob, Berger, Stefan P

“…The role of the complement system in antibody-mediated rejection (ABMR) is insufficiently understood. We aimed to investigate the role of local and systemic…”
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Urinary Properdin and sC5b-9 Are Independently Associated With Increased Risk for Graft Failure in Renal Transplant Recipients by Lammerts, Rosa G M, Eisenga, Michele F, Alyami, Mohammed, Daha, Mohamed R, Seelen, Marc A, Pol, Robert A, van den Born, Jacob, Sanders, Jan-Stephan, Bakker, Stephan J L, Berger, Stefan P

“…The pathophysiology of late kidney-allograft failure remains complex and poorly understood. Activation of filtered or locally produced complement may…”
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Factor H and Properdin Recognize Different Epitopes on Renal Tubular Epithelial Heparan Sulfate by Zaferani, Azadeh, Vivès, Romain R., van der Pol, Pieter, Navis, Gerjan J., Daha, Mohamed R., van Kooten, Cees, Lortat-Jacob, Hugues, Seelen, Marc A., van den Born, Jacob

“…During proteinuria, renal tubular epithelial cells become exposed to ultrafiltrate-derived serum proteins, including complement factors. Recently, we showed…”
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Blocking Complement Factor B Activation Reduces Renal Injury and Inflammation in a Rat Brain Death Model by Jager, Neeltina M, van Zanden, Judith E, Subías, Marta, Leuvenink, Henri G D, Daha, Mohamed R, Rodríguez de Córdoba, Santiago, Poppelaars, Felix, Seelen, Marc A

“…The majority of kidneys used for transplantation are retrieved from brain-dead organ donors. In brain death, the irreversible loss of brain functions results…”
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Administration of Intravenous Iron Formulations Induces Complement Activation in-vivo by Faria, Bernardo, Gaya da Costa, Mariana, Poppelaars, Felix, Franssen, Casper F M, Pestana, Manuel, Berger, Stefan P, Daha, Mohamed R, Gaillard, Carlo A J M, Seelen, Marc A

“…Intravenous (IV) iron is widely used to treat anemia in chronic kidney disease patients. Previously, iron formulations were shown to induce immune activation …”
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Identification of Tubular Heparan Sulfate as a Docking Platform for the Alternative Complement Component Properdin in Proteinuric Renal Disease by Zaferani, Azadeh, Vivès, Romain R., van der Pol, Pieter, Hakvoort, Jelleke J., Navis, Gerjan J., van Goor, Harry, Daha, Mohamed R., Lortat-Jacob, Hugues, Seelen, Marc A., van den Born, Jacob

“…Properdin binds to proximal tubular epithelial cells (PTEC) and activates the complement system via the alternative pathway in vitro. Cellular ligands for…”
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