Search Results - "Seeher, Sandra"
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The RNA-binding protein Secisbp2 differentially modulates UGA codon reassignment and RNA decay
Published in Nucleic acids research (20-04-2017)“…Dual-assignment of codons as termination and elongation codons is used to expand the genetic code. In mammals, UGA can be reassigned to selenocysteine during…”
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2
Secisbp2 is essential for embryonic development and enhances selenoprotein expression
Published in Antioxidants & redox signaling (20-08-2014)“…The selenocysteine insertion sequence (SECIS)-binding protein 2 (Secisbp2) binds to SECIS elements located in the 3'-untranslated region of eukaryotic…”
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3
No evidence for XMRV in German CFS and MS patients with fatigue despite the ability of the virus to infect human blood cells in vitro
Published in PloS one (22-12-2010)“…Xenotropic murine leukemia virus-related virus (XMRV), a novel human retrovirus originally identified in prostate cancer tissues, has recently been associated…”
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Reconstitution of the Ancestral Glycoprotein of Human Endogenous Retrovirus K and Modulation of Its Functional Activity by Truncation of the Cytoplasmic Domain
Published in Journal of Virology (15-12-2009)“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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5
Post-transcriptional control of selenoprotein biosynthesis
Published in Current protein & peptide science (01-06-2012)“…Selenoproteins are defined as proteins containing the 21st proteinogenic amino acid, selenocysteine (Sec). Sec is encoded by UGA (STOP) codons which are…”
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Targeted deletion of Secisbp2 reduces, but does not abrogate, selenoprotein expression and leads to striatal interneuron loss
Published in Free radical biology & medicine (01-10-2014)“…Selenoproteins contain the amino acid selenocysteine (Sec). The Sec insertion sequence (SECIS)-binding protein 2 (Secisbp2) binds to SECIS elements in the…”
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S6-2 - Targeted deletion of Secisbp2 reduces, but does not abrogate, selenoprotein expression and leads to striatal interneuron loss
Published in Free radical biology & medicine (01-10-2014)“…Selenoproteins contain the amino acid selenocysteine (Sec). The Sec insertion sequence (SECIS)-binding protein 2 (Secisbp2) binds to SECIS elements in the…”
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8
Ribosome profiling of selenoproteins in vivo reveals consequences of pathogenic Secisbp2 missense mutations
Published in The Journal of biological chemistry (27-09-2019)“…Recoding of UGA codons as selenocysteine (Sec) codons in selenoproteins depends on a selenocysteine insertion sequence (SECIS) in the 3′-UTR of mRNAs of…”
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Impaired selenoprotein expression in brain triggers striatal neuronal loss leading to co-ordination defects in mice
Published in Biochemical journal (15-08-2014)“…Secisbp2 [SECIS (selenocysteine insertion sequence)-binding protein 2] binds to SECIS elements located in the 3'-UTR region of eukaryotic selenoprotein mRNAs…”
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10
Homozygous mutation in TXNRD1 is associated with genetic generalized epilepsy
Published in Free radical biology & medicine (01-05-2017)“…Increased oxidative stress has been widely implicated in the pathogenesis in various forms of human epilepsy. Here, we report a homozygous mutation in TXNRD1…”
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Creating a mouse model for SECISBP2 syndrome
Published in The FASEB journal (01-04-2011)“…SECISBP2 is pivotal in the biosynthesis of proteins containing the amino acid selenocysteine (Sec). Incorporation of Sec into the 25 selenoproteins of the…”
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Contrasting roles of dietary selenium and selenoproteins in chemically induced hepatocarcinogenesis
Published in Carcinogenesis (New York) (01-05-2013)“…Selenium (Se) has long been known for its cancer prevention properties, but the molecular basis remains unclear. The principal questions in assessing the…”
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