Search Results - "Seeger, R C"

Augmented expression of MYC and/or MYCN protein defines highly aggressive MYC-driven neuroblastoma: a Children’s Oncology Group study by Wang, L L, Teshiba, R, Ikegaki, N, Tang, X X, Naranjo, A, London, W B, Hogarty, M D, Gastier-Foster, J M, Look, A T, Park, J R, Maris, J M, Cohn, S L, Seeger, R C, Asgharzadeh, S, Shimada, H

“…Background: MYCN amplification with subsequent MYCN protein overexpression is a powerful indicator of poor prognosis of neuroblastoma patients. Little is known…”
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Evidence for an Age Cutoff Greater Than 365 Days for Neuroblastoma Risk Group Stratification in the Children's Oncology Group by LONDON, W. B, CASTLEBERRY, R. P, COHN, S. L, MATTHAY, K. K, LOOK, A. T, SEEGER, R. C, SHIMADA, H, THORNER, P, BRODEUR, G, MARIS, J. M, REYNOLDS, C. P

“…In the Children's Oncology Group, risk group assignment for neuroblastoma is critical for therapeutic decisions, and patients are stratified by International…”
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Consensus criteria for sensitive detection of minimal neuroblastoma cells in bone marrow, blood and stem cell preparations by immunocytology and QRT-PCR: recommendations by the International Neuroblastoma Risk Group Task Force by Beiske, K, Burchill, S A, Cheung, I Y, Hiyama, E, Seeger, R C, Cohn, S L, Pearson, A D J, Matthay, K K

“…Disseminating disease is a predictive and prognostic indicator of poor outcome in children with neuroblastoma. Its accurate and sensitive assessment can…”
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Increase of Ceramide and Induction of Mixed Apoptosis/Necrosis by N-(4-Hydroxyphenyl)- retinamide in Neuroblastoma Cell Lines by Maurer, Barry J., Metelitsa, Leonid S., Seeger, Robert C., Cabot, Myles C., Reynolds, C. Patrick

“…BACKGROUND: The synthetic retinoid N-(4-hydroxyphenyl)retinamide (4-HPR or fenretinide) is toxic to myeloid leukemia and cervical carcinoma cell lines,…”
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Expression of CD1d by myelomonocytic leukemias provides a target for cytotoxic NKT cells by METELITSA, L. S, WEINBERG, K. I, EMANUEL, P. D, SEEGER, R. C

“…Natural killer T (NKT) cells with an invariant T-cell receptor for alpha-galactosylceramide (alphaGalCer) that is presented by CD1d have been reported to be…”
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Antibody targeting of anaplastic lymphoma kinase induces cytotoxicity of human neuroblastoma by Carpenter, E L, Haglund, E A, Mace, E M, Deng, D, Martinez, D, Wood, A C, Chow, A K, Weiser, D A, Belcastro, L T, Winter, C, Bresler, S C, Asgharzadeh, S, Seeger, R C, Zhao, H, Guo, R, Christensen, J G, Orange, J S, Pawel, B R, Lemmon, M A, Mossé, Y P

“…Anaplastic lymphoma kinase (ALK) is a receptor tyrosine kinase aberrantly expressed in neuroblastoma, a devastating pediatric cancer of the sympathetic nervous…”
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Treatment of High-Risk Neuroblastoma with Intensive Chemotherapy, Radiotherapy, Autologous Bone Marrow Transplantation, and 13-cis-Retinoic Acid by Matthay, Katherine K, Villablanca, Judith G, Seeger, Robert C, Stram, Daniel O, Harris, Richard E, Ramsay, Norma K, Swift, Patrick, Shimada, Hiroyuki, Black, C. Thomas, Brodeur, Garrett M, Gerbing, Robert B, Reynolds, C. Patrick

“…Neuroblastoma, the most common extracranial solid tumor of childhood, has a long-term survival rate of only 15 percent. 1 At diagnosis the defining…”
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Human NKT Cells Mediate Antitumor Cytotoxicity Directly by Recognizing Target Cell CD1d with Bound Ligand or Indirectly by Producing IL-2 to Activate NK Cells by Metelitsa, Leonid S, Naidenko, Olga V, Kant, Anita, Wu, Hong-Wei, Loza, Matthew J, Perussia, Bice, Kronenberg, Mitchell, Seeger, Robert C

“…alpha-Galactosylceramide (alphaGalCer) stimulates NKT cells and has antitumor activity in mice. Murine NKT cells may directly kill tumor cells and induce NK…”
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Successful treatment of stage III neuroblastoma based on prospective biologic staging: a Children's Cancer Group study by Matthay, K K, Perez, C, Seeger, R C, Brodeur, G M, Shimada, H, Atkinson, J B, Black, C T, Gerbing, R, Haase, G M, Stram, D O, Swift, P, Lukens, J N

“…To identify a biologically favorable and unfavorable subset of patients with Evans stage III neuroblastoma and to determine whether treatment stratification…”
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Drug resistance patterns of human neuroblastoma cell lines derived from patients at different phases of therapy by KESHELAVA, N, SEEGER, R. C, GROSHEN, S, REYNOLDS, C. P

“…To determine whether neuroblastomas acquire a sustained drug-resistant phenotype from exposure to chemotherapeutic agents given to patients in vivo, we studied…”
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Gain of chromosome 17 is the most frequent abnormality detected in neuroblastoma by comparative genomic hybridization by Plantaz, D, Mohapatra, G, Matthay, KK, Pellarin, M, Seeger, RC, Feuerstein, BG

“…Neuroblastoma behavior is variable and outcome partially depends on genetic factors. However, tumors that lack high-risk factors such as MYCN amplification or…”
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Consolidation chemoradiotherapy and autologous bone marrow transplantation versus continued chemotherapy for metastatic neuroblastoma: a report of two concurrent Children's Cancer Group studies by Stram, D O, Matthay, K K, O'Leary, M, Reynolds, C P, Haase, G M, Atkinson, J B, Brodeur, G M, Seeger, R C

“…To compare event-free survival (EFS) for patients with stage IV neuroblastoma who were treated with induction chemotherapy followed by additional courses of…”
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Favorable Biology and Outcome of Stage IV-S Neuroblastoma With Supportive Care or Minimal Therapy: A Children’s Cancer Group Study by NICKERSON, H. J, MATTHAY, K. K, LUKENS, J, SEEGER, R. C, BRODEUR, G. M, SHIMADA, H, PEREZ, C, ATKINSON, J. B, SELCH, M, GERBING, R. B, STRAM, D. O

“…Stage IV-S neuroblastoma is a metastatic disease associated with spontaneous regression and good survival, but 10% to 20% of infants die from early…”
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Quantitative Tumor Cell Content of Bone Marrow and Blood as a Predictor of Outcome in Stage IV Neuroblastoma: A Children’s Cancer Group Study by SEEGER, Robert C, REYNOLDS, C. Patrick, GALLEGO, Richard, STRAM, Daniel O, GERBING, Robert B, MATTHAY, Katherine K

“…This study investigated the prognostic value of quantifying tumor cells in bone marrow and blood by immunocytology in children with high-risk, metastatic…”
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Biologic Factors Determine Prognosis in Infants With Stage IV Neuroblastoma: A Prospective Children’s Cancer Group Study by SCHMIDT, M. L, LUKENS, J. N, SEEGER, R. C, BRODEUR, G. M, SHIMADA, H, GERBING, R. B, STRAM, D. O, PEREZ, C, HAASE, G. M, MATTHAY, K. K

“…A prospective Children's Cancer Group study, CCG-3881, has been completed to determine if a more accurate prediction of prognosis by biologic features can…”
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Allelic deletion at 11q23 is common in MYCN single copy neuroblastomas by CHUN GUO, WHITE, P. S, MARIS, J. M, WEISS, M. J, HOGARTY, M. D, THOMPSON, P. M, STRAM, D. O, GERBING, R, MATTHAY, K. K, SEEGER, R. C, BRODEUR, G. M

“…Deletions of the long arm of chromosome 11 (11q) have been noted in primary neuroblastomas, but a comprehensive analysis has not been performed. Therefore, we…”
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Biologic Variables in the Outcome of Stages I and II Neuroblastoma Treated With Surgery as Primary Therapy: A Children’s Cancer Group Study by PEREZ, C. A, MATTHAY, K. K, ATKINSON, J. B, SEEGER, R. C, SHIMADA, H, HAASE, G. M, STRAM, D. O, GERBING, R. B, LUKENS, J. N

“…To determine prospectively whether surgery alone is sufficient therapy for Evans stages I and II neuroblastoma and to define biologic and clinical features…”
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Lack of high-affinity nerve growth factor receptors in aggressive neuroblastomas by Suzuki, T, Bogenmann, E, Shimada, H, Stram, D, Seeger, R C

“…Neuroblastoma is a malignancy of the sympathetic nervous system. Nerve growth factor, which has a major role in development of the sympathetic nervous system,…”
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Metastatic sites in stage IV and IVS neuroblastoma correlate with age, tumor biology, and survival by DUBOIS, S. G, KALIKA, Y, GERBING, R, STRAM, D. O, MATTHAY, K. K, LUKENS, J. N, BRODEUR, G. M, SEEGER, R. C, ATKINSON, J. B, HAASE, G. M, BLACK, C. T, PEREZ, C, SHIMADA, H

“…The goal of this study was to determine the incidence of metastatic sites in neuroblastoma and the extent to which metastatic sites correlate with age, tumor…”
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Matrix metalloproteinases-2 and -9 are expressed in human neuroblastoma : Contribution of stromal cells to their production and correlation with metastasis by SUGIURA, Y, SHIMADA, H, SEEGER, R. C, LAUG, W. E, DECLERCK, Y. A

“…Neuroblastoma, the second most common solid childhood tumor, can be a highly invasive and metastatic form of cancer. To assess the role of matrix-degrading…”
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