Search Results - "Seeger, Mary"

Endoproteolysis of Presenilin 1 and Accumulation of Processed Derivatives In Vivo by Thinakaran, Gopal, Borchelt, David R, Lee, Michael K, Slunt, Hilda H, Spitzer, Lia, Kim, Grace, Ratovitsky, Tamara, Davenport, Frances, Nordstedt, Christer, Seeger, Mary, Hardy, John, Levey, Allan I, Gandy, Samuel E, Jenkins, Nancy A, Copeland, Neal G, Price, Donald L, Sisodia, Sangram S

“…The majority of early-onset cases of familial Alzheimer's disease (FAD) are linked to mutations in two related genesPS1 and PS2, located on chromosome 14 and…”
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Expression of Presenilin 1 and 2 (PS1 and PS2) in Human and Murine Tissues by Lee, Michael K, Slunt, Hilda H, Martin, Lee J, Thinakaran, Gopal, Kim, Grace, Gandy, Samuel E, Seeger, Mary, Koo, Edward, Price, Donald L, Sisodia, Sangram S

“…Mutations in genes encoding related proteins, termed presenilin 1 (PS1) and presenilin 2 (PS2), are linked to the majority of cases with early-onset familial…”
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Evidence for Phosphorylation and Oligomeric Assembly of Presenilin 1 by Seeger, Mary, Nordstedt, Christer, Petanceska, Suzana, Kovacs, Dora M., Gouras, Gunnar K., Hahne, Solveig, Fraser, Paul, Levesque, Lyne, Czernik, Andrew J., St George-Hyslop, Peter, Sisodia, Sangram S., Thinakaran, Gopal, Tanzi, Rudolph E., Greengard, Paul, Gandy, Sam

“…Pathogenic mutations in presenilin 1 (PS1) are associated with ≈ 50% of early-onset familial Alzheimer disease. PS1 is endoproteolytically cleaved to yield a…”
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Estrogen reduces neuronal generation of Alzheimer β-amyloid peptides by Xu, Huaxi, Gouras, Gunnar K, Greenfield, Jeffrey P, Vincent, Bruno, Naslund, Jan, Mazzarelli, Louis, Fried, Gabriel, Jovanovic, Jasmina N, Seeger, Mary, Relkin, Norman R, Liao, Fang, Checler, Frédéric, Buxbaum, Joseph D, Chait, Brian T, Thinakaran, Gopal, Sisodia, Sangram S, Wang, Rong, Greengard, Paul, Gandy, Sam

“…Alzheimer's disease (AD) is characterized by the accumulation of cerebral plaques composed of 40- and 42-amino acid beta-amyloid (Abeta) peptides, and…”
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Protein Topology of Presenilin 1 by Doan, Andrew, Thinakaran, Gopal, Borchelt, David R, Slunt, Hilda H, Ratovitsky, Tamara, Podlisny, Marcia, Selkoe, Dennis J, Seeger, Mary, Gandy, Samuel E, Price, Donald L, Sisodia, Sangram S

“…Mutations in a gene encoding a multitransmembrane protein, termed presenilin 1 (PS1), are causative in the majority of early-onset cases of AD. To determine…”
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Mutant Presenilin 1 Increases the Levels of Alzheimer Amyloid β‐Peptide Aβ42 in Late Compartments of the Constitutive Secretory Pathway by Petanceska, Suzana S., Seeger, Mary, Checler, Frederic, Gandy, Sam

“…: Mutations in the presenilin 1 (PS1) gene are associated with autosomal dominant, early‐onset, familial Alzheimer's disease and result in increased release of…”
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Performance evaluation of the ADVIA Centaur® anti-HBe and HBeAg assays by van Helden, Josef, Cornely, Carl, Dati, Francesco, Levy, H. Roma, Bal, Tricia, Seeger, Mary, Wright, Theodore, Baker, Lawrence

“…Abstract Background Detection of HBeAg and anti-HBe is valuable for the evaluation and therapeutic management of hepatitis B infection. Objectives To determine…”
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Clathrin-Dependent Localization of α1,3 Mannosyltransferase to the Golgi Complex of Saccharomyces cerevisiae by Graham, Todd R., Seeger, Mary, Payne, Gregory S., MacKay, Vivian L., Emr, Scott D.

“…Posttranslational modification of yeast glycoproteins with α1,3-linked mannose is initiated within a Golgi compartment analogous to the medial Golgi cisternae…”
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Mutant Presenilin 1 Increases the Levels of Alzheimer Amyloid beta -Peptide A beta 42 in Late Compartments of the Constitutive Secretory Pathway by Petanceska, S S, Seeger, M, Checler, F, Gandy, S

“…Mutations in the presenilin 1 (PS1) gene are associated with autosomal dominant, early-onset, familial Alzheimer's disease and result in increased release of…”
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role for clathrin in the sorting of vacuolar proteins in the Golgi complex of yeast by Seeger, M, Payne, G.S

“…We have investigated the role of clathrin in vacuolar protein sorting using yeast strains harboring a temperature-sensitive allele of clathrin heavy chain…”
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Involvement of Cell Surface Glycosyl-phosphatidylinositol-linked Aspartyl Proteases in α-Secretase-type Cleavage and Ectodomain Solubilization of Human Alzheimer β-Amyloid Precursor Protein in Yeast by Komano, Hiroto, Seeger, Mary, Gandy, Sam, Wang, Gary T., Krafft, Grant A., Fuller, Robert S.

“…Human β-amyloid precursor protein (APP) introduced into yeast undergoes α-secretase-type cleavage, suggesting that yeast have α-secretase-like protease(s)…”
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Selective and immediate effects of clathrin heavy chain mutations on golgi membrane protein retention in Saccharomyces cerevisiae by Seeger, M. (UCLA School of Medicine, Los Angeles, CA), Payne, G.S

“…The role of clathrin in retention of Golgi membrane proteins has been investigated. Prior work showed that a precursor form of the peptide mating pheromone…”
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The effects of clathrin inactivation on localization of Kex2 protease are independent of the TGN localization signal in the cytosolic tail of Kex2p by Redding, K, Seeger, M, Payne, G S, Fuller, R S

“…Localization of Kex2 protease (Kex2p) to the yeast trans-Golgi network (TGN) requires a TGN localization signal (TLS) in the Kex2p C-terminal cytosolic tail…”
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Generation of the amyloid-beta peptide N terminus in Saccharomyces cerevisiae expressing human Alzheimer's amyloid-beta precursor protein by Greenfield, J P, Xu, H, Greengard, P, Gandy, S, Seeger, M

“…The Alzheimer's amyloid-beta precursor protein (betaAPP) is a type 1 membrane-spanning protein from which the Alzheimer's disease amyloid-beta peptide (Abeta)…”
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Antibiotic Proteins of Human Polymorphonuclear Leukocytes by Gabay, Joelle E., Scott, Randy W., Campanelli, David, Griffith, Joe, Wilde, Craig, Marra, Marian N., Seeger, Mary, Nathan, Carl F.

“…Nine polypeptide peaks with antibiotic activity were resolved from human polymorphonuclear leukocyte azurophil granule membranes. All but 1 of the 12…”
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Generation of the Amyloid-β Peptide N Terminus inSaccharomyces cerevisiae Expressing Human Alzheimer's Amyloid-β Precursor Protein by Jeffrey P. Greenfield, Huaxi Xu, Paul Greengard, Sam Gandy, Mary Seeger

“…The Alzheimer's amyloid-β precursor protein (βAPP) is a type 1 membrane-spanning protein from which the Alzheimer's disease amyloid-β peptide (Aβ) is…”
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Generation of the Amyloid-β Peptide N Terminus inSaccharomyces cerevisiae Expressing Human Alzheimer's Amyloid-β Precursor Protein by Greenfield, Jeffrey P., Xu, Huaxi, Greengard, Paul, Gandy, Sam, Seeger, Mary

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Involvement of Cell Surface Glycosyl-phosphatidylinositol-linked Aspartyl Proteases in α-Secretase-type Cleavage and Ectodomain Solubilization of Human Alzheimer β-Amyloid Precursor Protein in Yeast by Hiroto Komano, Mary Seeger, Sam Gandy, Gary T. Wang, Grant A. Krafft, Robert S. Fuller

“…Human β-amyloid precursor protein (APP) introduced into yeast undergoes α-secretase-type cleavage, suggesting that yeast have α-secretase-like protease(s)…”
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Developmental expression of wild-type and mutant presenilin-1 in hippocampal neurons from transgenic mice: evidence for novel species-specific properties of human presenilin-1 by Lévesque, L, Annaert, W, Craessaerts, K, Mathews, P M, Seeger, M, Nixon, R A, Van Leuven, F, Gandy, S, Westaway, D, St George-Hyslop, P, De Strooper, B, Fraser, P E

“…Presenilins 1 (PS1) and 2 (PS2) are multispanning transmembrane proteins associated with familial Alzheimer disease (FAD). They are developmentally regulated,…”
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Clathrin-dependent Localization of alpha1,3 Mannosyltransferase to the Golgi Complex of Saccharomyces cerevisiae by Graham, Todd R, Seeger, Mary, Payne, Gregory S, MacKay, Vivian L, Emr, Scott D

“…Posstranslational modification of yeast glycoproteins with alpha1,3-linked mannose is initiated within a Golgi compartment analogous to the medial Golgi…”
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