Search Results - "Seeger, Markus"

Membrane transporter research in times of countless structures by Seeger, Markus A.

“…Structural biology has advanced our understanding of membrane proteins like no other scientific discipline in the past two decades and the number of high…”
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Structures of ABC transporters: handle with care by Lewinson, Oded, Orelle, Cédric, Seeger, Markus A.

“…In the past two decades, the ATP‐binding cassette (ABC) transporters' field has undergone a structural revolution. The importance of structural biology to the…”
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Critical discussion on drug efflux in Mycobacterium tuberculosis by Remm, Sille, Earp, Jennifer C, Dick, Thomas, Dartois, Véronique, Seeger, Markus A

“…Abstract Mycobacterium tuberculosis (Mtb) can withstand months of antibiotic treatment. An important goal of tuberculosis research is to shorten the treatment…”
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Structural basis for pH-dependent retrieval of ER proteins from the Golgi by the KDEL receptor by Bräuer, Philipp, Parker, Joanne L, Gerondopoulos, Andreas, Zimmermann, Iwan, Seeger, Markus A, Barr, Francis A, Newstead, Simon

“…Selective export and retrieval of proteins between the endoplasmic reticulum (ER) and Golgi apparatus is indispensable for eukaryotic cell function. An…”
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Crystal structure of a heterodimeric ABC transporter in its inward-facing conformation by Hohl, Michael, Briand, Christophe, Grütter, Markus G, Seeger, Markus A

“…TM287/288 is a heterodimeric ABC transporter found in Thermotoga maritima . The crystal structure of TM287/288 in the inward-facing AMP-PNP–bound state…”
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Electronically Controlled Dual‐Wavelength Switchable SRS Fiber Amplifier in the NIR‐II Region for Multispectral Photoacoustic Microscopy by Lee, Hwidon, Seeger, Markus R., Bouma, Brett E.

“…Photoacoustic microscopy (PAM) is a high‐resolution and non‐invasive imaging modality that provides optical absorption contrast. By employing dual‐ or…”
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Fatty acid transporter MFSD2A is a multifunctional gatekeeper in brain and placenta by Walter, Justin D., Remm, Sille, Seeger, Markus A.

“…MFSD2A mediates uptake of the essential fatty acid DHA across the blood–brain barrier. Separately, via interactions with syncytin-2, MFSD2A contributes to the…”
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From in vitro towards in situ: structure‐based investigation of ABC exporters by electron paramagnetic resonance spectroscopy by Bordignon, Enrica, Seeger, Markus A., Galazzo, Laura, Meier, Gianmarco

“…ATP‐binding cassette (ABC) exporters have been studied now for more than four decades, and recent structural investigation has produced a large number of…”
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Synthetic single domain antibodies for the conformational trapping of membrane proteins by Zimmermann, Iwan, Egloff, Pascal, Hutter, Cedric Aj, Arnold, Fabian M, Stohler, Peter, Bocquet, Nicolas, Hug, Melanie N, Huber, Sylwia, Siegrist, Martin, Hetemann, Lisa, Gera, Jennifer, Gmür, Samira, Spies, Peter, Gygax, Daniel, Geertsma, Eric R, Dawson, Roger Jp, Seeger, Markus A

“…Mechanistic and structural studies of membrane proteins require their stabilization in specific conformations. Single domain antibodies are potent reagents for…”
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Selection, biophysical and structural analysis of synthetic nanobodies that effectively neutralize SARS-CoV-2 by Custódio, Tânia F., Das, Hrishikesh, Sheward, Daniel J., Hanke, Leo, Pazicky, Samuel, Pieprzyk, Joanna, Sorgenfrei, Michèle, Schroer, Martin A., Gruzinov, Andrey Yu, Jeffries, Cy M., Graewert, Melissa A., Svergun, Dmitri I., Dobrev, Nikolay, Remans, Kim, Seeger, Markus A., McInerney, Gerald M., Murrell, Ben, Hällberg, B. Martin, Löw, Christian

“…The coronavirus SARS-CoV-2 is the cause of the ongoing COVID-19 pandemic. Therapeutic neutralizing antibodies constitute a key short-to-medium term approach to…”
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Structural insights into Legionella RidL-Vps29 retromer subunit interaction reveal displacement of the regulator TBC1D5 by Bärlocher, Kevin, Hutter, Cedric A. J., Swart, A. Leoni, Steiner, Bernhard, Welin, Amanda, Hohl, Michael, Letourneur, François, Seeger, Markus A., Hilbi, Hubert

“…Legionella pneumophila can cause Legionnaires’ disease and replicates intracellularly in a distinct Legionella -containing vacuole (LCV). LCV formation is a…”
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Structural insights into the inhibition of glycine reuptake by Shahsavar, Azadeh, Stohler, Peter, Bourenkov, Gleb, Zimmermann, Iwan, Siegrist, Martin, Guba, Wolfgang, Pinard, Emmanuel, Sinning, Steffen, Seeger, Markus A., Schneider, Thomas R., Dawson, Roger J. P., Nissen, Poul

“…The human glycine transporter 1 (GlyT1) regulates glycine-mediated neuronal excitation and inhibition through the sodium- and chloride-dependent reuptake of…”
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Label-free metabolic imaging by mid-infrared optoacoustic microscopy in living cells by Pleitez, Miguel A., Khan, Asrar Ali, Soldà, Alice, Chmyrov, Andriy, Reber, Josefine, Gasparin, Francesca, Seeger, Markus R., Schätz, Benedikt, Herzig, Stephan, Scheideler, Marcel, Ntziachristos, Vasilis

“…We develop mid-infrared optoacoustic microscopy (MiROM) for label-free, bond-selective, live-cell metabolic imaging, enabling spatiotemporal monitoring of…”
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Overdriven laser diode optoacoustic microscopy by Seeger, Markus, Stylogiannis, Antonios, Prade, Ludwig, Glasl, Sarah, Ntziachristos, Vasilis

“…Laser diodes are small and inexpensive but don’t afford the pulse energy and beam profile required for optoacoustic (photoacoustic) microscopy. Using two novel…”
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A synthetic nanobody targeting RBD protects hamsters from SARS-CoV-2 infection by Li, Tingting, Cai, Hongmin, Yao, Hebang, Zhou, Bingjie, Zhang, Ning, van Vlissingen, Martje Fentener, Kuiken, Thijs, Han, Wenyu, GeurtsvanKessel, Corine H., Gong, Yuhuan, Zhao, Yapei, Shen, Quan, Qin, Wenming, Tian, Xiao-Xu, Peng, Chao, Lai, Yanling, Wang, Yanxing, Hutter, Cedric A. J., Kuo, Shu-Ming, Bao, Juan, Liu, Caixuan, Wang, Yifan, Richard, Audrey S., Raoul, Hervé, Lan, Jiaming, Seeger, Markus A., Cong, Yao, Rockx, Barry, Wong, Gary, Bi, Yuhai, Lavillette, Dimitri, Li, Dianfan

“…SARS-CoV-2, the causative agent of COVID-19 1 , features a receptor-binding domain (RBD) for binding to the host cell ACE2 protein 1 – 6 . Neutralizing…”
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Generation of synthetic nanobodies against delicate proteins by Zimmermann, Iwan, Egloff, Pascal, Hutter, Cedric A. J., Kuhn, Benedikt T., Bräuer, Philipp, Newstead, Simon, Dawson, Roger J. P., Geertsma, Eric R., Seeger, Markus A.

“…Here, we provide a protocol to generate synthetic nanobodies, known as sybodies, against any purified protein or protein complex within a 3-week period. Unlike…”
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Transport of drugs by the multidrug transporter AcrB involves an access and a deep binding pocket that are separated by a switch-loop by Eicher, Thomas, Cha, Hi-jea, Seeger, Markus A, Brandstätter, Lorenz, El-Delik, Jasmin, Bohnert, Jürgen A, Kern, Winfried V, Verrey, François, Grütter, Markus G, Diederichs, Kay, Pos, Klaas M

“…AcrAB-TolC is the major efflux protein complex in Escherichia coli extruding a vast variety of antimicrobial agents from the cell. The inner membrane component…”
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The ABC exporter IrtAB imports and reduces mycobacterial siderophores by Arnold, Fabian M., Weber, Miriam S., Gonda, Imre, Gallenito, Marc J., Adenau, Sophia, Egloff, Pascal, Zimmermann, Iwan, Hutter, Cedric A. J., Hürlimann, Lea M., Peters, Eike E., Piel, Jörn, Meloni, Gabriele, Medalia, Ohad, Seeger, Markus A.

“…Intracellular replication of the deadly pathogen Mycobacterium tuberculosis relies on the production of small organic molecules called siderophores that…”
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Structural basis for allosteric cross-talk between the asymmetric nucleotide binding sites of a heterodimeric ABC exporter by Hohl, Michael, Hürlimann, Lea M., Böhm, Simon, Schöppe, Jendrik, Grütter, Markus G., Bordignon, Enrica, Seeger, Markus A.

“…ATP binding cassette (ABC) transporters mediate vital transport processes in every living cell. ATP hydrolysis, which fuels transport, displays positive…”
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Interdomain-linkers control conformational transitions in the SLC23 elevator transporter UraA by Kuhn, Benedikt T., Zöller, Jonathan, Zimmermann, Iwan, Gemeinhardt, Tim, Özkul, Dogukan H., Langer, Julian D., Seeger, Markus A., Geertsma, Eric R.

“…Uptake of nucleobases and ascorbate is an essential process in all living organisms mediated by SLC23 transport proteins. These transmembrane carriers operate…”
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